Abstract:
OBJECTIVES:To identify the use and adverse drug reactions associated with azithromycin in neonates. SETTING:Databases MEDLINE (1948-August 2015), EMBASE (1980-August 2015) and Pubmed (August 2015) were searched for studies on azithromycin in neonates. PARTICIPANTS:All studies involving neonates (<28 days old) who have received at least a single dose of azithromycin for which safety was evaluated. PRIMARY AND SECONDARY OUTCOME MEASURES:The primary outcome was adverse event (AE) associated with use of azithromycin. Use of azithromycin in neonates was the secondary outcome. RESULTS:A total of 11 articles involving 473 neonates were identified. 371 AEs were reported. Adverse events were mainly respiratory (358/1000 neonate), neurological (273/1000 neonates) and gastrointestinal (196/1000 neonates) in origin. Azithromycin significantly reduced the risk of bronchopulmonary dysplasia (BPD) in extremely premature neonates (RR=0.83, 95% CI 0.71 to 0.98, p=0.02). There was no significant difference in the incidence of elevated liver enzymes between the azithromycin and placebo group (p=0.76). There were four cases of infantile hypertrophic pyloric stenosis (IHPS). CONCLUSIONS:Azithromycin significantly reduces the risk of BPD in preterm neonates. The relationship between azithromycin and IHPS requires further investigation.
journal_name
BMJ Openjournal_title
BMJ openauthors
Smith C,Egunsola O,Choonara I,Kotecha S,Jacqz-Aigrain E,Sammons Hdoi
10.1136/bmjopen-2015-008194subject
Has Abstractpub_date
2015-12-09 00:00:00pages
e008194issue
12issn
2044-6055pii
bmjopen-2015-008194journal_volume
5pub_type
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