Spatio-temporal dynamics of EEG features during sleep in major depressive disorder after treatment with escitalopram: a pilot study.

Abstract:

BACKGROUND:Previous studies have shown escitalopram is related to sleep quality. However, effects of escitalopram on dynamics of electroencephalogram (EEG) features especially during different sleep stages have not been reported. This study may help to reveal pharmacological mechanism underlying escitalopram treatment. METHODS:The spatial and temporal responses of patients with major depressive disorder (MDD) to escitalopram treatment were analyzed in this study. Eleven MDD patients and eleven healthy control subjects who completed eight weeks' treatment of escitalopram were included in the final statistics. Six-channel sleep EEG signals were acquired during sleep. Power spectrum and nonlinear dynamics were used to analyze the spatio-temporal dynamics features of the sleep EEG after escitalopram treatment. RESULTS:For temporal dynamics: after treatment, there was a significant increase in the relative energy (RE) of δ1 band (0.5 - 2 Hz), accompanied by a significant decrease in the RE of β2 band (20 - 30 Hz). Lempel-Ziv complexity and Co - complexity values were significantly lower. EEG changes at different sleep stages also showed the same regulation as throughout the night sleep. For spatio dynamics: after treatment, the EEG response of the left and right hemisphere showed asymmetry. Regarding band-specific EEG complexity estimations, δ1 and β2 in stage-1 and δ1 in stage-2 sleep stage in frontal cortex is found to be much more sensitive to escitalopram treatment in comparison to central and occipital cortices. CONCLUSIONS:The sleep quality of MDD patients improved, EEG response occurred asymmetry in left and right hemispheres due to escitalopram treatment, and frontal cortex is found to be much more sensitive to escitalopram treatment. These findings may contribute to a comprehensive understanding of the pharmacological mechanism of escitalopram in the treatment of depression.

journal_name

BMC Psychiatry

journal_title

BMC psychiatry

authors

Wu L,Wang XQ,Yang Y,Dong TF,Lei L,Cheng QQ,Li SX

doi

10.1186/s12888-020-02519-x

subject

Has Abstract

pub_date

2020-03-14 00:00:00

pages

124

issue

1

issn

1471-244X

pii

10.1186/s12888-020-02519-x

journal_volume

20

pub_type

临床试验,杂志文章
  • The prevalence and burden of subthreshold generalized anxiety disorder: a systematic review.

    abstract:BACKGROUND:To review the prevalence and impact of generalized anxiety disorder (GAD) below the diagnostic threshold and explore its treatment needs in times of scarce healthcare resources. METHODS:A systematic literature search was conducted until January 2013 using PUBMED/MEDLINE, PSYCINFO, EMBASE and reference lists...

    journal_title:BMC psychiatry

    pub_type: 杂志文章,评审

    doi:10.1186/1471-244X-14-128

    authors: Haller H,Cramer H,Lauche R,Gass F,Dobos GJ

    更新日期:2014-05-01 00:00:00

  • Who is actually asked about their mental health in pregnancy and the postnatal period? Findings from a national survey.

    abstract:BACKGROUND:Pregnancy and the postnatal period is a period of potential vulnerability for women and families. It is UK policy that all women are asked about their mental health and wellbeing early in pregnancy and following the birth to help detect potential problems and prevent serious adverse outcome. However, identif...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/s12888-016-1029-9

    authors: Redshaw M,Henderson J

    更新日期:2016-09-15 00:00:00

  • A case study of suicidality presenting as a restricted interest in autism Spectrum disorder.

    abstract:BACKGROUND:Suicidality has been under-researched in autism spectrum disorders (ASD). Most studies have linked increased suicidality in ASD to psychiatric comorbidities such as depression. Here we investigated, from a neuropsychological and clinical standpoint, the relationship between core ASD symptoms, i.e., restricte...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/s12888-019-2122-7

    authors: Weiner L,Flin A,Causin JB,Weibel S,Bertschy G

    更新日期:2019-04-27 00:00:00

  • Does Chinese calligraphy therapy reduce neuropsychiatric symptoms: a systematic review and meta-analysis.

