Abstract:
OBJECTIVES:The detailed course of mental disorders at the acute and subacute stages of mild traumatic brain injury (mTBI), especially with regard to recovery from sleep disturbances, has not been well characterised. The aim of this study was to determine the course of depression, anxiety and sleep disturbance, following an mTBI. SETTING:We recruited patients with mTBI from three university hospitals in Taipei and healthy participants as control group for this study. PARTICIPANTS:100 patients with mTBI (35 men) who were older than 20 years, with a Glasgow Coma Scale score of 13-15 and loss of consciousness for <30 min, completed the baseline and 6-week follow-up assessments. 137 controls (47 men) without TBI were recruited in the study. None of the participants had a history of cerebrovascular disease, mental retardation, previous TBI, epilepsy or severe systemic medical illness. PRIMARY OUTCOME MEASURES:The Beck Anxiety Inventory (BAI), the Beck Depression Inventory II (BDI), the Epworth Sleepiness Scale (ESS) and the Pittsburgh Sleep Quality Index (PSQI) were assessed for the patients with mTBI at baseline and 6 weeks after mTBI and for the controls. RESULTS:The ESS scores were not significantly different between the mTBI at baseline or at 6 weeks after mTBI and controls. Although the BAI, BDI and PSQI scores of the mTBI group were significantly different than those of the control group at baseline, all had improved significantly 6 weeks later. However, only the PSQI score improved to a level that was not significantly different from that of the control group. CONCLUSIONS:Daytime sleepiness is not affected by mTBI. However, mTBI causes depression and anxiety and diminished sleep quality. Although all these conditions improve significantly within 6 weeks post-mTBI, only sleep quality improves to a pre-mTBI level. Thus, recovery from mTBI-induced sleep disturbance occurs more rapidly than that of mTBI-induced depression and anxiety.
journal_name
BMJ Openjournal_title
BMJ openauthors
Ma HP,Ou JC,Yeh CT,Wu D,Tsai SH,Chiu WT,Hu CJdoi
10.1136/bmjopen-2013-004205subject
Has Abstractpub_date
2014-01-23 00:00:00pages
e004205issue
1issn
2044-6055pii
bmjopen-2013-004205journal_volume
4pub_type
杂志文章相关文献
BMJ Open文献大全abstract:OBJECTIVE:Multimorbidity in patients with heart failure (HF) results in poor prognosis and is an increasing public health concern. We aim to examine the effect of multimorbidity focusing on type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) on all-cause and cardiovascular disease (CVD)-specific mortality ...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2017-021291
更新日期:2018-05-20 00:00:00
abstract:OBJECTIVE:To describe health-related quality of life (HRQOL) and psychological well-being of children and adolescents at enrolment in a multidisciplinary community-based obesity programme and to determine association with ethnicity. This programme targeted indigenous people and those from most deprived households. Furt...
journal_title:BMJ open
pub_type: 杂志文章,随机对照试验
doi:10.1136/bmjopen-2016-015776
更新日期:2017-08-09 00:00:00
abstract:INTRODUCTION AND OBJECTIVES:Macrolides have been associated with proarrhythmic properties, but the evidence is conflicting. We evaluated the risk of out-of-hospital cardiac arrest (OHCA) associated with specific macrolides in a retrospective study. Associations between specific macrolides and OHCA were examined by cond...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-019997
更新日期:2018-02-23 00:00:00
abstract:BACKGROUND:Mentoring is frequently suggested as an intervention to address gender inequalities in the workplace. OBJECTIVES:To systematically review evidence published since a definitive review in 2006 on the effectiveness of mentoring interventions aimed at achieving gender equality in academic medicine. DESIGN:Syst...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-040355
更新日期:2021-01-26 00:00:00
abstract:OBJECTIVE:Identification of older patients at risk, among those accessing the emergency department (ED), may support clinical decision-making. To this purpose, we developed and validated the Dynamic Silver Code (DSC), a score based on real-time linkage of administrative data. DESIGN AND SETTING:The 'Silver Code Nation...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-033374
更新日期:2019-12-22 00:00:00
abstract:OBJECTIVE:This study was aimed to explore parents' experience of assisting children affected by tuberous sclerosis complex (TSC) with subependymal giant-cell astrocytoma (SEGA) manifestation, in order to understand their caring needs and expectation of support. SETTING AND PROCEDURE:The study was designed according to...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-003707
更新日期:2013-12-06 00:00:00
abstract:INTRODUCTION:Bladder cancer (BC) (including renal pelvis, ureter and urethra) is one of the most common urogenital cancers and the fourth most frequent cancer in men in the USA. In Norway, the incidence of BC has increased over the last decades. The age-standardised incidence rates per 100 000 for 2011-2015 were 53.7 i...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-019309
更新日期:2018-03-30 00:00:00
abstract:OBJECTIVES:To engage children and young people with conditions that impair learning, their parents/carers and the health, education, social work and third sector professionals to identify and prioritise research questions for learning difficulties. DESIGN:Prospective surveys and consensus meeting guided by methods adv...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-028780
更新日期:2019-10-30 00:00:00
abstract:INTRODUCTION:Obstructive sleep apnoea (OSA) is caused by complete or partial obstruction of the upper airway resulting in repeated episodes of interrupted or shallow breaths. OSA is associated with significant morbidity and mortality. The prevalence is estimated to range from 3% to 7% in the general population but may ...
