Protein Phosphatase 1 Regulatory Subunit SDS22 Inhibits Breast Cancer Cell Tumorigenesis by Functioning as a Negative Regulator of the AKT Signaling Pathway.

abstract：:Surgery is the most effective therapy for cancer in the United States, but disease still recurs in more than 40% of patients within 5 years after resection. Chemotherapy is given postoperatively to prevent relapses; however, this approach has had marginal success. After surgery, recurrent tumors depend on rapid neovas...

journal_title：Neoplasia (New York, N.Y.)

authors： Judy BF,Aliperti LA,Predina JD,Levine D,Kapoor V,Thorpe PE,Albelda SM,Singhal S

更新日期：2012-04-01 00:00:00

abstract：:Neurofibromatosis type 2 (NF2) is an inherited predisposition cancer syndrome characterized by the development of multiple benign tumors in the nervous system including schwannomas, meningiomas, and ependymomas. Using a disease model comprising primary human schwannoma cells, we previously demonstrated that adherens j...

journal_title：Neoplasia (New York, N.Y.)

authors： Zhou L,Ercolano E,Ammoun S,Schmid MC,Barczyk MA,Hanemann CO

更新日期：2011-12-01 00:00:00

abstract：:Epithelial-myoepithelial carcinoma (EMC) is a rare subtype of salivary gland neoplasms. Since the initial description of the cancer, just over 300 cases have been reported. EMCs occupy a biphasic cellular differentiation-state defined by the constitution of two cell types representing epithelial and myoepithelial line...

journal_title：Neoplasia (New York, N.Y.)

authors： Mäkelä R,Arjonen A,Suryo Rahmanto A,Härmä V,Lehtiö J,Kuopio T,Helleday T,Sangfelt O,Kononen J,Rantala JK

更新日期：2020-09-01 00:00:00

abstract：:Alveolar soft part sarcoma is an extremely rare soft tissue sarcoma with poor prognosis. It is characterized by the unbalanced recurrent chromosomal translocation der(17)t(X;17)(p11;q25), resulting in the generation of an ASPL-TFE3 fusion gene. ASPL-TFE3 oncoprotein functions as an aberrant transcriptional factor and ...

journal_title：Neoplasia (New York, N.Y.)

authors： Ishiguro N,Yoshida H

更新日期：2016-10-01 00:00:00

abstract：:Interstitial fluid pressure (IFP) has been shown to be an independent prognostic parameter for disease-free survival in cervical carcinoma patients treated with radiation therapy. However, the underlying mechanisms are not fully understood. The main aims of this study were to investigate whether tumor radiocurability ...

journal_title：Neoplasia (New York, N.Y.)

authors： Rofstad EK,Gaustad JV,Brurberg KG,Mathiesen B,Galappathi K,Simonsen TG

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Well-differentiated gastroenteropancreatic neuroendocrine neoplasms are rare tumors with a slow proliferation. They are virtually resistant to many DNA-damaging therapeutic approaches, such as chemo- and external beam therapy, which might be overcome by DNA damage inhibition induced by proteasome inhibitors ...

journal_title：Neoplasia (New York, N.Y.)

authors： Briest F,Koziolek EJ,Albrecht J,Schmidt F,Bernsen MR,Haeck J,Kühl AA,Sedding D,Hartung T,Exner S,Welzel M,Fischer C,Grötzinger C,Brenner W,Baum RP,Grabowski P

更新日期：2021-01-01 00:00:00

abstract：:For improved tumor staging and therapy control, imaging biomarkers are of great interest allowing a noninvasive characterization of invasiveness. In squamous epithelial skin and cervix lesions, transition to invasive stages is associated with enhanced matrix metalloproteinase (MMP) activity, increased angiogenesis, an...

journal_title：Neoplasia (New York, N.Y.)

authors： Al Rawashdeh W,Arns S,Gremse F,Ehling J,Knüchel-Clarke R,Kray S,Spöler F,Kiessling F,Lederle W

更新日期：2014-03-01 00:00:00

abstract：:Several observations suggest a potential role of T-cell-mediated immunity in the control of neuroblastoma (NB). However, the generation of NB-specific cytotoxic T lymphocytes (CTL) on T-cell priming with tumor mRNA-transfected dendritic cells (DC) has never been investigated before. In the present study, the feasibili...

