Abstract：
BACGROUND:Although the contribution of fibroblast growth factor (FGF)-2 and mesenchymal stromal cells (MSCs) to bone formation is well known, few studies have investigated the combination of an autologous bone graft with FGF-2 or MSCs for large bone defects. METHODS:We studied an atrophic non-union model with a large bone defect, created by resecting a 10-mm section from the center of each femoral shaft of 12-week-old Sprague-Dawley rats. The periosteum of the proximal and distal ends of the femur was cauterized circumferentially, and excised portions were used in the contralateral femur as autologous bone grafts. The rats were randomized to three groups and given no further treatment (group A), administered FGF-2 at 20 μg/20 μL (group B), or 1.0 × 106 MSCs (group C). Radiographs were taken every 2 weeks up to 12 weeks, with CT performed at 12 weeks. Harvested femurs were stained with toluidine blue and evaluated using radiographic and histology scores. RESULTS:Radiographic and histological evaluation showed that bone union had been achieved at 12 weeks in group C, while group B showed callus formation and bridging callus but non-union, and in group A, callus formation alone was evident. Both radiographic and histological scores were significantly higher at 2, 4, 6, 8, 10, and 12 weeks in groups B and C than group A and also significantly higher in group C than group B at 12 weeks. CONCLUSIONS:These data suggest that autologous bone grafts in combination with MSCs benefit difficult cases which cannot be treated with autologous bone grafts alone.
journal_name
J Orthop Surg Resjournal_title
Journal of orthopaedic surgery and researchauthors
Murakami H,Nakasa T,Ishikawa M,Adachi N,Ochi Mdoi
10.1186/s13018-016-0442-6subject
Has Abstractpub_date
2016-09-26 00:00:00pages
105issue
1issn
1749-799Xpii
10.1186/s13018-016-0442-6journal_volume
11pub_type
杂志文章abstract：BACKGROUND:Limited-incision total hip arthroplasty (THA) preserves hip abductors, posterior capsule, and external rotators potentially diminishing dislocation risk. However, potential complications also exist, such as component malposition. Specific implants have been manufactured that enhance compatibility with this t...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
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journal_title：Journal of orthopaedic surgery and research
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journal_title：Journal of orthopaedic surgery and research
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pub_type： 杂志文章
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journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
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journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
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更新日期：2019-11-14 00:00:00
