On the role of tyrosine phosphatases as negative regulators of STAT signaling in breast cancers: new findings and future perspectives.

abstract：BACKGROUND:Chemotherapy is the standard treatment for breast cancer; however, the response to chemotherapy is disappointingly low. Here, we investigated the alternative therapeutic efficacy of novel combination treatment with necroptosis-inducing small molecules to overcome chemotherapeutic resistance in tyrosine amino...

journal_title：Breast cancer research : BCR

authors： Lee KM,Lee H,Han D,Moon WK,Kim K,Oh HJ,Choi J,Hwang EH,Kang SE,Im SA,Lee KH,Ryu HS

更新日期：2020-11-25 00:00:00

abstract：INTRODUCTION:Breast cancer researchers use cell lines to model myriad phenomena ranging from DNA repair to cancer stem cell phenotypes. Though appropriate, and even requisite, for many studies, the suitability of cell lines as tumour models has come into question owing to possibilities of tissue culture artefacts and c...

journal_title：Breast cancer research : BCR

authors： Vincent KM,Findlay SD,Postovit LM

更新日期：2015-08-20 00:00:00

abstract：INTRODUCTION:MBD2, the gene encoding methyl-CpG-binding domain (MBD)2, is a major methylation related gene and functions as a transcriptional repressor that can specifically bind to the methylated regions of other genes. MBD2 may also mediate gene activation because of its potential DNA demethylase activity. The presen...

journal_title：Breast cancer research : BCR

authors： Zhu Y,Brown HN,Zhang Y,Holford TR,Zheng T

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Early life exposures, including diet, have been implicated in the etiology of breast cancer. METHODS:A nested case-control study was conducted among participants in the Nurses' Health Study who completed a 24-item questionnaire about diet during high school. There were 843 eligible cases diagnosed between o...

journal_title：Breast cancer research : BCR

authors： Frazier AL,Ryan CT,Rockett H,Willett WC,Colditz GA

更新日期：2003-01-01 00:00:00

abstract：INTRODUCTION:During selective segregation of DNA, a cell asymmetrically divides and retains its template DNA. Asymmetric division yields daughter cells whose genome reflects that of the parents', simultaneously protecting the parental cell from genetic errors that may occur during DNA replication. We hypothesized that ...

journal_title：Breast cancer research : BCR

authors： Bussard KM,Boulanger CA,Kittrell FS,Behbod F,Medina D,Smith GH

更新日期：2010-01-01 00:00:00

abstract：:PIK3CA mutations represent one of the most common genetic aberrations in breast cancer. They have been reported to be present in over one-third of cases, with enrichment in the luminal and in human epidermal growth factor receptor 2-positive subtypes. Substantial preclinical data on the oncogenic properties of these m...

journal_title：Breast cancer research : BCR

authors： Zardavas D,Phillips WA,Loi S

更新日期：2014-01-23 00:00:00

abstract：BACKGROUND:Although parity and age at first pregnancy are among the most known extrinsic factors that modulate breast cancer risk, their impact on the biology of subsequent breast cancer has never been explored in depth. Recent data suggest that pregnancy-induced tumor protection is different according to breast cancer...

journal_title：Breast cancer research : BCR

authors： Nguyen B,Venet D,Lambertini M,Desmedt C,Salgado R,Horlings HM,Rothé F,Sotiriou C

更新日期：2019-02-15 00:00:00

abstract：BACKGROUND:Tumor-derived extracellular vesicles (tdEVs) and circulating tumor cells (CTCs) in the blood of metastatic cancer patients associate with poor outcomes. In this study, we explored the human epidermal growth factor receptor 2 (HER2) expression on CTCs and tdEVs of metastatic breast cancer patients. METHODS:B...

journal_title：Breast cancer research : BCR

authors： Nanou A,Zeune LL,Bidard FC,Pierga JY,Terstappen LWMM

更新日期：2020-08-12 00:00:00

abstract：:Dendritic cells (DCs) are a complex network of antigen-presenting cells that have an essential role in the modulation of primary immunity. There has been increasing evidence that DCs isolated from patients with malignancy demonstrate functional deficiencies that inhibit the capacity to mount an effective anti-tumor re...

journal_title：Breast cancer research : BCR

authors： Lenahan C,Avigan D

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Breast cancer patients with early-stage disease are increasingly administered neoadjuvant chemotherapy (NAC) to downstage their tumors prior to surgery. In this setting, approximately 31% of patients fail to respond to therapy. This demonstrates the need for techniques capable of providing personalized feedb...

journal_title：Breast cancer research : BCR

authors： Tank A,Peterson HM,Pera V,Tabassum S,Leproux A,O'Sullivan T,Jones E,Cabral H,Ko N,Mehta RS,Tromberg BJ,Roblyer D

