Establishment of the Ivermectin Research for Malaria Elimination Network: updating the research agenda.

abstract：BACKGROUND:The production and use of malaria rapid diagnostic tests (RDTs) has risen dramatically over the past 20 years. In view of weak or non-existing in vitro diagnostics (IVD) regulations and post-marketing surveillance (PMS) systems in malaria endemic countries, the World Health Organization, later joined by the ...

journal_title：Malaria journal

authors： Incardona S,Bell D,Campillo A,Cunningham J,Ariey F,Fandeur T,Luchavez J,Luna CA,Ménard D,Nhem S,Sornillo JB,Witkowski B,Katz Z,Dittrich S,Ding XC

更新日期：2020-07-13 00:00:00

abstract：BACKGROUND:Cerebral malaria (CM) is associated with morbidity and mortality despite the use of potent anti-malarial agents. Brain endothelial cell activation and dysfunction from oxidative and inflammatory host responses and products released by Plasmodium falciparum-infected erythrocytes (IE), are likely the major con...

journal_title：Malaria journal

authors： Mita-Mendoza NK,Magallon-Tejada A,Parmar P,Furtado R,Aldrich M,Saidi A,Taylor T,Smith J,Seydel K,Daily JP

更新日期：2020-10-21 00:00:00

abstract：BACKGROUND:Rapid diagnostic tests (RDTs) for histidine rich protein 2 (HRP2) are often used to determine whether persons with fever should be treated with anti-malarials. However, Plasmodium falciparum parasites with a deletion of the hrp2 gene yield false-negative RDTs and there are concerns the sensitivity of HRP2-ba...

journal_title：Malaria journal

authors： Kozycki CT,Umulisa N,Rulisa S,Mwikarago EI,Musabyimana JP,Habimana JP,Karema C,Krogstad DJ

更新日期：2017-03-20 00:00:00

abstract：BACKGROUND:Plasmodium falciparum circumsporozoite protein (CSP) is a leading malaria vaccine candidate antigen, known to elicit protective antibody responses in humans (RTS,S vaccine). Recently, a DNA prime / adenovirus (Ad) vector boost vaccine encoding CSP and a second P. falciparum antigen, apical membrane antigen-1...

journal_title：Malaria journal

authors： Sedegah M,Kim Y,Ganeshan H,Huang J,Belmonte M,Abot E,Banania JG,Farooq F,McGrath S,Peters B,Sette A,Soisson L,Diggs C,Doolan DL,Tamminga C,Villasante E,Hollingdale MR,Richie TL

更新日期：2013-06-05 00:00:00

abstract：BACKGROUND:In view of the close relationship of Portugal with African countries, particularly former Portuguese colonies, the diagnosis of malaria is not a rare thing. When a traveller returns ill from endemic areas, malaria should be the number one suspect. World Health Organization treatment guidelines recommend that...

journal_title：Malaria journal

authors： Santos LC,Abreu CF,Xerinda SM,Tavares M,Lucas R,Sarmento AC

更新日期：2012-03-29 00:00:00

abstract：BACKGROUND:Despite some problems related to accuracy and applicability, malaria rapid diagnostic tests (RDTs), are currently considered the best option in areas with limited laboratory services for improving case management and reducing over-treatment. However, their performance must be established taking into the acco...

journal_title：Malaria journal

authors： Muhindo HM,Ilombe G,Meya R,Mitashi PM,Kutekemeni A,Gasigwa D,Lutumba P,Van Geertruyden JP

更新日期：2012-07-06 00:00:00

abstract：BACKGROUND:Over the last decade, the incidence of confirmed malaria has declined significantly in Nepal. The aim of this paper is to assess the spatio-temporal distribution of malaria and its association with climatic factors and vector control interventions in two high-risk districts of Nepal. METHODS:Hotspot analysi...

