Polymorphic and Quantum Chemistry Characterization of Candesartan Cilexetil: Importance for the Correct Drug Classification According to Biopharmaceutics Classification System.

abstract：:This study examined the effect of rotor speed, amount of water sprayed, and atomizing air pressure on the geometric mean diameter and geometric standard deviation of pellets produced in a fluid-bed rotor granulator using a 23 factorial design and an optimization technique. Pellets were prepared by wet granulation. Equ...

journal_title：AAPS PharmSciTech

authors： Korakianiti ES,Rekkas DM,Dallas PP,Choulis NH

更新日期：2000-12-01 00:00:00

abstract：:Our aim was to investigate the cellular uptake, in vitro cytotoxicity and bioavailability of ginsenoside-modified nanostructured lipid carrier loaded with curcumin (G-NLC). The formulation was prepared by melt emulsification technique, in which water was added to the melted lipids and homogenized to give a uniform sus...

journal_title：AAPS PharmSciTech

authors： Vijayakumar A,Baskaran R,Baek JH,Sundaramoorthy P,Yoo BK

更新日期：2019-01-23 00:00:00

abstract：:Rifaximin (RFX), a semi-synthetic antibiotic belonging to BCS class IV category, has been used in the treatment of traveler's diarrhea. An attempt has been made to improve aqueous solubility of RFX in the presence of β-cyclodextrin (β-CD) and hydroxy propyl β-cyclodextrin (HP-β-CD) and control its release in the gut b...

journal_title：AAPS PharmSciTech

authors： Karanje RV,Bhavsar YV,Jahagirdar KH,Bhise KS

更新日期：2013-06-01 00:00:00

abstract：:Colorectal cancer is a global concern, and its treatment is fraught with non-selective effects including adverse side effects requiring hospital visits and palliative care. A relatively safe drug formulated in a bioavailability enhancing and targeting delivery platform will be of significance. Metformin-loaded solid l...

journal_title：AAPS PharmSciTech

authors： Ngwuluka NC,Kotak DJ,Devarajan PV

更新日期：2017-02-01 00:00:00

abstract：:Modifications to the surface chemistry, charge, and hydrophilicity/hydrophobicity of nanoparticles are applicable approaches to the alterations of the in vivo fate of intravenously administered nano-sized drug carriers. The objective of this study is to investigate the in vitro and in vivo antitumor efficacies of curc...

journal_title：AAPS PharmSciTech

authors： Sun L,Xu H,Xu JH,Wang SN,Wang JW,Zhang HF,Jia WR,Li LS

更新日期：2020-06-11 00:00:00

abstract：:The objectives of this study were to formulate, characterize silymarin-loaded Eudragit nanoparticles (SNPs) and evaluate their hepatoprotective and cytotoxic effects after oral administration. SNPs were prepared by nanoprecipitation technique and were evaluated for particle size, entrapment efficiency, TEM, solid-stat...

journal_title：AAPS PharmSciTech

authors： El-Nahas AE,Allam AN,Abdelmonsif DA,El-Kamel AH

更新日期：2017-11-01 00:00:00

abstract：:A hydroxyethylcellulose-poly(acrylic acid) (HEC-PAA) lyomatrix was developed for ganciclovir (GCV) intestine targeting to overcome its undesirable degradation in the stomach. GCV was encapsulated within the HEC-PAA lyomatrix prepared by lyophilization. Conventional tablets were also prepared with identical GCV concent...

journal_title：AAPS PharmSciTech

authors： Mabrouk M,Mulla JA,Kumar P,Chejara DR,Badhe RV,Choonara YE,du Toit LC,Pillay V

更新日期：2016-10-01 00:00:00

abstract：:Pluronic F127 (PF-127) shows thermoreversible property, which is of the utmost interest in optimizing drug formulation and delivery. However, its hitherto unresolved drawback of a low phase transition temperature (T (tr)) has limited its application in injectable drug delivery systems. We have ...

journal_title：AAPS PharmSciTech

authors： Ma Y,Zhang C,Chen X,Jiang H,Pan S,Easteal AJ,Sun X

更新日期：2012-06-01 00:00:00

abstract：:The purpose of this research was to evaluate a novel fiber-optic photometer for its ability to monitor physical instabilities occurring in concentrated emulsions during storage. For this, the fiber-optic photometer was used to measure transmission of oil-in-water emulsions stabilized with hypromellose (HPMC) as a func...

journal_title：AAPS PharmSciTech

authors： Oliczewski S,Daniels R

更新日期：2007-08-31 00:00:00

abstract：:The use of amorphous solid dispersions to improve the bioavailability of active ingredients from the BCS II and IV classifications continues to gain interest in the pharmaceutical industry. Over the last decade, methods for generating amorphous solid dispersions have been well established in commercially available pro...

