Cytoplasmic location of factor-inhibiting hypoxia-inducible factor is associated with an enhanced hypoxic response and a shorter survival in invasive breast cancer.

abstract：INTRODUCTION:Our efforts to prevent and treat breast cancer are significantly impeded by a lack of knowledge of the biology and developmental genetics of the normal mammary gland. In order to provide the specimens that will facilitate such an understanding, The Susan G. Komen for the Cure Tissue Bank at the IU Simon Ca...

journal_title：Breast cancer research : BCR

authors： Pardo I,Lillemoe HA,Blosser RJ,Choi M,Sauder CA,Doxey DK,Mathieson T,Hancock BA,Baptiste D,Atale R,Hickenbotham M,Zhu J,Glasscock J,Storniolo AM,Zheng F,Doerge RW,Liu Y,Badve S,Radovich M,Clare SE,Susan G. Komen f

更新日期：2014-03-17 00:00:00

abstract：BACKGROUND:Breast cancer subtype can be classified using standard clinical markers (estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2)), supplemented with additional markers. However, automated biomarker scoring and classification schemes have not been standardized. T...

journal_title：Breast cancer research : BCR

authors： Allott EH,Geradts J,Cohen SM,Khoury T,Zirpoli GR,Bshara W,Davis W,Omilian A,Nair P,Ondracek RP,Cheng TD,Miller CR,Hwang H,Thorne LB,O'Connor S,Bethea TN,Bell ME,Hu Z,Li Y,Kirk EL,Sun X,Ruiz-Narvaez EA,Perou CM

更新日期：2018-02-06 00:00:00

abstract：BACKGROUND:E74-like factor 5 (ELF5) is an epithelial-specific member of the E26 transforming sequence (ETS) transcription factor family and a critical regulator of cell fate in the placenta, pulmonary bronchi, and milk-producing alveoli of the mammary gland. ELF5 also plays key roles in malignancy, particularly in basa...

journal_title：Breast cancer research : BCR

authors： Piggin CL,Roden DL,Gallego-Ortega D,Lee HJ,Oakes SR,Ormandy CJ

更新日期：2016-01-07 00:00:00

abstract：INTRODUCTION:Before any new methodology can be introduced into the routine diagnostic setting it must be technically validated against the established standards. To this end, a ring study involving five international pathology laboratories was initiated to validate chromogenic in situ hybridisation (CISH) against fluor...

journal_title：Breast cancer research : BCR

authors： van de Vijver M,Bilous M,Hanna W,Hofmann M,Kristel P,Penault-Llorca F,Rüschoff J

更新日期：2007-01-01 00:00:00

abstract：:The transition from pregnancy to lactation is a critical event in the survival of the newborn since all the nutrient requirements of the infant are provided by milk. While milk contains numerous components, including proteins, that aid in maintaining the health of the infant, lactose and milk fat represent the critica...

journal_title：Breast cancer research : BCR

authors： Anderson SM,Rudolph MC,McManaman JL,Neville MC

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:Mutations in BRCA1 and BRCA2 confer a high risk of breast cancer (BC), but the magnitude of this risk seems to vary according to the study and various factors. Although controversial, there are data to support the hypothesis of allelic risk heterogeneity. METHODS:We assessed variation in BC risk according...

journal_title：Breast cancer research : BCR

authors： Lecarpentier J,Noguès C,Mouret-Fourme E,Gauthier-Villars M,Lasset C,Fricker JP,Caron O,Stoppa-Lyonnet D,Berthet P,Faivre L,Bonadona V,Buecher B,Coupier I,Gladieff L,Gesta P,Eisinger F,Frénay M,Luporsi E,Lortholary A,

更新日期：2012-07-03 00:00:00

abstract：:Although the stroma in which carcinomas arise has been previously regarded as a bystander to the clonal expansion and acquisition of malignant characteristics of tumor cells, it is now generally acknowledged that stromal changes are required for the establishment of cancer. In the present article, we discuss three rec...

journal_title：Breast cancer research : BCR

authors： Barcellos-Hoff MH,Medina D

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:There is a growing interest in delivering more personalised, risk-based breast cancer screening protocols. This requires population-level validation of practical models that can stratify women into breast cancer risk groups. Few studies have evaluated the Gail model (NCI Breast Cancer Risk Assessment Tool) i...

journal_title：Breast cancer research : BCR

authors： Nickson C,Procopio P,Velentzis LS,Carr S,Devereux L,Mann GB,James P,Lee G,Wellard C,Campbell I

更新日期：2018-12-20 00:00:00

abstract：INTRODUCTION:The re-emergence of the tumour growth factor-beta (TGF-beta)-related embryonic morphogen Nodal has recently been reported in several different human cancers. In this study, we examined the expression of Nodal in a series of benign and malignant human breast tissues to determine the clinical significance of...

journal_title：Breast cancer research : BCR

authors： Strizzi L,Hardy KM,Margaryan NV,Hillman DW,Seftor EA,Chen B,Geiger XJ,Thompson EA,Lingle WL,Andorfer CA,Perez EA,Hendrix MJ

