当前位置： SCI文献检索 > BMC Cardiovascular Disorders期刊下所有文献 > Prognostic significance of factor XIIIA promoter methylation status in aneurysmal subarachnoid haemorrhage (aSAH).

Prognostic significance of factor XIIIA promoter methylation status in aneurysmal subarachnoid haemorrhage (aSAH).

Abstract：

BACKGROUND:Aneurysmal subarachnoid hemorrhage is a life- threatening condition with high rate of disability and mortality. Apolipoprotein E (APOE) and Factor XIIIA (F13A) genes are involved in the pathogenetic mechanism of aneurysmal subarachnoid haemorrhage (aSAH). We evaluated the association of promoter methylation status of APOE and F13A gene and risk of aSAH. METHODS:For evaluating the effect of hypermethylation in the promoter region of these genes with risk of aSAH, we conducted a case -control study with 50 aSAH patients and 50 healthy control. The methylation pattern was analysed using methylation specific PCR. The risk factors associated with poor outcome after aSAH was also analysed in this study. The outcome was assessed using Glasgow outcome score (GOS) after 3 months from the initial bleed. RESULTS:The frequency of APOE and F13A methylation pattern showed insignificant association with risk of aSAH in this study. Gender stratification analysis suggests that F13A promoter methylation status was significantly associated with the risk of aSAH in male gender. Age, aneurysm located at the anterior communicating artery and diabetes mellitus showed significant association with poor outcome after aSAH. CONCLUSION:There was no significant association with APOE promoter methylation with the risk as well as outcome of patients after aSAH. F13A promoter methylation status was significantly associated with risk of aSAH in male gender, with no significant association with outcome after aSAH.

journal_name

BMC Cardiovasc Disord

journal_title

BMC cardiovascular disorders

authors

Arati S,Chetan GK,Sibin MK,Bhat DI,Vazhayil V,Narasingarao KVL

doi

10.1186/s12872-019-1146-8

subject

Has Abstract

pub_date

2019-07-17 00:00:00

pages

170

issue

1

issn

1471-2261

pii

10.1186/s12872-019-1146-8

journal_volume

19

pub_type

杂志文章

相关文献

BMC Cardiovascular Disorders文献大全
  • Effects of an interactive CD-program on 6 months readmission rate in patients with heart failure - a randomised, controlled trial [NCT00311194].

    abstract：BACKGROUND:Disease-management programmes including patient education have promoted improvement in outcome for patients with heart failure. However, there is sparse evidence concerning which component is essential for success, and very little is known regarding the validity of methods or material used for the education....

    journal_title：BMC cardiovascular disorders

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1186/1471-2261-6-30

    authors： Linné AB,Liedholm H

    更新日期：2006-06-24 00:00:00

  • Prevalence of heart failure in Australia: a systematic review.

    abstract：BACKGROUND:In the absence of a systematic collection of data pertaining to heart failure, summarizing the data available from individual studies provides an opportunity to estimate the burden of heart failure. The present study systematically reviewed the literature to estimate the incidence and prevalence rates of hea...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章,评审

    doi：10.1186/s12872-016-0208-4

    authors： Sahle BW,Owen AJ,Mutowo MP,Krum H,Reid CM

    更新日期：2016-02-06 00:00:00

  • Prasugrel or ticagrelor relative to clopidogrel in triple-antiplatelet treatment combined with glycoprotein IIb/IIIa inhibitor for patients with STEMI undergoing PCI: a meta-analysis.

    abstract：BACKGROUND:For patients with ST-segment elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI), the efficacy and safety of novel P2Y12 antagonists, including prasugrel or ticagrelor, has not been established relative to that of the clopidogrel-based triple-antiplatelet treatments (T...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章,meta分析

    doi：10.1186/s12872-020-01403-6

    authors： Wang Z,Zhou DY,Su Y,Si LY,Xu Q

    更新日期：2020-03-12 00:00:00

  • Takotsubo cardiomyopathy in a patient with ileus: a case report.