    abstract:BACKGROUND:There are currently no systematic reviews or meta-analyses of Chinese calligraphy therapy (CCT) to reduce neuropsychiatric symptoms. The aim of this systematic review and meta-analysis was to explore the efficacy of CCT for people with neuropsychiatric symptoms. METHODS:We searched Chinese and English datab...

    journal_title:BMC psychiatry

    pub_type: 杂志文章,meta分析,评审

    doi:10.1186/s12888-018-1611-4

    authors: Chu KY,Huang CY,Ouyang WC

    更新日期:2018-03-07 00:00:00

  • Psychiatric stigma and discrimination in South Africa: perspectives from key stakeholders.

    abstract:BACKGROUND:Stigma and discrimination against people with mental illness remain barriers to help seeking and full recovery for people in need of mental health services. Yet there is scarce research investigating the experiences of psychiatric stigma on mental health service users in low- and middle-income countries (LMI...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/1471-244X-14-191

    authors: Egbe CO,Brooke-Sumner C,Kathree T,Selohilwe O,Thornicroft G,Petersen I

    更新日期:2014-07-04 00:00:00

  • Treatment for illegal drug use disorders: the role of comorbid mood and anxiety disorders.

    abstract:BACKGROUND:Our aim was to examine whether comorbid mood and anxiety disorders influence patterns of treatment or the perceived unmet need for treatment among those not receiving treatment for illegal drug use disorders. METHODS:Data came from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC,...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/1471-244X-14-89

    authors: Melchior M,Prokofyeva E,Younès N,Surkan PJ,Martins SS

    更新日期:2014-03-26 00:00:00

  • Paris MEM: a study protocol for an effectiveness and efficiency trial on the treatment of traumatic stress in France after the 2015-16 terrorist attacks.

    abstract:BACKGROUND:The Paris and Nice terrorist attacks affected a thousand of trauma victims and first-line responders. Because there were concerns that this might represent the first of several attacks, there was a need to quickly enhance the local capacities to treat a large number of individuals suffering from trauma-relat...

    journal_title:BMC psychiatry

    pub_type: 历史文章,杂志文章,多中心研究

    doi:10.1186/s12888-019-2283-4

    authors: Brunet A,Ayrolles A,Gambotti L,Maatoug R,Estellat C,Descamps M,Girault N,Kalalou K,Abgrall G,Ducrocq F,Vaiva G,Jaafari N,Krebs MO,Castaigne E,Hanafy I,Benoit M,Mouchabac S,Cabié MC,Guillin O,Hodeib F,Durand-Zalesk

    更新日期:2019-11-08 00:00:00

  • White matter integrity in individuals at ultra-high risk for psychosis: a systematic review and discussion of the role of polyunsaturated fatty acids.

    abstract:BACKGROUND:Schizophrenia is thought to be a neurodevelopmental disorder with pathophysiological processes beginning in the brain prior to the emergence of clinical symptoms. Recent evidence from neuroimaging studies using techniques such as diffusion tensor imaging has identified white matter abnormalities that are sug...

    journal_title:BMC psychiatry

    pub_type: 杂志文章,评审

    doi:10.1186/s12888-016-0932-4

    authors: Vijayakumar N,Bartholomeusz C,Whitford T,Hermens DF,Nelson B,Rice S,Whittle S,Pantelis C,McGorry P,Schäfer MR,Amminger GP

    更新日期:2016-08-11 00:00:00

  • Characterizing the experience of agitation in patients with bipolar disorder and schizophrenia.

    abstract:BACKGROUND:Agitation is a common manifestation of bipolar disorder and schizophrenia which includes symptoms ranging from inner tension and unease to violence and aggression. Much of the existing literature has focused on agitation in the acute setting, with the patient experience poorly defined. Thus, the aim of this ...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/s12888-018-1673-3

    authors: Roberts J,Gracia Canales A,Blanthorn-Hazell S,Craciun Boldeanu A,Judge D