journal_title：Neoplasia (New York, N.Y.)

authors： Morandi F,Chiesa S,Bocca P,Millo E,Salis A,Solari M,Pistoia V,Prigione I

更新日期：2006-10-01 00:00:00

abstract：:The biologic plausibility of an association between type 2 diabetes mellitus (T2D) and lung cancer has received increasing attention, but the results of investigations remain largely inconclusive. In the present study we investigated the influence of the anti-diabetic drug metformin on the cytotoxic effects of EGFR ta...

journal_title：Neoplasia (New York, N.Y.)

authors： Xiao Z,Gaertner S,Morresi-Hauf A,Genzel R,Duell T,Ullrich A,Knyazev PG

更新日期：2017-05-01 00:00:00

abstract：:Tumor-associated macrophages (TAMs) invade the tumor stroma in many cancers, yet their role is incompletely understood. To visualize and better understand these critical cells in tumor progression, we screened a portfolio of rationally selected, injectable agents to image endogenous TAMs ubiquitously in three differen...

journal_title：Neoplasia (New York, N.Y.)

authors： Leimgruber A,Berger C,Cortez-Retamozo V,Etzrodt M,Newton AP,Waterman P,Figueiredo JL,Kohler RH,Elpek N,Mempel TR,Swirski FK,Nahrendorf M,Weissleder R,Pittet MJ

更新日期：2009-05-01 00:00:00

abstract：:It has been proposed that the structural and numerical chromosome abnormalities recorded in breast cancer could be the result of telomere dysfunction and that telomerase is activated de novo to provide a survival mechanism curtailing further chromosomal aberrations. However, recent in vivo and in vitro data show that ...

journal_title：Neoplasia (New York, N.Y.)

authors： Papadopoulou A,Trangas T,Teixeira MR,Heim S,Dimitriadis E,Tsarouha H,Andersen JA,Evangelou E,Ioannidis P,Agnantis NJ,Pandis N

更新日期：2003-03-01 00:00:00

abstract：:The goal of oncology is the individualization of patient care to optimize therapeutic responses and minimize toxicities. Achieving this will require noninvasive, quantifiable, and early markers of tumor response. Preclinical data from xenografted tumors using a variety of antitumor therapies have shown that magnetic r...

journal_title：Neoplasia (New York, N.Y.)

authors： Theilmann RJ,Borders R,Trouard TP,Xia G,Outwater E,Ranger-Moore J,Gillies RJ,Stopeck A

更新日期：2004-11-01 00:00:00

abstract：:Peritoneal metastasis (PM) is a very serious complication of gastrointestinal and gynecological malignancies which is poorly documented. Modified mesothelial cell layer and their microenvironments can favor fibrin deposition for cancer cell adhesion. Scanning and transmission electron microscopy of peritoneal surface ...

journal_title：Neoplasia (New York, N.Y.)

authors： Shahid S,Iman A,Matti U,Rachid K,Assaf A,Eveno C,Marc P,Massoud M

更新日期：2019-11-01 00:00:00

abstract：:Epstein-Barr virus (EBV) latent infection is a critical event in nasopharyngeal carcinoma (NPC) tumorigenesis. EBV-encoded genes have been shown to be involved in immune evasion and in the regulation of various cellular signaling cascades. To elucidate the roles of EBV in NPC development, stable infection of EBV in na...

journal_title：Neoplasia (New York, N.Y.)

authors： Lo AK,Lo KW,Tsao SW,Wong HL,Hui JW,To KF,Hayward DS,Chui YL,Lau YL,Takada K,Huang DP

更新日期：2006-03-01 00:00:00

abstract：:It has long been a puzzle in cancer treatment that despite the initial appearance of apoptosis, the process could be reversed in some cancer cells and often results in more aggressive tumors and metastasis. The mechanism for this recurrence is yet unknown. Here we report that human mammary carcinoma cells induced to u...

journal_title：Neoplasia (New York, N.Y.)

