Abstract：
BACKGROUND:The purpose of the study is to investigate the role and mechanisms of hydrogen-saturated saline (HSS) in the acute lung injury (ALI) induced by oleic acid (OA) in rats. METHODS:Rats were treated with OA (0.1 mL/kg) to induce ALI and then administered with HSS (5 mL/kg) by intravenous (iv) and intraperitoneal (ip) injection, respectively. Three hours after the injection with OA, the arterial oxygen partial pressure (PaO2), arterial oxygen saturation (SaO2), carbon dioxide partial pressure (PaCO2), and bicarbonate (HCO3-) levels were analyzed using blood gas analyzer. In addition, the levels of malondialdehyde (MDA), tumor necrosis factor-α (TNF-α), and interleukin 1β (IL-1β) and myeloperoxidase (MPO) activity were measured by commercial kits, and pathological changes of lung tissue were examined by HE staining. Finally, the correlations of MPO activity or MDA level with the levels of TNF-α or IL-1β were analyzed by Pearson's correlation analysis. RESULTS:We found decreased PaO2 levels and the pathological changes of lung tissue of ALI after OA injection. In addition, OA increased the levels of MDA, TNF-α, and IL-1β, as well as MPO activity in lung tissues (P < 0.05). However, after treatment with HSS, all of these changes were alleviated (P < 0.05), and these changes were mitigated when treated with HSS by ip then iv injection (P < 0.05). Furthermore, MDA level and MPO activity were positively correlated with TNF-α and IL-1β levels in the lung tissue, respectively (P < 0.01). CONCLUSION:HSS attenuated ALI induced by OA in rats and might protect against ALI through selective resistance to oxidation and inhibiting inflammatory infiltration.
journal_name
J Orthop Surg Resjournal_title
Journal of orthopaedic surgery and researchauthors
Ying Y,Xu H,Yao M,Qin Zdoi
10.1186/s13018-017-0633-9subject
Has Abstractpub_date
2017-09-19 00:00:00pages
134issue
1issn
1749-799Xpii
10.1186/s13018-017-0633-9journal_volume
12pub_type
杂志文章abstract：BACKGROUND:Percutaneous fixation with cannulated screws is an effective method for treating medial malleolar epiphyseal fractures, which comprise a portion of bimalleolar and trimalleolar fractures. Lateral malleolar fractures also need to be fixed to achieve anatomical reduction and absolute stable fixation of the ank...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-019-1287-6
更新日期：2019-08-08 00:00:00
abstract：BACKGROUND:The aim of this study was to analyze and compare the surgical data, clinical outcomes, and complications between three-column osteotomy (3-COS) and standard surgical management (SSM) for the treatment of adult spine deformity (ASD). METHODS:A total of 112 patients who underwent consecutive 3-COS (n = 48) an...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-015-0154-3
更新日期：2015-02-03 00:00:00
abstract：:Acute traumatic patellar dislocation is a common injury in the active and young adult populations. MRI of the knee is recommended in all patients who present with acute patellar dislocation. Numerous operative and non-operative methods have been described to treat the injuries; however, the ideal management of the acu...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章,评审
doi：10.1186/1749-799X-7-21
更新日期：2012-06-06 00:00:00
abstract：BACKGROUND:Long-term success reports by Dr. Ponseti with the Ponseti method in the treatment of congenital idiopathic clubfoot have led to a renewed interest in this method among pediatric orthopedists. The purpose of this study is to evaluate mid-term effectiveness of Ponseti method for the treatment of congenital idi...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/1749-799X-6-3
更新日期：2011-01-12 00:00:00
abstract：PURPOSE:The orientation of the acetabular component in metal-on-metal hip resurfacing arthroplasty affects wear rate and hence failure. This study aimed to establish if interpretation of pelvic radiographs with TraumaCad software can provide a reliable alternative to CT in measuring the acetabular inclination and versi...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/1749-799X-8-8
更新日期：2013-04-11 00:00:00
abstract：BACKGROUND:The differences in the clinical and functional outcomes of closed reduction and percutaneous pin fixation and open reduction with internal fixation (ORIF) using plate and screws have been systematically synthesized by one meta-analysis. With newer studies being published, an effort to update the earlier meta...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-020-02057-y
更新日期：2020-11-19 00:00:00
abstract：BACGROUND:Although the contribution of fibroblast growth factor (FGF)-2 and mesenchymal stromal cells (MSCs) to bone formation is well known, few studies have investigated the combination of an autologous bone graft with FGF-2 or MSCs for large bone defects. METHODS:We studied an atrophic non-union model with a large ...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-016-0442-6
更新日期：2016-09-26 00:00:00
abstract：BACKGROUND:The purpose of the study was to examine the effect of a foot-worn biomechanical device on the clinical measurements and gait patterns of patients with total hip arthroplasty (THA). METHODS:Nineteen patients, up to 3 months post-THA, were enrolled to the study. Patients underwent a computerized gait analysis...
