Abstract:
OBJECTIVES:To describe the nature, frequency and content of non-vitamin K oral anticoagulant (NOAC)-related events for healthcare professionals sponsored by the manufacturers of the NOACs in Australia. A secondary objective is to compare these data to the rate of dispensing of the NOACs in Australia. DESIGN AND SETTING:This cross-sectional study examined consolidated data from publicly available Australian pharmaceutical industry transparency reports from October 2011 to September 2015 on NOAC-related educational events. Data from April 2011 to June 2016 on NOAC dispensing, subsidised under Australia's Pharmaceutical Benefits Scheme (PBS), were obtained from the Department of Health and the Department of Human Services. MAIN OUTCOME MEASURES:Characteristics of NOAC-related educational events including costs (in Australian dollars, $A), numbers of events, information on healthcare professional attendees and content of events; and NOAC dispensing rates. RESULTS:During the study period, there were 2797 NOAC-related events, costing manufacturers a total of $A10 578 745. Total expenditure for meals and beverages at all events was $A4 238 962. Events were predominantly attended by general practitioners (42%, 1174/2797), cardiologists (35%, 977/2797) and haematologists (23%, 635/2797). About 48% (1347/2797) of events were held in non-clinical settings, mainly restaurants, bars and cafes. Around 55% (1551/2797) of events consisted of either conferences, meetings or seminars. The analysis of the content presented at two events detected promotion of NOACs for unapproved indications, an emphasis on a favourable benefit/harm profile, and that all speakers had close ties with the manufacturers of the NOACs. Following PBS listings relevant to each NOAC, the numbers of events related to that NOAC and the prescribing of that NOAC increased. CONCLUSIONS:Our findings suggest that the substantial investment in NOAC-related events made by four pharmaceutical companies had a promotional purpose. Healthcare professionals should seek independent information on newly subsidised medicines from, for example, government agencies or drug bulletins.
journal_name
BMJ Openjournal_title
BMJ openauthors
Behdarvand B,Karanges EA,Bero Ldoi
10.1136/bmjopen-2019-030253subject
Has Abstractpub_date
2019-08-20 00:00:00pages
e030253issue
8issn
2044-6055pii
bmjopen-2019-030253journal_volume
9pub_type
杂志文章相关文献
BMJ Open文献大全abstract:INTRODUCTION:Pharmacological interventions to address behavioural and psychological symptoms of dementia (BPSD) can have undesirable side effects, therefore non-pharmacological approaches to managing symptoms may be preferable. Past studies show that music therapy can reduce BPSD, and other studies have explored how fo...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-031332
更新日期:2019-11-19 00:00:00
abstract:OBJECTIVE:To investigate variations in quality of acute stroke care and outcomes by day and time of admission in London hyperacute stroke units compared with the rest of England. DESIGN:Prospective cohort study using anonymised patient-level data from the Sentinel Stroke National Audit Programme. SETTING:Acute stroke...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2018-025366
更新日期:2019-11-07 00:00:00
abstract:OBJECTIVE:To examine whether confidence in primary healthcare (PHC) differs among ethnic-linguistic groups and which PHC experiences are associated with confidence. DESIGN:A cross-sectional study where patient surveys were administered using random digit dialling. Regression models identify whether ethnic-linguistic g...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-003884
更新日期:2014-02-25 00:00:00
abstract:OBJECTIVES:To examine the extent of primary care follow-up and mental health outcomes among women referred for ultrasound assessment of pain and/or bleeding in early pregnancy, including those whose pregnancy is found to be viable on ultrasound assessment. DESIGN:Questionnaire study with prospective follow-up. SETTIN...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-002595
更新日期:2013-04-11 00:00:00
abstract:OBJECTIVES:The study examined medical care utilisation by health insurance status changes. SETTING:The Korean Welfare Panel Study (KoWePs) was used. PARTICIPANTS:This study analysed 14,267 participants at baseline (2006). INTERVENTIONS:The individuals were categorised into four health insurance status groups: contin...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-009538
更新日期:2016-04-01 00:00:00
abstract:INTRODUCTION:Increasing prevalence of both thinness and excess weight during childhood and adolescence is a significant public health issue because of short-term health consequences and long-term tracking of weight status. Monitoring weight status in Europe may serve to identify countries and regions where rates of the...