authors： Xu Y,So C,Lam HM,Fung MC,Tsang SY

更新日期：2018-03-01 00:00:00

abstract：:The high prevalence and long latency period of prostate cancer (PCa) provide a unique opportunity to control disease progression with dietary and nutraceutical approaches. We developed ProFine, a standardized composition of luteolin, quercetin, and kaempferol, and investigated its potential as a nutraceutical for PCa ...

journal_title：Neoplasia (New York, N.Y.)

authors： Mamouni K,Zhang S,Li X,Chen Y,Yang Y,Kim J,Bartlett MG,Coleman IM,Nelson PS,Kucuk O,Wu D

更新日期：2018-08-01 00:00:00

abstract：:Incomplete spontaneous regression of melanoma is common. However, complete melanoma regression is still a very rare phenomenon. Because melanoma is the most immunogenic human malignancy, the mechanisms leading to regression, based on accumulative evidence, are the host's immune responses. Unfortunately, therapies aimi...

journal_title：Neoplasia (New York, N.Y.)

authors： Rambow F,Piton G,Bouet S,Leplat JJ,Baulande S,Marrau A,Stam M,Horak V,Vincent-Naulleau S

更新日期：2008-07-01 00:00:00

abstract：:Chromobox 4 (CBX4) is a core component of polycomb-repressive complex 1 with important roles in cancer biology and tissue homeostasis. Aberrant expression of CBX4 has been implicated in several human malignancies. However, its role and underlying mechanisms in the tumorigenesis of lung adenocarcinoma (LUAD) have not b...

journal_title：Neoplasia (New York, N.Y.)

authors： Wang Z,Fang Z,Chen G,Liu B,Xu J,Li F,Li F,Liu H,Zhang H,Sun Y,Tian G,Chen H,Xu G,Zhang L,Hu L,Ji H

更新日期：2021-02-01 00:00:00

abstract：:TMPRSS2-ERG gene fusions are the predominant molecular subtype of prostate cancer. Here, we explored the role of TMPRSS2-ERG gene fusion product using in vitro and in vivo model systems. Transgenic mice expressing the ERG gene fusion product under androgen-regulation develop mouse prostatic intraepithelial neoplasia (...

journal_title：Neoplasia (New York, N.Y.)

authors： Tomlins SA,Laxman B,Varambally S,Cao X,Yu J,Helgeson BE,Cao Q,Prensner JR,Rubin MA,Shah RB,Mehra R,Chinnaiyan AM

更新日期：2008-02-01 00:00:00

abstract：:Lysophosphatidic acid (LPA), a blood-borne lipid mediator, is present in elevated concentrations in ascites of ovarian cancer patients and other malignant effusions. LPA is a potent mitogen in cancer cells. The mechanism linking LPA signal to cancer cell proliferation is not well understood. Little is known about whet...

journal_title：Neoplasia (New York, N.Y.)

authors： Mukherjee A,Ma Y,Yuan F,Gong Y,Fang Z,Mohamed EM,Berrios E,Shao H,Fang X

更新日期：2015-09-01 00:00:00

abstract：:Adenomatous polyposis coli (APC) is a multifunctional protein having diverse cellular functions including cell migration, cell-cell adhesion, cell cycle control, chromosomal segregation, and apoptosis. Recently, we found a new role of APC in base excision repair (BER) and showed that it interacts with DNA polymerase β...

journal_title：Neoplasia (New York, N.Y.)

authors： Jaiswal AS,Panda H,Pampo CA,Siemann DW,Gairola CG,Hromas R,Narayan S

更新日期：2013-04-01 00:00:00

abstract：:The bcl-2 and c-myc oncogenes cooperate to transform multiple cell types. In the pediatric malignancy NB(2), Bcl-2 is highly expressed. In tumors with a poor prognosis, N-Myc, a protein homologous to c-Myc, is overexpressed as a result of gene amplification. The present study was designed to determine whether Bcl-2 co...

journal_title：Neoplasia (New York, N.Y.)

authors： Jasty R,van Golen C,Lin HJ,Solomon G,Heidelberger K,Polverini P,Opipari A,Feldman E,Castle VP

