Abstract:
BACKGROUND:There is no consensus on the therapeutic approach to ECOG 2 patients with locally advanced non-small-cell lung cancer (LA-NSCLC), despite the sizable percentage of these patients in clinical practice. This study focused on the efficacy, toxicity and the optimal chemotherapy regimen of CCRT in ECOG 2 patients in a phase III trial. METHODS:Patients capable of all self-care with bed rest for less than 50% of daytime were classified as ECOG 2 subgroup. A subgroup analysis was performed for ECOG 2 patients recruited in the phase III trial receiving concurrent EP (etoposide + cisplatin)/PC (paclitaxel + carboplatin) chemotherapy with intensity-modulated radiation therapy (IMRT) or three-dimensional conformal external beam radiation therapy (3D-CRT). RESULTS:A total of 71 ECOG 2 patients were enrolled into the study. Forty-six (64.8%) patients were treated with IMRT technique. The median overall survival (OS) and progression free survival (PFS) for ECOG 2 patients were 16.4 months and 9 months, respectively. No difference was observed in treatment compliance and toxicities between ECOG 2 patients and ECOG 0-1 patients. Within the ECOG 2 group (31 in the EP arm and 40 in the PC arm), median OS and 3-year OS were 15.7 months and 37.5% for the EP arm, and 16.8 months and 7.5% for the PC arm, respectively (p = 0.243). The incidence of grade ≥ 3 radiation pneumonitis was higher in the PC arm (17.5% vs. 0.0%, p = 0.014) with 5 radiation pneumonitis related deaths, while the incidence of grade 3 esophagitis was numerically higher in the EP arm (25.8% vs. 10.0%, p = 0.078). CONCLUSIONS:CCRT provided ECOG 2 patients promising outcome with acceptable toxicities. EP might be superior to PC in terms of safety profile in the setting of CCRT for ECOG 2 patients. Prospective randomized studies based on IMRT technique are warranted to validate our findings. TRIAL REGISTRATION:ClinicalTrials.gov registration number: NCT01494558. (Registered 19 December 2011).
journal_name
BMC Cancerjournal_title
BMC cancerauthors
Bi N,Liu L,Liang J,Wu S,Chen M,Lv C,Zhao L,Shi A,Jiang W,Xu Y,Zhou Z,Wang J,Wang W,Chen D,Hui Z,Lv J,Zhang H,Feng Q,Xiao Z,Wang X,Zhang T,Yin W,Li J,He J,Wang Ldoi
10.1186/s12885-020-06780-xsubject
Has Abstractpub_date
2020-04-06 00:00:00pages
278issue
1issn
1471-2407pii
10.1186/s12885-020-06780-xjournal_volume
20pub_type
杂志文章相关文献
BMC CANCER文献大全abstract:BACKGROUND:Thyroid transcription factor (TTF)-1 expression is a diagnostic marker and a good prognostic indicator for lung adenocarcinoma. However, its good prognostic ability might be due to epidermal growth factor receptor (EGFR)-sensitizing mutations as shown by the positive correlation between TTF-1 expression and ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5792-0
更新日期:2019-06-13 00:00:00
abstract:BACKGROUND:Early diagnosis is important for the timely treatment of gallbladder carcinoma (GBC) patients and may lead to increased survival outcomes. Here, we have applied serological proteome analysis (SERPA), an immunoproteomics approach, for the detection of 'tumor-associated antigens (TAAs) that elicit humoral resp...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-07676-6
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:In order to maximize later health, there are established components and guidelines for quality follow-up care of breast cancer survivors. However, adherence to quality follow-up in Canada may not be optimal, and may vary by province. We determined and compared the proportion of patients in each province who ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5882-z
更新日期:2019-07-04 00:00:00
abstract:BACKGROUND:The majority of patients undergoing hepatectomy for hepatocellular carcinoma (HCC) suffer from underlying liver disease and are exposed to the risk of postoperative ascites, which is favored by an imbalance between portal venous inflow and a diminished hepatic volume. Finding a reversible, non-invasive metho...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12885-018-4667-0
更新日期:2018-08-23 00:00:00
abstract:BACKGROUND:Tumor associated macrophages (TAMs) are alternatively activated macrophages that enhance tumor progression by promoting tumor cell invasion, migration and angiogenesis. TAMs have an anti-inflammatory function resembling M2 macrophages. CD163 is regarded as a highly specific monocyte/macrophage marker for M2 ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-306
更新日期:2012-07-23 00:00:00
abstract:BACKGROUND:Utilisation of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and guide sheath (EBUS-GS) for diagnosis and staging of lung cancer is gaining popularity, however, its impact on clinical practice is unclear. This study aimed to determine the impact of the introduction of endobronc...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-016-2081-z
更新日期:2016-01-28 00:00:00
abstract:BACKGROUND:Ovarian cancer is the leading cause of death among gynecologic diseases in Western countries. We have previously identified a miR-200-E-cadherin axis that plays an important role in ovarian inclusion cyst formation and tumor invasion. The purpose of this study was to determine if the miR-200 pathway is invol...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3417-z
更新日期:2017-06-17 00:00:00
abstract:BACKGROUND:Inducible nitric oxide synthase (iNOS) metabolizes L-arginine to produce nitric oxide (NO) which was originally identified in myeloid cells as a host defense mechanism against pathogens. Recent studies, however, have revealed that iNOS is often induced in tumor cells and myeloid cells in the tumor microenvir...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1808-6
更新日期:2015-10-23 00:00:00
abstract:BACKGROUND:Pancreatic paragangliomas are rare tumors, with only 16 reported cases to date. One of these cases demonstrates metastasis to lymph node, while another case was functional, however, none of these cases showed malignant and large, pancreatic paraganglioma with marked invasion. Also another unique feature was ...