journal_title：AAPS PharmSciTech

authors： Huang S,Williams RO 3rd

更新日期：2018-07-01 00:00:00

abstract：:Freeze-dried immunoglobulin G (IgG) incorporating trehalose and human serum albumin (HSA) was statistically evaluated regarding the existence of synergism between additives on the stability profile. The levels of HSA (X1) and trehalose (X2) were independent variables. Aggregation following the process (Y1), after 2 an...

journal_title：AAPS PharmSciTech

authors： Nouraei MS,Faghihi H,Najafabadi AR,Zadeh AHM,Darabi M,Vatanara A

更新日期：2019-10-28 00:00:00

abstract：:A new, simple, inexpensive, and rapid 96-well plate UV spectrophotometric method was developed and validated for the quantification of compound 48/80 (C48/80) associated with particles. C48/80 was quantified at 570 nm after reaction with acetaldehyde and sodium nitroprusside in an alkaline solution (pH 9.6). The metho...

journal_title：AAPS PharmSciTech

authors： Bento D,Borchard G,Gonçalves T,Borges O

更新日期：2013-06-01 00:00:00

abstract：:The present study was carried out with a view to enhance the dissolution of poorly water-soluble BCS-class II drug aceclofenac by co-grinding with novel porous carrier Neusilin US(2.) (amorphous microporous granules of magnesium aluminosilicate, Fuji Chemical Industry, Toyama, Japan). Neusilin US(2) has been used as a...

journal_title：AAPS PharmSciTech

authors： Vadher AH,Parikh JR,Parikh RH,Solanki AB

更新日期：2009-01-01 00:00:00

abstract：:Bimatoprost is widely used for the management of glaucoma. Currently, it is delivered via eye drop solution, which is highly inefficient due to low bioavailability. To control the release of ocular drugs, contact lenses are used by scientists. However, the conventional soaking method showed high burst release due to a...

journal_title：AAPS PharmSciTech

authors： Yan F,Liu Y,Han S,Zhao Q,Liu N

更新日期：2020-01-13 00:00:00

abstract：:Non-invasive administration of insulin is expected for better diabetes mellitus therapy. In this report, we developed intraoral preparation for insulin. Insulin was encapsulated into nanocarrier using self-assembly emulsification process. To increase lipophilicity of insulin, it was dispersed in phospholipid resulted ...

journal_title：AAPS PharmSciTech

authors： Rachmawati H,Haryadi BM,Anggadiredja K,Suendo V

更新日期：2015-06-01 00:00:00

abstract：:The main objective of the present study is the physicochemical characterization of naturally available Terminalia catappa gum (Badam gum [BG]) as a novel pharmaceutical excipient and its suitability in the development of gastroretentive floating drug delivery systems (GRFDDS) to retard the drug for 12 h when the dosag...

journal_title：AAPS PharmSciTech

authors： Meka VS,Nali SR,Songa AS,Kolapalli VR

更新日期：2012-12-01 00:00:00

abstract：:A large number of pharmaceuticals exhibit polymorphism; 23% steroids, 60% sulfonamides, and 70% of barbiturates have shown this property. In this study, we have investigated and compared a new technique termed as melt sonocrystallization (MSC) with melt and sonocrystallization (SC) for induction of polymorphism in pro...

journal_title：AAPS PharmSciTech

authors： Tripathi R,Biradar SV,Mishra B,Paradkar AR

更新日期：2010-09-01 00:00:00

abstract：:Triple-negative breast (TNBC) cancer that is upregulated with epidermal growth factor receptor (EGFR), and devoid of both the hormonal receptors and epidermal growth factor receptor 2 (HER 2), has led to a concept of treating TNBC with EGFR-targeted therapeutics. The combination of paclitaxel (PTX) and piperine (PIP) ...

journal_title：AAPS PharmSciTech

authors： Burande AS,Viswanadh MK,Jha A,Mehata AK,Shaik A,Agrawal N,Poddar S,Mahto SK,Muthu MS

更新日期：2020-05-21 00:00:00

abstract：:This study assessed the utility of near-infrared (NIR) spectroscopy for the real-time monitoring of content uniformity and critical quality attributes (tensile strength, Young's modulus, and relative density) of ribbed roller compacted flakes made by axially corrugated or ribbed rolls. A custom-built setup was used to...

journal_title：AAPS PharmSciTech

authors： Samanta AK,Karande AD,Ng KY,Heng PW

更新日期：2013-03-01 00:00:00

abstract：:The aim of this work was to assess the effect of formulation parameters of a mucoadhesive vaginal gel based on chitosan and lactic acid, and to highlight its release mechanisms. Two molecular weight chitosans were used to prepare gels with 2 lactic acid concentrations. Both chitosan molecular weight and lactic acid co...

