Progesterone receptors--animal models and cell signalling in breast cancer. Diverse activation pathways for the progesterone receptor: possible implications for breast biology and cancer.

abstract：BACKGROUND:Mammographic density (MD) is a strong and heritable intermediate phenotype of breast cancer, but much of its genetic variation remains unexplained. METHODS:We conducted a genetic association study of volumetric MD in a Swedish mammography screening cohort (n = 9498) to identify novel MD loci. Associations w...

journal_title：Breast cancer research : BCR

authors： Brand JS,Humphreys K,Li J,Karlsson R,Hall P,Czene K

更新日期：2018-04-17 00:00:00

abstract：:This cross-sectional investigation in Hawaii explored the relation between soy foods and mammographic characteristics using two food frequency questionnaires and a computer-assisted density assessment method. Japanese and Chinese women reported significantly greater soy food intake than Caucasian women. Whereas soy in...

journal_title：Breast cancer research : BCR

authors： Maskarinec G,Meng L

更新日期：2001-01-01 00:00:00

abstract：:RAD51C is an integral part of the DNA double-strand repair through homologous recombination, and monoallelic mutations were found in ~1.3% of BRCA1/2-negative breast cancer (BC) and/or ovarian cancer (OC) families. Several studies confirmed the occurrence of RAD51C mutations predominantly in BC and/or OC families, alt...

journal_title：Breast cancer research : BCR

authors： Schnurbein G,Hauke J,Wappenschmidt B,Weber-Lassalle N,Engert S,Hellebrand H,Garbes L,Becker A,Neidhardt G,Rhiem K,Meindl A,Schmutzler RK,Hahnen E

更新日期：2013-12-20 00:00:00

abstract：INTRODUCTION:Hypoxia-inducible factor (HIF)-1alpha levels in invasive breast carcinoma have been shown to be an adverse prognostic indicator. Cellular HIF-1alpha activity is regulated by factor-inhibiting hypoxia-inducible factor 1 (FIH-1). In hypoxia, FIH-1 hydroxylation of Asn803 within the C-terminal transactivation...

journal_title：Breast cancer research : BCR

authors： Tan EY,Campo L,Han C,Turley H,Pezzella F,Gatter KC,Harris AL,Fox SB

更新日期：2007-01-01 00:00:00

abstract：:Although the stroma in which carcinomas arise has been previously regarded as a bystander to the clonal expansion and acquisition of malignant characteristics of tumor cells, it is now generally acknowledged that stromal changes are required for the establishment of cancer. In the present article, we discuss three rec...

journal_title：Breast cancer research : BCR

authors： Barcellos-Hoff MH,Medina D

更新日期：2005-01-01 00:00:00

abstract：:The ductal approach to breast cancer, encompassing nipple aspiration, ductal lavage and duct endoscopy, allows assessment of breast ductal epithelial cells and their local microenvironment in a graded process of increasing invasiveness. Samples of ductal epithelial cells sufficient for cytological diagnosis may be saf...

journal_title：Breast cancer research : BCR

authors： Locke I,Mitchell G,Eeles R

更新日期：2004-01-01 00:00:00

abstract：INTRODUCTION:Earlier menarche is related to subsequent breast cancer risk, yet international differences in the age and tempo of other pubertal milestones and their relationships with body mass index (BMI) are not firmly established in populations at differing risk for breast cancer. We compared age and tempo of adrena...

journal_title：Breast cancer research : BCR

authors： Houghton LC,Cooper GD,Bentley GR,Booth M,Chowdhury OA,Troisi R,Ziegler RG,Hoover RN,Katki HA

更新日期：2014-11-15 00:00:00

abstract：INTRODUCTION:Focal adhesion kinase (FAK) regulates multiple cellular processes including growth, differentiation, adhesion, motility and apoptosis. In breast carcinoma, FAK overexpression has been linked to cancer progression but the prognostic relevance remains unknown. In particular, with regard to lymph node-negativ...

journal_title：Breast cancer research : BCR

authors： Schmitz KJ,Grabellus F,Callies R,Otterbach F,Wohlschlaeger J,Levkau B,Kimmig R,Schmid KW,Baba HA

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Experimental evidence suggests a protective role for circulating 25-hydroxyvitamin D (25(OH)D) in breast cancer development, but the results of epidemiological studies have been inconsistent. METHODS:We conducted a case-control study nested within two prospective cohorts, the New York University Women's H...

journal_title：Breast cancer research : BCR

authors： Scarmo S,Afanasyeva Y,Lenner P,Koenig KL,Horst RL,Clendenen TV,Arslan AA,Chen Y,Hallmans G,Lundin E,Rinaldi S,Toniolo P,Shore RE,Zeleniuch-Jacquotte A

更新日期：2013-02-26 00:00:00

abstract：INTRODUCTION:Surgery is currently the definitive treatment for early-stage breast cancer. However, the rate of positive surgical margins remains unacceptably high. The human sodium iodide symporter (hNIS) is a naturally occurring protein in human thyroid tissue, which enables cells to concentrate radionuclides. The hNI...

