Abstract：
BACKGROUND:This study aimed to investigate the effects of stromal cell-derived factor-1 (SDF-1) on biphasic ceramic-like biologic bone (BCBB) in vivo on the repair of large segment bone defect in rabbits. METHODS:A large-segment radius defect model of the rabbits was constructed. In the experimental group, BCBB with SDF-1 sustained-release system were implanted into the bone defect site. Other three groups including normal control, autologous bone graft, and BCBB implantation without SDF-1 were set. After surgery, general observation, X-ray radiography and scoring, and tissue section staining were performed at 2, 4, 8, 12, and 24 weeks post-implantation. RESULTS:By general observation, X-ray radiography and grading and tissue section staining observation, we found that the BCBB carrying SDF-1 was better than those in the group of BCBB without SDF-1 (P < 0.05). BCBB scaffold had certain bone conduction capacity, and the BCBB scaffold carrying SDF-1 had improved bone conduction ability and possessed bone induction ability. In the case of carrying SDF-1, it can be used to repair large bone defects in a shorter time than simply using BCBB, which is equivalent to the effect of autologous bone. CONCLUSION:BCBB scaffold carrying SDF-1 can promote the repair effect on a large bone defect, which is equivalent to the effect of autologous bone.
journal_name
J Orthop Surg Resjournal_title
Journal of orthopaedic surgery and researchauthors
Wang F,Yang G,Xiao Y,He C,Cai G,Song E,Li Ydoi
10.1186/s13018-019-1277-8subject
Has Abstractpub_date
2019-07-22 00:00:00pages
231issue
1issn
1749-799Xpii
10.1186/s13018-019-1277-8journal_volume
14pub_type
杂志文章abstract：BACKGROUND:The stability of acetabulum reconstructions using reinforcement rings and hooks is important for successful replacement surgery. The objective of this study was to biomechanically determine the effects of the hook on stress and the related micromotions of the acetabular reinforcement ring during the immediat...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-018-1023-7
更新日期：2018-12-07 00:00:00
abstract：BACKGROUND:Recently, there has been increasing interest in mobile-bearing total knee arthroplasty (TKA). However, changes in biomechanics with respect to femoral component alignment in mobile-bearing TKA have not been explored in depth. This study aims to evaluate the biomechanical effect of sagittal alignment of the f...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-019-1458-5
更新日期：2019-11-28 00:00:00
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journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-016-0506-7
更新日期：2017-01-13 00:00:00
abstract：BACKGROUND:Lumbar floating fusion occasionally causes postoperative adjacent segment disorder (ASD) at lumbosacral level, causing L5 spinal nerve disorder by L5-S1 foraminal stenosis. The disorder is considered to be one of the major outcomes of L5-S1 ASD, which has not been evaluated yet. The present study aimed to ev...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-015-0307-4
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abstract：BACKGROUND:This study aimed to investigate the roles of lncRNA SNHG10 (SNHG10) and miR-218 in osteosarcoma (OS). METHODS:Paired OS and non-tumor tissues were collected from 58 OS patients. The expression of SNHG10 and miR-218 in tissue samples were determined by RT-qPCR. The interaction between SNHG10 and miR-218 was ...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-020-01865-6
更新日期：2020-08-26 00:00:00
abstract：BACKGROUND:The zero-profile anchored cage (ZP) has been widely used for its lower occurrence of dysphagia. However, it is still controversial whether it has the same stability as the cage-plate construct (CP) and increases the incidence of postoperative subsidence. We compared the rate of subsidence after anterior cerv...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-020-01711-9
更新日期：2020-05-24 00:00:00
abstract：OBJECTIVE:After reverse shoulder arthroplasty (RSA) external and internal rotation will often remain restricted. A postoperative alteration of the biomechanics in the remaining cuff is discussed as a contributing factor to these functional deficits. METHODS:In this study, muscle moment arms as well as origin-to-insert...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/1749-799X-6-42
更新日期：2011-08-16 00:00:00
abstract：BACKGROUND:The major disadvantage of using a stem cell-based bone morphogenetic protein-4 (BMP4) gene therapy for skull defect is the overgrowth of generated bone tissue in situ. In the present study, to overcome bony overgrowth of stem cell based-gene therapy, a new strategy of two-stage bone tissue engineering by an ...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-015-0229-1
更新日期：2015-05-30 00:00:00
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journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章,评审
doi：10.1186/s13018-020-02189-1
更新日期：2021-01-14 00:00:00
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journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-019-1451-z
更新日期：2019-12-16 00:00:00