    abstract：BACKGROUND:Takotsubo cardiomyopathy (TCM) is a form of stress-induced cardiomyopathy featured by the dilatation of the apex of the left ventricle during systole. Whereas the pathogenesis of this disorder is not well understood, it usually occurs after an emotional or physical stress such as acute asthma, surgery, chemo...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章

    doi：10.1186/s12872-017-0700-5

    authors： Guo CC,Chou NS

    更新日期：2017-10-17 00:00:00

  • Myocardial fibrosis as the first sign of cardiac involvement in a male patient with Fabry disease: report of a clinical case and discussion on the utility of the magnetic resonance in Fabry pathology.

    abstract：BACKGROUND:Cardiovascular magnetic resonance (CMR) with late gadolinium enhancement (LGE) imaging is increasingly used to assess myocardial involvement in patients with Fabry disease, an X linked lipid storage disorder. However, it is often proposed as an optional tool. A different cardiomyopathic disease progression b...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章

    doi：10.1186/1471-2261-14-86

    authors： Sechi A,Nucifora G,Piccoli G,Dardis A,Bembi B

    更新日期：2014-07-16 00:00:00

  • Idiopathic premature ventricular contractions and ventricular tachycardias originating from the vicinity of tricuspid annulus: results of radiofrequency catheter ablation in thirty-five patients.

    abstract：BACKGROUND:In recent years, catheter ablation has increasingly been used for ablation of idiopathic premature ventricular complexes (PVCs) or ventricular tachycardias (IVTs). However, the mapping and catheter ablation of the arrhythmias originating from the vicinity of tricuspid annulus (TA) may not be fully understood...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章

    doi：10.1186/1471-2261-12-32

    authors： Yue-Chun L,Wen-Wu Z,Na-Dan Z,Teng Z,Pin-Xiao W,Bei G,Jia L,Kang-Ting J,Jia-Feng L

    更新日期：2012-07-10 00:00:00

  • A 10- and 15-year performance analysis of ESC/EAS and ACC/AHA cardiovascular risk scores in a Southern European cohort.

    abstract：BACKGROUND:A key strategy for the primary prevention of cardiovascular disease (CVD) is the use of risk prediction algorithms. We aimed to investigate the predictive ability of SCORE (Systematic COronary Risk Estimation) and PCE (Pooled Cohort Equations) systems for atherosclerotic CVD (ASCVD) risk in Portugal, a low C...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章

    doi：10.1186/s12872-020-01574-2

    authors： Santos-Ferreira C,Baptista R,Oliveira-Santos M,Moura JP,Gonçalves L

    更新日期：2020-06-19 00:00:00

  • Effect of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on cardiovascular events in patients with heart failure: a meta-analysis of randomized controlled trials.

    abstract：BACKGROUND:Heart failure (HF) remains a significant cause of morbidity and mortality. Multiple trials over the past several years have examined the effects of both angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) in the treatment of left ventricular dysfunction, both acutely ...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章,meta分析

    doi：10.1186/s12872-017-0686-z

    authors： Tai C,Gan T,Zou L,Sun Y,Zhang Y,Chen W,Li J,Zhang J,Xu Y,Lu H,Xu D

    更新日期：2017-10-05 00:00:00

  • The minimal informative monitoring interval of N-terminal pro-B-type natriuretic peptide in patients with stable heart failure.

    abstract：BACKGROUND:N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a potential biomarker for monitoring the status of heart failure. However, the optimal monitoring interval of NT-proBNP is unknown. This study sought to investigate the minimal informative monitoring interval of NT-proBNP in patients with stable chroni...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章

    doi：10.1186/s12872-020-01537-7

    authors： Dai Z,Asano T,Takahashi O,Komiyama N,Ohde S

    更新日期：2020-06-01 00:00:00

  • Omentin-1 is associated with atrial fibrillation in patients with cardiac valve disease.

    abstract：BACKGROUND:Epicardial adipose tissue (EAT) remodeling and adipocytokines are associated with structural remodeling in atrial fibrillation (AF). However, the role of omentin-1, a novel adipocytokine, in structural remodeling remains unknown. METHODS:Hematoxylin and eosin (H&E) and Masson's trichrome stains were used to...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章

    doi：10.1186/s12872-020-01478-1

    authors： Chen Y,Liu F,Han F,Lv L,Tang CE,Xie Z,Luo F

    更新日期：2020-05-06 00:00:00

  • Application of strain and other echocardiographic parameters in the evaluation of early and long-term clinical outcomes after cardiac surgery revascularization.

