Abstract:
:The high prevalence and long latency period of prostate cancer (PCa) provide a unique opportunity to control disease progression with dietary and nutraceutical approaches. We developed ProFine, a standardized composition of luteolin, quercetin, and kaempferol, and investigated its potential as a nutraceutical for PCa in preclinical models. The three ingredients of ProFine demonstrated synergistic in vitro cytotoxicity and effectively induced apoptosis in PCa cells. ProFine markedly affected the transcriptome of PCa cells, suppressed the expression of androgen receptor, and inhibited androgen-regulated genes. Oral administration of ProFine did not exhibit obvious toxicities in mice, and the three ingredients retained their individual pharmacokinetic and bioavailability profiles. Importantly, ProFine significantly retarded the growth of PCa xenografts in athymic nude mice and extended the survival of animals. This study provides preclinical evidence supporting the promise of ProFine as a safe, efficacious, and affordable intervention to control PCa progression and improve clinical outcomes.
journal_name
Neoplasiajournal_title
Neoplasia (New York, N.Y.)authors
Mamouni K,Zhang S,Li X,Chen Y,Yang Y,Kim J,Bartlett MG,Coleman IM,Nelson PS,Kucuk O,Wu Ddoi
10.1016/j.neo.2018.06.003subject
Has Abstractpub_date
2018-08-01 00:00:00pages
789-799issue
8eissn
1522-8002issn
1476-5586pii
S1476-5586(18)30265-3journal_volume
20pub_type
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