CXCL17-derived CD11b+Gr-1+ myeloid-derived suppressor cells contribute to lung metastasis of breast cancer through platelet-derived growth factor-BB.

abstract：INTRODUCTION:Breast cancer subtyping and prognosis have been studied extensively by gene expression profiling, resulting in disparate signatures with little overlap in their constituent genes. Although a previous study demonstrated a prognostic concordance among gene expression signatures, it was limited to only one da...

journal_title：Breast cancer research : BCR

authors： Wirapati P,Sotiriou C,Kunkel S,Farmer P,Pradervand S,Haibe-Kains B,Desmedt C,Ignatiadis M,Sengstag T,Schütz F,Goldstein DR,Piccart M,Delorenzi M

更新日期：2008-01-01 00:00:00

abstract：:Genome-wide expression microarray studies have revealed that the biological and clinical heterogeneity of breast cancer can be partly explained by information embedded within a complex but ordered transcriptional architecture. Comprising this architecture are gene expression networks, or signatures, reflecting biochem...

journal_title：Breast cancer research : BCR

authors： Miller LD,Liu ET

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:Mammary stem cells are bipotential and suggested to be the origin of breast cancer development, but are elusive and vaguely characterized. Breast tumors can be divided into subgroups, each one requiring specific treatment. To determine a possible association between mammary stem cells and breast cancer, a ...

journal_title：Breast cancer research : BCR

authors： Williams C,Helguero L,Edvardsson K,Haldosén LA,Gustafsson JA

更新日期：2009-01-01 00:00:00

abstract：:PIK3CA mutations confer constitutive activation of PI3K, which initiates intracellular kinase signaling cascades that promote cell proliferation and survival. Recent studies by Meyer and colleagues, and Liu and colleagues demonstrate that expression of the H1047R exon 20 mutant of PIK3CA in luminal mammary epithelial ...

journal_title：Breast cancer research : BCR

authors： Miller TW

更新日期：2012-02-07 00:00:00

abstract：INTRODUCTION:Estrogens play a pivotal role in the initiation and progression of breast cancer. The genes that mediate these processes are not fully defined, but potentially include the known mammary oncogene MYC. Characterization of estrogen-target genes may help to elucidate further the mechanisms of estrogen-induced ...

journal_title：Breast cancer research : BCR

authors： Butt AJ,Sergio CM,Inman CK,Anderson LR,McNeil CM,Russell AJ,Nousch M,Preiss T,Biankin AV,Sutherland RL,Musgrove EA

更新日期：2008-01-01 00:00:00

abstract：:Four trials of high-dose chemotherapy with stem cell support in breast cancer in the adjuvant and metastatic settings have shown no long-term disease-free or overall survival gain. This relative failure of a single high-dose therapy we believe opens up the development of a dose-dense approach with block scheduling as ...

journal_title：Breast cancer research : BCR

authors： Mayer A,Earl H

更新日期：2001-01-01 00:00:00

abstract：:The concept of cancer stem cells responsible for tumour origin, maintenance, and resistance to treatment has gained prominence in the field of breast cancer research. The therapeutic targeting of these cells has the potential to eliminate residual disease and may become an important component of a multimodality treatm...

journal_title：Breast cancer research : BCR

authors： Morrison BJ,Schmidt CW,Lakhani SR,Reynolds BA,Lopez JA

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Surgery is currently the definitive treatment for early-stage breast cancer. However, the rate of positive surgical margins remains unacceptably high. The human sodium iodide symporter (hNIS) is a naturally occurring protein in human thyroid tissue, which enables cells to concentrate radionuclides. The hNI...

journal_title：Breast cancer research : BCR

authors： Gholami S,Chen CH,Belin LJ,Lou E,Fujisawa S,Antonacci C,Carew A,Chen NG,De Brot M,Zanzonico PB,Szalay AA,Fong Y

