Abstract:
:Yokukansankachimpihange (YKSCH), a traditional Japanese medicine, is widely used for the amelioration of the behavioral and psychological symptoms of dementia with digestive dysfunction. Regardless of its successful use for digestive dysfunction, the effect of YKSCH on body weight was unknown. Furthermore, if YKSCH increased body weight, it might increase motivation according to Kampo medicine theory. Therefore, we investigated whether YKSCH had the potential to increase body weight and enhance motivation in mice. To address this, C57BL/6J mice were used to evaluate the long-term effect of YKSCH on body weight and food-incentive motivation. As part of the evaluation, we optimized an operant test for use over the long-term. We found that feeding mice YKSCH-containing chow increased body weight, but did not increase their motivation to food reward. We propose that YKSCH may be a good treatment option for preventing decrease in body weight in patients with dementia.
journal_name
Nagoya J Med Scijournal_title
Nagoya journal of medical scienceauthors
Hamaguchi T,Tsutsui-Kimura I,F Tanaka K,Mimura Mdoi
10.18999/nagjms.79.3.351subject
Has Abstractpub_date
2017-08-01 00:00:00pages
351-362issue
3eissn
0027-7622issn
2186-3326journal_volume
79pub_type
杂志文章abstract::The Japan Agency of Medical Research and Development (AMED) has approved the budget for the 5-year project called Establishment of the JAPAN Brain Bank Network, which commenced in 2016. This project was established with the aim of storing brain tissue samples to enable research on the etiologies and mechanisms of psyc...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章,评审
doi:10.18999/nagjms.80.3.309
更新日期:2018-08-01 00:00:00
abstract::Temporary threshold shifts (TSSs) in vibrotactile perception produced by continuous vibration and repetitive shocks having one complete cycle of a 100 Hz sine wave and exponential decays. The repetition rate of the cycles was 5, 25, 50, or 100/s, while the root-mean-square (r.m.s.) acceleration measured over exposure ...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:1994-05-01 00:00:00
abstract::Autologous nerve transplantation has been the gold standard in the treatment of facial nerve injury, however it has not been achieved satisfactory result and needs donor sacrifice. A polyglycolic acid collagen conduit (Nerbridge, Toyobo Co., Japan) has the potential to compare to or exceed autologous nerve grafts in p...
journal_title:Nagoya journal of medical science
pub_type:
doi:10.18999/nagjms.82.1.123
更新日期:2020-02-01 00:00:00
abstract::The Japanese Orthopaedic Association has proposed the term "locomotive syndrome" to designate a condition that places a person at high risk for long-term care. However, in daily clinical practice, even when a diagnosis of locomotive syndrome is made, exercise therapy often cannot be successfully performed in some pati...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.79.1.43
更新日期:2017-02-01 00:00:00
abstract::Respiratory exposure to asbestos fibers has been associated with diffuse malignant mesothelioma (DMM) in humans. Despite advancements in the molecular analyses of human DMM and the development of animal models, the carcinogenic mechanisms of the disease remain unclear. There are basically three hypotheses regarding th...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章,评审
doi:
更新日期:2009-02-01 00:00:00
abstract::Malignant lymphoma is a heterogeneous category embracing three major types of lymphoid neoplasms: B cell neoplasms, T and NK cell neoplasms, and Hodgkin lymphoma. Within each type, distinct disease entities are defined based on a combination of morphology, immunophenotype, genetic features and clinical syndromes, the ...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章,评审
doi:
更新日期:2006-01-01 00:00:00
abstract::A case treated with onlay bone grafting and simultaneous osseointegrated implant insertion is reported. The patient had an oronasal fistula in the center of the premaxillary region due to failed repair of a bilateral cleft palate. Four fixtures were inserted with onlay bone grafting of the maxillary alveolar ridge. Tw...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:1993-03-01 00:00:00
abstract::Umbilical metastasis from intra-abdominal or pelvic malignancy, which is called Sister Mary Joseph's nodule (SMJN), is rare, and it has a poor prognosis. Its most common primary sites are the stomach and ovaries. SMJN caused by colon cancer is uncommon. A 42-year-old woman visited local clinics with complaints of an u...