更新日期：2012-05-11 00:00:00

abstract：INTRODUCTION:Bisphosphonates are inhibitors of osteoclast-mediated tumor-stimulated osteolysis, and they have become standard therapy for the management of bone metastases from breast cancer. These drugs can also directly induce growth inhibition and apoptosis of osteotropic cancer cells, including estrogen receptor-po...

journal_title：Breast cancer research : BCR

authors： Journe F,Chaboteaux C,Magne N,Duvillier H,Laurent G,Body JJ

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Fragments of collagen type I containing the epitope AHDGGR (CTX) are generated during bone resorption. The aspartyl-glycine (DG) site within CTX is synthesised in the L-aspartyl peptide (alphaL) form, but converts to the age-modified forms L-isoaspartyl peptide (betaL) and D-aspartyl peptide (alphaD) over ti...

journal_title：Breast cancer research : BCR

authors： Cloos PA,Christgau S,Lyubimova N,Body JJ,Qvist P,Christiansen C

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Breast cancer intrinsic molecular subtype (IMS) as classified by the expression-based PAM50 assay is considered a strong prognostic feature, even when controlled for by standard clinicopathological features such as age, grade, and nodal status, yet the molecular testing required to elucidate these subtypes i...

journal_title：Breast cancer research : BCR

authors： Jaber MI,Song B,Taylor C,Vaske CJ,Benz SC,Rabizadeh S,Soon-Shiong P,Szeto CW

更新日期：2020-01-28 00:00:00

abstract：INTRODUCTION:Triple-negative breast cancer (TNBC), a subtype of breast cancer with negative expressions of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2), is frequently diagnosed in younger women and has poor prognosis for disease-free and overall survival. Due to the lack...

journal_title：Breast cancer research : BCR

authors： Chen YJ,Yeh MH,Yu MC,Wei YL,Chen WS,Chen JY,Shih CY,Tu CY,Chen CH,Hsia TC,Chien PH,Liu SH,Yu YL,Huang WC

更新日期：2013-11-12 00:00:00

abstract：BACKGROUND:Acquirement of resistance is always associated with a highly aggressive phenotype of tumor cells. Recent studies have revealed that Annexin A2 (Anxa2) is a key protein that links drug resistance and cancer metastasis. A high level of Anxa2 in cancer tissues is correlated to a highly aggressive phenotype. Inc...

journal_title：Breast cancer research : BCR

authors： Fan Y,Si W,Ji W,Wang Z,Gao Z,Tian R,Song W,Zhang H,Niu R,Zhang F

更新日期：2019-05-22 00:00:00

abstract：:A recent analysis by the Collaborative Group on Hormonal Factors in Breast Cancer has provided the most precise quantification to date of the familial risks of breast cancer. The familial relative risks are shown to decrease from more than fivefold in women younger than age 40 years with a first-degree relative aged y...

journal_title：Breast cancer research : BCR

authors： Easton DF

更新日期：2002-01-01 00:00:00

abstract：:Breast cancer is a heterogeneous disease with varied morphological appearances, molecular features, behavior, and response to therapy. Current routine clinical management of breast cancer relies on the availability of robust clinical and pathological prognostic and predictive factors to support clinical and patient de...

journal_title：Breast cancer research : BCR

authors： Rakha EA,Reis-Filho JS,Baehner F,Dabbs DJ,Decker T,Eusebi V,Fox SB,Ichihara S,Jacquemier J,Lakhani SR,Palacios J,Richardson AL,Schnitt SJ,Schmitt FC,Tan PH,Tse GM,Badve S,Ellis IO

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Epithelial-to-mesenchymal transition (EMT) promotes cell migration and is important in metastasis. Cellular proliferation is often downregulated during EMT, and the reverse transition (MET) in metastases appears to be required for restoration of proliferation in secondary tumors. We studied the interplay b...

journal_title：Breast cancer research : BCR

authors： Hugo HJ,Pereira L,Suryadinata R,Drabsch Y,Gonda TJ,Gunasinghe NP,Pinto C,Soo ET,van Denderen BJ,Hill P,Ramsay RG,Sarcevic B,Newgreen DF,Thompson EW

更新日期：2013-11-27 00:00:00

abstract：:Targeting the function of epidermal growth factor receptor (EGFR) has failed as an effective clinical option for breast cancer. Understanding the drivers of inherent resistance has been a challenge. One possible mechanism is the acquisition of stem-like properties through the process of epithelial-mesenchymal transiti...

journal_title：Breast cancer research : BCR

authors： Brown WS,Wendt MK

更新日期：2014-09-23 00:00:00

abstract：:The Developmental Origins of Health and Disease (DOHaD) theory focuses on the consequences of periconceptional and in utero exposures. A wide range of environmental conditions during early development are now being investigated as a driving force for epigenetic disruptions that enhance disease risk in later life, incl...

journal_title：Breast cancer research : BCR

authors： Romanus S,Neven P,Soubry A

更新日期：2016-10-12 00:00:00

abstract：:The metastatic process is a multistep coordinated event with a high degree of efficiency. Specific subpopulations of cancer stem cells, with tumor-initiating and migratory capacity, can selectively migrate towards sites that are able to promote survival and/or proliferation of metastatic tumor cells through a microenv...

