Abstract:
BACKGROUND:Kawasaki disease (KD) is an acute febrile childhood systemic vasculitis that disturbs coronary arteries. The pathogenesis remains unknown. The study of phosphorylated proteins helps to elucidate the relevant pathophysiological mechanisms of cardiovascular disease. However, few researches explored phosphorylated proteins in KD patients. METHODS:We compared phosphoprotein profiles of HCAECs stimulated by the serum of KD patients and normal children using iTRAQ technology, TiO2 enrichment phosphorylated peptide and MS analysis. Then we conducted the functional analysis by ClueGO and the biological interaction networking analysis by ReactomeFIViz. Western blotting was performed to identify the hub proteins. RESULTS:Our results revealed that phosphorylation of 148 proteins showed different intensities between the two HCAECs groups, which are enriched in MAPK, VEGFR, EGFR, Angiopoietin receptor, mTOR, FAK signaling pathway and so on. Through the Network Analyzer analysis, the hub proteins are CDKN1A, MAPK1 and POLR2A, which were experimentally validated. CONCLUSION:In summary, we provided evidence addressing the valuable phosphorylation signaling that could be useful resource to understand the molecular mechanism and the potential targets for novel therapy of KD.
journal_name
BMC Cardiovasc Disordjournal_title
BMC cardiovascular disordersauthors
Li SM,Liu WT,Yang F,Yi QJ,Zhang S,Jia HLdoi
10.1186/s12872-018-0982-2subject
Has Abstractpub_date
2019-01-17 00:00:00pages
21issue
1issn
1471-2261pii
10.1186/s12872-018-0982-2journal_volume
19pub_type
杂志文章abstract:BACKGROUND:The aim of this study was to evaluate the predictive value of cystatin C (CysC) and estimated glomerular filtration rate (eGFR) regarding vascular lesions and their severity in patients with acute coronary syndrome (ACS). METHODS:According to the results of coronary angiography, 195 ACS patients were divide...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-017-0483-8
更新日期:2017-01-31 00:00:00
abstract:BACKGROUND:Tobacco smoke is one of the most significant risk factors for cardiovascular diseases and damages in the myocardial tissue directly. Cardiac magnetic resonance (CMR) has been used and is a promising tool to evaluate morphometry and cardiac function in humans. The objective of this study was to evaluate assoc...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-020-01372-w
更新日期:2020-02-06 00:00:00
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journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,评审
doi:10.1186/s12872-020-01589-9
更新日期:2020-06-22 00:00:00
abstract:BACKGROUND:Previous renal denervation (RDN) studies showed controversial results in reducing blood pressure. The aim of this study was to provide evidence supporting the effectiveness of laparoscopic-based renal denervation (L-RDN) in treating hypertension. METHODS:Sixteen Beagle dogs were randomly divided into RDN gr...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-020-01546-6
更新日期:2020-06-11 00:00:00
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journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2261-11-55
更新日期:2011-08-31 00:00:00
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pub_type: 杂志文章,评审
doi:10.1186/1471-2261-12-46
更新日期:2012-06-24 00:00:00
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journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-016-0215-5
更新日期:2016-02-17 00:00:00
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journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/1471-2261-9-46
更新日期:2009-09-15 00:00:00
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pub_type: 杂志文章
doi:10.1186/1471-2261-14-190
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pub_type: 杂志文章
doi:10.1186/s12872-019-1174-4
更新日期:2019-08-07 00:00:00
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pub_type: 杂志文章
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更新日期:2012-09-24 00:00:00
abstract:BACKGROUND:Globally, rheumatic heart disease (RHD) remains an important cause of heart disease. In Australia it particularly affects younger Indigenous and older non-Indigenous Australians. Despite its impact there is limited understanding of the factors influencing outcome following surgery for RHD. METHODS:The Austr...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,多中心研究
doi:10.1186/s12872-015-0094-1
更新日期:2015-09-23 00:00:00
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journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/1471-2261-11-31
更新日期:2011-06-14 00:00:00
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journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/1471-2261-13-53
更新日期:2013-07-28 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12872-020-01451-y
更新日期:2020-04-15 00:00:00
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doi:10.1186/s12872-020-01472-7
更新日期:2020-04-16 00:00:00
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journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-016-0421-1
更新日期:2016-12-15 00:00:00
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doi:10.1186/s12872-019-01306-1
更新日期:2020-01-13 00:00:00
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journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-016-0259-6
更新日期:2016-05-23 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12872-017-0568-4
更新日期:2017-05-22 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12872-020-01680-1
更新日期:2020-09-07 00:00:00
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pub_type: 杂志文章
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更新日期:2013-09-10 00:00:00
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pub_type: 杂志文章
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更新日期:2020-12-09 00:00:00
abstract:BACKGROUND:Aortic regurgitation (AR) is a valvular disease that can lead to systolic heart failure. Treatment options besides cardiac surgery are limited and consequently severe AR is associated with higher mortality and morbidity when not operated. In this investigation, we examined the effects of a novel cardiac myos...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-018-0831-3
更新日期:2018-05-21 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12872-019-1096-1
更新日期:2019-05-14 00:00:00
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journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-018-0801-9
更新日期:2018-04-16 00:00:00
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journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,meta分析
doi:10.1186/s12872-019-1190-4
更新日期:2019-09-02 00:00:00
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journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-017-0700-5
更新日期:2017-10-17 00:00:00
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journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-020-01817-2
更新日期:2021-01-06 00:00:00
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journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12872-016-0221-7
更新日期:2016-02-13 00:00:00