Combined the SMAC mimetic and BCL2 inhibitor sensitizes neoadjuvant chemotherapy by targeting necrosome complexes in tyrosine aminoacyl-tRNA synthase-positive breast cancer.

abstract：BACKGROUND:Breast cancer patients with early-stage disease are increasingly administered neoadjuvant chemotherapy (NAC) to downstage their tumors prior to surgery. In this setting, approximately 31% of patients fail to respond to therapy. This demonstrates the need for techniques capable of providing personalized feedb...

journal_title：Breast cancer research : BCR

authors： Tank A,Peterson HM,Pera V,Tabassum S,Leproux A,O'Sullivan T,Jones E,Cabral H,Ko N,Mehta RS,Tromberg BJ,Roblyer D

更新日期：2020-03-13 00:00:00

abstract：INTRODUCTION:Phosphoinositide 3-kinase (PI3K)-activated signalling has a critical role in the evolution of aggressive tumourigenesis and is therefore a prime target for anticancer therapy. Previously we have shown that the beta galactoside binding protein (betaGBP) cytokine, an antiproliferative molecule, induces funct...

journal_title：Breast cancer research : BCR

authors： Wells V,Mallucci L

更新日期：2009-01-01 00:00:00

abstract：:Osteolytic metastases due to breast cancer are serious events. The interactions between breast cancer cells with the microenvironment of bone have been thought to provide an ideal milieu for cancer cells. Recent data now indicate that migration of breast cancer cells into bone and their subsequent growth into metastas...

journal_title：Breast cancer research : BCR

authors： Hofbauer LC,Rachner T,Singh SK

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:The HER (human EGFR related) family of receptor tyrosine kinases (HER1/EGFR (epidermal growth factor receptor)/c-erbB1, HER2/c-erbB2, HER3/c-erbB3 and HER4/c-erbB4) shares a high degree of structural and functional homology. It constitutes a complex network, coupling various extracellular ligands to intrac...

journal_title：Breast cancer research : BCR

authors： Sassen A,Rochon J,Wild P,Hartmann A,Hofstaedter F,Schwarz S,Brockhoff G

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Global gene expression analysis of tumor samples has been a valuable tool to subgroup tumors and has the potential to be of prognostic and predictive value. However, tumors are heterogeneous, and homogenates will consist of several different cell types. This study was designed to obtain more refined expres...

journal_title：Breast cancer research : BCR

authors： Winslow S,Leandersson K,Edsjö A,Larsson C

更新日期：2015-02-21 00:00:00

abstract：:The metastatic process is a multistep coordinated event with a high degree of efficiency. Specific subpopulations of cancer stem cells, with tumor-initiating and migratory capacity, can selectively migrate towards sites that are able to promote survival and/or proliferation of metastatic tumor cells through a microenv...

journal_title：Breast cancer research : BCR

authors： Santini D,Vincenzi B,Pantano F,Tonini G,Bertoldo F

更新日期：2011-08-16 00:00:00

abstract：BACKGROUND:Texture patterns have been shown to improve breast cancer risk segregation in addition to area-based mammographic density. The additional value of texture pattern scores on top of volumetric mammographic density measures in a large screening cohort has never been studied. METHODS:Volumetric mammographic den...

journal_title：Breast cancer research : BCR

authors： Wanders JOP,van Gils CH,Karssemeijer N,Holland K,Kallenberg M,Peeters PHM,Nielsen M,Lillholm M

更新日期：2018-05-02 00:00:00

abstract：BACKGROUND:Inflammation is an important candidate mechanism underlying cancer and cancer treatment-related cognitive impairment. We investigated levels of blood cell-based inflammatory markers in breast cancer survivors on average 20 years after chemotherapy and explored the relation between these markers and global co...

journal_title：Breast cancer research : BCR

authors： van der Willik KD,Koppelmans V,Hauptmann M,Compter A,Ikram MA,Schagen SB