更新日期：2013-03-18 00:00:00

abstract：BACKGROUND:Breast cancer stem cells (BCSCs) are typically seed cells of breast tumor that initiate and maintain tumor growth. MiR-7, as a cancer inhibitor, decreases the BCSC subset and inhibits tumor progression through mechanisms that remain unknown. METHODS:We examined miR-7 expression in breast cancer and develope...

journal_title：Breast cancer research : BCR

authors： Li M,Pan M,You C,Zhao F,Wu D,Guo M,Xu H,Shi F,Zheng D,Dou J

更新日期：2020-03-06 00:00:00

abstract：INTRODUCTION:Our efforts to prevent and treat breast cancer are significantly impeded by a lack of knowledge of the biology and developmental genetics of the normal mammary gland. In order to provide the specimens that will facilitate such an understanding, The Susan G. Komen for the Cure Tissue Bank at the IU Simon Ca...

journal_title：Breast cancer research : BCR

authors： Pardo I,Lillemoe HA,Blosser RJ,Choi M,Sauder CA,Doxey DK,Mathieson T,Hancock BA,Baptiste D,Atale R,Hickenbotham M,Zhu J,Glasscock J,Storniolo AM,Zheng F,Doerge RW,Liu Y,Badve S,Radovich M,Clare SE,Susan G. Komen f

更新日期：2014-03-17 00:00:00

abstract：INTRODUCTION:The actin binding protein Mammalian enabled (Mena), has been implicated in the metastatic progression of solid tumors in humans. Mena expression level in primary tumors is correlated with metastasis in breast, cervical, colorectal and pancreatic cancers. Cells expressing high Mena levels are part of the tu...

journal_title：Breast cancer research : BCR

authors： Roussos ET,Wang Y,Wyckoff JB,Sellers RS,Wang W,Li J,Pollard JW,Gertler FB,Condeelis JS

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Vitamin D has been suggested to prevent and improve the prognosis of several cancers, including breast cancer. We have previously shown a U-shaped association between pre-diagnostic serum levels of vitamin D and risk of breast cancer-related death, with poor survival in patients with the lowest and the highe...

journal_title：Breast cancer research : BCR

authors： Huss L,Butt ST,Borgquist S,Elebro K,Sandsveden M,Rosendahl A,Manjer J

更新日期：2019-07-29 00:00:00

abstract：INTRODUCTION:Incidence of breast cancer is increasing around the world and it is still the leading cause of cancer mortality in low- and middle-income countries. We utilized Swedish nationwide registers to study breast cancer incidence and case fatality to disentangle the effect of socioeconomic position (SEP) and immi...

journal_title：Breast cancer research : BCR

authors： Beiki O,Hall P,Ekbom A,Moradi T

更新日期：2012-01-06 00:00:00

abstract：:A new gene associated with a high risk of breast cancer, termed BRCAX, may exist on chromosome 13q. Tumours from multicase Nordic breast cancer families, in which mutations in BRCA1 and BRCA2 had been excluded, were analyzed using comparative genomic hybridization in order to identify a region of interest, which was a...

journal_title：Breast cancer research : BCR

authors： Hopper JL

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:CRIPTO is a multi-functional signaling protein that promotes stemness and oncogenesis. We previously developed a CRIPTO antagonist, ALK4L75A-Fc, and showed that it causes loss of the stem cell phenotype in normal mammary epithelia suggesting it may similarly inhibit CRIPTO-dependent plasticity in breast canc...

journal_title：Breast cancer research : BCR

authors： Balcioglu O,Heinz RE,Freeman DW,Gates BL,Hagos BM,Booker E,Mirzaei Mehrabad E,Diesen HT,Bhakta K,Ranganathan S,Kachi M,Leblanc M,Gray PC,Spike BT

更新日期：2020-11-13 00:00:00

abstract：INTRODUCTION:Focal adhesion kinase (FAK) regulates multiple cellular processes including growth, differentiation, adhesion, motility and apoptosis. In breast carcinoma, FAK overexpression has been linked to cancer progression but the prognostic relevance remains unknown. In particular, with regard to lymph node-negativ...