更新日期：2020-03-13 00:00:00

abstract：INTRODUCTION:Bcl-2 and Bcl-xL confer resistance to apoptosis, thereby reducing the effectiveness of chemotherapy. We examined the relationship between the expression of Bcl-2 and Bcl-xL and chemosensitivity of breast cancer cells, with the aim of developing specific targeted therapy. METHODS:Four human breast cancer c...

journal_title：Breast cancer research : BCR

authors： Emi M,Kim R,Tanabe K,Uchida Y,Toge T

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Vitamin D status measured during adulthood has been inversely associated with breast cancer risk in some, but not all, studies. Vitamin D has been hypothesized to prevent breast cancer through genomic and non-genomic actions in cell-cycle regulation. METHODS:A subset (n = 21,965) of female participants fr...

journal_title：Breast cancer research : BCR

authors： McCullough ML,Stevens VL,Patel R,Jacobs EJ,Bain EB,Horst RL,Gapstur SM,Thun MJ,Calle EE

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:The ataxia telangiectasia mutated (ATM) gene is a tumor suppressor gene with functions in cell cycle arrest, apoptosis, and repair of DNA double-strand breaks. Based on family studies, women heterozygous for mutations in the ATM gene are reported to have a fourfold to fivefold increased risk of breast canc...

journal_title：Breast cancer research : BCR

authors： Tamimi RM,Hankinson SE,Spiegelman D,Kraft P,Colditz GA,Hunter DJ

更新日期：2004-01-01 00:00:00

abstract：INTRODUCTION:Before any new methodology can be introduced into the routine diagnostic setting it must be technically validated against the established standards. To this end, a ring study involving five international pathology laboratories was initiated to validate chromogenic in situ hybridisation (CISH) against fluor...

journal_title：Breast cancer research : BCR

authors： van de Vijver M,Bilous M,Hanna W,Hofmann M,Kristel P,Penault-Llorca F,Rüschoff J

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Dysregulated DNA repair and cell proliferation controls are essential driving forces in mammary tumorigenesis. BCCIP was originally identified as a BRCA2 and CDKN1A interacting protein that has been implicated in maintenance of genomic stability, cell cycle regulation, and microtubule dynamics. The aims of t...

journal_title：Breast cancer research : BCR

authors： Droz-Rosario R,Lu H,Liu J,Liu NA,Ganesan S,Xia B,Haffty BG,Shen Z

更新日期：2017-10-18 00:00:00

abstract：:ErbB (also termed HER) receptors are expressed in various tissues of epithelial, mesenchymal and neuronal origin, in which they are involved in the control of diverse biological processes such as proliferation, differentiation, migration and apoptosis. Furthermore, their deregulated expression has been implicated in m...

journal_title：Breast cancer research : BCR

authors： Olayioye MA

更新日期：2001-01-01 00:00:00

abstract：INTRODUCTION:The status of tumor-infiltrating lymphocytes (TILs) has been recently proposed to predict clinical outcome of patients with breast cancer. We therefore studied the prognostic significance of CD8(+) TILs and FOXP3(+) TILs in residual tumors after neoadjuvant chemotherapy (NAC) and the alterations in these p...

journal_title：Breast cancer research : BCR

authors： Miyashita M,Sasano H,Tamaki K,Hirakawa H,Takahashi Y,Nakagawa S,Watanabe G,Tada H,Suzuki A,Ohuchi N,Ishida T

更新日期：2015-09-04 00:00:00

abstract：INTRODUCTION:Human epidermal growth factor 2 (Her2), a receptor tyrosine kinase, is overexpressed in breast cancers. It has been successfully targeted by small molecule kinase inhibitors and by antibodies. Recent clinical data show a synergistic response in patients when two antibodies, trastuzumab and pertuzumab, are ...

journal_title：Breast cancer research : BCR

authors： Fuentes G,Scaltriti M,Baselga J,Verma CS

更新日期：2011-05-22 00:00:00

abstract：:Array-based comparative genomic hybridization, RNA expression profiling, and proteomic analyses are new molecular technologies used to study breast cancer. Invasive breast cancers were originally evaluated because they provided ample quantities of DNA, RNA, and protein. The application of these technologies to pre-inv...

journal_title：Breast cancer research : BCR

authors： Jeffrey SS,Pollack JR

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Mammographic density (MD) is a strong and heritable intermediate phenotype of breast cancer, but much of its genetic variation remains unexplained. METHODS:We conducted a genetic association study of volumetric MD in a Swedish mammography screening cohort (n = 9498) to identify novel MD loci. Associations w...

journal_title：Breast cancer research : BCR

authors： Brand JS,Humphreys K,Li J,Karlsson R,Hall P,Czene K

更新日期：2018-04-17 00:00:00

abstract：INTRODUCTION:Estrogen receptor-α (ER) and human epidermal growth factor receptor 2 (HER2) positivity are inversely correlated by standard criteria. However, we investigated the quantitative relation between ER and HER2 expression at both RNA and protein levels in HER2+ve and HER2-ve breast carcinomas. METHODS:ER and H...

journal_title：Breast cancer research : BCR

authors： Pinhel I,Hills M,Drury S,Salter J,Sumo G,A'Hern R,Bliss JM,Sestak I,Cuzick J,Barrett-Lee P,Harris A,Dowsett M,NCRI Adjuvant Breast Cancer Trial Management Group.

