PIAS1-FAK Interaction Promotes the Survival and Progression of Non-Small Cell Lung Cancer.

abstract：:The WNT/beta-catenin (CTNNB1) pathway is commonly activated in the carcinogenic process. Cross-talks between the WNT and cyclooxygenase-2 (COX-2 or PTGS2)/prostaglandin pathways have been suggested. The relationship between beta-catenin activation and microsatellite instability (MSI) in colorectal cancer has been cont...

journal_title：Neoplasia (New York, N.Y.)

authors： Kawasaki T,Nosho K,Ohnishi M,Suemoto Y,Kirkner GJ,Dehari R,Meyerhardt JA,Fuchs CS,Ogino S

更新日期：2007-07-01 00:00:00

abstract：:Aberrant activation of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) 3 has been implicated in cell proliferation and survival of many cancers including head and neck squamous cell carcinoma (HNSCC). AZD1480, an orally active pharmacologic inhibitor of JAK1/JAK2, has been tested in seve...

journal_title：Neoplasia (New York, N.Y.)

authors： Sen M,Pollock NI,Black J,DeGrave KA,Wheeler S,Freilino ML,Joyce S,Lui VW,Zeng Y,Chiosea SI,Grandis JR

更新日期：2015-03-01 00:00:00

abstract：:We have demonstrated that modifying the tumor microenvironment through intratumoral administration of adenoviral vectors (Ad) encoding the conditional cytotoxic molecule, i.e., HSV1-TK and the immune-stimulatory cytokine, i.e., fms-like tyrosine kinase 3 ligand (Flt3L) leads to T-cell-dependent tumor regression in rod...

journal_title：Neoplasia (New York, N.Y.)

authors： Candolfi M,Curtin JF,Yagiz K,Assi H,Wibowo MK,Alzadeh GE,Foulad D,Muhammad AK,Salehi S,Keech N,Puntel M,Liu C,Sanderson NR,Kroeger KM,Dunn R,Martins G,Lowenstein PR,Castro MG

更新日期：2011-10-01 00:00:00

abstract：:Metastatic dissemination of primary tumors is responsible for 90% of colorectal cancer (CRC) deaths. The presence of positive lymph nodes, which separates stage I/II from stage III CRC, is a particularly key factor in patient management. Here, we describe results of a quantitative proteomic survey to identify molecula...

journal_title：Neoplasia (New York, N.Y.)

authors： Lin Y,Buckhaults PJ,Lee JR,Xiong H,Farrell C,Podolsky RH,Schade RR,Dynan WS

更新日期：2009-09-01 00:00:00

abstract：:Using bioinformatics, we have identified a novel tumor-specific gene BJ-TSA-9, which has been validated by Northern blot analysis and reverse transcription-polymerase chain reaction (RT-PCR). BJ-TSA-9 mRNA was expressed in 52.5% (21 of 40) of human lung cancer tissues and was especially higher in lung adenocarcinoma (...

journal_title：Neoplasia (New York, N.Y.)

authors： Li Y,Dong X,Yin Y,Su Y,Xu Q,Zhang Y,Pang X,Zhang Y,Chen W

更新日期：2005-12-01 00:00:00

abstract：PURPOSE:Upregulation of Bcl-2 family members is a well-established mechanism in the development of androgen-independent prostate cancer. Inhibition of the antiapoptotic proteins Bcl-2 and Mcl-1 may delay the transition to androgen-independent growth. EXPERIMENTAL DESIGN:We have established a prostate cancer model with...

journal_title：Neoplasia (New York, N.Y.)

authors： Loberg RD,McGregor N,Ying C,Sargent E,Pienta KJ

更新日期：2007-12-01 00:00:00

abstract：:p21-activated kinase 2 (PAK-2) seems to be a regulatory switch between cell survival and cell death signaling. We have shown previously that activation of full-length PAK-2 by Rac or Cdc42 stimulates cell survival, whereas caspase activation of PAK-2 to the proapoptotic PAK-2p34 fragment is involved in the cell death ...

journal_title：Neoplasia (New York, N.Y.)