journal_title：Breast cancer research : BCR

authors： Schmitz KJ,Grabellus F,Callies R,Otterbach F,Wohlschlaeger J,Levkau B,Kimmig R,Schmid KW,Baba HA

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Breast cancer is a highly heterogeneous disease characterized by multiple histologic and molecular subtypes. While a myriad of breast cancer cell lines have been developed over the past 60 years, estrogen receptor alpha (ER)+ disease and some mutations associated with this subtype remain underrepresented. He...

journal_title：Breast cancer research : BCR

authors： Finlay-Schultz J,Jacobsen BM,Riley D,Paul KV,Turner S,Ferreira-Gonzalez A,Harrell JC,Kabos P,Sartorius CA

更新日期：2020-06-23 00:00:00

abstract：BACKGROUND:The PAM50-based (Prosigna) risk of recurrence (ROR) score and intrinsic subtypes are prognostic for women with high-risk breast cancer. We investigate the predictive ability of Prosigna regarding the effectiveness of cyclophosphamide-based adjuvant chemotherapy in premenopausal patients with high-risk breast...

journal_title：Breast cancer research : BCR

authors： Jensen MB,Lænkholm AV,Nielsen TO,Eriksen JO,Wehn P,Hood T,Ram N,Buckingham W,Ferree S,Ejlertsen B

更新日期：2018-07-27 00:00:00

abstract：INTRODUCTION:Cellular senescence is a terminal cell proliferation arrest that can be triggered by oncogenes. One of the traits of oncogene-induced senescence (OIS) is the so-called senescence-associated secretory phenotype or senescence secretome. Depending on the context, the non-cell autonomous effects of OIS may var...

journal_title：Breast cancer research : BCR

authors： Morancho B,Martínez-Barriocanal Á,Villanueva J,Arribas J

更新日期：2015-08-12 00:00:00

abstract：INTRODUCTION:Estrogen receptor-alpha (ER-alpha) and progesterone receptor (PgR) are consolidated predictors of response to hormonal therapy (HT). In contrast, little information regarding the role of estrogen receptor-beta (ER-beta) in various breast cancer risk groups treated with different therapeutic regimens is ava...

journal_title：Breast cancer research : BCR

authors： Novelli F,Milella M,Melucci E,Di Benedetto A,Sperduti I,Perrone-Donnorso R,Perracchio L,Venturo I,Nisticò C,Fabi A,Buglioni S,Natali PG,Mottolese M

更新日期：2008-01-01 00:00:00

abstract：:The metastatic process is a multistep coordinated event with a high degree of efficiency. Specific subpopulations of cancer stem cells, with tumor-initiating and migratory capacity, can selectively migrate towards sites that are able to promote survival and/or proliferation of metastatic tumor cells through a microenv...

journal_title：Breast cancer research : BCR

authors： Santini D,Vincenzi B,Pantano F,Tonini G,Bertoldo F

更新日期：2011-08-16 00:00:00

abstract：:HER2 amplification and overexpression is observed in approximately 20% of breast cancers and is strongly associated with poor prognosis and therapeutic responsiveness to HER2 targeted agents. A recent study by Bose and colleagues suggests that another subset of breast cancer patients without HER2 amplification but wit...

journal_title：Breast cancer research : BCR

authors： Acharyya S

更新日期：2013-04-23 00:00:00

abstract：PURPOSE:The therascreen PIK3CA mutation assay and the alpha-specific PI3K inhibitor alpelisib are FDA-approved for identifying and treating patients with advanced PIK3CA-mutated (PIK3CAmut) breast cancer (BC). However, it is currently unknown to what extend this assay detects most PIK3CA mutations in BC. This informati...

