Estrogen regulation of mammary gland development and breast cancer: amphiregulin takes center stage.

Abstract:

:Estrogen-mediated proliferation is fundamental to normal mammary gland development. Recent studies have demonstrated that amphiregulin is a critical paracrine regulator of estrogen action during ductal morphogenesis. These studies implicate a critical role for amphiregulin in mammary stem cell differentiation as well as breast cancer initiation and progression.

journal_name

Breast Cancer Res

authors

LaMarca HL,Rosen JM

doi

10.1186/bcr1740

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

304

issue

4

eissn

1465-5411

issn

1465-542X

pii

bcr1740

journal_volume

9

pub_type

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