journal_title:Nagoya journal of medical science
pub_type:
doi:10.18999/nagjms.81.2.325
更新日期:2019-05-01 00:00:00
abstract::Thoracoscopic lobectomy has recently become a widely used surgical treatment for congenital cystic lung disease, but significant issues can arise in some cases, such as a limited working space in neonates, a limited view in cases involving large cystic lesions. We reviewed the treatment outcomes of neonates that under...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.78.4.447
更新日期:2016-12-01 00:00:00
abstract::Hyperperfusion syndrome occurs after treatment of a large or giant cerebral aneurysm. Recently, flow-diverter stent placement has emerged as an effective treatment method for a large cerebral aneurysm, but postoperative ipsilateral delayed intraparenchymal hemorrhage occurs in a minority of cases. The mechanism underl...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.81.4.629
更新日期:2019-11-01 00:00:00
abstract::Anastomotic leakage after esophagectomy is associated with prolonged hospitalization and increased medical cost. Additionally, it sometimes leads to a fatal condition and impaired postoperative quality of life. During the process of wound healing, β-hydroxy-β-methylbutyrate (HMB) is important for collagen biosynthesis...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.82.1.33
更新日期:2020-02-01 00:00:00
abstract::API2-MALT1 translocation-positive gastric marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT) lymphoma is thought to transform to diffuse large B-cell lymphoma (DLBCL) rarely. A 69-year-old man presented with epigastralgia. Esophagogastroduodenoscopy showed multiple ulcerations in the stomach. Endoscop...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.79.2.251
更新日期:2017-02-01 00:00:00
abstract::Aging is accelerated by metabolic and cardiovascular diseases, and the risk of these diseases increases with age. Obesity is an important risk factor for many age-related diseases and is linked to reduced telomere length in white blood cells. We investigated whether cardiac senescence might be enhanced in DahlS.Z-Lepr...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2014-02-01 00:00:00
abstract::Surgical site infections (SSIs) are one of the most serious complications in spine surgery. We investigated the efficacy of locally administered vancomycin (VCM) powder for prophylaxis on SSI after invasive spine surgery. We retrospectively studied 174 consecutive patients who underwent spine surgery. In patients of t...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.79.4.545
更新日期:2017-11-01 00:00:00
abstract::The immunohistochemical localization of basic fibroblast growth factor (FGF-2) in the submandibular glands of the rat was investigated by use of an antiserum to FGF-2. Nerve fiber bundles with FGF-2-immunoreactivity were found in association with interlobular ducts and blood vessels; they dissociated into single immun...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:1994-12-01 00:00:00
abstract::The increasing burden of noncommunicable diseases (NCDs) in Bangladesh can be attributable to rapid urbanization and coinciding changes in lifestyle accompanied by nutrition transition. The objective of this study is to explore respondents' lived experiences and perceptions relating to NCDs and nutrition change in an ...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.80.4.559
更新日期:2018-11-01 00:00:00
abstract::Mediastinal embryonal carcinoma is rare, and the life prognosis of this disease is assumed to be relatively short. We encountered a case of mediastinal embryonal carcinoma for which we could perform radical surgical resection. The patient was male, aged 16 years, and acutely aware of back pain. Because the pain increa...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2014-02-01 00:00:00
abstract::The influence of total ischemia on the formation of products of anaerobic metabolism was investigated in canine hearts in vitro. Contents of organic acids were quantitatively analyzed by gas chromatography-mass spectrometry, and high energy phosphate compounds were determined using the luciferin-luciferase enzyme syst...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章,评审
doi:
更新日期:1994-03-01 00:00:00
abstract::In endovascular coil embolization for intracranial aneurysms, as coils are filled in the aneurysm and the stage of procedure is advanced, the force to push forward the coil delivery wire (insertion force) increases. However, the coil insertion force that interventionist's felt at his fingertips does not directly refle...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.81.2.217
更新日期:2019-05-01 00:00:00
abstract::A 67-year-old man underwent posterior cervical decompression surgery for ossification of the posterior longitudinal ligament (OPLL) with fixation using cervical pedicle screws (CPSs) guided by intraoperative 3D image-based navigation. Intraoperatively, while creating the screw hole using the navigation probe, the virt...