    更新日期:2018-04-16 00:00:00

  • Universality of interpersonal psychotherapy (IPT) problem areas in Thai depressed patients.

    abstract:BACKGROUND:Many studies have shown the efficacy of interpersonal psychotherapy (IPT) on depression; however, there are limited studies concerning the universality of the IPT problem areas in different countries. This study identifies whether the interpersonal problem areas defined in the IPT manual are endorsed by Thai...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/1471-244X-10-87

    authors: Lueboonthavatchai P,Thavichachart N

    更新日期:2010-10-21 00:00:00

  • Treatment recommendations made by a consultant psychiatrist to improve the quality of care in a collaborative mental health intervention in rural Nepal.

    abstract:BACKGROUND:The Collaborative Care Model (CoCM) for mental healthcare, where a consulting psychiatrist supports primary care and behavioral health workers, has the potential to address the large unmet burden of mental illness worldwide. A core component of this model is that the psychiatrist reviews treatment plans for ...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/s12888-020-2464-1

    authors: Rimal P,Maru D,Chwastiak L,Agrawal P,Rao D,Swar S,Citrin D,Acharya B

    更新日期:2020-02-05 00:00:00

  • Training community mental health staff in Guangzhou, China: evaluation of the effect of a new training model.

    abstract:BACKGROUND:Increasing numbers of people with mental disorders receive services at primary care in China. The aims of this study are to evaluate impact of a new training course and supervision for community mental health staff to enhance their levels of mental health knowledge and to reduce their stigmatization toward p...

    journal_title:BMC psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12888-015-0660-1

    authors: Li J,Li J,Thornicroft G,Yang H,Chen W,Huang Y

    更新日期:2015-10-26 00:00:00

  • Characteristics, motivations and experiences of volunteer befrienders for people with mental illness: a systematic review and narrative synthesis.

    abstract:BACKGROUND:The literature suggests that many people in the general population tend to distance themselves from those with mental illness. However, there are volunteers that behave differently, spending their free time with people with mental illness and providing direct input in the form of befriending. Whilst there ar...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/s12888-018-1960-z

    authors: Toner S,Hickling LM,Pinto da Costa M,Cassidy M,Priebe S

    更新日期:2018-12-04 00:00:00

  • Depressive symptoms and negative life events: What psycho-social factors protect or harm left-behind children in China?

    abstract:BACKGROUND:In China, children under 18 years old who are left at rural residences for at least 6 months by either one or both of their parents migrating to work in cities are called "left-behind children (LBC)". Due to restricted family support, they are at a greater risk of developing depressive symptoms than non-left...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/s12888-017-1554-1

    authors: Guang Y,Feng Z,Yang G,Yang Y,Wang L,Dai Q,Hu C,Liu K,Zhang R,Xia F,Zhao M

    更新日期:2017-12-15 00:00:00

  • Factors and predictors of length of stay in offenders diagnosed with schizophrenia - a machine-learning-based approach.

    abstract:BACKGROUND:Prolonged forensic psychiatric hospitalizations have raised ethical, economic, and clinical concerns. Due to the confounded nature of factors affecting length of stay of psychiatric offender patients, prior research has called for the application of a new statistical methodology better accommodating this dat...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/s12888-020-02612-1

    authors: Kirchebner J,Günther MP,Sonnweber M,King A,Lau S

    更新日期:2020-05-06 00:00:00

  • Predictors of psychiatric hospitalization during 6 months of maintenance treatment with olanzapine long-acting injection: post hoc analysis of a randomized, double-blind study.

    abstract:BACKGROUND:Hospitalization is a costly and distressing event associated with relapse during schizophrenia treatment. No information is available on the predictors of psychiatric hospitalization during maintenance treatment with olanzapine long-acting injection (olanzapine-LAI) or how the risk of hospitalization differs...

    journal_title:BMC psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1471-244X-13-224

    authors: Ascher-Svanum H,Novick D,Haro JM,Bertsch J,McDonnell D,Detke H

    更新日期:2013-09-16 00:00:00

  • Problematic internet use in children and adolescents: associations with psychiatric disorders and impairment.