authors： Marlin JW,Eaton A,Montano GT,Chang YW,Jakobi R

更新日期：2009-03-01 00:00:00

abstract：:Originally identified as an oncogene activated by amplification in squamous cell carcinomas, several lines of evidence now suggest that squamous cell carcinoma-related oncogene (SCCRO; aka DCUN1D1) may play a role in the pathogenesis of a wide range of human cancers including gliomas. SCCRO's oncogenic function is sub...

journal_title：Neoplasia (New York, N.Y.)

authors： Broderick SR,Golas BJ,Pham D,Towe CW,Talbot SG,Kaufman A,Bains S,Huryn LA,Yonekawa Y,Carlson D,Hambardzumyan D,Ramanathan Y,Singh B

更新日期：2010-06-01 00:00:00

abstract：:The transforming growth factorbeta (TGFbeta) superfamily regulates a broad spectrum of biological responses throughout embryonic development and adult life, including cell proliferation and differentiation, epithelial-to-mesenchymal transition, apoptosis, and angiogenesis. TGFbeta members initiate signaling by bringin...

journal_title：Neoplasia (New York, N.Y.)

authors： Izzi L,Attisano L

更新日期：2006-08-01 00:00:00

abstract：:Glioblastoma (GBM) is the most common malignant primary tumor of the central nervous system. With no effective therapy, the prognosis for patients is terrible poor. It is highly heterogeneous and EGFR amplification is its most frequent molecular alteration. In this light, we aimed to examine the genetic heterogeneity ...

journal_title：Neoplasia (New York, N.Y.)

authors： Muñoz-Hidalgo L,San-Miguel T,Megías J,Monleón D,Navarro L,Roldán P,Cerdá-Nicolás M,López-Ginés C

更新日期：2020-01-01 00:00:00

abstract：:Activation of the Wnt-signaling pathway is known to play a crucial role in carcinogenesis of various human organs including the colon, liver, prostate, and endometrium. To investigate the mechanisms underlying hepatocellular carcinogenesis, we attempted to identify genes regulated by beta-catenin/Tcf complex in a huma...

journal_title：Neoplasia (New York, N.Y.)

authors： Kato T,Satoh S,Okabe H,Kitahara O,Ono K,Kihara C,Tanaka T,Tsunoda T,Yamaoka Y,Nakamura Y,Furukawa Y

更新日期：2001-01-01 00:00:00

abstract：:Incomplete spontaneous regression of melanoma is common. However, complete melanoma regression is still a very rare phenomenon. Because melanoma is the most immunogenic human malignancy, the mechanisms leading to regression, based on accumulative evidence, are the host's immune responses. Unfortunately, therapies aimi...

journal_title：Neoplasia (New York, N.Y.)

authors： Rambow F,Piton G,Bouet S,Leplat JJ,Baulande S,Marrau A,Stam M,Horak V,Vincent-Naulleau S

更新日期：2008-07-01 00:00:00

abstract：:Transforming growth factor-beta1 (TGF-beta1) can be tumor-suppressive through the activation of the Smad-mediated signaling pathway. TGF-beta1 can also enhance tumor progression by stimulating epithelial-to-mesenchymal transition (EMT) through additional pathways. EMT is characterized by the acquisition of a fibroblas...

journal_title：Neoplasia (New York, N.Y.)

authors： Xie L,Law BK,Chytil AM,Brown KA,Aakre ME,Moses HL

更新日期：2004-09-01 00:00:00

abstract：:To survive and metastasize, tumors interact with surrounding tissues by secreting growth factors and cytokines. In return, surrounding host tissues respond by changing their secretome. Numerous factors theoretically function as therapeutic targets or biomarkers of cancer growth and metastatic risk. However, it is uncl...

journal_title：Neoplasia (New York, N.Y.)

authors： Kerr BA,Miocinovic R,Smith AK,Klein EA,Byzova TV

更新日期：2010-05-01 00:00:00

abstract：:We have recently reported that elastin microfibril interface located protein 2 (EMILIN2), an extracellular matrix (ECM) glycoprotein, triggers cell death through a direct binding to death receptors. EMILIN2 thus influences cell viability through a mechanism that is unique for an ECM molecule. In the present work, we r...

journal_title：Neoplasia (New York, N.Y.)