    abstract：BACKGROUND:Coronary artery bypass graft (CABG) surgery is an effective therapeutic strategy for coronary heart disease (CHD). Myocardial longitudinal strain echocardiography with 2D speckle tracking could obtain ventricular function with better accuracy and reliability than the left ventricular ejection fraction. The a...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章

    doi：10.1186/s12872-019-1162-8

    authors： Gozdzik A,Letachowicz K,Grajek BB,Plonek T,Obremska M,Jasinski M,Gozdzik W

    更新日期：2019-08-05 00:00:00

  • In vitro and clinical studies examining the expression of osteopontin in cigarette smoke-exposed endothelial cells and cigarette smokers.

    abstract：BACKGROUND:Cigarette smoking is a leading cause of mortality and morbidity and is associated with cardiovascular disease via contributory processes such as endothelial dysfunction, inflammation and thrombosis. Cigarette smoke both contains and stimulates the production of cellular oxidants and it may also promote vascu...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章,随机对照试验

    doi：10.1186/1471-2261-12-75

    authors： Bishop E,Theophilus EH,Fearon IM

    更新日期：2012-09-17 00:00:00

  • Comparison of platelet reactivity between prasugrel and ticagrelor in patients with acute coronary syndrome: a meta-analysis.

    abstract：BACKGROUND:This meta-analysis aimed to compare the effects of prasugrel and ticagrelor on high (HTPR) and low on-treatment platelet reactivity (LTPR) in patients with acute coronary syndrome (ACS). METHODS:Eligible studies were retrieved from PubMed, Embase, and the Cochrane Library. HTPR and LTPR were evaluated on th...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章,meta分析

    doi：10.1186/s12872-020-01603-0

    authors： Wen M,Li Y,Qu X,Zhu Y,Tian L,Shen Z,Yang X,Shi X

    更新日期：2020-10-01 00:00:00

  • Meta-analysis of the growth rates of abdominal aortic aneurysm in the Chinese population.

    abstract：BACKGROUND:Several studies on the growth rates of abdominal aortic aneurysm (AAA) in Chinese population have been conducted; however, this issue remains unclear. The aim of this study is to systematically review published data of the AAA growth rates among people in China. METHODS:We conducted a comprehensive search o...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章,meta分析

    doi：10.1186/s12872-019-1160-x

    authors： Huang T,Liu S,Huang J,Xu B,Bai Y,Wang W

    更新日期：2019-08-22 00:00:00

  • Development of an Australian cardiovascular disease mortality risk score using multiple imputation and recalibration from national statistics.

    abstract：OBJECTIVE:To develop and recalibrate an Australian 5-year cardiovascular disease (CVD) mortality risk score to produce contemporary predictions of risk. METHODS:Data were pooled from six Australian cohort studies (n = 54,829), with baseline data collected between 1989 and 2003. Participants included were aged 40-74 ye...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章,多中心研究

    doi：10.1186/s12872-016-0462-5

    authors： Backholer K,Hirakawa Y,Tonkin A,Giles G,Magliano DJ,Colagiuri S,Harris M,Mitchell P,Nelson M,Shaw JE,Simmons D,Simons L,Taylor A,Harding J,Gopinath B,Woodward M

    更新日期：2017-01-06 00:00:00

  • Dotted collar placed around carotid artery induces asymmetric neointimal lesion formation in rabbits without intravascular manipulations.

    abstract：BACKGROUND:Neointimal formation in atherosclerosis has been subject for intense research. However, good animal models mimicking asymmetrical lesion formation in human subjects have been difficult to establish. The aim of this study was to develop a model which would lead to the formation of eccentric lesions under macr...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章

    doi：10.1186/1471-2261-12-91

    authors： Kivelä A,Hartikainen J,Ylä-Herttuala S

    更新日期：2012-10-17 00:00:00

  • Anomalous aortic origin of coronary arteries from the opposite sinus: a critical appraisal of risk.

    abstract：BACKGROUND:Anomalous aortic origin of the coronary artery (AAOCA) from the opposite sinus of Valsalva with an interarterial course has received much attention due to its association with sudden death in otherwise healthy individuals. AAOCA is relatively common and may have significant public health implications. While ...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章,评审

    doi：10.1186/1471-2261-12-83

    authors： Peñalver JM,Mosca RS,Weitz D,Phoon CK

    更新日期：2012-10-01 00:00:00

  • A potential marker of bare metal stent restenosis: monocyte count - to- HDL cholesterol ratio.

