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Targeting bone metastases starting from the preneoplastic niche: home sweet home.

Abstract：

:The metastatic process is a multistep coordinated event with a high degree of efficiency. Specific subpopulations of cancer stem cells, with tumor-initiating and migratory capacity, can selectively migrate towards sites that are able to promote survival and/or proliferation of metastatic tumor cells through a microenvironment modification. Cross-talk between the bone microenvironment and cancer cells can facilitate bone tropism of cancer cells. Fully understanding this complexity represents a major challenge in anti-cancer research and a mandatory step towards the development of new drugs potentially able not only to reduce the consequences of bone lesions but also to target the metastatic process in visceral sites.

journal_name

Breast Cancer Res

journal_title

Breast cancer research : BCR

authors

Santini D,Vincenzi B,Pantano F,Tonini G,Bertoldo F

doi

10.1186/bcr2911

subject

Has Abstract

pub_date

2011-08-16 00:00:00

pages

111

issue

4

eissn

1465-5411

issn

1465-542X

pii

bcr2911

journal_volume

13

pub_type

社论,评审

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