    abstract:BACKGROUND:Problematic internet use (PIU) is an increasingly worrisome issue, as youth population studies are establishing links with internalizing and externalizing problems. There is a need for a better understanding of psychiatric diagnostic profiles associated with this issue, as well as its unique contributions to...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/s12888-020-02640-x

    authors: Restrepo A,Scheininger T,Clucas J,Alexander L,Salum GA,Georgiades K,Paksarian D,Merikangas KR,Milham MP

    更新日期:2020-05-27 00:00:00

  • Service user views of spiritual and pastoral care (chaplaincy) in NHS mental health services: a co-produced constructivist grounded theory investigation.

    abstract:BACKGROUND:Within the UK National Health Service (NHS), Spiritual and Pastoral Care (SPC) Services (chaplaincies) have not traditionally embraced research due to the intangible nature of their work. However, small teams like SPC can lead the way towards services across the NHS becoming patient- centred and patient-led....

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/s12888-016-0903-9

    authors: Raffay J,Wood E,Todd A

    更新日期:2016-06-17 00:00:00

  • Weight management in a cohort of Irish inpatients with serious mental illness (SMI) using a modular behavioural programme. A preliminary service evaluation.

    abstract:BACKGROUND:Weight gain is commonly observed during psychotropic treatments for chronic forms of severe mental illness and is most rapid during the early treatment phases. All formats of behavioural weight intervention programmes have suggested that weight gain can be prevented or reversed in some patients. There is no ...

    journal_title:BMC psychiatry

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1471-244X-8-76

    authors: Bushe CJ,McNamara D,Haley C,McCrossan MF,Devitt P

    更新日期:2008-09-15 00:00:00

  • Long-term psychiatric inpatients' perspectives on weight gain, body satisfaction, diet and physical activity: a mixed methods study.

    abstract:BACKGROUND:Obesity is a significant problem for people with serious mental illness. We aimed to consider body size from the perspective of long-stay psychiatric inpatients, focussing on: weight gain and its causes and impacts; diet and physical activity; and the perceived ability to make meaningful change in these doma...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/s12888-018-1878-5

    authors: Every-Palmer S,Huthwaite MA,Elmslie JL,Grant E,Romans SE

    更新日期:2018-09-18 00:00:00

  • Depression, risk factors, and coping strategies in the context of social dislocations resulting from the second wave of COVID-19 in Japan.

    abstract:BACKGROUND:Social dislocations resulting from coronavirus disease 2019 (COVID-19) pandemic have been prolonged, which has led to general population social suppression. The present study aimed to reveal risk factors associated with mental health problems and suggest concrete coping strategies in the context of COVID-19....

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/s12888-021-03047-y

    authors: Fukase Y,Ichikura K,Murase H,Tagaya H

    更新日期:2021-01-12 00:00:00

  • The co-administration of quetiapine or placebo to cognitive-behavior therapy in treatment refractory depression: a preliminary trial.

    abstract:BACKGROUND:Patients with major depression refractory to repeated pharmacological trials (TRD) may remain symptomatic for many years after their index episode. Augmentation strategies (with lithium or an atypical antipsychotic) or combining an antidepressant with short-term psychotherapy have been used with relative suc...

    journal_title:BMC psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1471-244X-8-73

    authors: Chaput Y,Magnan A,Gendron A

    更新日期:2008-08-28 00:00:00

  • Association of various reproductive rights, domestic violence and marital rape with depression among Pakistani women.

    abstract:BACKGROUND:Depression among women is common in developing countries. Gender inequality can contribute to women's risk for depression. Lack of reproductive and sexual rights is an important marker of gender inequality and women do not have the freedom to express their reproductive and sexual needs in many parts of the w...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/1471-244X-9-77

    authors: Ali FA,Israr SM,Ali BS,Janjua NZ

    更新日期:2009-12-01 00:00:00

  • Investigating the (cost-) effectiveness of attention bias modification (ABM) for outpatients with major depressive disorder (MDD): a randomized controlled trial protocol.

