当前位置： SCI文献检索 > BMJ Open期刊下所有文献 > Investigation of surfactant protein-D and interleukin-6 levels in patients with blunt chest trauma with multiple rib fractures and pulmonary contusions: a cross-sectional study in Black Sea Region of Turkey.

Investigation of surfactant protein-D and interleukin-6 levels in patients with blunt chest trauma with multiple rib fractures and pulmonary contusions: a cross-sectional study in Black Sea Region of Turkey.

Abstract：

OBJECTIVE:Multiple rib fractures (RFs) and pulmonary contusions (PCs), with resulting systemic lung inflammation, are the most common injuries caused by blunt chest trauma (BCT) in motor vehicle accidents. This study examined levels of the inflammation marker interleukin (IL)-6 and those of the acute-phase reactant surfactant protein (SP)-D in patients with BCT. DESIGN:Prospective, cross-sectional, observational study. SETTING:Single-centre, tertiary care hospital in the Black Sea Region of Turkey. PARTICIPANTS:The study included 60 patients with BCT who were hospitalised in our thoracic surgery department. PARAMETERS MEASURES:The SP-D and IL-6 serum levels of patients with RFs (two or more RFs) (n=30) and patients with PCs (n=30) were measured after 6 hours, 24 hours and 7 days, and compared with those of age-matched and gender-matched healthy participants. RESULTS:The 6-hour serum SP-D levels of the RFs (p=0.017) and PCs (p<0.001) groups were significantly higher than those of the healthy controls. The 24-hour and 7-day SP-D levels of both groups were also higher than the control group. The serum IL-6 levels of both groups were significantly higher than those of the control group. We have found Injury Severity Score to be independently related to 6-hour IL-6 (β=1.414, p<0.001) and 24-hour IL-6 levels (β=1.067, p<0.001). The development of complications was independently related to 6-hour SP-D level (β=0.211, p=0.047). CONCLUSIONS:RFs and PCs after BCT lead to local and systemic inflammation due to lung injury. The levels of the systemic inflammation marker IL-6 and those of the acute-phase reactant SP-D were elevated in the present study. The SP-D level may be used as a marker in the follow-up of BCT-related complications.

journal_name

BMJ Open

journal_title

BMJ open

authors

Kurt A,Turut H,Acipayam A,Kirbas A,Yuce S,Cumhur Cure M,Cure E

doi

10.1136/bmjopen-2016-011797

subject

Has Abstract

pub_date

2016-10-12 00:00:00

pages

e011797

issue

10

issn

2044-6055

pii

bmjopen-2016-011797

journal_volume

6

pub_type

杂志文章

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