Abstract：
BACKGROUND:Plasmodium vivax uses multiple ligand-receptor interactions for preferential invasion of human reticulocytes. Several of these ligands have been identified by in silico approaches based on the role displayed by their orthologs in other Plasmodium species during initial adhesion or invasion. However, the cell adhesion role of proteins that are exclusive to species that specifically invade reticulocytes (as P. vivax and P. cynomolgi) has not been evaluated to date. This study aimed to characterise an antigen shared between Plasmodium species that preferentially infect reticulocytes with a focus on assessing its binding activity to target cells. RESULTS:An in silico analysis was performed using P. vivax proteome data to identify and characterise one antigen shared between P. vivax and P. cynomolgi. This led to identification of the pvrbsa gene present in the P. vivax VCG-I strain genome. This gene is transcribed in mature schizonts and encodes a protein located on the parasite surface. rPvRBSA was antigenic and capable of binding to a population of reticulocytes with a different Duffy phenotype. Interestingly, the molecule showed a higher percentage of binding to immature human reticulocytes (CD71hi). CONCLUSIONS:This study describes for the first time, a molecule involved in host cell binding that is exclusive in reticulocyte-infecting Plasmodium species. This suggest that PvRBSA is an antigenic adhesin that plays a role in parasite binding to target cells.
journal_name
Parasit Vectorsjournal_title
Parasites & vectorsauthors
Moreno-Pérez DA,Baquero LA,Chitiva-Ardila DM,Patarroyo MAdoi
10.1186/s13071-017-2185-6subject
Has Abstractpub_date
2017-05-18 00:00:00pages
243issue
1issn
1756-3305pii
10.1186/s13071-017-2185-6journal_volume
10pub_type
杂志文章abstract：BACKGROUND:The Culex pipiens complex (Diptera: Culicidae) includes the most widespread mosquito species in the world. Members of this complex are the primary enzootic and epidemic vectors of the West Nile virus (genus Flavivirus) in several countries. The two recognized forms of Cx. pipiens (Linnaeus, 1758) - pipiens a...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-017-2265-7
更新日期：2017-07-10 00:00:00
abstract：BACKGROUND:Plasmodium falciparum delayed clearance with the use of artemisinin-based combination therapy (ACTs) has been reported in some African countries. Single nucleotide polymorphisms (SNPs) in two genes, P. falciparum adaptor protein complex 2 mu subunit (pfap2mu) and ubiquitin specific protease 1 (pfubp1), have ...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-018-2762-3
更新日期：2018-03-12 00:00:00
abstract：BACKGROUND:Low-density asymptomatic infections of Plasmodium spp. are common in low endemicity areas worldwide, but outside Africa, their contribution to malaria transmission is poorly understood. Community-based studies with highly sensitive molecular diagnostics are needed to quantify the asymptomatic reservoir of Pl...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-017-2407-y
更新日期：2017-10-24 00:00:00
abstract：BACKGROUND:Multiplicity and genetic diversity of Plasmodium falciparum infection might play a role in determining the clinical outcome of malaria infection and could be a fair reflection of the disease transmission rate. This study investigated the genetic diversity of P. falciparum and multiplicity of infection in rel...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-016-1641-z
更新日期：2016-06-27 00:00:00
abstract：BACKGROUND:The East Route Project (ERP) of the South-to-North Water Diversion Project (SNWDP) stretches across schistosomiasis endemic and non-endemic areas in China, which may lead to the dispersal of Oncomelania hupensis, the intermediate host of Schistosoma japonicum, from permissive areas along the Yangtze River Ba...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-020-4004-8
更新日期：2020-03-19 00:00:00
abstract：BACKGROUND:Taenia ovis is a tapeworm that is mainly transmitted between dogs and sheep. Although T. ovis infection is not a public health issue, it causes a great financial loss due to condemnation of carcasses. The first outbreak of T. ovis infection in China occurred in 2015. Reassessment of adverse effects of T. ov...