journal_title:Nagoya journal of medical science
pub_type:
doi:10.18999/nagjms.82.4.799
更新日期:2020-11-01 00:00:00
abstract::Neoadjuvant chemotherapy (NAC) using the combination of anthracycline and taxanes is the standard regimen for patients with primary breast cancer. Among the taxanes, conventional paclitaxel (PTX) and docetaxel have usually been adopted in the neoadjuvant or adjuvant setting. Nanoparticle albumin-bound paclitaxel (nab-...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.82.3.457
更新日期:2020-08-01 00:00:00
abstract::This study was aimed to evaluate the relationship between serum interleukin-23 (IL-23) levels and ankylosing spondylitis (AS).Twenty male patients diagnosed with ankylosing spondylitis according to the 1984 modified New York criteria for AS and twenty male healthy controls were included in this study.The demographic c...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2015-11-01 00:00:00
abstract::We conducted a study of the effect of intravitreal plasmin on retinal thickness in rabbits. Forty rabbit eyes were injected with 0.4, 1, 2, and 5 IU of plasmin (8 eyes/group). The same volume of BSS-plus(®) was injected in control eyes. Four eyes in each group underwent vitrectomy 60 minutes after the injections. The ...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2015-02-01 00:00:00
abstract::The aim of this study was to determine the clinical safety and efficacy of preoperative embolization of meningiomas with low-concentration n-butyl cyanoacrylate (NBCA). Nineteen cases of hypervascular intracranial meningiomas were treated by preoperative embolization with 14% NBCA, using a wedged superselective cathet...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2015-08-01 00:00:00
abstract::In the present study, we developed quantitative index for evaluating regional liver function using 99mTc diethylenetriamine-pentaacetic acid galactosyl human serum albumin (GSA). A three head SPECT equipped with a low energy high resolution parallel hole collimator was used. Used pre-filter was Butterworth and axial i...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2003-05-01 00:00:00
abstract::Liver biopsy specimens from 18 patients with primary biliary cirrhosis were examined histochemically and by energy-dispersive x-ray microanalysis. Using two indices, we classified hepatic copper accumulation into three stages based on the Cu x-ray intensity of cuproproteins that had accumulated in hepatocyte lysosomes...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:1993-03-01 00:00:00
abstract::The number of pollinosis patients in Japan has significantly increased over the past 20 years. The majority of genome-wide association studies (GWAS) on pollinosis have been conducted in subjects of European descent, with few studies in Japanese populations. The aim of our GWAS was to identify genetic loci associated ...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:10.18999/nagjms.80.1.109
更新日期:2018-02-01 00:00:00
abstract::To evaluate the circulatory disturbances, sensory disturbances and damage to muscles and joints by chain saw vibration exposure, the process of the deterioration of the symptoms with chain saw operating time was studied. Subjects were classified into eight groups according to TOT (Total Operating Time): Group 0, 46 co...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:1994-05-01 00:00:00
abstract::As molecular biology has developed, several new diagnostic techniques have found application in the clinical setting. The use of the polymerase chain reaction (PCR) assay to study the molecular biology of microbial organisms has led to unparalleled advances, largely due to the rapidity with which results can be obtain...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章,评审
doi:
更新日期:1999-11-01 00:00:00
abstract::To evaluate the adaptability of children with cleft lip and/or palate to school, their mental images of the school environment were investigated in a semantic differential method survey using 23 pairs of adjectives. The following eight places on and off the school grounds were chosen as environmental factors; classroo...
journal_title:Nagoya journal of medical science
pub_type: 杂志文章
doi:
更新日期:2001-05-01 00:00:00