Abstract：
BACKGROUND:Hyperleptinemia is a common feature of obese people, and leptin, an adipocyte-derived cytokine, is believed to be an important factor in the pathogenesis of cervical ossification of the posterior longitudinal ligament(C-OPLL). So this research was to identify the relation between the serum leptin and bone metabolic markers and how the leptin induced osteogenic effect in C-OPLL. METHODS:Sixty-four samples were selected to determine the concentration of leptin, insulin, and alkaline phosphatase. And the association of leptin with these factors was also examined. We also evaluate the effect of leptin on the development of C-OPLL and further explored the possible underlying mechanism in vitro. RESULTS:We found that serum leptin concentrations were higher in females than in males. Serum leptin and ALP concentrations were increased significantly in C-OPLL females compared to non-OPLL females. In OPLL subjects, the serum leptin concentration corrected for body mass index correlated negatively with the ALP concentrations. In C-OPLL cells, leptin treatment led to a significant increase in mRNA expressions of ALP and OCN and formation of mineralized nodule. Our experiments reported here that osteogenic effect of leptin in C-OPLL cells could be mediated via ERK1/2, p38 MAPK, and/or JNK signaling pathways. CONCLUSIONS:From this research, we got that leptin treatment led to a significant increase in mRNA expressions of ALP and OCN and formation of mineralized nodule. And the osteogenic effect of leptin in C-OPLL cells could be mediated via ERK1/2, p38 MAPK, and/or JNK signaling pathways.
journal_name
J Orthop Surg Resjournal_title
Journal of orthopaedic surgery and researchauthors
Feng B,Cao S,Zhai J,Ren Y,Hu J,Tian Y,Weng Xdoi
10.1186/s13018-018-0864-4subject
Has Abstractpub_date
2018-07-03 00:00:00pages
165issue
1issn
1749-799Xpii
10.1186/s13018-018-0864-4journal_volume
13pub_type
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journal_title：Journal of orthopaedic surgery and research
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journal_title：Journal of orthopaedic surgery and research
pub_type： 杂志文章
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