abstract：BACKGROUND:Femoral and sciatic nerves could be damaged during various stages of the periacetabular osteotomy. Changing the position of the hip could be the most effective way of preventing nerve injuries. The purpose of the present study was to investigate the distances of the nerves to various bony landmarks with diff...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-020-01937-7
更新日期：2020-09-11 00:00:00
abstract：:In the original publication of this article [1], Chinese text of the Figs. 3, 4, 5 has not been converted to English. ...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章,已发布勘误
doi：10.1186/s13018-020-01612-x
更新日期：2020-03-09 00:00:00
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journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-020-01948-4
更新日期：2020-09-22 00:00:00
abstract：BACKGROUND:The aim of this study was to analyze the pattern and types of sensory nerve endings in ankle collateral ligaments using histological techniques, in order to observe the morphology and distribution of mechanoreceptors in the collateral ligaments of cadaver ankle joint, and to provide the morphological evidenc...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-015-0215-7
更新日期：2015-06-12 00:00:00
abstract：BACKGROUND:This study aims to compare clinical outcomes of distraction arthroplasty alone versus combined with arthroscopic microfracture in treating post-traumatic ankle arthritis. METHODS:The study cohort consisted of 96 patients (96 ankles) who underwent distraction arthroplasty alone or combined with arthroscopic ...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-017-0546-7
更新日期：2017-03-17 00:00:00
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journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-016-0442-6
更新日期：2016-09-26 00:00:00
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journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章,评审
doi：10.1186/s13018-020-01823-2
更新日期：2020-08-05 00:00:00
abstract：BACKGROUND:We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the efficacy and safety of local infiltration anesthesia (LIA) versus epidural analgesia (EPA) for postoperative pain control in total knee arthroplasty (TKA). METHODS:In December 2017, a systematic compute...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章,meta分析,评审
doi：10.1186/s13018-018-0770-9
更新日期：2018-05-16 00:00:00
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journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-019-1329-0
更新日期：2019-08-28 00:00:00
abstract：BACKGROUND:To investigate the distribution and characteristics of the lumbar intervertebral disc height (IDH) in asymptomatic Asian population and to determine whether the lumbar IDH is related to the lumbar spine sagittal alignment. METHODS:A cohort of 169 cases of asymptomatic volunteers was enrolled from January 20...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-018-0737-x
更新日期：2018-02-12 00:00:00
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journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-019-1302-y
更新日期：2019-08-15 00:00:00
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journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/1749-799X-1-13
更新日期：2006-11-04 00:00:00
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journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-019-1504-3
更新日期：2019-12-11 00:00:00
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journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-018-0964-1
更新日期：2018-10-16 00:00:00
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journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章,meta分析
doi：10.1186/s13018-015-0161-4
更新日期：2015-01-28 00:00:00
abstract：BACKGROUND:The purpose of this study was to determine errors in measurement of torsional profiles (TP) (torsional femoral angle, torsional tibial angle, and femoral ankle angle) among four orthopedic surgeons, experts, and non-experts in measurement, and the learning curve. METHODS:Twenty-six lower extremities of 13 p...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-015-0200-1
更新日期：2015-05-15 00:00:00
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journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/1749-799X-6-34
更新日期：2011-07-13 00:00:00
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journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/s13018-015-0303-8
更新日期：2015-10-20 00:00:00
abstract：BACKGROUND:Failure of pedicle screw fixation is often seen in patients with severe osteoporosis. We developed new lumbar spinal instrumentation (Tadpole system) for elderly patients who have osteoporotic bone and poor general health status. The objective of this study was to document the long-term clinical outcomes aft...
journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
doi：10.1186/1749-799X-9-33
更新日期：2014-05-12 00:00:00
abstract：BACKGROUND:The purpose of the study was to examine the effect of a foot-worn biomechanical device on the clinical measurements and gait patterns of patients with total hip arthroplasty (THA). METHODS:Nineteen patients, up to 3 months post-THA, were enrolled to the study. Patients underwent a computerized gait analysis...
journal_title：Journal of orthopaedic surgery and research
pub_type： 临床试验,杂志文章
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更新日期：2013-05-21 00:00:00