更新日期：2001-07-01 00:00:00

abstract：:Fbw7 is a tumor suppressor that regulates the degradation of oncogenic substrates such as c-Jun, c-Myc, Notch1 intracellular domain (ICD), and cyclin E by functioning as the substrate recognition protein in the Skp1-Cullin-F-box (SCF) ubiquitin ligase complex. Consequently, low expression or loss of FBXW7 in breast ca...

journal_title：Neoplasia (New York, N.Y.)

authors： Meyer AE,Furumo Q,Stelloh C,Minella AC,Rao S

更新日期：2020-11-01 00:00:00

abstract：:Since loss of VHL is frequently detected early phase genetic event in human renal cell carcinoma, pVHL is assumed to be indispensable for suppression of tumor initiation step. However, induction of HIF-1α, target of pVHL E3 ligase, is more adequate to angiogenesis step after tumor mass formation. Concerning this, it h...

journal_title：Neoplasia (New York, N.Y.)

authors： Jung YS,Chun HY,Yoon MH,Park BJ

更新日期：2014-12-01 00:00:00

abstract：:We have demonstrated that modifying the tumor microenvironment through intratumoral administration of adenoviral vectors (Ad) encoding the conditional cytotoxic molecule, i.e., HSV1-TK and the immune-stimulatory cytokine, i.e., fms-like tyrosine kinase 3 ligand (Flt3L) leads to T-cell-dependent tumor regression in rod...

journal_title：Neoplasia (New York, N.Y.)

authors： Candolfi M,Curtin JF,Yagiz K,Assi H,Wibowo MK,Alzadeh GE,Foulad D,Muhammad AK,Salehi S,Keech N,Puntel M,Liu C,Sanderson NR,Kroeger KM,Dunn R,Martins G,Lowenstein PR,Castro MG

更新日期：2011-10-01 00:00:00

abstract：:Telomerase, a cellular reverse transcriptase, adds telomeric repeats to chromosome ends. In normal human somatic cells, telomerase is repressed and telomeres progressively shorten, leading to proliferative senescence. Introduction of the telomerase (hTERT) cDNA is sufficient to produce telomerase activity and immortal...

journal_title：Neoplasia (New York, N.Y.)

authors： Yi X,White DM,Aisner DL,Baur JA,Wright WE,Shay JW

更新日期：2000-09-01 00:00:00

abstract：:We previously discovered that a fat-metabolizing enzyme, 15-lipoxygenase-1 (15-LO-1), is high in human prostate cancer (PCa) and correlates with disease progression. The biologic link between the aberrant 15-LO-1/linoleic acid (LA) metabolism and fat (which is a rich source of growth factors) in PCa is unknown. Theref...

journal_title：Neoplasia (New York, N.Y.)

authors： Kelavkar UP,Cohen C

更新日期：2004-01-01 00:00:00

abstract：:A mathematical model is presented for the cellular uptake and cytotoxicity of the anticancer drug doxorubicin. The model assumes sigmoidal, Hill-type dependence of cell survival on drug-induced damage. Experimental evidence indicates distinct intracellular and extracellular mechanisms of doxorubicin cytotoxicity. Drug...

journal_title：Neoplasia (New York, N.Y.)

authors： El-Kareh AW,Secomb TW

更新日期：2005-07-01 00:00:00

abstract：:The sequence of genomic alterations acquired by cancer cells during tumor progression and metastasis is poorly understood. Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that integrates cytoskeleton remodeling, mitogenic signaling and cell survival. FAK has previously been reported to undergo nuclear lo...

journal_title：Neoplasia (New York, N.Y.)

authors： Constanzo JD,Tang KJ,Rindhe S,Melegari M,Liu H,Tang X,Rodriguez-Canales J,Wistuba I,Scaglioni PP

更新日期：2016-05-01 00:00:00

abstract：:Soluble CD44 proteins generated by proteolytic cleavage or aberrant intron retention have been shown to antagonize the ligand binding activity of the corresponding cell surface receptor, inducing apoptosis and inhibiting tumor growth. Interestingly, such findings appear to contradict recent studies demonstrating a cor...

journal_title：Neoplasia (New York, N.Y.)

authors： Chiu RK,Carpenito C,Dougherty ST,Hayes GM,Dougherty GJ

更新日期：1999-11-01 00:00:00