Phosphorylated proteomics analysis of human coronary artery endothelial cells stimulated by Kawasaki disease patients serum.

Abstract:

BACKGROUND:Kawasaki disease (KD) is an acute febrile childhood systemic vasculitis that disturbs coronary arteries. The pathogenesis remains unknown. The study of phosphorylated proteins helps to elucidate the relevant pathophysiological mechanisms of cardiovascular disease. However, few researches explored phosphorylated proteins in KD patients. METHODS:We compared phosphoprotein profiles of HCAECs stimulated by the serum of KD patients and normal children using iTRAQ technology, TiO2 enrichment phosphorylated peptide and MS analysis. Then we conducted the functional analysis by ClueGO and the biological interaction networking analysis by ReactomeFIViz. Western blotting was performed to identify the hub proteins. RESULTS:Our results revealed that phosphorylation of 148 proteins showed different intensities between the two HCAECs groups, which are enriched in MAPK, VEGFR, EGFR, Angiopoietin receptor, mTOR, FAK signaling pathway and so on. Through the Network Analyzer analysis, the hub proteins are CDKN1A, MAPK1 and POLR2A, which were experimentally validated. CONCLUSION:In summary, we provided evidence addressing the valuable phosphorylation signaling that could be useful resource to understand the molecular mechanism and the potential targets for novel therapy of KD.

journal_name

BMC Cardiovasc Disord

authors

Li SM,Liu WT,Yang F,Yi QJ,Zhang S,Jia HL

doi

10.1186/s12872-018-0982-2

subject

Has Abstract

pub_date

2019-01-17 00:00:00

pages

21

issue

1

issn

1471-2261

pii

10.1186/s12872-018-0982-2

journal_volume

19

pub_type

杂志文章
  • Correlations of serum cystatin C and glomerular filtration rate with vascular lesions and severity in acute coronary syndrome.

    abstract:BACKGROUND:The aim of this study was to evaluate the predictive value of cystatin C (CysC) and estimated glomerular filtration rate (eGFR) regarding vascular lesions and their severity in patients with acute coronary syndrome (ACS). METHODS:According to the results of coronary angiography, 195 ACS patients were divide...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-017-0483-8

    authors: Zhang J,Wu X,Gao P,Yan P

    更新日期:2017-01-31 00:00:00

  • Comparison of morphometry and ventricular function of healthy and smoking young people.

    abstract:BACKGROUND:Tobacco smoke is one of the most significant risk factors for cardiovascular diseases and damages in the myocardial tissue directly. Cardiac magnetic resonance (CMR) has been used and is a promising tool to evaluate morphometry and cardiac function in humans. The objective of this study was to evaluate assoc...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-020-01372-w

    authors: Batista ANR,Garcia T,Franco EAT,Azevedo PS,Barbosa MF,Zornoff LAM,Minicucci MF,de Paiva SAR,Zucchi JW,de Godoy I,Tanni SE

    更新日期:2020-02-06 00:00:00

  • Late discovery of left atrial appendage occluder device embolization: a case report.

    abstract:BACKGROUND:Left atrial appendage (LAA) closure has been well evaluated in the prevention of stroke in patients with atrial fibrillation. Device embolization remains one of the most common complications. To the best of our knowledge, there have been no reports of late discovery of LAA occluder device embolization at 1.5...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章,评审

    doi:10.1186/s12872-020-01589-9

    authors: Mansour MJ,Bénic C,Didier R,Noel A,Gilard M,Mansourati J

    更新日期:2020-06-22 00:00:00

  • Laparoscopic based renal denervation in a canine neurogenic hypertension model.

    abstract:BACKGROUND:Previous renal denervation (RDN) studies showed controversial results in reducing blood pressure. The aim of this study was to provide evidence supporting the effectiveness of laparoscopic-based renal denervation (L-RDN) in treating hypertension. METHODS:Sixteen Beagle dogs were randomly divided into RDN gr...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-020-01546-6

    authors: Shao C,Zhou Y,You T,Xue B,Stella PR,Jiang TB,Miao Z,Xu L,Yin,Lan L,Rong G