journal_title：Journal of orthopaedic surgery and research
pub_type： 临床试验,杂志文章
doi：10.1186/1749-799X-8-13
更新日期：2013-05-21 00:00:00
abstract：PURPOSE:This meta-analysis compared the clinical outcomes of locking plate with intramedullary nail in the treatment of displaced proximal humeral fractures. METHODS:We searched PubMed, Embase, and the Cochrane databases for studies comparing locking plate and intramedullary nail treatment of displaced two-, three-, o...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章,meta分析
doi：10.1186/s13018-015-0242-4
更新日期：2015-09-15 00:00:00
abstract：BACKGROUND:It is known that mortality after hip fracture increases compared to the general population; the trend in mortality is a controversial issue. The objective of this study is to examine incidence, trends, and factors associated with mortality in patients with osteoporotic hip fractures. METHODS:This is a retro...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-019-1226-6
更新日期：2019-07-04 00:00:00
abstract：BACKGROUND:Evaluation of knee and lower limb function alone is not sufficient to assess gait. For accurate assessment of gait abnormality, gait oscillation should also be measured. The goal of this analysis was to assess the influence of the knee joint on gait oscillation during gait and stair-stepping in patients with...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-019-1064-6
更新日期：2019-01-16 00:00:00
abstract：BACKGROUND:Entrapment of the superior cluneal nerve (SCN) in an osteofibrous tunnel has been reported as a cause of low back pain (LBP). However, there are few reports on the prevalence of SCN disorder and there are several reports only on favorable outcomes of treatment of SCN disorder on LBP. The purposes of this pro...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-014-0139-7
更新日期：2014-12-31 00:00:00
abstract：BACKGROUND:This study aimed to investigate the effects of stromal cell-derived factor-1 (SDF-1) on biphasic ceramic-like biologic bone (BCBB) in vivo on the repair of large segment bone defect in rabbits. METHODS:A large-segment radius defect model of the rabbits was constructed. In the experimental group, BCBB with S...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-019-1277-8
更新日期：2019-07-22 00:00:00
abstract：BACKGROUND:Lubrication function is impaired and the lubricant content of synovial fluid (SF) changes immediately after plateau tibia fractures. Here, we aimed to analyze the lubricant content of SF at chronic term following plateau tibia fracture. METHODS:Forty-eight surgically treated patients without joint incongrue...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-015-0232-6
更新日期：2015-06-03 00:00:00
abstract：BACKGROUND:Core decompression (CD) is an important method for the treatment of osteonecrosis of the femoral head (ONFH). Few articles investigate the influence of core decompression on outcomes of ONFH. This study was carried out to observe the safety and effectiveness of core decompression in the treatment of ONFH. M...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章,meta分析
doi：10.1186/s13018-019-1359-7
更新日期：2019-09-11 00:00:00
abstract：:The use of computer navigation is becoming a well-recognized technical alternative to conventional total knee arthroplasty (TKA). However, computer navigation has a substantial learning curve and the use of commercially available navigation systems increases surgical time. In addition, the potential risks associated w...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/1749-799X-6-26
更新日期：2011-05-26 00:00:00
abstract：BACKGROUND:The purpose of this study was to determine errors in measurement of torsional profiles (TP) (torsional femoral angle, torsional tibial angle, and femoral ankle angle) among four orthopedic surgeons, experts, and non-experts in measurement, and the learning curve. METHODS:Twenty-six lower extremities of 13 p...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-015-0200-1
更新日期：2015-05-15 00:00:00
abstract：OBJECTIVE:To assess the clinical effect of staged joint replacement for the treatment of septic arthritic knee and the therapeutic differences between antibiotic cement beads and the tibial plateau spacer. METHODS:Twenty-three patients (24 knee joints) treated with a staged joint replacement for septic arthritis knee ...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-020-02062-1
更新日期：2020-11-11 00:00:00
abstract：BACKGROUND:This study aimed to investigate the incidence and risk factors of postoperative urinary retention (POUR) among elderly patients who underwent hip fracture surgery and to evaluate the effect of indwelling catheterization on the occurrence of POUR. MATERIALS AND METHODS:From January 2012 to January 2015, cons...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-019-1360-1
更新日期：2019-09-18 00:00:00
abstract：BACKGROUND:This study was aimed at investigating the causes of lower extremity weaknesses after posterior lumbar spine fusion surgery and looking at subsequent treatment strategies. METHODS:Patients who underwent posterior lumbar spine fusion surgery in the Peking University First Hospital between January 2009 and Dec...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-020-01948-4
更新日期：2020-09-22 00:00:00
abstract：BACKGROUND:By comparing clinical outcomes between dual plating (DP) and exchange nailing with augmentation plating (EN/AP), we aimed to provide better treatment strategies for femoral shaft non-union. METHODS:We retrospectively reviewed 30 patients with aseptic femoral shaft non-union at our level 1 trauma center betw...