journal_title：Parasites & vectors
pub_type： 信件
doi：10.1186/s13071-016-1700-5
更新日期：2016-07-26 00:00:00
abstract：BACKGROUND:Free-living amoebae of the genus Acanthamoeba are cosmopolitan, widely distributed protozoans that cause a severe, vision-threatening corneal infection known as Acanthamoeba keratitis (AK). The majority of the increasing number of AK cases are associated with contact lens use. Appropriate eye hygiene and eff...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-020-04453-z
更新日期：2020-12-22 00:00:00
abstract：BACKGROUND:Leishmaniasis remains a major public health problem in African nations, including Morocco, where little is known about the vertebrate reservoirs involved in the causal parasites' transmission cycles. The present study investigates the role of rodent species as potential reservoirs of Leishmania spp. in centr...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-017-2398-8
更新日期：2017-10-02 00:00:00
abstract：BACKGROUND:Cathepsin cysteine proteases play multiple roles in the life cycle of parasites such as food uptake, immune invasion and pathogenesis, making them valuable targets for diagnostic assays, vaccines and drugs. The purpose of this study was to identify a cathepsin B of Clonorchis sinensis (CsCB) and to investiga...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-4-149
更新日期：2011-07-27 00:00:00
abstract：BACKGROUND:An active immune surveillance and a range of barriers to infection allow the host to effectively eliminate microbial pathogens. However, pathogens may use diverse strategies to subdue such host defences. For instance, one such mechanism is the use of leucine-rich repeat (LRR) proteins by pathogens (microbial...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-016-1842-5
更新日期：2016-10-21 00:00:00
abstract：BACKGROUND:Host specificity is one of the outputs of the coevolution between parasites and their associated hosts. Several scenarios have been proposed to explain the pattern of parasite distribution in parental and hybrid genotypes ranging from hybrid resistance to hybrid susceptibility. We hypothesized that host-para...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-020-04271-3
更新日期：2020-08-08 00:00:00
abstract：BACKGROUND:Animal trypanosomosis is endemic in Nigeria, while the human disease caused by Trypanosoma brucei gambiense is rarely reported nowadays after efforts to bring it under control in the 20th century. The University of Nigeria Veterinary Teaching Hospital (UNVTH) is a reference centre located within the Nsukka a...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-019-3680-8
更新日期：2019-08-27 00:00:00
abstract：BACKGROUND:An accurate diagnosis of soil-transmitted helminthiasis is important for individual patient management, for drug efficacy evaluation and for monitoring control programmes. The Kato-Katz technique is the most widely used method detecting soil-transmitted helminth eggs in faecal samples. However, detailed anal...
journal_title：Parasites & vectors
pub_type： 杂志文章,随机对照试验
doi：10.1186/s13071-015-0702-z
更新日期：2015-02-05 00:00:00
abstract：BACKGROUND:To reveal the spatio-temporal distribution of malaria vectors in the national malaria surveillance sites from 2005 to 2010 and provide reference for the current National Malaria Elimination Programme (NMEP) in China. METHODS:A 6-year longitudinal surveillance on density of malaria vectors was carried out in...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-015-0741-5
更新日期：2015-03-07 00:00:00
abstract：BACKGROUND:Pig keeping is becoming increasingly common across sub-Saharan Africa. Domestic pigs from the Arusha region of northern Tanzania were screened for trypanosomes using PCR-based methods to examine the role of pigs as a reservoir of human and animal trypanosomiasis. METHODS:A total of 168 blood samples were ob...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-6-322
更新日期：2013-11-09 00:00:00
abstract：BACKGROUND:Chikungunya virus (CHIKV) is a mosquito-borne alphavirus associated with epidemics of acute and chronic arthritic disease in humans. Aedes albopictus has emerged as an important new natural vector for CHIKV transmission; however, mouse models for studying transmission have not been developed. METHODS:Aedes ...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-016-1838-1
更新日期：2016-10-19 00:00:00
abstract：BACKGROUND:In the Eastern and Upper Midwestern regions of North America, Ixodes scapularis (L.) is the most abundant tick species encountered by humans and the primary vector of B. burgdorferi, whereas in the southeastern region Amblyomma americanum (Say) is the most abundant tick species encountered by humans but cann...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-5-139
更新日期：2012-07-10 00:00:00
abstract：BACKGROUND:Intestinal protozoan parasites are major contributors to the global burden of gastrointestinal disease causing significant socioeconomic consequences. Children living in resource-poor settings with restricted access to water and sanitary services are particularly at risk of these infections. METHODS:A prosp...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-018-3054-7