    abstract：BACKGROUND:Oxidation and inflammation play significant roles in the pathogenesis of coronary artery diseases. Monocyte count to high-density lipoprotein (HDL) cholesterol ratio (MHR) is a new marker and has revealed as an indicator of inflammation in the literature. The present study aimed to search the effect of MHR o...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章

    doi：10.1186/s12872-016-0367-3

    authors： Ucar FM

    更新日期：2016-10-03 00:00:00

  • Approach selection of radiofrequency catheter ablation for ventricular arrhythmias originating from the left ventricular summit: potential relevance of Pseudo Delta wave, Intrinsicoid deflection time, maximal deflection index.

    abstract：BACKGROUND:Ventricular arrhythmias (VAs) originating from the left ventricular summit is a challenge for radiofrequency catheter ablation (RFCA). The present study aimed to investigate the appropriate RFCA strategy for VAs originating from the left ventricular summit. METHODS:Forty-five consecutive patients with VAs a...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章

    doi：10.1186/s12872-017-0575-5

    authors： Zheng C,Li J,Li J,Zhou DP,Li XW,Wu SJ,Lin JF

    更新日期：2017-05-30 00:00:00

  • Left ventricular diastolic dysfunction in nonhuman primate model of dysmetabolism and diabetes.

    abstract：BACKGROUND:Diabetes is one of the major risk factors for cardiomyopathy and heart failure with reduced ejection fraction (EF) and highly associated with left ventricular (LV) dysfunction in human. This study aimed 1) to noninvasively assess cardiac function using echocardiography; 2) to test the hypothesis that like di...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章

    doi：10.1186/s12872-015-0133-y

    authors： Gu H,Liu Y,Mei S,Wang B,Sun G,Wang X,Xiao Y,Staup M,Gregoire FM,Chng K,Wang YJ

    更新日期：2015-10-30 00:00:00

  • Associations among different functional and structural arterial wall properties and their relations to traditional cardiovascular risk factors in healthy subjects: a cross-sectional study.

    abstract：BACKGROUND:The arterial wall possesses several functional and structural properties that define arterial health. Once they become impaired, cardiovascular risk increases. We aimed to ascertain the pattern of correlations among different arterial wall properties and to explore their relations to traditional risk factors...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章

    doi：10.1186/1471-2261-12-29

    authors： Lunder M,Janic M,Kejzar N,Sabovic M

    更新日期：2012-04-25 00:00:00

  • Phosphorylated proteomics analysis of human coronary artery endothelial cells stimulated by Kawasaki disease patients serum.

    abstract：BACKGROUND:Kawasaki disease (KD) is an acute febrile childhood systemic vasculitis that disturbs coronary arteries. The pathogenesis remains unknown. The study of phosphorylated proteins helps to elucidate the relevant pathophysiological mechanisms of cardiovascular disease. However, few researches explored phosphoryla...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章

    doi：10.1186/s12872-018-0982-2

    authors： Li SM,Liu WT,Yang F,Yi QJ,Zhang S,Jia HL

    更新日期：2019-01-17 00:00:00

  • Auscultatory versus oscillometric blood pressure measurement in patients with atrial fibrillation and arterial hypertension.

    abstract：BACKGROUND:The aim of our study was to investigate the reliability of automated oscillometric blood pressure (BP) monitoring in the presence and absence of atrial fibrillation (AF) in hypertensive patients. METHODS:BP was measured and compared in 71 randomly selected patients with AF and arterial hypertension diagnosi...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章

    doi：10.1186/s12872-017-0521-6

    authors： Šelmytė-Besusparė A,Barysienė J,Petrikonytė D,Aidietis A,Marinskis G,Laucevičius A

    更新日期：2017-03-23 00:00:00

  • Current status and factors influencing oral anticoagulant therapy among patients with non-valvular atrial fibrillation in Jiangsu province, China: a multi-center, cross-sectional study.