    更新日期:2020-06-11 00:00:00

  • HYPEST study: profile of hypertensive patients in Estonia.

    abstract:BACKGROUND:More than one third of adult population in Estonia has problems with elevated blood pressure (BP). The Hypertension in Estonia (HYPEST) study represents the country's first hypertension-targeted sample collection aiming to examine the epidemiological and genetic determinants for hypertension (HTN) and relate...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1471-2261-11-55

    authors: Org E,Veldre G,Viigimaa M,Juhanson P,Putku M,Rosenberg M,Tomberg K,Uuetoa T,Laan M

    更新日期:2011-08-31 00:00:00

  • Heart disease and left ventricular rotation - a systematic review and quantitative summary.

    abstract:BACKGROUND:Left ventricular (LV) rotation is increasingly examined in those with heart disease. The available evidence measuring LV rotation in those with heart diseases has not been systematically reviewed. METHODS:To review systematically the evidence measuring LV rotational changes in various heart diseases compare...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章,评审

    doi:10.1186/1471-2261-12-46

    authors: Phillips AA,Cote AT,Bredin SS,Warburton DE

    更新日期:2012-06-24 00:00:00

  • Decreasing incidence of ruptured abdominal aortic aneurysm already before start of screening.

    abstract:BACKGROUND:The aim of this study was to evaluate whether screening for abdominal aortic aneurysm (AAA) has led to a decrease in ruptured AAA (rAAA) incidence. METHOD:The Malmö population was evaluated regarding the incidence of rAAA and elective AAA surgery 4 years before and after start of AAA-screening in 2010. Data...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-016-0215-5

    authors: Otterhag SN,Gottsäter A,Lindblad B,Acosta S

    更新日期:2016-02-17 00:00:00

  • Atherosclerosis profile and incidence of cardiovascular events: a population-based survey.

    abstract:BACKGROUND:Atherosclerosis is a chronic progressive disease often presenting as clinical cardiovascular disease (CVD) events. This study evaluated the characteristics of individuals with a diagnosis of atherosclerosis and estimated the incidence of CVD events to assist in the early identification of high-risk individua...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2261-9-46

    authors: Robinson JG,Fox KM,Bullano MF,Grandy S,SHIELD Study Group.

    更新日期:2009-09-15 00:00:00

  • Endurance training or beta-blockade can partially block the energy metabolism remodeling taking place in experimental chronic left ventricle volume overload.

    abstract:BACKGROUND:Patients with chronic aortic valve regurgitation (AR) causing left ventricular (LV) volume overload can remain asymptomatic for many years despite having a severely dilated heart. The sudden development of heart failure is not well understood but alterations of myocardial energy metabolism may be contributiv...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2261-14-190

    authors: Lachance D,Dhahri W,Drolet MC,Roussel É,Gascon S,Sarrhini O,Rousseau JA,Lecomte R,Arsenault M,Couet J

    更新日期:2014-12-17 00:00:00

  • Swallow syncope: a case report and review of literature.

    abstract:BACKGROUND:Swallow or deglutition syncope is an unusual type of neurally-mediated syncope associated with life-threatening bradyarrhythmia and hypotension. It is a difficult condition to diagnose with commonly delayed diagnosis and management. There is lack of review articles that elucidate the basic demographics, clin...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-019-1174-4

    authors: Siew KSW,Tan MP,Hilmi IN,Loch A

    更新日期:2019-08-07 00:00:00

  • Prognosis after percutaneous coronary intervention in patients with psoriasis: a cohort study using Danish nationwide registries.

    abstract:BACKGROUND:Psoriasis is an inflammatory disease associated with increased risk of coronary artery disease. However, the potential impact of psoriasis on the prognosis following percutaneous coronary revascularization (PCI) is unknown. METHODS:The study comprised the entire Danish population undergoing first-time PCI i...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2261-12-79

    authors: Ahlehoff O,Lindhardsen J,Gislason GH,Olesen JB,Charlot M,Skov L,Torp-Pedersen C,Hansen PR

