Haplotype analysis of the internationally distributed BRCA1 c.3331_3334delCAAG founder mutation reveals a common ancestral origin in Iberia.

abstract：BACKGROUND:Breast cancer patients with early-stage disease are increasingly administered neoadjuvant chemotherapy (NAC) to downstage their tumors prior to surgery. In this setting, approximately 31% of patients fail to respond to therapy. This demonstrates the need for techniques capable of providing personalized feedb...

journal_title：Breast cancer research : BCR

authors： Tank A,Peterson HM,Pera V,Tabassum S,Leproux A,O'Sullivan T,Jones E,Cabral H,Ko N,Mehta RS,Tromberg BJ,Roblyer D

更新日期：2020-03-13 00:00:00

abstract：INTRODUCTION:The ataxia telangiectasia mutated (ATM) gene is a tumor suppressor gene with functions in cell cycle arrest, apoptosis, and repair of DNA double-strand breaks. Based on family studies, women heterozygous for mutations in the ATM gene are reported to have a fourfold to fivefold increased risk of breast canc...

journal_title：Breast cancer research : BCR

authors： Tamimi RM,Hankinson SE,Spiegelman D,Kraft P,Colditz GA,Hunter DJ

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:In over 20% of breast conserving operations, postoperative pathological assessment of the excised tissue reveals positive margins, requiring additional surgery. Current techniques for intra-operative assessment of tumor margins are insufficient in accuracy or resolution to reliably detect small tumors. There...

journal_title：Breast cancer research : BCR

authors： Shipp DW,Rakha EA,Koloydenko AA,Macmillan RD,Ellis IO,Notingher I

更新日期：2018-07-09 00:00:00

abstract：:Epigenetic changes are critical for development and progression of cancers, including breast cancer. Significant progress has been made in the basic understanding of how various epigenetic changes such as DNA methylation, histone modification, miRNA expression, and higher order chromatin structure affect gene expressi...

journal_title：Breast cancer research : BCR

authors： Huang Y,Nayak S,Jankowitz R,Davidson NE,Oesterreich S

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Before any new methodology can be introduced into the routine diagnostic setting it must be technically validated against the established standards. To this end, a ring study involving five international pathology laboratories was initiated to validate chromogenic in situ hybridisation (CISH) against fluor...

journal_title：Breast cancer research : BCR

authors： van de Vijver M,Bilous M,Hanna W,Hofmann M,Kristel P,Penault-Llorca F,Rüschoff J

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Tumor hypoxia is an independent prognostic factor associated with poor patient survival. Emerging evidence suggests that hypoxia can potentially maintain or enhance the stem cell phenotype of both normal stem cells and cancer cells. However, it remains to be determined whether cell fate is regulated in vivo ...

journal_title：Breast cancer research : BCR

authors： Kim H,Lin Q,Glazer PM,Yun Z

更新日期：2018-03-06 00:00:00

abstract：INTRODUCTION:Triple-negative breast cancer (TNBC), a subtype of breast cancer with negative expressions of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2), is frequently diagnosed in younger women and has poor prognosis for disease-free and overall survival. Due to the lack...

journal_title：Breast cancer research : BCR

authors： Chen YJ,Yeh MH,Yu MC,Wei YL,Chen WS,Chen JY,Shih CY,Tu CY,Chen CH,Hsia TC,Chien PH,Liu SH,Yu YL,Huang WC

更新日期：2013-11-12 00:00:00

abstract：INTRODUCTION:Vitamin D status measured during adulthood has been inversely associated with breast cancer risk in some, but not all, studies. Vitamin D has been hypothesized to prevent breast cancer through genomic and non-genomic actions in cell-cycle regulation. METHODS:A subset (n = 21,965) of female participants fr...

journal_title：Breast cancer research : BCR

authors： McCullough ML,Stevens VL,Patel R,Jacobs EJ,Bain EB,Horst RL,Gapstur SM,Thun MJ,Calle EE

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Breast cancer is a heterogeneous disease. Hence, stratification of patients based on the subtype of breast cancer is key to its successful treatment. Among all the breast cancer subtypes, basal-like breast cancer is the most aggressive subtype with limited treatment options. Interestingly, we found focal adh...

journal_title：Breast cancer research : BCR

authors： Paul R,Luo M,Mo X,Lu J,Yeo SK,Guan JL

更新日期：2020-06-03 00:00:00

abstract：INTRODUCTION:Breast tumor kinase (Brk/protein tyrosine kinase 6 (PTK6)) is a nonreceptor, soluble tyrosine kinase overexpressed in the majority of breast tumors. Previous work has placed Brk downstream of epidermal growth factor receptor (ErbB) activation and upstream of extracellular signal-regulated kinase 5 (ERK5) a...