更新日期：2018-08-30 00:00:00
abstract：BACKGROUND:Control of the mosquito vector Culex pipiens with insecticides is the main way to control arboviruses that the species can transmit such as West Nile virus (WNV) and Rift Valley fever virus (RVFV). However, its efficiency has been hampered by the emergence of insecticide resistance. Little is known about the...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-018-2625-y
更新日期：2018-01-22 00:00:00
abstract：BACKGROUND:This study focused on the distribution and abundance of the eggs of Aedes aegypti and Aedes albopictus. METHODS:Eighty ovitraps were exposed for four days of each month in peri- and intradomiciliary environments of 40 urban residences on 20 street blocks that were drawn monthly in Sebastião, SP, between Feb...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-6-321
更新日期：2013-11-06 00:00:00
abstract：BACKGROUND:Certain municipalities in the Belo Horizonte Metropolitan Area (BHMA), Minas Gerais, Brazil, have the highest human visceral leishmaniasis (VL) mortality rates in the country and also demonstrate high canine seropositivity. In Brazil, the etiologic agent of VL is Leishmania (Leishmania) infantum. The aim of ...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-015-0837-y
更新日期：2015-04-15 00:00:00
abstract：BACKGROUND:Fluralaner is a novel isoxazoline eliciting both acaricidal and insecticidal activity through potent blockage of GABA- and glutamate-gated chloride channels. The aim of the study was to investigate the susceptibility of juvenile stages of common tick species exposed to fluralaner through either contact (Rhip...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-015-0704-x
更新日期：2015-02-08 00:00:00
abstract：BACKGROUND:Surveillance of outdoor resting malaria vector populations is crucial to monitor possible changes in vector resting and feeding behaviour following the widespread use of indoor-based vector control interventions. However, it is seldom included in the routine vector surveillance system in Africa due to lack o...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-019-3535-3
更新日期：2019-05-31 00:00:00
abstract：BACKGROUND:Recent global changes have led to an increase in distribution of ticks towards higher elevation and latitude in Europe and livestock are at increasing risk of contracting tick-borne diseases, but psychological aspects of how this affects human well-being are rarely assessed. Departing from the theory on emot...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-020-04162-7
更新日期：2020-06-30 00:00:00
abstract：BACKGROUND:Survival to dry season conditions of sub-Saharan savannahs is a major challenge for insects inhabiting such environments, especially regarding the desiccation threat they are exposed to. While extensive literature about insect seasonality has revealed morphologic, metabolic and physiological changes in many ...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-015-1289-0
更新日期：2016-01-07 00:00:00
abstract：BACKGROUND:Schistosomiasis is a prevalent but neglected tropical disease caused by parasitic trematodes of the genus Schistosoma, with the primary disease-causing species being S. haematobium, S. mansoni and S. japonicum. Male-female pairing of schistosomes is necessary for sexual maturity and the production of a large...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-019-3672-8
更新日期：2019-08-23 00:00:00
abstract：BACKGROUND:The invasive temperate mosquito Aedes japonicus japonicus is a potential vector for various infectious diseases and therefore a target of vector control measures. Even though established in Germany, it is unclear whether the species has already reached its full distribution potential. The possible range of t...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-019-3366-2
更新日期：2019-03-25 00:00:00
abstract：BACKGROUND:Sand flies (Diptera: Psychodidae) are the vectors of Leishmania parasites, the causative agents of leishmaniasis. Cutaneous leishmaniasis is an increasing public health problem in the Republic of Suriname and is mainly caused by Leishmania (Vianna) guyanensis, but L. (V.) braziliensis, L. (L.) amazonensis, a...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/1756-3305-6-318
更新日期：2013-11-04 00:00:00
abstract：BACKGROUND:Persistent covert infections of the myxozoan, Tetracapsuloides bryosalmonae, in primary invertebrate hosts (the freshwater bryozoan, Fredericella sultana) have been proposed to represent a reservoir for proliferative kidney disease in secondary fish hosts. However, we have limited understanding of how covert...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-017-2495-8
更新日期：2017-11-02 00:00:00
abstract：BACKGROUND:Genetic information for Toxoplasma gondii isolates from pigs in eastern, south, and southwestern regions of China has been reported previously. However, there are no data from pigs in the northeastern area of the country. To better understand the epidemiology of T. gondii, we determined the seroprevalence an...
journal_title：Parasites & vectors
pub_type： 杂志文章
doi：10.1186/s13071-016-1525-2
更新日期：2016-04-29 00:00:00