更新日期：2012-03-14 00:00:00

abstract：INTRODUCTION:Metastasis is a common event and the main cause of death in cancer patients. Lymphangiogenesis refers to the formation of new lymphatic vessels and is thought to be involved in the development of metastasis. Sunitinib is a multi-kinase inhibitor that blocks receptor tyrosine kinase activity, including that...

journal_title：Breast cancer research : BCR

authors： Kodera Y,Katanasaka Y,Kitamura Y,Tsuda H,Nishio K,Tamura T,Koizumi F

更新日期：2011-06-21 00:00:00

abstract：:Homeobox (HOX) genes play key roles in embryogenesis and tissue differentiation. Recently, a number of groups have reported altered HOX gene expression in breast cancer. However, the mechanism of HOX gene regulation and the search for direct targets of its transcriptional regulatory function have been minimally fruitf...

journal_title：Breast cancer research : BCR

authors： Jin K,Sukumar S

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Studies have identified multi-potent stem cells in the adult mammary gland. More recent studies have suggested that the embryonic mammary gland may also contain stem/progenitor cells that contribute to initial ductal development. We were interested in determining whether embryonic cells might also directly...

journal_title：Breast cancer research : BCR

authors： Boras-Granic K,Dann P,Wysolmerski JJ

更新日期：2014-12-03 00:00:00

abstract：INTRODUCTION:Mutations in BRCA1 and BRCA2 confer a high risk of breast cancer (BC), but the magnitude of this risk seems to vary according to the study and various factors. Although controversial, there are data to support the hypothesis of allelic risk heterogeneity. METHODS:We assessed variation in BC risk according...

journal_title：Breast cancer research : BCR

authors： Lecarpentier J,Noguès C,Mouret-Fourme E,Gauthier-Villars M,Lasset C,Fricker JP,Caron O,Stoppa-Lyonnet D,Berthet P,Faivre L,Bonadona V,Buecher B,Coupier I,Gladieff L,Gesta P,Eisinger F,Frénay M,Luporsi E,Lortholary A,

更新日期：2012-07-03 00:00:00

abstract：:Proteins belonging to the profilin family of actin-binding proteins are considered to be important control elements for actin polymerization and have been linked to a broad spectrum of cellular functions, including cell migration. An intriguing paper recently published in Cancer Cell unveils differential effects of pr...

journal_title：Breast cancer research : BCR

authors： Ding Z,Roy P

更新日期：2013-06-27 00:00:00

abstract：:Breast cancer arises from multiple genetic events that together contribute to the established, irreversible malignant phenotype. The development of inducible tissue-specific transgenics has allowed a careful dissection of the events required for induction and subsequent maintenance of tumorigenesis. Mammary gland targ...

journal_title：Breast cancer research : BCR

authors： Hulit J,Di Vizio D,Pestell RG

更新日期：2001-01-01 00:00:00

abstract：:The potential for a reduction in dietary fat or for an increase in dietary fiber to reduce breast cancer risk has been debated for some years. It is argued here that available research data, even though extensive, leave open hypotheses ranging from little or no potential to major public health potential for breast can...

journal_title：Breast cancer research : BCR

authors： Prentice RL

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:A novel line of research suggests that eating at nighttime may have several metabolic consequences that are highly relevant to breast cancer. We investigated the association between nighttime eating habits after 10 p.m. and breast cancer in Hong Kong women. METHODS:A hospital-based case-control study was co...

journal_title：Breast cancer research : BCR

authors： Li M,Tse LA,Chan WC,Kwok CH,Leung SL,Wu C,Yu WC,Lee PM,Tsang KH,Law SH,Vermeulen R,Gu F,Caporaso NE,Yu IT,Wang F,Yang XR

更新日期：2017-03-17 00:00:00

abstract：INTRODUCTION:Incidence of breast cancer is increasing around the world and it is still the leading cause of cancer mortality in low- and middle-income countries. We utilized Swedish nationwide registers to study breast cancer incidence and case fatality to disentangle the effect of socioeconomic position (SEP) and immi...

journal_title：Breast cancer research : BCR

authors： Beiki O,Hall P,Ekbom A,Moradi T

更新日期：2012-01-06 00:00:00