journal_title：Breast cancer research : BCR

authors： Castro NE,Lange CA

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Current approaches to inhibit oestrogen receptor-alpha (ERα) are focused on targeting its hormone-binding pocket and have limitations. Thus, we propose that inhibitors that bind to a coactivator-binding pocket on ERα, called activation function 2 (AF2), might overcome some of these limitations. METHODS:In...

journal_title：Breast cancer research : BCR

authors： Singh K,Munuganti RS,Leblanc E,Lin YL,Leung E,Lallous N,Butler M,Cherkasov A,Rennie PS

更新日期：2015-02-25 00:00:00

abstract：BACKGROUND:There is a growing interest in delivering more personalised, risk-based breast cancer screening protocols. This requires population-level validation of practical models that can stratify women into breast cancer risk groups. Few studies have evaluated the Gail model (NCI Breast Cancer Risk Assessment Tool) i...

journal_title：Breast cancer research : BCR

authors： Nickson C,Procopio P,Velentzis LS,Carr S,Devereux L,Mann GB,James P,Lee G,Wellard C,Campbell I

更新日期：2018-12-20 00:00:00

abstract：BACKGROUND:While dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) is recognized as the most sensitive examination for breast cancer detection, it has a substantial false positive rate and gadolinium (Gd) contrast agents are not universally well tolerated. As a result, alternatives to diagnosing breast can...

journal_title：Breast cancer research : BCR

authors： Feng J,Xu J,Jiang S,Yin H,Zhao Y,Gui J,Wang K,Lv X,Ren F,Pogue BW,Paulsen KD

更新日期：2017-10-24 00:00:00

abstract：:The Developmental Origins of Health and Disease (DOHaD) theory focuses on the consequences of periconceptional and in utero exposures. A wide range of environmental conditions during early development are now being investigated as a driving force for epigenetic disruptions that enhance disease risk in later life, incl...

journal_title：Breast cancer research : BCR

authors： Romanus S,Neven P,Soubry A

更新日期：2016-10-12 00:00:00

abstract：:A recent analysis by the Collaborative Group on Hormonal Factors in Breast Cancer has provided the most precise quantification to date of the familial risks of breast cancer. The familial relative risks are shown to decrease from more than fivefold in women younger than age 40 years with a first-degree relative aged y...

journal_title：Breast cancer research : BCR

authors： Easton DF

更新日期：2002-01-01 00:00:00

abstract：:ErbB (also termed HER) receptors are expressed in various tissues of epithelial, mesenchymal and neuronal origin, in which they are involved in the control of diverse biological processes such as proliferation, differentiation, migration and apoptosis. Furthermore, their deregulated expression has been implicated in m...

journal_title：Breast cancer research : BCR

authors： Olayioye MA

更新日期：2001-01-01 00:00:00

abstract：INTRODUCTION:Activated leukocyte cell adhesion molecule (ALCAM) (CD166) is an immunoglobulin molecule that has been implicated in cell migration. The present study examined the expression of ALCAM in human breast cancer and assessed its prognostic value. METHODS:The immunohistochemical distribution and location of ALC...

journal_title：Breast cancer research : BCR

authors： King JA,Ofori-Acquah SF,Stevens T,Al-Mehdi AB,Fodstad O,Jiang WG

更新日期：2004-01-01 00:00:00

abstract：INTRODUCTION:The main prognostic variables in early breast cancer are tumor size, histological grade, estrogen receptor/progesterone receptor (ER/PgR) status, number of positive nodes and human epidermal growth factor receptor 2 (HER2) status. The present study evaluated the prognostic and/or predictive value of vascul...

journal_title：Breast cancer research : BCR

authors： Linardou H,Kalogeras KT,Kronenwett R,Kouvatseas G,Wirtz RM,Zagouri F,Gogas H,Christodoulou C,Koutras AK,Samantas E,Pectasides D,Bafaloukos D,Fountzilas G

更新日期：2012-11-12 00:00:00

abstract：:Improvements in the detection and treatment of breast cancer have dramatically altered its clinical course and outcome. However, prevention of breast cancer remains an elusive goal. Parity, age of menarche, and age at menopause are major risk factors drawing attention to the important role of the endocrine system in d...

journal_title：Breast cancer research : BCR

authors： Jerry DJ,Minter LM,Becker KA,Blackburn AC

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Chemotherapy is the standard treatment for breast cancer; however, the response to chemotherapy is disappointingly low. Here, we investigated the alternative therapeutic efficacy of novel combination treatment with necroptosis-inducing small molecules to overcome chemotherapeutic resistance in tyrosine amino...

journal_title：Breast cancer research : BCR

authors： Lee KM,Lee H,Han D,Moon WK,Kim K,Oh HJ,Choi J,Hwang EH,Kang SE,Im SA,Lee KH,Ryu HS

