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Measuring proliferation in breast cancer: practicalities and applications.

Abstract：

:Various methods are available for the measurement of proliferation rates in tumours, including mitotic counts, estimation of the fraction of cells in S-phase of the cell cycle and immunohistochemistry of proliferation-associated antigens. The evidence, advantages and disadvantages for each of these methods along with other novel approaches is reviewed in relation to breast cancer. The potential clinical applications of proliferative indices are discussed, including their use as prognostic indicators and predictors of response to systemic therapy.

journal_name

Breast Cancer Res

journal_title

Breast cancer research : BCR

authors

Beresford MJ,Wilson GD,Makris A

doi

10.1186/bcr1618

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

216

issue

6

eissn

1465-5411

issn

1465-542X

pii

bcr1618

journal_volume

8

pub_type

杂志文章,评审

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