    更新日期:2012-09-24 00:00:00

  • A review of outcome following valve surgery for rheumatic heart disease in Australia.

    abstract:BACKGROUND:Globally, rheumatic heart disease (RHD) remains an important cause of heart disease. In Australia it particularly affects younger Indigenous and older non-Indigenous Australians. Despite its impact there is limited understanding of the factors influencing outcome following surgery for RHD. METHODS:The Austr...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12872-015-0094-1

    authors: Russell EA,Tran L,Baker RA,Bennetts JS,Brown A,Reid CM,Tam R,Walsh WF,Maguire GP

    更新日期:2015-09-23 00:00:00

  • Circulating angiopoietins-1 and -2, angiopoietin receptor Tie-2 and vascular endothelial growth factor-A as biomarkers of acute myocardial infarction: a prospective nested case-control study.

    abstract:BACKGROUND:Angiogenesis is up-regulated in myocardial ischemia. However, limited data exist assessing the value of circulating angiogenic biomarkers in predicting future incidence of acute myocardial infarction (AMI). Our aim was to examine the association between circulating levels of markers of angiogenesis with risk...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2261-11-31

    authors: Iribarren C,Phelps BH,Darbinian JA,McCluskey ER,Quesenberry CP,Hytopoulos E,Vogelman JH,Orentreich N

    更新日期:2011-06-14 00:00:00

  • Loss of ectonucleotidases from the coronary vascular bed after ischemia-reperfusion in isolated rat heart.

    abstract:BACKGROUND:Ectonucleotidase plays an important role in the regulation of cardiac function by controlling extracellular levels of adenine nucleotides and adenosine. To determine the influence of ischemia-reperfusion injury on ectonucleotidase activity in coronary vascular bed, we compared the metabolic profile of adenin...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2261-13-53

    authors: Takahashi-Sato K,Murakawa M,Kimura J,Ito MA,Matsuoka I

    更新日期:2013-07-28 00:00:00

  • High plasma levels of pro-inflammatory factors interleukin-17 and interleukin-23 are associated with poor outcome of cardiac-arrest patients: a single center experience.

    abstract:BACKGROUND:Systemic inflammation is an important feature of post-cardiac arrest syndrome (PCAS). This study was designed to determine whether the plasma concentrations of some circulating pro-inflammatory cytokines (interleukin-17 [IL-8], IL-22, IL-23 and IL-33) are of value in predicting the outcome of patients after ...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-020-01451-y

    authors: Zhuang YG,Chen YZ,Zhou SQ,Peng H,Chen YQ,Li DJ

    更新日期:2020-04-15 00:00:00

  • Aggravated endothelial endocrine dysfunction and intimal thickening of renal artery in high-fat diet-induced obese pigs following renal denervation.

    abstract:BACKGROUND:Renal denervation (RDN) targeting the sympathetic nerves in the renal arterial adventitia as a treatment of resistant hypertension can cause endothelial injury and vascular wall injury. This study aims to evaluate the risk of atherosclerosis induced by RDN in renal arteries. METHODS:A total of 15 minipigs w...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-020-01472-7

    authors: Su E,Zhao L,Yang X,Zhu B,Liu Y,Zhao W,Wang X,Qi D,Zhu L,Gao C

    更新日期:2020-04-16 00:00:00

  • Asymptomatic hyperuricemia is not an independent risk factor for cardiovascular events or overall mortality in the general population of the Busselton Health Study.

    abstract:BACKGROUND:To investigate the impact of uric acid (UA) levels on cardiovascular disease and mortality at a population level. METHODS:Prospective analysis of baseline serum UA measurement and 15 year follow-up data from the Busselton Health Survey (n = 4,173), stratified by existence or absence of baseline cardiovascul...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-016-0421-1

    authors: Nossent J,Raymond W,Divitini M,Knuiman M

    更新日期:2016-12-15 00:00:00

  • Value of the Barthel scale in prognostic prediction for patients with cerebral infarction.