journal_title：Breast cancer research : BCR

authors： Gholami S,Chen CH,Belin LJ,Lou E,Fujisawa S,Antonacci C,Carew A,Chen NG,De Brot M,Zanzonico PB,Szalay AA,Fong Y

更新日期：2013-03-18 00:00:00

abstract：BACKGROUND:The PAM50-based (Prosigna) risk of recurrence (ROR) score and intrinsic subtypes are prognostic for women with high-risk breast cancer. We investigate the predictive ability of Prosigna regarding the effectiveness of cyclophosphamide-based adjuvant chemotherapy in premenopausal patients with high-risk breast...

journal_title：Breast cancer research : BCR

authors： Jensen MB,Lænkholm AV,Nielsen TO,Eriksen JO,Wehn P,Hood T,Ram N,Buckingham W,Ferree S,Ejlertsen B

更新日期：2018-07-27 00:00:00

abstract：BACKGROUND:Several anthropometric measures have been found to be associated with the risk of breast cancer. Current weight, body mass index, and adult weight gain appear to be predictors of postmenopausal breast cancer. These factors have been associated with a reduced risk of premenopausal breast cancer. We asked whet...

journal_title：Breast cancer research : BCR

authors： Kotsopoulos J,Olopado OI,Ghadirian P,Lubinski J,Lynch HT,Isaacs C,Weber B,Kim-Sing C,Ainsworth P,Foulkes WD,Eisen A,Sun P,Narod SA

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Breast cancer researchers use cell lines to model myriad phenomena ranging from DNA repair to cancer stem cell phenotypes. Though appropriate, and even requisite, for many studies, the suitability of cell lines as tumour models has come into question owing to possibilities of tissue culture artefacts and c...

journal_title：Breast cancer research : BCR

authors： Vincent KM,Findlay SD,Postovit LM

更新日期：2015-08-20 00:00:00

abstract：:The Breast Cancer Site Group (BCSG) of the National Cancer Institute of Canada (NCIC) Clinical Trials Group (CTG) has conducted a wide variety of clinical trials focussing on large phase III trials of adjuvant chemotherapy, adjuvant hormonal therapy, and optimal delivery of adjuvant radiation therapy. The Group has al...

journal_title：Breast cancer research : BCR

authors： Pritchard K,Whelan T

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:The tumour-suppressive effects of transforming growth factor-beta (TGF-beta) are well documented; however, the mechanistic basis of these effects is not fully understood. Previously, we showed that a non-canonical member of the Wingless-related protein family, Wnt5a, is required for TGF-beta-mediated effec...

journal_title：Breast cancer research : BCR

authors： Roarty K,Baxley SE,Crowley MR,Frost AR,Serra R

更新日期：2009-01-01 00:00:00

abstract：:Various methods are available for the measurement of proliferation rates in tumours, including mitotic counts, estimation of the fraction of cells in S-phase of the cell cycle and immunohistochemistry of proliferation-associated antigens. The evidence, advantages and disadvantages for each of these methods along with ...

journal_title：Breast cancer research : BCR

authors： Beresford MJ,Wilson GD,Makris A

更新日期：2006-01-01 00:00:00

abstract：:Many women newly diagnosed with breast cancer and with a strong family history of breast cancer are referred to a family cancer service for genetic counselling and for consideration of genetic testing for germline mutations in cancer predisposition genes following completion of their cancer treatment. However, there i...

journal_title：Breast cancer research : BCR

authors： Meiser B,Tucker K,Friedlander M,Barlow-Stewart K,Lobb E,Saunders C,Mitchell G

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Early life exposures, including diet, have been implicated in the etiology of breast cancer. METHODS:A nested case-control study was conducted among participants in the Nurses' Health Study who completed a 24-item questionnaire about diet during high school. There were 843 eligible cases diagnosed between o...

journal_title：Breast cancer research : BCR

authors： Frazier AL,Ryan CT,Rockett H,Willett WC,Colditz GA

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Bone is one of the most frequent metastatic sites of advanced breast cancer. Current therapeutic agents aim to inhibit osteoclast-mediated bone resorption but only have palliative effects. During normal bone remodeling, the balance between bone resorption and osteoblast-mediated bone formation is essential f...

journal_title：Breast cancer research : BCR

authors： Liu X,Cao M,Palomares M,Wu X,Li A,Yan W,Fong MY,Chan WC,Wang SE

更新日期：2018-10-22 00:00:00

abstract：:Certain laminins of vascular basement membranes have been identified in human breast tumors and brain gliomas that share the same beta1 chain. These laminins are new carcinoma angiogenic markers and might represent potential targets for antiangiogenic therapy. ...

journal_title：Breast cancer research : BCR

authors： Holler E

更新日期：2005-01-01 00:00:00

abstract：:Two articles previously published in Breast Cancer Research illustrate the high rates of breast cancer in Marin County, a wealthy, urban county immediately northwest of the city of San Francisco. I herein comment on these articles, and on the political/psychological/scientific dilemma presented by regions with high ca...