更新日期：2020-11-25 00:00:00

abstract：:The metastatic process is a multistep coordinated event with a high degree of efficiency. Specific subpopulations of cancer stem cells, with tumor-initiating and migratory capacity, can selectively migrate towards sites that are able to promote survival and/or proliferation of metastatic tumor cells through a microenv...

journal_title：Breast cancer research : BCR

authors： Santini D,Vincenzi B,Pantano F,Tonini G,Bertoldo F

更新日期：2011-08-16 00:00:00

abstract：:Estrogen receptor α (ER) is a major driver of breast cancer and the target of endocrine therapy. Full disclosure of the cofactors regulating ER interactions with chromatin and its transcriptional regulatory activity is still elusive. Novel genome-wide profiling tools have mapped ER binding events in breast cancer cell...

journal_title：Breast cancer research : BCR

authors： Fu X,Huang C,Schiff R

更新日期：2011-04-20 00:00:00

abstract：BACKGROUND:Recent genome-wide profiling by sequencing and distinctive chromatin signatures has identified thousands of long non-coding RNA (lncRNA) species (>200 nt). LncRNAs have emerged as important regulators of gene expression, involving in both developmental and pathological processes. While altered expression of ...

journal_title：Breast cancer research : BCR

authors： Jiang Z,Slater CM,Zhou Y,Devarajan K,Ruth KJ,Li Y,Cai KQ,Daly M,Chen X

更新日期：2017-05-30 00:00:00

abstract：:Various methods are available for the measurement of proliferation rates in tumours, including mitotic counts, estimation of the fraction of cells in S-phase of the cell cycle and immunohistochemistry of proliferation-associated antigens. The evidence, advantages and disadvantages for each of these methods along with ...

journal_title：Breast cancer research : BCR

authors： Beresford MJ,Wilson GD,Makris A

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:Aromatase inhibitor-associated arthralgia (AIAA) is a common and often debilitating symptom in breast cancer survivors. Since joint symptoms have been related to estrogen deprivation through the menopausal transition, we hypothesized that genetic polymorphisms in CYP19A1, the final enzyme in estrogen synth...

journal_title：Breast cancer research : BCR

authors： Mao JJ,Su HI,Feng R,Donelson ML,Aplenc R,Rebbeck TR,Stanczyk F,DeMichele A

更新日期：2011-01-20 00:00:00

abstract：INTRODUCTION:Breast tumors are comprised of distinct cancer cell populations which differ in their tumorigenic and metastatic capacity. Characterization of cell surface markers enables investigators to distinguish between cancer stem cells and their counterparts. CD24 is a well-known cell surface marker for mammary epi...

journal_title：Breast cancer research : BCR

authors： Rostoker R,Abelson S,Genkin I,Ben-Shmuel S,Sachidanandam R,Scheinman EJ,Bitton-Worms K,Orr ZS,Caspi A,Tzukerman M,LeRoith D

更新日期：2015-06-04 00:00:00

abstract：INTRODUCTION:AIB1, located at 20q12, is a member of the steroid hormone coactivator family. It contains a glutamine repeat (CAG/CAA) polymorphism at its carboxyl-terminal region that may alter the transcriptional activation of the receptor and affect susceptibility to breast cancer through altered sensitivity to hormon...

journal_title：Breast cancer research : BCR

authors： Montgomery KG,Chang JH,Gertig DM,Dite GS,McCredie MR,Giles GG,Southey MC,Hopper JL,Campbell IG

更新日期：2005-01-01 00:00:00

abstract：:The concept of cancer stem cells responsible for tumour origin, maintenance, and resistance to treatment has gained prominence in the field of breast cancer research. The therapeutic targeting of these cells has the potential to eliminate residual disease and may become an important component of a multimodality treatm...

journal_title：Breast cancer research : BCR

authors： Morrison BJ,Schmidt CW,Lakhani SR,Reynolds BA,Lopez JA

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Breast magnetic resonance imaging (MRI) has been reported to frequently result in false-positive diagnoses, limiting its positive predictive value (PPV). However, for PPV calculation, all nonmalignant tissue changes are equally considered false-positive, although the respective prognostic importance, and thu...

journal_title：Breast cancer research : BCR

authors： Kuhl CK,Keulers A,Strobel K,Schneider H,Gaisa N,Schrading S

更新日期：2018-02-09 00:00:00

abstract：INTRODUCTION:Breast cancer is the most common female malignancy worldwide and, despite improvements in treatment modalities, there are increased chances of recurrence and metastasis in a substantial number of cases and it remains one of the major causes of mortality among female cancer patients. Anaplastic lymphoma kin...

journal_title：Breast cancer research : BCR

authors： Siraj AK,Beg S,Jehan Z,Prabhakaran S,Ahmed M,R Hussain A,Al-Dayel F,Tulbah A,Ajarim D,Al-Kuraya KS

更新日期：2015-09-17 00:00:00