    abstract:BACKGROUND:This study aims to evaluate the ADL(activity of daily living) of patients with acute cerebral infarction through BI scoring, in order to observe its predictive value in the prognosis of these patients. METHODS:According to the inclusion and exclusion criteria, patients with acute anterior circulation cerebr...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-019-01306-1

    authors: Li QX,Zhao XJ,Wang Y,Wang DL,Zhang J,Liu TJ,Peng YB,Fan HY,Zheng FX

    更新日期:2020-01-13 00:00:00

  • A comparative study of time-specific oxidative stress after acute myocardial infarction in patients with and without diabetes mellitus.

    abstract:BACKGROUND:Oxidative stress is involved in the initiation and progression of atherosclerosis, and hyperglycemia is known to increase oxidative stress, which injures the endothelium and accelerates atherosclerosis. To clarify the relation between oxidative stress, diabetes mellitus (DM), and acute myocardial infarction ...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-016-0259-6

    authors: Kitano D,Takayama T,Nagashima K,Akabane M,Okubo K,Hiro T,Hirayama A

    更新日期:2016-05-23 00:00:00

  • A retrospective cohort study on the risk of stroke in relation to a priori health knowledge level among people with type 2 diabetes mellitus in Taiwan.

    abstract:BACKGROUND:Intervention of diabetes care education with regular laboratory check-up in outpatient visits showed long-term benefits to reduce the risk of macrovascular complications among people with type 2 diabetes. However, research on the level of a priori health knowledge to the prevention of diabetic complications ...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-017-0568-4

    authors: Lai YJ,Hu HY,Lee YL,Ku PW,Yen YF,Chu D

    更新日期:2017-05-22 00:00:00

  • The role of Asprosin in patients with dilated cardiomyopathy.

    abstract:BACKGROUND:Asprosin is a novel fasting glucogenic adipokine discovered in 2016. Asprosin induces rapid glucose releases from the liver. However, its molecular mechanisms and function are still unclear. Adaptation of energy substrates from fatty acid to glucose is recently considered a novel therapeutic target in heart ...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-020-01680-1

    authors: Wen MS,Wang CY,Yeh JK,Chen CC,Tsai ML,Ho MY,Hung KC,Hsieh IC

    更新日期:2020-09-07 00:00:00

  • Early changes in myocardial repolarization and coronary perfusion after cardiopulmonary bypass surgery for ASD repair in children.

    abstract:BACKGROUND:In adults, impaired myocardial repolarization and increased risk of arrhythmia are known consequences of open heart surgery. Little is known, however, about post-operative consequences of cardiopulmonary bypass surgery in children. The aim of this study was to assess ventricular repolarization and coronary p...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2261-13-67

    authors: Aburawi EH,Souid AK,Liuba P,Zoubeidi T,Pesonen E

    更新日期:2013-09-10 00:00:00

  • Genetic determinants of clinical phenotype in hypertrophic cardiomyopathy.

    abstract:BACKGROUND:Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disease that affects approximately one in 500 people. HCM is a recognized genetic disorder most often caused by mutations involving myosin-binding protein C (MYBPC3) and β-myosin heavy chain (MYH7) which are responsible for approxi...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-020-01807-4

    authors: Velicki L,Jakovljevic DG,Preveden A,Golubovic M,Bjelobrk M,Ilic A,Stojsic S,Barlocco F,Tafelmeier M,Okwose N,Tesic M,Brennan P,Popovic D,Ristic A,MacGowan GA,Filipovic N,Maier LS,Olivotto I

    更新日期:2020-12-09 00:00:00

  • Effects of the cardiac myosin activator Omecamtiv-mecarbil on severe chronic aortic regurgitation in Wistar rats.