journal_title：Malaria journal

authors： Dhimal M,O'Hara RB,Karki R,Thakur GD,Kuch U,Ahrens B

更新日期：2014-11-25 00:00:00

abstract：BACKGROUND:Plasmodium vivax is very rarely seen in West Africa, although specific detection methods are not widely applied in the region, and it is now considered to be absent from North Africa. However, this parasite species has recently been reported to account for most malaria cases in Nouakchott, the capital of Mau...

journal_title：Malaria journal

authors： Ba H,Duffy CW,Ahouidi AD,Deh YB,Diallo MY,Tandia A,Conway DJ

更新日期：2016-02-09 00:00:00

abstract：BACKGROUND:As in other countries of the Greater Mekong Sub-region (GMS), the private health sector constitutes a significant avenue where malaria services are provided and presents a unique opportunity for public-private collaboration. In September 2008, a public-private mix (PPM) strategy was launched initially in fou...

journal_title：Malaria journal

authors： Simmalavong N,Phommixay S,Kongmanivong P,Sichanthongthip O,Hongvangthong B,Gopinath D,Sintasath DM

更新日期：2017-11-13 00:00:00

abstract：BACKGROUND:Chloroquine-resistant Plasmodium falciparum was first described in the Republic of Vanuatu in the early 1980s. In 1991, the Vanuatu Ministry of Health instituted new treatment guidelines for uncomplicated P. falciparum infection consisting of chloroquine/sulphadoxine-pyrimethamine combination therapy. Chloro...

journal_title：Malaria journal

authors： Kinzer MH,Chand K,Basri H,Lederman ER,Susanti AI,Elyazar I,Taleo G,Rogers WO,Bangs MJ,Maguire JD

更新日期：2010-04-06 00:00:00

abstract：BACKGROUND:Malaria rapid diagnostic tests (RDTs) enable point-of-care testing to be nearly as sensitive and specific as reference microscopy. The Senegal National Malaria Control Programme introduced RDTs in 2007, along with a case management algorithm for uncomplicated febrile illness, in which the first step stipulat...

journal_title：Malaria journal

authors： Thwing J,Ba F,Diaby A,Diedhiou Y,Sylla A,Sall G,Diouf MB,Gueye AB,Gaye S,Ndiop M,Cisse M,Ndiaye D,Ba M

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Understanding of malaria vector density, distribution, insecticide resistance, vector incrimination, infection status, and identification of sibling species are some of the essential components of vector control measures for achieving malaria elimination goals. METHODS:As part of the malaria elimination dem...

journal_title：Malaria journal

authors： Mishra AK,Bharti PK,Vishwakarma A,Nisar S,Rajvanshi H,Sharma RK,Saha KB,Shukla MM,Jayswar H,Das A,Kaur H,Wattal SL,Lal AA

更新日期：2020-12-02 00:00:00

abstract：BACKGROUND:Information is needed on the expected durability of insecticidal nets under operational conditions. The persistence of insecticidal efficacy is important to estimate the median serviceable life of nets under field conditions and to plan for net replacement. METHODS:Deltamethrin residue levels were evaluated...

journal_title：Malaria journal

authors： Anshebo GY,Graves PM,Smith SC,Wills AB,Damte M,Endeshaw T,Shargie EB,Gebre T,Mosher AW,Patterson AE,Emerson PM

更新日期：2014-03-06 00:00:00

abstract：BACKGROUND:Antiplasmodial activities of angiotensin II and its analogues have been extensively investigated in Plasmodium gallinaceum and Plasmodium falciparum parasite species. Due to its vasoconstrictor property angiotensin II cannot be used as an anti-malarial drug. METHODS:This work presents the solid-phase synthe...

journal_title：Malaria journal

authors： Silva AF,Torres MD,Silva Lde S,Alves FL,Pinheiro AA,Miranda A,Capurro ML,Oliveira VX Jr