journal_title：Journal of orthopaedic surgery and research
pub_type： 临床试验,杂志文章
doi：10.1186/s13018-018-1002-z
更新日期：2018-11-20 00:00:00
abstract：BACKGROUND:In total knee arthroplasty (TKA) a flexible intramedullary rod can be used to account for sagittal bowing of the distal femur. Although patients report better post-operative functional outcome when the flexible rod was used, it is unknown how the use of the flexible rod affects the placement of the femoral T...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-020-01989-9
更新日期：2020-10-14 00:00:00
abstract：BACKGROUND:Sensory nerve endings in ligaments play an important role for the proprioceptive function. Clinical trials show that the sense of body position does not fully recover in the knee joint after reconstructive surgery of the ruptured anterior cruciate ligament. The aim of this study is to identify sensory corpus...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-020-01785-5
更新日期：2020-07-17 00:00:00
abstract：BACKGROUND:Sternoclavicular joint (SCJ) infectious arthritis is a rare disease. A standard treatment for SCJ infection has not been established. This study aimed to assess the clinical outcomes of a three-stage procedure with bone transportation (BT) for treating SCJ infectious arthritis. METHODS:Six patients (mean ag...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-016-0480-0
更新日期：2016-11-25 00:00:00
abstract：BACKGROUND:Hyperleptinemia is a common feature of obese people, and leptin, an adipocyte-derived cytokine, is believed to be an important factor in the pathogenesis of cervical ossification of the posterior longitudinal ligament(C-OPLL). So this research was to identify the relation between the serum leptin and bone me...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-018-0864-4
更新日期：2018-07-03 00:00:00
abstract：:Soy protein, a rich source of phytoestrogens, exhibit estrogen-type bioactivity. The purpose of this study was to determine if ingestion of isoflavones before ovariectomy can prevent bone loss following ovariectomy. Twenty-four nulliparous Wistar rats were randomly divided into four groups. In the normal diet groups, ...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/1749-799X-3-12
更新日期：2008-03-02 00:00:00
abstract：BACKGROUND:The study aims to compare the long-term functional and radiographic outcomes of two devices for the treatment of primary intertrochanteric fractures (IFs, OTA 3.1A2.1-A2.3) in elderly patients with osteoporosis. METHODS:Between December 2010 and August 2014, 332 elderly osteoporosis patients with IFs (OTA 3...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-017-0648-2
更新日期：2017-10-10 00:00:00
abstract：BACKGROUND:Additively manufactured porous metallic structures have recently received great attention for bone implant applications. The morphological characteristics and mechanical behavior of 3D printed titanium alloy trabecular structure will affect the effects of artificial prosthesis replacement. However, the mecha...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-019-1489-y
更新日期：2020-02-07 00:00:00
abstract：BACKGROUND:We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the efficacy and safety of local infiltration anesthesia (LIA) versus epidural analgesia (EPA) for postoperative pain control in total knee arthroplasty (TKA). METHODS:In December 2017, a systematic compute...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章,meta分析,评审
doi：10.1186/s13018-018-0770-9
更新日期：2018-05-16 00:00:00
abstract：BACKGROUND:The aim of this research is to analyze the influence of Modic types on the clinical results of cervical spondylotic myelopathy treated by anterior cervical diskectomy and fusion. METHODS:A total of 106 patients with a mean age of 55.8 ± 6.5 years were included in this study. Patients with Modic changes were...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-014-0146-8
更新日期：2015-01-28 00:00:00