journal_title:BMJ open
pub_type: 杂志文章,meta分析
doi:10.1136/bmjopen-2017-018241
更新日期:2017-12-21 00:00:00
abstract:OBJECTIVE:To examine geographic variation in use of surgery for female stress urinary incontinence (SUI), mainly midurethral mesh tape insertions, in the English National Health Service (NHS). DESIGN:National cohort study. SETTING:NHS hospitals. PARTICIPANTS:27 997 women aged 20 years or older who had a first SUI su...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-029878
更新日期:2019-08-28 00:00:00
abstract:OBJECTIVE:To determine the influence of age and gender, respectively, on the association between employment status and body mass index (BMI) in Korean adults using a large, nationally representative sample. DESIGN:Cross-sectional study. SETTING:South Korea. PARTICIPANTS:7228 from fourth wave of the Korean Longitudin...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-012117
更新日期:2016-11-15 00:00:00
abstract:OBJECTIVE:To investigate if continuation rates in first-time users of oral hormonal contraceptives differed between different formulations and to measure if the rates were related to the prescribing categories, that is, physicians and midwives. DESIGN:A longitudinal national population-based registry study. SETTING:T...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-003401
更新日期:2013-10-18 00:00:00
abstract:OBJECTIVES:To assess the relationship between occupational health and safety (OH&S)-related behaviours of migrating workers in China and their knowledge regarding OH&S laws and regulations (L&Rs). MATERIALS AND METHODS:We sampled 1282 migrant workers from 12 labour-intensive manufacturers in Guangdong, China, with a r...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-040143
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:To assess the seroprevalence of recent/acute and past exposure to rubella virus infection and associated risk factors among pregnant women. DESIGN:A hospital-based cross-sectional study. SETTING:The study was conducted in two public hospitals in Hawassa City, Southern Ethiopia. PARTICIPANTS:A total of 422 ...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2017-016824
更新日期:2017-10-05 00:00:00
abstract:OBJECTIVES:The aim of this study was to critically explore the views of the public about the acceptability and feasibility of proactive approaches to earlier dementia diagnosis and also identification of people at high risk of dementia. DESIGN:Qualitative study using task group methodology and thematic data analysis. ...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2017-018677
更新日期:2018-02-03 00:00:00
abstract:OBJECTIVE:History and physical examination do not reliably exclude serious bacterial infections (SBIs) in infants. We examined potential markers of SBI in young febrile infants. DESIGN:We reviewed white cell count (WBC), absolute neutrophil count (ANC), neutrophil to lymphocyte count ratio (NLR) and C reactive protein...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-018092
更新日期:2018-01-24 00:00:00
abstract:OBJECTIVE:To determinate the prevalence and correlates of cardiometabolic multimorbidity (CMM), and their cross-country variation among individuals with hypertension residing in rural communities in South Asia. DESIGN:A cross-sectional study. SETTING:Rural communities in Bangladesh, Pakistan and Sri Lanka. PARTICIPA...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-030584
更新日期:2019-09-04 00:00:00
abstract:OBJECTIVE:To evaluate sex-specific and age-specific associations of active living environments (ALEs) with premature cardiometabolic mortality. DESIGN:Population-based retrospective cohort study. SETTING:Residential neighbourhoods (1000-metre circular buffers from the centroids of dissemination areas) across Canada f...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-035942
更新日期:2020-11-20 00:00:00
abstract:INTRODUCTION:Rotator cuff injuries account for up to 70% of pain in the shoulder. However, there remains no consensus on the best surgical treatment for patients with rotator cuff injuries, in terms of the cost-effectiveness and cost-utility of open and arthroscopic methods for rotator cuff repair. The objective of thi...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-043126
更新日期:2020-12-28 00:00:00
abstract:OBJECTIVES:Transcranial magnetic stimulation (TMS) has been used therapeutically for functional (conversion) motor symptoms but there is limited evidence for its efficacy and the optimal protocol. We examined the feasibility of a novel randomised controlled trial (RCT) protocol of TMS to treat functional limb weakness....