journal_title：Breast cancer research : BCR

authors： Martínez-Sáez O,Chic N,Pascual T,Adamo B,Vidal M,González-Farré B,Sanfeliu E,Schettini F,Conte B,Brasó-Maristany F,Rodríguez A,Martínez D,Galván P,Rodríguez AB,Martinez A,Muñoz M,Prat A

更新日期：2020-05-13 00:00:00

abstract：INTRODUCTION:The Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab) is a multidisciplinary, collaborative framework for the investigation of familial breast cancer. Based in Australia, the primary aim of kConFab is to facilitate high-quality research by amassing a large and comp...

journal_title：Breast cancer research : BCR

authors： Mann GJ,Thorne H,Balleine RL,Butow PN,Clarke CL,Edkins E,Evans GM,Fereday S,Haan E,Gattas M,Giles GG,Goldblatt J,Hopper JL,Kirk J,Leary JA,Lindeman G,Niedermayr E,Phillips KA,Picken S,Pupo GM,Saunders C,Scott CL

更新日期：2006-01-01 00:00:00

abstract：:High mammographic density is the most important risk factor for breast cancer, after ageing. However, the composition, architecture, and mechanical properties of high X-ray density soft tissues, and the causative mechanisms resulting in different mammographic densities, are not well described. Moreover, it is not know...

journal_title：Breast cancer research : BCR

authors： Sherratt MJ,McConnell JC,Streuli CH

更新日期：2016-05-03 00:00:00

abstract：INTRODUCTION:Tamoxifen, a selective estrogen receptor (ER) modulator, may affect cancer cell survival through mechanisms other than ER antagonism. In the present study, we tested the efficacy of tamoxifen in a panel of ER-negative breast cancer cell lines and examined the drug mechanism. METHODS:In total, five ER-nega...

journal_title：Breast cancer research : BCR

authors： Liu CY,Hung MH,Wang DS,Chu PY,Su JC,Teng TH,Huang CT,Chao TT,Wang CY,Shiau CW,Tseng LM,Chen KF

更新日期：2014-09-17 00:00:00

abstract：INTRODUCTION:Aberrant activation of Wnt/β-catenin signaling plays an important role in the pathogenesis of breast cancer. DACT1 (Dapper/Frodo) has been identified as involved in antagonizing Wnt/β-catenin signaling through interacting with Dishevelled (Dvl), a central mediator of Wnt signaling, whereas its role in brea...

journal_title：Breast cancer research : BCR

authors： Yin X,Xiang T,Li L,Su X,Shu X,Luo X,Huang J,Yuan Y,Peng W,Oberst M,Kelly K,Ren G,Tao Q

更新日期：2013-03-12 00:00:00

abstract：INTRODUCTION:Hypoxia-inducible factor (HIF)-1alpha levels in invasive breast carcinoma have been shown to be an adverse prognostic indicator. Cellular HIF-1alpha activity is regulated by factor-inhibiting hypoxia-inducible factor 1 (FIH-1). In hypoxia, FIH-1 hydroxylation of Asn803 within the C-terminal transactivation...

journal_title：Breast cancer research : BCR

authors： Tan EY,Campo L,Han C,Turley H,Pezzella F,Gatter KC,Harris AL,Fox SB

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:Studies on the association between the cytochrome P450c17alpha gene (CYP17) 5'-untranslated region MspA1 genetic polymorphism and breast cancer risk have yielded inconsistent results. Higher levels of estrogen have been reported among young nulliparous women with the A2 allele. Therefore we assessed the im...

journal_title：Breast cancer research : BCR

authors： Verla-Tebit E,Wang-Gohrke S,Chang-Claude J

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Breast cancer researchers use cell lines to model myriad phenomena ranging from DNA repair to cancer stem cell phenotypes. Though appropriate, and even requisite, for many studies, the suitability of cell lines as tumour models has come into question owing to possibilities of tissue culture artefacts and c...

journal_title：Breast cancer research : BCR

authors： Vincent KM,Findlay SD,Postovit LM

更新日期：2015-08-20 00:00:00