journal_title：Breast cancer research : BCR

authors： Santini D,Vincenzi B,Pantano F,Tonini G,Bertoldo F

更新日期：2011-08-16 00:00:00

abstract：:The European Network for Breast Development and Cancer (ENBDC) Workshop on ‘Methods in Mammary Gland Development and Cancer’ has grown into the essential, international technical discussion forum for scientists with interests in the normal and neoplastic breast. The fifth ENBDC meeting was held in Weggis, Switzerland ...

journal_title：Breast cancer research : BCR

authors： Clarke RB,Stingl J,Vivanco M,Bentires-Alj M

更新日期：2013-01-01 00:00:00

abstract：:A series of recent studies have demonstrated that the retinoblastoma tumor suppressor (RB) pathway plays a critical role in multiple clinically relevant aspects of breast cancer biology, spanning early stage lesions to targeted treatment of metastatic disease. In ductal carcinoma in situ, multiple groups have shown th...

journal_title：Breast cancer research : BCR

authors： Witkiewicz AK,Knudsen ES

更新日期：2014-05-07 00:00:00

abstract：:Estrogen-mediated proliferation is fundamental to normal mammary gland development. Recent studies have demonstrated that amphiregulin is a critical paracrine regulator of estrogen action during ductal morphogenesis. These studies implicate a critical role for amphiregulin in mammary stem cell differentiation as well ...

journal_title：Breast cancer research : BCR

authors： LaMarca HL,Rosen JM

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:Microtubule-associated protein tau (MAPT) inhibits the function of taxanes and high expression of MAPT decreases the sensitivity to taxanes. The relationship between estrogen receptor (ER) and MAPT in breast cancer is unclear. In this study, we examined the correlation of MAPT expression with the sensitivi...

journal_title：Breast cancer research : BCR

authors： Ikeda H,Taira N,Hara F,Fujita T,Yamamoto H,Soh J,Toyooka S,Nogami T,Shien T,Doihara H,Miyoshi S

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Human epidermal growth factor receptor HER3 has been implicated in promoting the aggressiveness and metastatic potential of breast cancer. Upregulation of HER3 has been found to be a major mechanism underlying drug resistance to EGFR and HER2 tyrosine kinase inhibitors and to endocrine therapy in the treat...

journal_title：Breast cancer research : BCR

authors： Ren XR,Wang J,Osada T,Mook RA Jr,Morse MA,Barak LS,Lyerly HK,Chen W

更新日期：2015-02-15 00:00:00

abstract：INTRODUCTION:Breast cancer subtyping and prognosis have been studied extensively by gene expression profiling, resulting in disparate signatures with little overlap in their constituent genes. Although a previous study demonstrated a prognostic concordance among gene expression signatures, it was limited to only one da...

journal_title：Breast cancer research : BCR

authors： Wirapati P,Sotiriou C,Kunkel S,Farmer P,Pradervand S,Haibe-Kains B,Desmedt C,Ignatiadis M,Sengstag T,Schütz F,Goldstein DR,Piccart M,Delorenzi M

更新日期：2008-01-01 00:00:00

abstract：:The potential for a reduction in dietary fat or for an increase in dietary fiber to reduce breast cancer risk has been debated for some years. It is argued here that available research data, even though extensive, leave open hypotheses ranging from little or no potential to major public health potential for breast can...

journal_title：Breast cancer research : BCR

authors： Prentice RL

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Breast cancer patients with early-stage disease are increasingly administered neoadjuvant chemotherapy (NAC) to downstage their tumors prior to surgery. In this setting, approximately 31% of patients fail to respond to therapy. This demonstrates the need for techniques capable of providing personalized feedb...

journal_title：Breast cancer research : BCR

authors： Tank A,Peterson HM,Pera V,Tabassum S,Leproux A,O'Sullivan T,Jones E,Cabral H,Ko N,Mehta RS,Tromberg BJ,Roblyer D

更新日期：2020-03-13 00:00:00

abstract：INTRODUCTION:Human epidermal growth factor receptor-2 (HER2) gene amplification (HER2+) drives tumor cell growth and survival in ~25% of breast cancers. HER2 signaling activates the type I phosphoinositide 3-kinase (PI3K), upon which these tumors rely. Consequently, inhibitors of HER2 and type I PI3K block growth and i...

journal_title：Breast cancer research : BCR

authors： Young CD,Arteaga CL,Cook RS

更新日期：2015-12-04 00:00:00

abstract：INTRODUCTION:The association of breast cancer patients’ mortality with estrogen receptor (ER) status (ER + versus ER-) has been well studied. However, little attention has been paid to the relationship between the quantitative measures of ER expression and mortality. METHODS:We evaluated the association between semi-q...

journal_title：Breast cancer research : BCR

authors： Ma H,Lu Y,Marchbanks PA,Folger SG,Strom BL,McDonald JA,Simon MS,Weiss LK,Malone KE,Burkman RT,Sullivan-Halley J,Deapen DM,Press MF,Bernstein L

更新日期：2013-01-01 00:00:00