    abstract:BACKGROUND:Aortic regurgitation (AR) is a valvular disease that can lead to systolic heart failure. Treatment options besides cardiac surgery are limited and consequently severe AR is associated with higher mortality and morbidity when not operated. In this investigation, we examined the effects of a novel cardiac myos...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-018-0831-3

    authors: El-Oumeiri B,Mc Entee K,Annoni F,Herpain A,Vanden Eynden F,Jespers P,Van Nooten G,van de Borne P

    更新日期:2018-05-21 00:00:00

  • Comparison short time discharge with long time discharge following uncomplicated percutaneous coronary intervention for Non-ST elevation myocardial infarction patients.

    abstract:BACKGROUND:The rational length of stay following non-complicated percutaneous coronary intervention (PCI) for Non-ST elevation myocardial infarction (NSTEMI) patients remains controversial. Few studies have examined the impact of early discharge on short-term outcomes in NSTEMI patients, but short-time discharge is not...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-019-1096-1

    authors: Wang G,Zhao Q,Cheng Q,Zhang X,Tian L,Wu X

    更新日期:2019-05-14 00:00:00

  • A moderate 500-m treadmill walk for estimating peak oxygen uptake in men with NYHA class I-II heart failure and reduced left ventricular ejection fraction.

    abstract:BACKGROUND:Maximal cardiopulmonary exercise testing (CPX) is the gold-standard for cardiorespiratory fitness assessment in chronic heart failure (CHF) patients. However, high costs, required medical supervision, and safety concerns make maximal exercise testing impractical for evaluating mobility-impaired adults. Thus,...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-018-0801-9

    authors: Mazzoni G,Sassone B,Pasanisi G,Myers J,Mandini S,Volpato S,Conconi F,Chiaranda G,Grazzi G

    更新日期:2018-04-16 00:00:00

  • Meta-analysis for the value of colchicine for the therapy of pericarditis and of postpericardiotomy syndrome.

    abstract:BACKGROUND:Colchicine has been used as anti-inflammatory agent in pericardial effusion (PE). We sought to perform a meta-analysis of randomized trials assessing the efficacy and safety of colchicine in patients with pericarditis or postpericardiotomy syndrome (PPS). METHODS:In the systematic literature search followin...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章,meta分析

    doi:10.1186/s12872-019-1190-4

    authors: Lutschinger LL,Rigopoulos AG,Schlattmann P,Matiakis M,Sedding D,Schulze PC,Noutsias M

    更新日期:2019-09-02 00:00:00

  • Takotsubo cardiomyopathy in a patient with ileus: a case report.

    abstract:BACKGROUND:Takotsubo cardiomyopathy (TCM) is a form of stress-induced cardiomyopathy featured by the dilatation of the apex of the left ventricle during systole. Whereas the pathogenesis of this disorder is not well understood, it usually occurs after an emotional or physical stress such as acute asthma, surgery, chemo...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-017-0700-5

    authors: Guo CC,Chou NS

    更新日期:2017-10-17 00:00:00

  • Arterial duct stent versus surgical shunt for patients with duct-dependent pulmonary circulation: a meta-analysis.

    abstract:BACKGROUND:Both systemic-pulmonary shunt and arterial duct stent could be the palliation of duct-dependent pulmonary circulation. We aimed to compare the safety and efficacy of the two approaches. METHODS:The PubMed, EMBASE, and Cochrane Library databases were searched through December 2019 for studies comparing stent...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-020-01817-2

    authors: Li D,Zhou X,Li M

    更新日期:2021-01-06 00:00:00

  • Can BNP-guided therapy improve health-related quality of life, and do responders to BNP-guided heart failure treatment have improved health-related quality of life? Results from the UPSTEP study.

    abstract:BACKGROUND:To investigate whether B-type natriuretic peptide (NP)-guided treatment of heart failure (HF) patients improved their health related quality of life (Hr-QoL) compared to routine HF treatment, and whether changes in Hr-QoL differed depending on whether the patient was a responder to NP-guided therapy or not. ...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/s12872-016-0221-7

    authors: Karlström P,Johansson P,Dahlström U,Boman K,Alehagen U

    更新日期:2016-02-13 00:00:00