更新日期：2015-11-04 00:00:00

abstract：:The fight against malaria is increasingly threatened by failures in vector control due to growing insecticide resistance. This review examines the recent primary research that addresses the putative relationship between agricultural insecticide use and trends in insecticide resistance. To do so, descriptive evidence o...

journal_title：Malaria journal

authors： Reid MC,McKenzie FE

更新日期：2016-02-19 00:00:00

abstract：BACKGROUND:In clinical trials of therapy for uncomplicated Plasmodium falciparum, there are usually some patients who fail treatment even in the absence of drug resistance. Treatment failures, which can be due to recrudescence or re-infection, are categorized as 'clinical' or 'parasitological' failures, the former indi...

journal_title：Malaria journal

authors： Mumtaz R,Okell LC,Challenger JD

更新日期：2020-12-09 00:00:00

abstract：BACKGROUND:A successful malaria control programme began in 2004 on Bioko Island, Equatorial Guinea. From 2007, the same multiple malaria interventions, though reduced in scope for funding reasons, were introduced to the four mainland provinces of Equatorial Guinea (the continental region) aiming to recreate Bioko's suc...

journal_title：Malaria journal

authors： Rehman AM,Mann AG,Schwabe C,Reddy MR,Roncon Gomes I,Slotman MA,Yellott L,Matias A,Caccone A,Nseng Nchama G,Kleinschmidt I

更新日期：2013-05-07 00:00:00

abstract：BACKGROUND:Anti-malarial resistance in Plasmodium falciparum remains an obstacle for malaria control. Resistance-associated genes were analysed in Brazilian samples over four decades to evaluate the impact of different treatment regimens on the parasite genetic profile. METHODS:Samples were collected on filter paper f...

journal_title：Malaria journal

authors： Inoue J,Lopes D,do Rosário V,Machado M,Hristov AD,Lima GF,Costa-Nascimento MJ,Segurado AC,Di Santi SM

更新日期：2014-09-19 00:00:00

abstract：BACKGROUND:Cases of transfusion-transmitted malaria have been described around the world and highlighted in some studies. Semi-immune individuals are more likely to transmit malaria as they may be asymptomatic. Some countries allow blood donations only based on epidemiological criteria while others reinforce their crit...

journal_title：Malaria journal

authors： Portugal-Calisto D,Ferreira AR,Silva MS,Teodósio R

更新日期：2016-11-09 00:00:00

abstract：BACKGROUND:In Vietnam, malaria transmission has been reduced to very low levels over the past 20 years, and as a consequence, the country aims to eliminate malaria by 2030. This study aimed to characterize the dynamics and extent of the parasite reservoir in Central Vietnam, in order to further target elimination strat...

journal_title：Malaria journal

authors： Kattenberg JH,Erhart A,Truong MH,Rovira-Vallbona E,Vu KAD,Nguyen THN,Nguyen VH,Nguyen VV,Bannister-Tyrrell M,Theisen M,Bennet A,Lover AA,Tran TD,Nguyen XX,Rosanas-Urgell A

更新日期：2018-04-27 00:00:00

abstract：BACKGROUND:Global efforts to address the burden of malaria have stagnated in recent years with malaria cases beginning to rise. Substandard and falsified anti-malarial treatments contribute to this stagnation. Poor quality anti-malarials directly affect health outcomes by increasing malaria morbidity and mortality, as ...

journal_title：Malaria journal

authors： Ozawa S,Evans DR,Higgins CR,Laing SK,Awor P

更新日期：2019-01-09 00:00:00

abstract：:After publication of the article [1], it has been brought to our attention that a funding acknowledgement has been omitted from the original article. The authors would like to include the following, "The study was undertaken as part of the Target Malaria consortium, which receives core funding from the Bill & Melinda ...

journal_title：Malaria journal

authors： Ogola E,Villinger J,Mabuka D,Omondi D,Orindi B,Mutunga J,Owino V,Masiga DK

