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Breast cancer intra-tumor heterogeneity.

Abstract：

:In recent years it has become clear that cancer cells within a single tumor can display striking morphological, genetic and behavioral variability. Burgeoning genetic, epigenetic and phenomenological data support the existence of intra-tumor genetic heterogeneity in breast cancers; however, its basis is yet to be fully defined. Two of the most widely evoked concepts to explain the origin of heterogeneity within tumors are the cancer stem cell hypothesis and the clonal evolution model. Although the cancer stem cell model appeared to provide an explanation for the variability among the neoplastic cells within a given cancer, advances in massively parallel sequencing have provided several lines of evidence to suggest that intra-tumor genetic heterogeneity likely plays a fundamental role in the phenotypic heterogeneity observed in cancers. Many challenges remain, however, in the interpretation of the next generation sequencing results obtained so far. Here we review the models that explain tumor heterogeneity, the causes of intra-tumor genetic diversity and their impact on our understanding and management of breast cancer, methods to study intra-tumor heterogeneity and the assessment of intra-tumor genetic heterogeneity in the clinic.

journal_name

Breast Cancer Res

journal_title

Breast cancer research : BCR

authors

Martelotto LG,Ng CK,Piscuoglio S,Weigelt B,Reis-Filho JS

doi

10.1186/bcr3658

subject

Has Abstract

pub_date

2014-05-20 00:00:00

pages

210

issue

3

eissn

1465-5411

issn

1465-542X

pii

10.1186/bcr3658

journal_volume

16

pub_type

杂志文章,评审

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