Abstract:
BACKGROUND:Dual antiplatelet therapy (DAPT) is frequently discontinued after drug-eluting stent (DES) implantation, which could increase the risk of major adverse cardiovascular events (MACEs). Few studies have attempted to improve DAPT adherence through web-based social media. OBJECTIVE:To explore the effect of social media on DAPT adherence following DES implantation. METHODS/DESIGN:The WeChat trial is a multicentre, single-blind, randomised study (1:1). It will recruit 760 patients with DES who require 12 months of DAPT. The control group will only receive usual care and general educational messages on medical knowledge. The intervention group will receive a personalised intervention, including interactive responses and medication and follow-up reminders beyond the general educational messages. The primary endpoint will be the discontinuation rate which is defined as the cessation of any dual antiplatelet drug owing to the participants' discretion within 1 year of DES implantation. The secondary endpoints will include medication adherence and MACEs. Both groups will receive messages or reminders four times a week with follow-ups over 12 months. ETHICS AND DISSEMINATION:Ethical approval was granted by Ethics Committee of Guangdong Provincial People's Hospital (GDREC2018327H). Results will be disseminated via peer-reviewed publications and presentations at international conferences. TRIAL REGISTRATION NUMBER:NCT03732066.
journal_name
BMJ Openjournal_title
BMJ openauthors
Sun GL,Lei L,Liu L,Liu J,He Y,Guo Z,Dai X,He L,Chen SQ,Liang Y,Ye J,Hu Y,Chen G,Chen JY,Liu Ydoi
10.1136/bmjopen-2019-033017subject
Has Abstractpub_date
2020-01-07 00:00:00pages
e033017issue
1issn
2044-6055pii
bmjopen-2019-033017journal_volume
10pub_type
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