journal_title:BMJ open
pub_type: 杂志文章,meta分析
doi:10.1136/bmjopen-2017-020876
更新日期:2018-08-29 00:00:00
abstract:INTRODUCTION:Millions of women suffer from the consequences of endometriosis and uterine fibroids, with fibroids the cause for over 50% of hysterectomies in the USA, and direct costs for their treatment estimated at between US$4 and US$9 billion. Endometriosis commonly affects millions of women worldwide predominantly ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-032220
更新日期:2020-03-04 00:00:00
abstract:OBJECTIVE:This study sought to assess knowledge of schizophrenia and help-seeking behaviour among undergraduate students of a Nigerian university. Sociodemographic predictors of correct recognition were also explored. DESIGN:The study was a cross-sectional descriptive survey. SETTING:The study was carried out at the ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-028913
更新日期:2019-09-12 00:00:00
abstract:OBJECTIVES:Chromosome 9p21 single nucleotide polymorphism (SNP) is a susceptibility variant for acute myocardial infarction (AMI) in the primary prevention setting. However, it is controversial whether this SNP is also associated with recurrent myocardial infarction (ReMI) in the secondary prevention setting. The purpo...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究
doi:10.1136/bmjopen-2014-005438
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION:Diabetic kidney disease (DKD) is a prevalent and costly complication of diabetes with limited therapeutic options, being the leading cause of end-stage kidney disease in most developed regions. Recent big data studies showed that add-on Chinese medicine (CM) led to a reduced risk of end-stage kidney diseas...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-042686
更新日期:2021-01-12 00:00:00
abstract:OBJECTIVES:To establish the minimally important difference (MID) that would prompt parents and clinicians to use probiotics for prevention of paediatric antibiotic-associated diarrhoea (AAD) and to obtain parent and clinician opinion about the most important outcomes in clinical trials of AAD. METHODS:In this survey, ...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-024651
更新日期:2019-04-02 00:00:00
abstract:OBJECTIVES:To investigate leftover antibiotics and their influence on self-medication with antibiotics (SMA) for Chinese children, and further explore the different influences of leftovers from two main sources: previous prescriptions and pharmaceutical purchases. DESIGN:A cross-sectional questionnaire study. SETTING...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-033679
更新日期:2019-12-15 00:00:00
abstract:OBJECTIVE:We aimed to determine the key predictors of perinatal deaths using machine learning models compared with the logistic regression model. DESIGN:A secondary data analysis using the Kilimanjaro Christian Medical Centre (KCMC) Medical Birth Registry cohort from 2000 to 2015. We assessed the discriminative abilit...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2020-040132
更新日期:2020-10-19 00:00:00
abstract:INTRODUCTION:Auditory verbal hallucinations (AVH) are prevalent experiences that can induce distress and impede social functioning. While most voice hearers benefit from antipsychotic medication or cognitive-behavioural therapy, additional effective interventions are needed to reduce the burden of experiencing AVH. 'Te...