authors： Mongiat M,Marastoni S,Ligresti G,Lorenzon E,Schiappacassi M,Perris R,Frustaci S,Colombatti A

更新日期：2010-04-01 00:00:00

abstract：:It is known that total telomere length is shorter in invasive breast cancer than in normal breast tissue but the status of individual telomere lengths has not been studied. Part of the difficulty is that usually telomere length in interphase cells is measured on all chromosomes together. In this study we compared norm...

journal_title：Neoplasia (New York, N.Y.)

authors： Rashid-Kolvear F,Pintilie M,Done SJ

更新日期：2007-04-01 00:00:00

abstract：:In ovarian cancer, loss of BRCA gene expression in tumors is associated with improved response to chemotherapy and increased survival. A means to pharmacologically downregulate BRCA gene expression could improve the outcomes of patients with BRCA wild-type tumors. We report that vascular endothelial growth factor rece...

journal_title：Neoplasia (New York, N.Y.)

authors： Lim JJ,Yang K,Taylor-Harding B,Wiedemeyer WR,Buckanovich RJ

更新日期：2014-04-01 00:00:00

abstract：:Several studies have linked vascular density, identified in histologic sections, to "metastatic risk." Functional information of the vasculature, not readily available from histologic sections, can be obtained with contrast-enhanced MRI to exploit for therapy or metastasis prevention. Our aims were to determine if hum...

journal_title：Neoplasia (New York, N.Y.)

authors： Bhujwalla ZM,Artemov D,Natarajan K,Ackerstaff E,Solaiyappan M

更新日期：2001-03-01 00:00:00

abstract：:Recent studies suggest that tumor-infiltrating immune cells can benefit the tumor by producing factors that promote angiogenesis and suppress immunity. Because the tumor microenvironment is characterized by high adenosine levels, we hypothesized that the low-affinity A(2B) adenosine receptor located on host immune cel...

journal_title：Neoplasia (New York, N.Y.)

authors： Ryzhov S,Novitskiy SV,Zaynagetdinov R,Goldstein AE,Carbone DP,Biaggioni I,Dikov MM,Feoktistov I

更新日期：2008-09-01 00:00:00

abstract：:Tumor cells in the bone interact with the microenvironment to promote tumor cell survival and proliferation, resulting in a lethal phenotype for patients with advanced prostate cancer. Monocyte chemoattractant protein 1 (CCL2) is a member of the CC chemokine family and is known to promote monocyte chemotaxis to sites ...

journal_title：Neoplasia (New York, N.Y.)

authors： Loberg RD,Day LL,Harwood J,Ying C,St John LN,Giles R,Neeley CK,Pienta KJ

更新日期：2006-07-01 00:00:00

abstract：:Wnt/beta-catenin signaling plays an important role in normal development. However, its aberrant activation is associated with several cancers. The aim of this study is to examine the Wnt/beta-catenin pathway in patients with advanced pancreatic adenocarcinoma (n = 31). Paraffin sections from tumors (n = 16) and normal...

journal_title：Neoplasia (New York, N.Y.)

authors： Zeng G,Germinaro M,Micsenyi A,Monga NK,Bell A,Sood A,Malhotra V,Sood N,Midda V,Monga DK,Kokkinakis DM,Monga SP

更新日期：2006-04-01 00:00:00

abstract：:High microvascular density (MVD) in the primary tumor has been shown to be associated with increased incidence of lymph node metastases and poor clinical outcome. Other investigations have revealed that a large fraction of hypoxic tissue in the primary tumor is associated with metastatic disease and impaired survival....

journal_title：Neoplasia (New York, N.Y.)

authors： Rofstad EK,Galappathi K,Mathiesen BS

更新日期：2014-07-01 00:00:00

abstract：:T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy originating from T-cell precursors. The genetic landscape of T-ALL has been largely characterized by next-generation sequencing. Yet, the transcriptome of miRNAs (miRNome) of T-ALL has been less extensively studied. Using small RNA sequencing, we ...

journal_title：Neoplasia (New York, N.Y.)

