Abstract:
INTRODUCTION:Ambient air pollution is a global environmental problem, which causes adverse health effects and premature deaths worldwide. Although regular exercise and physical activity have evident health benefits, the influence of long-term air pollution exposure during regular outdoor running has not been definitively clarified. METHODS AND ANALYSIS:This study protocol describes the physiological and anthropometric perspectives of the 'Healthy Aging in Industrial Environment' Study - Programme 4 (4HAIE). The 4HAIE research project is intended to be a single-centre, prospective, longitudinal and multidisciplinary cohort study. The presented study protocol describes the cross-sectional measurements and analyses. Overall, 1500 adult participants (age 18-65 years), runners and inactive individuals, living in a high or low air-polluted area of the Czech Republic will be recruited. We will measure and analyse biomarkers of oxidative stress and inflammation in the blood, exercise capacity (graded exercise test and spiroergometry), blood pressure, lung function (spirometry), cardiac autonomic regulation and anthropometry (body composition). ETHICS AND DISSEMINATION:The 4HAIE study protocol has already been approved by the Ethics Committee of the University of Ostrava (3/2018). A detailed participant information sheet will be provided to each individual prior to obtaining their written informed consent. The study poses little to no risk to participants. The findings of this study will be disseminated at regional and international conferences, in peer-reviewed journals and via social and broadcast media.
journal_name
BMJ Openjournal_title
BMJ openauthors
Cipryan L,Kutac P,Dostal T,Zimmermann M,Krajcigr M,Jandackova V,Sram R,Jandacka D,Hofmann Pdoi
10.1136/bmjopen-2020-040529subject
Has Abstractpub_date
2020-12-10 00:00:00pages
e040529issue
12issn
2044-6055pii
bmjopen-2020-040529journal_volume
10pub_type
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