journal_title：Breast cancer research : BCR

authors： Whittemore AS

更新日期：2003-01-01 00:00:00

abstract：:Currently, there is limited data regarding the effectiveness of standard subsequent line therapies such as endocrine therapy, chemotherapy, or targeted agents after progression on CDK4/6 inhibitor-based regimens. This paper describes time-to-treatment failure beyond progression on palbociclib or palbociclib+endocrine ...

journal_title：Breast cancer research : BCR

authors： Rossi L,Biagioni C,McCartney A,Migliaccio I,Curigliano G,Sanna G,Moretti E,Minisini AM,Cinieri S,Tondini C,Arpino G,Bernardo A,Martignetti A,Risi E,Pestrin M,Boni L,Benelli M,Biganzoli L,Di Leo A,Malorni L

更新日期：2019-05-29 00:00:00

abstract：INTRODUCTION:The aim of this study was to describe breast tumor subtypes by common breast cancer risk factors and to determine correlates of subtypes using baseline data from two pooled prospective breast cancer studies within a large health maintenance organization. METHODS:Tumor data on 2544 invasive breast cancer c...

journal_title：Breast cancer research : BCR

authors： Kwan ML,Kushi LH,Weltzien E,Maring B,Kutner SE,Fulton RS,Lee MM,Ambrosone CB,Caan BJ

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:We previously reported an association between tumor-specific 3-hydroxy-3-methylglutharyl-coenzyme A reductase (HMG-CoAR) expression and a good prognosis in breast cancer. Here, the predictive value of HMG-CoAR expression in relation to tamoxifen response was examined. METHODS:HMG-CoAR protein and RNA expr...

journal_title：Breast cancer research : BCR

authors： Brennan DJ,Laursen H,O'Connor DP,Borgquist S,Uhlen M,Gallagher WM,Pontén F,Millikan RC,Rydén L,Jirström K

更新日期：2011-01-31 00:00:00

abstract：INTRODUCTION:Rapamycin, an inhibitor of the serine/threonine kinase target of rapamycin, induces G1 arrest and/or apoptosis. Although rapamycin and its analogues are attractive candidates for cancer therapy, their sensitivities with respect to growth inhibition differ markedly among various cancer cells. Using human br...

journal_title：Breast cancer research : BCR

authors： Kasukabe T,Okabe-Kado J,Kato N,Sassa T,Honma Y

更新日期：2005-01-01 00:00:00

abstract：:The increasing importance of signal transducer and activator of transcription 3 (STAT3) expression in human cancers has led several laboratories to examine in detail the expression of one of its major negative regulators in oncogenesis--the T-cell protein tyrosine phosphatase, nonreceptor type 2 (PTPN2). A recent pape...

journal_title：Breast cancer research : BCR

authors： Tremblay ML

更新日期：2013-07-31 00:00:00

abstract：BACKGROUND:The BRCA1 c.3331_3334delCAAG founder mutation has been reported in hereditary breast and ovarian cancer families from multiple Hispanic groups. We aimed to evaluate BRCA1 c.3331_3334delCAAG haplotype diversity in cases of European, African, and Latin American ancestry. METHODS:BC mutation carrier cases from...

journal_title：Breast cancer research : BCR

authors： Tuazon AMA,Lott P,Bohórquez M,Benavides J,Ramirez C,Criollo A,Estrada-Florez A,Mateus G,Velez A,Carmona J,Olaya J,Garcia E,Polanco-Echeverry G,Stultz J,Alvarez C,Tapia T,Ashton-Prolla P,Brazilian Familial Cancer Network

更新日期：2020-10-21 00:00:00

abstract：:Targeting the function of epidermal growth factor receptor (EGFR) has failed as an effective clinical option for breast cancer. Understanding the drivers of inherent resistance has been a challenge. One possible mechanism is the acquisition of stem-like properties through the process of epithelial-mesenchymal transiti...

journal_title：Breast cancer research : BCR

authors： Brown WS,Wendt MK

更新日期：2014-09-23 00:00:00

abstract：BACKGROUND:Approximately 100 common breast cancer susceptibility alleles have been identified in genome-wide association studies (GWAS). The utility of these variants in breast cancer risk prediction models has not been evaluated adequately in women of Asian ancestry. METHODS:We evaluated 88 breast cancer risk variant...

journal_title：Breast cancer research : BCR

authors： Wen W,Shu XO,Guo X,Cai Q,Long J,Bolla MK,Michailidou K,Dennis J,Wang Q,Gao YT,Zheng Y,Dunning AM,García-Closas M,Brennan P,Chen ST,Choi JY,Hartman M,Ito H,Lophatananon A,Matsuo K,Miao H,Muir K,Sangrajrang S,

更新日期：2016-12-08 00:00:00

abstract：:Anti-angiogenic therapies have demonstrated their value in the setting of advanced cancer, and are being explored for use in micrometastatic disease. Recent preclinical studies suggest that adjuvant anti-vascular endothelial growth factor (VEGF) therapies may increase the risk of metastasis. How concerning are these p...

journal_title：Breast cancer research : BCR

authors： Schneider BP,Sledge GW Jr

更新日期：2009-01-01 00:00:00