authors： Dawidowska M,Jaksik R,Drobna M,Szarzyńska-Zawadzka B,Kosmalska M,Sędek Ł,Machowska L,Lalik A,Lejman M,Ussowicz M,Kałwak K,Kowalczyk JR,Szczepański T,Witt M

更新日期：2019-03-01 00:00:00

abstract：:Ras-transformed intestinal epithelial cells are resistant to the growth inhibitory actions of TGFbeta and have a marked decrease in expression of the TGFbeta type II receptor (TGFbetaRII). Rat intestinal epithelial cells (RIE) were stably transfected with activated Ras, Sos and Raf constructs and tested for expression...

journal_title：Neoplasia (New York, N.Y.)

authors： Bulus NM,Sheng HM,Sizemore N,Oldham SM,Barnett JV,Coffey RJ,Beauchamp DR,Barnard JA

更新日期：2000-07-01 00:00:00

abstract：:The Nup98-HoxD13 (NHD13) fusion gene was identified in a patient with therapy-related myelodysplastic syndrome (MDS). When transgenically expressed in hematopoietic cells, mice faithfully recapitulate human disease with serial progression from peripheral blood (PB) cytopenias and increased bone marrow (BM) blasts to a...

journal_title：Neoplasia (New York, N.Y.)

authors： Byrne M,Bennett RL,Cheng X,May WS

更新日期：2014-08-01 00:00:00

abstract：:Protein phosphatases play a crucial role in cell cycle progression, cell survival, cellular signaling, and genomic integrity. The protein phosphatase 1 (PP1) regulatory subunit SDS22 plays a significant role in cell cycle progression. A recent study showed that SDS22 plays a vital role in epithelial integrity and tumo...

journal_title：Neoplasia (New York, N.Y.)

authors： Paul D,Bargale AB,Rapole S,Shetty PK,Santra MK

更新日期：2019-01-01 00:00:00

abstract：:Pancreatic cancer patients have an abysmal prognosis because of late diagnosis and lack of therapeutic options. Pancreatic intraepithelial neoplasias (PanINs), the precursor lesions, are a potential target for chemoprevention. Targeting eicosanoid pathways is an obvious choice because 5-lipoxygenase (5-LOX) has been s...

journal_title：Neoplasia (New York, N.Y.)

authors： Hennig R,Kehl T,Noor S,Ding XZ,Rao SM,Bergmann F,Fürstenberger G,Büchler MW,Friess H,Krieg P,Adrian TE

更新日期：2007-11-01 00:00:00

abstract：:The benefits of inhibiting vascular endothelial growth factor (VEGF) signaling in cancer patients are predominantly attributed to effects on tumor endothelial cells. Targeting non-endothelial stromal cells to further impact tumor cell growth and survival is being pursued through the inhibition of additional growth fac...

journal_title：Neoplasia (New York, N.Y.)

authors： Duignan IJ,Corcoran E,Pennello A,Plym MJ,Amatulli M,Claros N,Iacolina M,Youssoufian H,Witte L,Samakoglu S,Schwartz J,Surguladze D,Tonra JR

更新日期：2011-01-01 00:00:00

abstract：:There have been no reports describing the effects of cancer cell-derived extracellular vesicles (EVs) on three-dimensional organoids. In this study, we delineated the proneoplastic effects of esophageal adenocarcinoma (EAC)-derived EVs on gastric organoids (gastroids) and elucidated molecular mechanisms underlying the...

journal_title：Neoplasia (New York, N.Y.)

authors： Ke X,Yan R,Sun Z,Cheng Y,Meltzer A,Lu N,Shu X,Wang Z,Huang B,Liu X,Wang Z,Song JH,Ng CK,Ibrahim S,Abraham JM,Shin EJ,He S,Meltzer SJ

更新日期：2017-11-01 00:00:00

abstract：:Sporadic ovarian cancer is a particularly aggressive tumor characterized by highly abnormal karyotypes exhibiting many features of genomic instability. More complex genomic changes in tumors arise as a consequence of chromosomal instability (CIN), which can generate both numerical [(N)-CIN] and structural chromosomal ...

journal_title：Neoplasia (New York, N.Y.)

authors： Bayani J,Paderova J,Murphy J,Rosen B,Zielenska M,Squire JA

更新日期：2008-10-01 00:00:00