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-037198
更新日期:2020-10-06 00:00:00
abstract:OBJECTIVES:To describe low-density lipoprotein (LDL) cholesterol management and lipid-lowering treatment patterns in patients with a cardiovascular (CV) event. DESIGN:Retrospective cohort study using Clinical Practice Research Datalink records linked with Hospital Episode Statistics data. SETTING:Routine clinical pra...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-013851
更新日期:2017-05-10 00:00:00
abstract::Background Although recent genome-wide association studies have identified several genetic variants contributing to the complex aetiology of multiple sclerosis (MS), expression and functional studies are required to further understand its molecular basis. Objectives To identify genes and pathways with differential ex...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2011-000053
更新日期:2011-07-18 00:00:00
abstract:OBJECTIVES:There has been increased interest in screening for atrial fibrillation (AF) with commissioned pilot schemes, ongoing large clinical trials and the emergence of inexpensive consumer single-lead ECG devices that can be used to detect AF. This qualitative study aimed to explore patients' views and understanding...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-033061
更新日期:2020-03-18 00:00:00
abstract:OBJECTIVES:We investigated associations of officially recorded crime and perceived neighbourhood safety with physical health, evaluating potential effect modification by gender. SETTING:Nationally representative population-based survey in New Zealand. PARTICIPANTS:Individual-level data from 6995 New Zealand General S...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-004058
更新日期:2014-03-10 00:00:00
abstract:INTRODUCTION:Chronic kidney disease is a serious and a frequent disease associated with a high risk of morbi-mortality. Although several risk factors have already been well addressed, mostly diabetes and hypertension, many remain underappreciated, such as chronic exposure to air pollution. METHODS AND ANALYSIS:We will...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-041088
更新日期:2021-01-17 00:00:00
abstract:OBJECTIVE:To explore the optimal content and design of a clinical trial of an end-of-life intervention for advanced heart disease with patients, carers and healthcare professionals. DESIGN:Qualitative interview and focus group study. SETTING:Community and hospital-based focus groups and interviews. PARTICIPANTS:Stab...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-005021
更新日期:2014-07-14 00:00:00
abstract:PURPOSE:Despite the growing evidence that physical activity and familial factors play a role in low back pain (LBP), there is a lack of robust longitudinal studies that (1) investigate the types and dosages of physical activity that are protective or harmful for LBP, (2) employ objective measures of physical activity a...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-036301
更新日期:2020-07-28 00:00:00
abstract:INTRODUCTION:Stroke is among the leading causes of death and disability worldwide. Poststroke cognitive impairment is a common sequela of stroke. The burden of cognitive impairment poststroke has significant impacts on the individual poststroke, their family and wider society. Despite the prevalence and associated burd...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-031052
更新日期:2019-11-07 00:00:00
abstract:OBJECTIVE:The risk of fetal death increases steeply after 42 gestational weeks. Since 2009, Denmark has had a more proactive policy including prevention of prolonged pregnancy, and early intervention in women with diabetes, preeclampsia, high body mass index and of a higher age group. The aim of this study was to descr...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2014-005785
更新日期:2014-08-14 00:00:00
abstract:OBJECTIVES:To simplify our previous risk score for predicting the in-hospital mortality risk in patients with non-ST-segment elevation myocardial infarction (NSTEMI) by dropping laboratory data. DESIGN:Prospective cohort. SETTING:Multicentre, 108 hospitals across three levels in China. PARTICIPANTS:A total of 5775 p...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2019-030772
更新日期:2019-09-12 00:00:00
abstract:OBJECTIVES:Multimorbidity, defined as the presence of 2 or more chronic medical conditions in an individual, is associated with poorer health outcomes. Several multimorbidity measures exist, and the challenge is to decide which to use preferentially in predicting health outcomes. The study objective was to compare the ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-013089
更新日期:2016-09-20 00:00:00
abstract:PURPOSE:The Buffalo Osteoporosis and Periodontal Disease (OsteoPerio) study is a prospective cohort study focused on the relationship between the microbiome and oral and systemic health outcomes in postmenopausal women. The cohort was established to examine how the oral microbiome is affected by (and how it affects) pe...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-024263
更新日期:2018-12-04 00:00:00
abstract:OBJECTIVES:The aim of this review was to identify the cultural, social, structural and behavioural factors that influence asymptomatic breast and cervical cancer screening attendance in South Asian populations, in order to improve uptake and propose priorities for further research. DESIGN:A systematic review of the li...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-020892
更新日期:2018-07-07 00:00:00