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Reduced risk of recurrent myocardial infarction in homozygous carriers of the chromosome 9p21 rs1333049 C risk allele in the contemporary percutaneous coronary intervention era: a prospective observational study.

Abstract：

OBJECTIVES:Chromosome 9p21 single nucleotide polymorphism (SNP) is a susceptibility variant for acute myocardial infarction (AMI) in the primary prevention setting. However, it is controversial whether this SNP is also associated with recurrent myocardial infarction (ReMI) in the secondary prevention setting. The purpose of this study is to evaluate the impact of chromosome 9p21 SNP on ReMI in patients receiving secondary prevention programmes after AMI. DESIGN:A prospective observational study. SETTING:Osaka Acute Coronary Insufficiency Study (OACIS) in Japan. PARTICIPANTS:2022 patients from the OACIS database. INTERVENTIONS:Genotyping of the 9p21 rs1333049 variant. PRIMARY OUTCOME MEASURES:ReMI event after survival discharge for 1 year. RESULTS:A total of 43 ReMI occurred during the 1 year follow-up period. Although the rs1333049 C allele had an increased susceptibility to their first AMI in an additive model when compared with 1373 healthy controls (OR 1.20, 95% CI 1.09 to 1.33, p=2.3*10(−4)), patients with the CC genotype had a lower incidence of ReMI at 1 year after discharge of AMI (log-rank p=0.005). The adjusted HR of the CC genotype as compared with the CG/GG genotypes was 0.20 (0.06 to 0.65, p=0.007). Subgroup analysis demonstrated that the association between the rs1333049 CC genotype and a lower incidence of 1 year ReMI was common to all subgroups. CONCLUSIONS:Homozygous carriers of the rs1333049 C allele on chromosome 9p21 showed a reduced risk of 1 year ReMI in the contemporary percutaneous coronary intervention era, although the C allele had conferred susceptibility to their first AMI.

journal_name

BMJ Open

journal_title

BMJ open

authors

Hara M,Sakata Y,Nakatani D,Suna S,Usami M,Matsumoto S,Ozaki K,Nishino M,Sato H,Kitamura T,Nanto S,Hamasaki T,Tanaka T,Hori M,Komuro I,OACIS Investigators.

doi

10.1136/bmjopen-2014-005438

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

e005438

issue

8

issn

2044-6055

journal_volume

4

pub_type

杂志文章,多中心研究

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