Abstract：
BACKGROUND:Anopheles mosquitoes transmit malaria which is one of the world's most threatening diseases. Anopheles dirus (sensu stricto) is among the main vectors of malaria in South East Asia. The mosquito innate immune response is the first line of defence against malaria parasites during its development. The immune deficiency (IMD) pathway, a conserved immune signaling pathway, influences anti-Plasmodium falciparum activity in Anopheles gambiae, An. stephensi and An. albimanus. The aim of the study was to determine the role of Rel2, an IMD pathway-controlled NF-kappaβ transcription factor, in An. dirus. METHODS:RACE (Rapid amplification of cDNA ends) was performed on the Rel2 gene. Double-stranded Rel2 was constructed and injected into the thorax of female mosquitoes. The injected mosquitoes were fed on a P. falciparum gametocyte culture and dissected on day 7-9 post-feeding in order to count the oocysts. A survival analysis was conducted by exposing the dsRNA injected mosquitoes to Gram-positive and Gram-negative bacteria. RESULTS:This study demonstrated that the Rel2 gene in An. dirus has two isoforms, short length and full length. RNA interference-mediated gene silencing of Rel2 showed that the latter is involved in protection against P. falciparum, Gram-positive bacteria (Micrococcus luteus) with Lys-type peptidoglycan and Gram-negative bacteria (Escherichia coli) with DAP-type peptidoglycan. CONCLUSION:This study suggested that there are similarities in the splicing events and functionality of the Rel2 gene, between the Anopheles species. Among all the important anophelines, the immunity of only a few has been thoroughly investigated. In order to develop novel vector-based control strategies and restrict malaria transmission, the immune pathways of these important vectors should be thoroughly investigated.
journal_name
Parasit Vectorsjournal_title
Parasites & vectorsauthors
Khan MB,Liew JW,Leong CS,Lau YLdoi
10.1186/s13071-016-1810-0subject
Has Abstractpub_date
2016-09-29 00:00:00pages
525issue
1issn
1756-3305pii
10.1186/s13071-016-1810-0journal_volume
9pub_type
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