journal_title：AAPS PharmSciTech

authors： Bonferoni MC,Giunchedi P,Scalia S,Rossi S,Sandri G,Caramella C

更新日期：2006-01-01 00:00:00

abstract：:Pharmaceutical excipients contain reactive groups and impurities due to manufacturing processes that can cause decomposition of active drug compounds. The aim of this investigation was to determine if commercially available oral disintegrating tablet (ODT) platforms induce active pharmaceutical ingredient (API) degrad...

journal_title：AAPS PharmSciTech

authors： Köllmer M,Popescu C,Manda P,Zhou L,Gemeinhart RA

更新日期：2013-12-01 00:00:00

abstract：:AR-12 is a novel small molecule with broad spectrum antifungal activity. Recently, AR-12 was found to be highly active against Trichophyton rubrum, one of the predominantly responsible organisms that cause onychomycosis. The primary objective of this project was to investigate the ability of AR-12 to penetrate into an...

journal_title：AAPS PharmSciTech

authors： Kushwaha AS,Sharma P,Shivakumar HN,Rappleye C,Zukiwski A,Proniuk S,Murthy SN

更新日期：2017-10-01 00:00:00

abstract：:This research aimed to synthesize and evaluate mucoadhesive catechol-functionalized alginate (Cat-Alg) nanoparticles (NPs) for bladder cancer. Cat-Alg was synthesized using coupling chemistry, and the structure was verified using NMR and FT-IR. Cat-Alg NPs were generated by ionic gelation between the synthesized Cat-A...

journal_title：AAPS PharmSciTech

authors： Sahatsapan N,Ngawhirunpat T,Rojanarata T,Opanasopit P,Patrojanasophon P

更新日期：2020-07-31 00:00:00

abstract：:The process of developing an old drug for new indications is now a widely accepted strategy of shortening drug development time, reducing drug costs, and improving drug availability, especially for rare and neglected diseases. In this mini-review, we highlighted the impact of drug delivery systems in the fulfillment o...

journal_title：AAPS PharmSciTech

authors： Czech T,Lalani R,Oyewumi MO

更新日期：2019-02-15 00:00:00

abstract：:While polyethylene oxide (PEO)-based matrix tablets are frequently used as abuse-deterrent dosage forms, there is limited information available regarding how the selection of formulation components and manufacturing processes affect the resulting abuse-deterrent properties. The objective of the current study was to ev...

journal_title：AAPS PharmSciTech

authors： Meruva S,Donovan MD

更新日期：2019-12-19 00:00:00

abstract：:This work aimed to develop a fast-dissolving film made of low dextrose equivalent maltodextrins (MDX) containing nicotine hydrogen tartrate salt (NHT). Particular attention was given to the selection of the suitable taste-masking agent (TMA) and the characterisation of the ductility and flexibility under different mec...

journal_title：AAPS PharmSciTech

authors： Cilurzo F,Cupone IE,Minghetti P,Buratti S,Selmin F,Gennari CG,Montanari L

更新日期：2010-12-01 00:00:00

abstract：:The present study introduces a new three-dimensional (3D) surface image analysis technique in which white light illumination from different incident angles is used to create 3D surfaces with a photometric approach. The three-dimensional features of the surface images created are then used in the characterization of pa...

journal_title：AAPS PharmSciTech

authors： Soppela I,Airaksinen S,Hatara J,Räikkönen H,Antikainen O,Yliruusi J,Sandler N

更新日期：2011-06-01 00:00:00

abstract：:Top-spray fluidized bed granulation with axial fluidization airflow from the bottom of the granulator is well-established in the pharmaceutical industry. The application of swirling airflow for fluidized bed granulation was more recently introduced. This study examined the effects of various process parameters on the ...

journal_title：AAPS PharmSciTech

authors： Wong PM,Chan LW,Heng PW

更新日期：2013-03-01 00:00:00

abstract：:Griseofulvin, an antifungal agent, is a BCS class II drug slowly, erratically, and incompletely absorbed from the gastrointestinal tract in humans. The clinical failure of the conventional oral therapy of griseofulvin is most likely attributed to its poor solubility and appreciable inter- and intra-subject variation i...

journal_title：AAPS PharmSciTech

authors： Aggarwal N,Goindi S,Mehta SD

更新日期：2012-03-01 00:00:00

abstract：:This study focused on the synthesis and characterization of a natural polymeric system employing the interpenetrating polymer network (IPN) comprising curcumin as a bioactive. Biopolymers and actives such as chitosan, hypromellose, citric acid, genipin, and curcumin were used to develop an effective, biodegradable, an...

journal_title：AAPS PharmSciTech

authors： Mayet N,Kumar P,Choonara YE,Tomar LK,Tyagi C,du Toit LC,Pillay V

更新日期：2014-12-01 00:00:00