Abstract:
BACKGROUND:This study aimed to summarize common pathogens and associated drug resistance in neonatal sepsis (NS). METHODS:Blood culture and drug sensitivity results from 96 NS cases treated from January 2010 to August 2014 were retrospectively analyzed. RESULTS:A total of 97 pathogenic bacteria were detected from these 96 NS cases; Gram-positive cocci accounted for 76.3% of the cases, among which 70.1% involved coagulase-negative staphylococcus (CONS), whereas Gram-negative bacilli and fungi accounted for 19.6% and fungi 4.1% of cases, respectively. Gram-positive cocci exhibited a higher penicillin resistance rate and full vancomycin sensitivity, whereas Gram-negative bacilli exhibited a higher cephalosporin resistance rate, low meropenem resistance rate (6.7%), and no resistance to amikacin. CONCLUSIONS:The main causative pathogens of NS in our hospital were Gram-positive cocci, among which coagulase-negative Staphylococcus spp such as S. epidermidis and S. haemolyticus were the main conditional pathogens; among Gram-negative pathogens, Klebsiella pneumoniae were most frequently isolated and showed widespread resistance to penicillins and cephalosporins.
journal_name
BMC Pediatrjournal_title
BMC pediatricsauthors
Dong H,Cao H,Zheng Hdoi
10.1186/s12887-017-0789-9subject
Has Abstractpub_date
2017-02-01 00:00:00pages
44issue
1issn
1471-2431pii
10.1186/s12887-017-0789-9journal_volume
17pub_type
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