更新日期：2017-09-19 00:00:00

abstract：BACKGROUND:Prior studies have shown that annual entomological inoculation rates (EIRs) must be reduced to less than one to substantially reduce the prevalence of malaria infection. In this study, EIR values were used to quantify the impact of insecticide-treated bed nets (ITNs), indoor residual spraying (IRS), and sour...

journal_title：Malaria journal

authors： Shaukat AM,Breman JG,McKenzie FE

更新日期：2010-05-12 00:00:00

abstract：BACKGROUND:In view of the need to continuously feed the pipeline with new anti-malarial agents adapted to differentiated and more stringent target product profiles (e.g., new modes of action, transmission-blocking activity or long-duration chemo-protection), a chemical library consisting of more than 250,000 compounds ...

journal_title：Malaria journal

authors： Avery VM,Bashyam S,Burrows JN,Duffy S,Papadatos G,Puthukkuti S,Sambandan Y,Singh S,Spangenberg T,Waterson D,Willis P

更新日期：2014-05-27 00:00:00

abstract：BACKGROUND:The successful control of insect disease vectors relies on a thorough understanding of their ecology and behaviour. However, knowledge of the ecology of many human disease vectors lags behind that of agricultural pests. This is partially due to the paucity of experimental tools for investigating their ecolog...

journal_title：Malaria journal

authors： Ng'habi KR,Mwasheshi D,Knols BG,Ferguson HM

更新日期：2010-12-08 00:00:00

abstract：BACKGROUND:Congenital malaria is the direct infection of an infant with malaria parasites from their mother prior to or during birth. Neonatal malaria is due to an infective mosquito bite after birth. Neonatal and congenital malaria (NCM) are potentially life-threatening conditions that are believed to occur at relativ...

journal_title：Malaria journal

authors： Olupot-Olupot P,Eregu EIE,Naizuli K,Ikiror J,Acom L,Burgoine K

更新日期：2018-04-20 00:00:00

abstract：BACKGROUND:Marking mosquitoes is vital for mark-release-recapture and many laboratory studies, but their small size precludes the use of methods that are available for larger animals such as unique identifier tags and radio devices. Fluorescent dust is the most commonly used method to distinguish released individuals f...

journal_title：Malaria journal

authors： Aviles EI,Rotenberry RD,Collins CM,Dotson EM,Benedict MQ

更新日期：2020-07-06 00:00:00

abstract：BACKGROUND:The present study evaluated the SD Bioline Malaria Ag 05FK40 (SDFK40), a three-band RDT detecting Plasmodium falciparum-specific parasite lactate dehydrogenase (Pf-pLDH) and pan Plasmodium-specific pLDH (pan-pLDH), in a reference setting. METHODS:The SDFK40 was retrospectively and prospectively tested again...

journal_title：Malaria journal

authors： Maltha J,Gillet P,Cnops L,Bottieau E,Van Esbroeck M,Bruggeman C,Jacobs J

更新日期：2011-01-12 00:00:00

abstract：BACKGROUND:Transmission of malaria from man to mosquito depends on the presence of gametocytes, the sexual stage of Plasmodium parasites in the infected host. Naturally acquired antibodies against gametocytes exist and may play a role in controlling transmission by limiting the gametocyte development in the circulation...

journal_title：Malaria journal

authors： Gebru T,Ajua A,Theisen M,Esen M,Ngoa UA,Issifou S,Adegnika AA,Kremsner PG,Mordmüller B,Held J

更新日期：2017-04-26 00:00:00

abstract：BACKGROUND:Several anti-malarial drugs are associated with adverse cardiovascular effects. These effects may be exacerbated when different anti-malarials are used in combination. There has been no report yet on the potential cardiac effects of the combination artesunate-amodiaquine. METHODS:Electrocardiographic (ECG) ...

journal_title：Malaria journal

authors： Adjei GO,Oduro-Boatey C,Rodrigues OP,Hoegberg LC,Alifrangis M,Kurtzhals JA,Goka BQ

更新日期：2012-12-17 00:00:00