journal_title:BMC cancer
pub_type: 杂志文章,评审
doi:10.1186/1471-2407-13-486
更新日期:2013-10-20 00:00:00
abstract:BACKGROUND:Microvascular invasion (MVI) is recognized as a prognostic factor associated with poor outcome in hepatocellular carcinoma (HCC) patients after curative resection. It remains unclear, however, whether MVI can provide prognostic information for patients at a specific tumor stage. METHODS:Consecutive HCC pati...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3050-x
更新日期:2017-01-17 00:00:00
abstract:BACKGROUND:Cell-surface glycoproteins play critical roles in cell-to-cell recognition, signal transduction and regulation, thus being crucial in cell proliferation and cancer etiogenesis and development. DPP IV and NEP are ubiquitous glycopeptidases closely linked to tumor pathogenesis and development, and they are use...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-193
更新日期:2010-05-11 00:00:00
abstract:BACKGROUND:Mammalian target of rapamycin (mTOR) inhibitors have anti-tumor effects against renal cell carcinoma, pancreatic neuroendocrine cancer and breast cancer. In this study, we analyzed the antitumor effects of mTOR inhibitors in small cell lung cancer (SCLC) cells and sought to clarify the mechanism of resistanc...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1202-4
更新日期:2015-04-09 00:00:00
abstract:BACKGROUND:Clear cell carcinomas are aggressive tumors with a distinct biologic behaviour. In a genome-wide screening for genes involved in chemo-resistance, NAPA was over-expressed in cisplatin-resistant cells. The NAPA (protein) Napsin A was described to promote resistance to cisplatin by degradation of the tumor sup...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-13-524
更新日期:2013-11-05 00:00:00
abstract:BACKGROUND:Adoptive T-cell therapy relying on conventional T cells transduced with T-cell receptors (TCRs) or chimeric antigen receptors (CARs) has caused substantial tumor regression in several clinical trials. However, genetically engineered T cells have been associated with serious side-effects due to off-target tox...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3539-3
更新日期:2017-08-17 00:00:00
abstract:BACKGROUND:The inflammatory chemokines CCL2 (MCP-1) & CCL5 (RANTES) and the inflammatory cytokines TNFα & IL-1β were shown to contribute to breast cancer development and metastasis. In this study, we wished to determine whether there are associations between these factors along stages of breast cancer progression, and ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-11-130
更新日期:2011-04-12 00:00:00
abstract:BACKGROUND:Genistein has been known to inhibit proliferation and induce apoptosis in several kinds of cancer cells. While knowledge of genistein in regulating epithelial mesenchymal transition (EMT) of colon cancer cells is unknown. METHODS:To investigate the effects and mechanisms of genistein on EMT of colon cancer ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-017-3829-9
更新日期:2017-12-04 00:00:00
abstract:BACKGROUND:Several stromal cell subtypes including macrophages contribute to tumor progression by inducing epithelial-mesenchymal transition (EMT) at the invasive front, a mechanism also linked to metastasis. Tumor associated macrophages (TAM) reside mainly at the invasive front but they also infiltrate tumors and in t...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-35
更新日期:2012-01-24 00:00:00
abstract:BACKGROUND:Acute myeloid leukemia (AML) is a heterogenic lethal disorder characterized by the accumulation of abnormal myeloid progenitor cells in the bone marrow which results in hematopoietic failure. Despite various efforts in detection and treatment, many patients with AML die of this cancer. That is why it is impo...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-020-06903-4
更新日期:2020-05-18 00:00:00
abstract::Following publication of the original article [1], the authors reported the following error is the article. ...