    abstract：BACKGROUND:It has been reported that oral anticoagulation (OAC) is underused among Chinese patients with non-valvular atrial fibrillation (NVAF). Non-vitamin K antagonist oral anticoagulants (NOAC) have been recommended by recent guidelines and have been covered since 2017 by the Chinese medical insurance; thus, the ov...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章,多中心研究

    doi：10.1186/s12872-020-01330-6

    authors： Liu T,Yang HL,Gu L,Hui J,Omorogieva O,Ren MX,Wang XH

    更新日期：2020-01-16 00:00:00

  • Ticagrelor and clopidogrel suppress NF-κB signaling pathway to alleviate LPS-induced dysfunction in vein endothelial cells.

    abstract：BACKGROUND:Ticagrelor and clopidogrel, P2Y12 receptor antagonists, can prevent thrombotic events and are used to treat cardiovascular diseases such as acute coronary syndrome and chronic obstructive pulmonary disease, in which inflammation is involved. Moreover, NF-B is the central regulator of inflammation. Thus, we s...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章

    doi：10.1186/s12872-019-01287-1

    authors： Jia Z,Huang Y,Ji X,Sun J,Fu G

    更新日期：2019-12-30 00:00:00

  • Systematic review and meta-analysis of music interventions in hypertension treatment: a quest for answers.

    abstract：BACKGROUND:Adverse effects, treatment resistance and high costs associated with pharmacological treatment of hypertension have led to growing interest in non-pharmacological complementary therapies such as music interventions. This meta-analysis aims to provide an overview of reported evidence on the efficacy of music ...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章,meta分析,评审

    doi：10.1186/s12872-016-0244-0

    authors： Kühlmann AY,Etnel JR,Roos-Hesselink JW,Jeekel J,Bogers AJ,Takkenberg JJ

    更新日期：2016-04-19 00:00:00

  • Correction to: Long-term effectiveness and safety of self-management of oral anticoagulants in real-world settings.

    abstract：:After publication of the original article [1], we were notified that the name of the software mentioned in the Background section is TAONET and not Tao Net. ...

    journal_title：BMC cardiovascular disorders

    pub_type： 已发布勘误

    doi：10.1186/s12872-019-1268-z

    authors： Menéndez-Jándula B,García-Erce JA,Zazo C,Larrad-Mur L

    更新日期：2019-11-26 00:00:00

  • Myocardial bridging as a cause of acute myocardial infarction: a case report.

    abstract：BACKGROUND:Systolic compression of a coronary artery by overlying myocardial tissue is termed myocardial bridging. Myocardial bridging usually has a benign prognosis, but some cases resulting in myocardial ischemia, infarction and sudden cardiac death have been reported. We are reporting a case of myocardial bridging w...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章

    doi：10.1186/1471-2261-2-15

    authors： Akdemir R,Gunduz H,Emiroglu Y,Uyan C

    更新日期：2002-09-21 00:00:00

  • A review of outcome following valve surgery for rheumatic heart disease in Australia.

    abstract：BACKGROUND:Globally, rheumatic heart disease (RHD) remains an important cause of heart disease. In Australia it particularly affects younger Indigenous and older non-Indigenous Australians. Despite its impact there is limited understanding of the factors influencing outcome following surgery for RHD. METHODS:The Austr...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章,多中心研究

    doi：10.1186/s12872-015-0094-1

    authors： Russell EA,Tran L,Baker RA,Bennetts JS,Brown A,Reid CM,Tam R,Walsh WF,Maguire GP

    更新日期：2015-09-23 00:00:00

  • Impact of the introduction of drug eluting stents on clinical outcomes in patients undergoing percutaneous and surgical coronary artery revascularisation procedures in Western Australia.

    abstract：BACKGROUND:Increasing rates of percutaneous coronary intervention (PCI) and decreasing rates of coronary artery bypass graft (CABG) surgery followed the introduction of drug eluting stents in Western Australia in 2002. We assessed the impact of these changes on one-year outcomes for the total population of patients und...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章,多中心研究

    doi：10.1186/1471-2261-13-47

    authors： Sanfilippo FM,Rankin JM,Hobbs MS,Nguyen M,Knuiman MW,Berg P,Whitford EG,Hendriks R,Hockings BE,Muhlmann M,Newman M,Larbalestier R,Gilfillan I,Briffa TG

    更新日期：2013-07-05 00:00:00