Abstract:
OBJECTIVES:To estimate the incidence and epidemiology of catheter-related bloodstream infections (CRBSIs) on a national scale by using prospective epidemiological data from the Swiss Antibiotic Resistance Surveillance System (ANRESIS). DESIGN:Observational study. SETTING:National surveillance from 2008 to 2015 of acute hospitals in Switzerland. PARTICIPANTS:We included acute Swiss hospitals that sent blood cultures and catheter tip culture results on a regular basis during the entire study period to the ANRESIS database. OUTCOME MEASURE:A catheter-related bloodstream infection (termed 'modified CRBSI', mCRBSI) was defined as isolating the same microorganism with identical antibiogram from ≥1 blood cultures (performed ±7 days around the catheter removal) as the one recovered from the catheter tip. Incidence rates of mCRBSI were calculated per 1000 admissions. RESULTS:From 2008 to 2015, the mCRBSI incidence rate decreased from 0.83 to 0.58 episodes/1000 admissions (-6% per year, p<0.001). Coagulase-negative staphylococci, Staphylococcus aureus and fungi all exhibited decreasing trends, while rates of enterococci and Gram-negative bacteria remained stable. CONCLUSIONS:The overall incidence of mCRBSI in Switzerland is decreasing; however, the incidence of mCRBSI due to Enterococci and Gram-negative micro-organisms did not change over time. These pathogens may grow in importance in catheter-related infections, which would have clinical implications for the choice of empirical treatment.
journal_name
BMJ Openjournal_title
BMJ openauthors
Buetti N,Lo Priore E,Atkinson A,Widmer AF,Kronenberg A,Marschall J,Swiss Centre for Antibiotic Resistance (ANRESIS).doi
10.1136/bmjopen-2018-023824subject
Has Abstractpub_date
2018-12-22 00:00:00pages
e023824issue
12issn
2044-6055pii
bmjopen-2018-023824journal_volume
8pub_type
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