journal_title:BMC cancer
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12885-019-6367-9
更新日期:2019-11-29 00:00:00
abstract:BACKGROUND:The causal association between persistent human papillomavirus (HPV) infection and cervical cancer has been established, but the mechanisms that favor HPV persistence in cervical cells are still unknown. The diminished capability of the immune system to control and resolve HPV infection is one of several hyp...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-618
更新日期:2012-12-24 00:00:00
abstract:BACKGROUND:To investigate on expressions and clinical significances of CD133 protein and vasculogenic mimicry (VM) in primary non-small cell lung cancer (NSCLC). METHODS:The specimens of NSCLC from 305 Chinese patients with follow-up were analyzed for CD133 protein expression and VM by immunohistochemical and histoche...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-12-535
更新日期:2012-11-21 00:00:00
abstract:BACKGROUND:Ovarian epithelial cancer (OEC) usually presents in the later stages of the disease. Factors, especially those associated with cell-cycle genes, affecting the genesis and tumour progression for ovarian cancer are largely unknown. We hypothesized that over-expressed transcription factors (TFs), as well as tho...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-10-64
更新日期:2010-02-24 00:00:00
abstract:BACKGROUND:We describe a patient who underwent transurethral resection of the prostate for urinary obstructive symptoms and had histological findings of adenocarcinoma of the prostate with prostatic localization of chronic lymphocitic leukemia (CLL). The contemporary presence of CLL, adenocarcinoma of the prostate and ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-4-95
更新日期:2004-12-22 00:00:00
abstract:BACKGROUND:Clinical studies implying the sunitinib multi-kinase inhibitor have led to disappointing results for breast cancer care but mostly focused on HER2-negative subtypes. Preclinical researches involving this drug mostly concern Triple Negative Breast Cancer (TNBC) murine models. Here, we explored the therapeutic...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-015-1540-2
更新日期:2015-07-22 00:00:00
abstract:BACKGROUND:Pseudomyogenic hemangioendothelioma (PMHE) is a rare endothelial neoplasm that involves the bones in only 14% of all cases. The optimal treatment strategy has not been established. We herein report a case of primary PMHE in which denosumab treatment showed activity in both imaging studies and the clinical ou...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-6072-8
更新日期:2019-09-03 00:00:00
abstract:BACKGROUND:Whether chronic inflammation increases prostate cancer risk remains unclear. This study investigated whether chronic inflammatory diseases (CID) or anti-inflammatory medication use (AIM) were associated with prostate cancer risk. METHODS:Fifty-five thousand nine hundred thirty-seven cases (all prostate canc...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-019-5846-3
更新日期:2019-06-21 00:00:00
abstract:BACKGROUND:Infection with human papillomavirus (HPV) is necessary for the development of cervical carcinoma. By contrast, the role of HPV in the pathogenesis of other malignancies, such as head and neck cancers, is less well characterised. This study aimed to address key information gaps by conducting a systematic revi...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1471-2407-14-968
更新日期:2014-12-17 00:00:00
abstract:BACKGROUND:Ameloblastomas are odontogenic neoplasms characterized by local invasiveness. This study was conducted to address the role of matrix metalloproteinase-2 (MMP-2) in the invasiveness of ameloblastomas. METHODS:Plasmids containing either MMP-2 siRNA or tissue inhibitor of metalloproteinase-2 (TIMP-2) cDNA were...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/1471-2407-8-182
更新日期:2008-06-30 00:00:00
abstract:BACKGROUND:Median OS after surgery in curative intent for non-metastasized pancreas cancer ranges under study conditions from 17.9 months to 23.6 months. Tumor recurrence occurs locally, at distant sites (liver, peritoneum, lungs), or both. Observational and autopsy series report local recurrence rates of up to 87% eve...
journal_title:BMC cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-2407-14-411
更新日期:2014-06-07 00:00:00
abstract:BACKGROUND:Well-designed clinical trials are of great importance in validating novel treatments and ensuring an evidence-based approach for sarcoma. This study aimed to provide a comprehensive landscape of the characteristics of metastatic or advanced sarcoma clinical trials using the substantial resource of the Clinci...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-018-5163-2
更新日期:2018-12-13 00:00:00