Abstract:
OBJECTIVES:The impact of lung cancer screening with low-dose chest CT (LDCT) on participants' anxiety levels and health-related quality of life (HRQoL) is an important consideration in the implementation of such programmes. We aimed to describe changes in anxiety and HRQoL in a high-risk Canadian cohort undergoing LDCT lung cancer screening. METHODS:2537 subjects who had 2% or greater lung cancer risk over 6 years using a risk prediction tool were recruited from eight centres across Canada in the Pan-Canadian Early Detection of Lung Cancer Study (2008-2010). We compared HRQoL and anxiety levels before and after screening of 1237 participants with LDCT (excluding a subset of 1300 participants who also underwent autofluorescence bronchoscopy screening), as well as after investigations performed because of a positive screening examination. The 12-item short-form Physical and Mental Component Scales (SF-12), EQ-5D-3L scores and State Trait Anxiety Inventory-State anxiety were used at each assessment. RESULTS:Overall, there were no clinically significant differences in HRQoL outcomes between baseline and each of the survey time points following initial screening. No mean change in anxiety in the overall cohort was noted following baseline LDCT, but more participants had clinically significant increase in anxiety versus decrease after baseline screening (increase >minimal clinically important difference (MCID) (n=180) vs decrease >MCID (n=50), p<0.001). This finding persisted but to a lesser degree at the 12 month time point (increase >MCID (n=146) vs decrease >MCID (n=87), p<0.001). CONCLUSIONS:CT screening for lung cancer has no major overall impact on HRQoL among participants, although a minority of participants (number-needed-to-harm=7 after baseline screening and 18 at 1 year) demonstrated clinically significant increased anxiety levels. TRIALREGISTRATION NUMBER:NCT00751660; Results.
journal_name
BMJ Openjournal_title
BMJ openauthors
Taghizadeh N,Tremblay A,Cressman S,Peacock S,McWilliams AM,MacEachern P,Johnston MR,Goffin J,Goss G,Nicholas G,Martel S,Laberge F,Bhatia R,Liu G,Schmidt H,Atkar-Khattra S,Tsao MS,Tammemagi MC,Lam SC,Pan-Canadian Eardoi
10.1136/bmjopen-2018-024719subject
Has Abstractpub_date
2019-01-17 00:00:00pages
e024719issue
1issn
2044-6055pii
bmjopen-2018-024719journal_volume
9pub_type
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