Abstract：
:This study was aimed to evaluate the relationship between serum interleukin-23 (IL-23) levels and ankylosing spondylitis (AS).Twenty male patients diagnosed with ankylosing spondylitis according to the 1984 modified New York criteria for AS and twenty male healthy controls were included in this study.The demographic characteristics, clinical and laboratory findings of the patients were recorded. Serum IL-23 levels, C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were measured in both the AS and control groups. The Bath ankylosing spondylitis disease activity ındex (BASDAI), the Bath ankylosing spondylitis functional index (BASFI), and the Bath ankylosing spondylitis metrology index (BASMI) were evaluated as disease activity parameters. The AS patients were divided into two subgroups as active and inactive in respect of CRP, ESR levels and BASDAI scores. The mean serum IL-23 levels of the AS and control groups were 334.45±176.54 pg/ml and 166.49±177.50 pg/ml respectively, and there was a significant difference between the groups. Correlation analysis of serum IL-23 levels with clinical and laboratory parameters showed that there were positive correlations between serum IL-23 levels and the BASDAI, BASFI scores in total, active and inactive patients and the BASMI scores in total and inactive patients and negative correlations between serum IL-23 levels and ESR in inactive patients. It was shown that altered serum IL-23 levels were related to AS disease activity. Further studies in large patient series are necessary to investigate the role of IL-23 protein in etiopathogenesis of AS.
journal_name
Nagoya J Med Scijournal_title
Nagoya journal of medical scienceauthors
Ugur M,Baygutalp NK,Melikoglu MA,Baygutalp F,Altas EU,Seferoglu Bsubject
Has Abstractpub_date
2015-11-01 00:00:00pages
621-7issue
4eissn
0027-7622issn
2186-3326journal_volume
77pub_type
杂志文章abstract：:The Japan Agency of Medical Research and Development (AMED) has approved the budget for the 5-year project called Establishment of the JAPAN Brain Bank Network, which commenced in 2016. This project was established with the aim of storing brain tissue samples to enable research on the etiologies and mechanisms of psyc...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章,评审
doi：10.18999/nagjms.80.3.309
更新日期：2018-08-01 00:00:00
abstract：:The catalytic subunit of human DNA polymerase (pol) delta, p125, was expressed in recombinant baculovirus-infected insect cells, separated from a baculovirus-encoded DNA polymerase, and was purified to homogeneity by affinity trapping with a histidine-octapeptide at the C-terminus of p125 as the ligand. Purified p125 ...
journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：2000-11-01 00:00:00
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journal_title：Nagoya journal of medical science
pub_type： 杂志文章,评审
doi：
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journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：2015-02-01 00:00:00
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journal_title：Nagoya journal of medical science
pub_type： 杂志文章
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journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：1995-12-01 00:00:00
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journal_title：Nagoya journal of medical science
pub_type： 杂志文章,多中心研究
doi：
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journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：10.18999/nagjms.79.4.443
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journal_title：Nagoya journal of medical science
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journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：2016-08-01 00:00:00
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journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：2015-02-01 00:00:00
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journal_title：Nagoya journal of medical science
pub_type：
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更新日期：2020-11-01 00:00:00
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journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：2015-08-01 00:00:00
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journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
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journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：2008-03-01 00:00:00
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journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：1993-03-01 00:00:00
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journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：10.18999/nagjms.79.2.251
更新日期：2017-02-01 00:00:00
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journal_title：Nagoya journal of medical science
pub_type： 杂志文章,评审
doi：
更新日期：1997-11-01 00:00:00
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journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：2012-02-01 00:00:00
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journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：1994-05-01 00:00:00
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journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：2014-08-01 00:00:00
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journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：2014-02-01 00:00:00
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journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：2000-05-01 00:00:00
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journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：10.18999/nagjms.80.2.227
更新日期：2018-05-01 00:00:00
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pub_type： 杂志文章
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更新日期：2018-08-01 00:00:00
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journal_title：Nagoya journal of medical science
pub_type： 杂志文章
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更新日期：2018-11-01 00:00:00
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pub_type： 杂志文章
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journal_title：Nagoya journal of medical science
pub_type： 杂志文章
doi：
更新日期：1993-03-01 00:00:00
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pub_type： 杂志文章
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