journal_title:BMJ open
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/bmjopen-2017-020537
更新日期:2018-03-06 00:00:00
abstract:OBJECTIVES:To clarify the association between glucose intolerance and high altitudes (2900-4800 m) in a hypoxic environment in Tibetan highlanders and to verify the hypothesis that high altitude dwelling increases vulnerability to diabetes mellitus (DM) accelerated by lifestyle change or ageing. DESIGN:Cross-sectional...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2015-009728
更新日期:2016-02-23 00:00:00
abstract:INTRODUCTION:Cyclooxygenase 2 (COX-2) inhibitors have less upper gastrointestinal toxicity than traditional non-steroidal anti-inflammatory drugs (NSAIDs). However, both COX-2 inhibitors and traditional NSAIDs may be associated with adverse cardiovascular side effects. Data from randomised and observational studies sug...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2012-002295
更新日期:2013-01-29 00:00:00
abstract:OBJECTIVE:History and physical examination do not reliably exclude serious bacterial infections (SBIs) in infants. We examined potential markers of SBI in young febrile infants. DESIGN:We reviewed white cell count (WBC), absolute neutrophil count (ANC), neutrophil to lymphocyte count ratio (NLR) and C reactive protein...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-018092
更新日期:2018-01-24 00:00:00
abstract:OBJECTIVE:To describe the prevalence of statin utilisation by people aged over 50 years in Ireland and the factors associated with the likelihood of using a statin, focusing particularly on those using statins for primary prevention of cardiovascular disease (CVD). METHODS:This is a cross-sectional analysis of cardiov...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2017-018524
更新日期:2018-02-08 00:00:00
abstract:INTRODUCTION:Though the importance of knowledge mobilisation has been established globally in health and wellness research, a certain degree of ambiguity remains regarding the meaning and extent of knowledge mobilisation activities and how they have been implemented. In this study, we aim to explore the different descr...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-036081
更新日期:2020-04-08 00:00:00
abstract:BACKGROUND:Atrial fibrillation (AF) is associated with a high risk of stroke and may often be asymptomatic. AF is commonly undiagnosed until patients present with sequelae, such as heart failure and stroke. Stroke secondary to AF is highly preventable with the use of appropriate thromboprophylaxis. Therefore, early ide...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2012-001355
更新日期:2012-06-25 00:00:00
abstract:OBJECTIVE:Multiple rib fractures (RFs) and pulmonary contusions (PCs), with resulting systemic lung inflammation, are the most common injuries caused by blunt chest trauma (BCT) in motor vehicle accidents. This study examined levels of the inflammation marker interleukin (IL)-6 and those of the acute-phase reactant sur...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-011797
更新日期:2016-10-12 00:00:00
abstract:OBJECTIVE:To assess the impact of chronic kidney disease (CKD) and cardiovascular comorbidity on mortality in a multiethnic primary care population. DESIGN:Retrospective cohort study. SETTING:Inner-city primary care trust in West Midlands, UK. PARTICIPANTS:Individuals aged 40 years and older, of South Asian, black o...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-003458
更新日期:2013-12-03 00:00:00
abstract:OBJECTIVES:To (1) provide an up-to-date overview of shared decision making (SDM)-models, (2) give insight in the prominence of components present in SDM-models, (3) describe who is identified as responsible within the components (patient, healthcare professional, both, none), (4) show the occurrence of SDM-components o...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2019-031763
更新日期:2019-12-17 00:00:00
abstract:INTRODUCTION:Coping skills training interventions have been found to be efficacious in helping both patients and their partners manage the physical and emotional challenges they face following a cancer diagnosis. However, many of these interventions are costly and not sustainable. To overcome these issues, a self-direc...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2013-003337
更新日期:2013-07-24 00:00:00
abstract:OBJECTIVES AND DESIGN:We identified a novel TRIM59 gene, as an early signal transducer in two (SV40Tag and Ras) oncogene pathways in murine prostate cancer (CaP) models. We explore its clinical applications as a multitumour marker detecting early tumorigenesis by immunohistochemistry (IHC). SETTING AND PARTICIPANTS:88...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2012-001410
更新日期:2012-10-08 00:00:00
abstract:INTRODUCTION:Systematic reviews of high-quality randomised controlled trials are necessary to identify effective interventions to impact burn wound infection (BWI) outcomes. Evidence synthesis requires that BWI is reported in a consistent manner. Cochrane reviews investigating interventions for burns report that the in...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2018-026056
更新日期:2019-05-14 00:00:00
abstract:INTRODUCTION:There is a growing proportion of population aged 65 years and older in low-income and middle-income countries. In Malaysia, this proportion is predicted to increase from 5.1% in 2010 to more than 15.4% by 2050. Cognitive ageing and dementia are global health priorities. However, risk factors and disease as...
journal_title:BMJ open
pub_type: 杂志文章
doi:10.1136/bmjopen-2016-013635
更新日期:2017-01-19 00:00:00