    abstract:BACKGROUND:Despite the range of available, evidence-based treatment options for Major Depressive Disorder (MDD), the rather low response and remission rates suggest that treatment is not optimal, yet. Computerized attention bias modification (ABM) trainings may have the potential to be provided as cost-effective interv...

    journal_title:BMC psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12888-016-1085-1

    authors: Ferrari GR,Becker ES,Smit F,Rinck M,Spijker J

    更新日期:2016-11-03 00:00:00

  • Posttraumatic growth following a first episode of psychosis: a mixed methods research protocol using a convergent design.

    abstract:BACKGROUND:The suffering people experience following a first episode of psychosis is great, and has been well-investigated. Conversely, potential positive outcomes following a first episode of psychosis have been under-investigated. One such outcome that may result from a first episode of psychosis is posttraumatic gro...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/s12888-016-0977-4

    authors: Jordan G,Malla A,Iyer SN

    更新日期:2016-07-25 00:00:00

  • Understanding discrepancies in parent-child reporting of emotional and behavioural problems: Effects of relational and socio-demographic factors.

    abstract:BACKGROUND:Discrepancies between parents and children in their assessment of children's mental health affect the evaluation of need for services and must be taken seriously. This article presents the differences between parents' and children's reports of the children's symptoms and social impairment, based on the resul...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/1471-244X-10-56

    authors: Van Roy B,Groholt B,Heyerdahl S,Clench-Aas J

    更新日期:2010-07-16 00:00:00

  • A standardized crisis management model for self-harming and suicidal individuals with three or more diagnostic criteria of borderline personality disorder: The Brief Admission Skåne randomized controlled trial protocol (BASRCT).

    abstract:BACKGROUND:Brief Admission is a crisis and risk management strategy in which self-harming and suicidal individuals with three or more diagnostic criteria of borderline personality disorder self-admit to hospital at times of increasing risk when other efforts to stay safe are failing. Standardized in the current randomi...

    journal_title:BMC psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12888-017-1371-6

    authors: Liljedahl SI,Helleman M,Daukantaité D,Westrin Å,Westling S

    更新日期:2017-06-15 00:00:00

  • Perceptions of problem-drinker patients' family members about their own hazardous-drinking behaviours in Chinese general hospitals: a qualitative study.

    abstract:BACKGROUND:Excessive alcohol use has been associated with health, social and legal problems. Alcohol-related problems have been studied primarily in problem-drinker patients, with few studies on their family members, particularly about their own hazardous or harmful alcohol-drinking behaviours. METHOD:In this qualitat...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/s12888-017-1348-5

    authors: Lin CC,Tsai YF,Yeh WL,Kao JT,Chen CY

    更新日期:2017-05-18 00:00:00

  • An exploratory mixed methods study of the acceptability and effectiveness of Mindfulness-Based Cognitive Therapy for patients with active depression and anxiety in primary care.

    abstract:BACKGROUND:Mindfulness Based Cognitive Therapy (MBCT) is an 8-week course developed for patients with relapsing depression that integrates mindfulness meditation practices and cognitive theory. Previous studies have demonstrated that non-depressed participants with a history of relapsing depression are protected from r...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/1471-244X-6-14

    authors: Finucane A,Mercer SW

    更新日期:2006-04-07 00:00:00

  • Analysis of the emotional experiences of Japanese Alcoholics Anonymous members striving for sobriety.

    abstract:BACKGROUND:Japan's tolerance of alcohol consumption and intoxication pose extreme difficulties for community-dwelling alcoholics who wish to abstain from alcohol and maintain sobriety. Emotional problems triggered in daily life can easily lead to relapse, especially after abstinence. Alcoholics Anonymous places great e...

    journal_title:BMC psychiatry

    pub_type: 杂志文章

    doi:10.1186/s12888-019-2226-0

    authors: Kihara M,Kitaoka K

    更新日期:2019-08-06 00:00:00