更新日期：2018-11-15 00:00:00

abstract：INTRODUCTION:Breast cancer is the most common female malignancy worldwide and, despite improvements in treatment modalities, there are increased chances of recurrence and metastasis in a substantial number of cases and it remains one of the major causes of mortality among female cancer patients. Anaplastic lymphoma kin...

journal_title：Breast cancer research : BCR

authors： Siraj AK,Beg S,Jehan Z,Prabhakaran S,Ahmed M,R Hussain A,Al-Dayel F,Tulbah A,Ajarim D,Al-Kuraya KS

更新日期：2015-09-17 00:00:00

abstract：INTRODUCTION:Current approaches to inhibit oestrogen receptor-alpha (ERα) are focused on targeting its hormone-binding pocket and have limitations. Thus, we propose that inhibitors that bind to a coactivator-binding pocket on ERα, called activation function 2 (AF2), might overcome some of these limitations. METHODS:In...

journal_title：Breast cancer research : BCR

authors： Singh K,Munuganti RS,Leblanc E,Lin YL,Leung E,Lallous N,Butler M,Cherkasov A,Rennie PS

更新日期：2015-02-25 00:00:00

abstract：BACKGROUND:The Cancer Genome Atlas analysis revealed that somatic EGFR, receptor tyrosine-protein kinase erbB-2 (ERBB2), Erb-B2 receptor tyrosine kinase 3 (ERBB3) and Erb-B2 receptor tyrosine kinase 4 (ERBB4) gene mutations (ERBB family mutations) occur alone or co-occur with somatic mutations in the gene encoding the ...

journal_title：Breast cancer research : BCR

authors： Toomey S,Eustace AJ,Fay J,Sheehan KM,Carr A,Milewska M,Madden SF,Teiserskiene A,Kay EW,O'Donovan N,Gallagher W,Grogan L,Breathnach O,Walshe J,Kelly C,Moulton B,Kennedy MJ,Gullo G,Hill AD,Power C,Duke D,Hambly N

更新日期：2017-07-27 00:00:00

abstract：INTRODUCTION:Tamoxifen, a selective estrogen receptor (ER) modulator, may affect cancer cell survival through mechanisms other than ER antagonism. In the present study, we tested the efficacy of tamoxifen in a panel of ER-negative breast cancer cell lines and examined the drug mechanism. METHODS:In total, five ER-nega...

journal_title：Breast cancer research : BCR

authors： Liu CY,Hung MH,Wang DS,Chu PY,Su JC,Teng TH,Huang CT,Chao TT,Wang CY,Shiau CW,Tseng LM,Chen KF

更新日期：2014-09-17 00:00:00

abstract：INTRODUCTION:Mammographic density has been established as a strong risk factor for breast cancer, primarily using digitized film mammograms. Full-field digital mammography (FFDM) is replacing film mammography, has different properties than film, and provides both raw and processed clinical display representation images...

journal_title：Breast cancer research : BCR

authors： Vachon CM,Fowler EE,Tiffenberg G,Scott CG,Pankratz VS,Sellers TA,Heine JJ

更新日期：2013-01-04 00:00:00

abstract：INTRODUCTION:During selective segregation of DNA, a cell asymmetrically divides and retains its template DNA. Asymmetric division yields daughter cells whose genome reflects that of the parents', simultaneously protecting the parental cell from genetic errors that may occur during DNA replication. We hypothesized that ...

journal_title：Breast cancer research : BCR

authors： Bussard KM,Boulanger CA,Kittrell FS,Behbod F,Medina D,Smith GH

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Menopausal hormone therapy has been reported to increase the risk of certain subtypes of breast cancer and to be associated with a favorable survival. These associations could either be due to an increased mammographic surveillance or to a biological effect. We assessed these associations in a Swedish coho...

journal_title：Breast cancer research : BCR

authors： Rosenberg LU,Granath F,Dickman PW,Einarsdóttir K,Wedrén S,Persson I,Hall P

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Breast cancer is a worldwide health problem and the leading cause of cancer death among females. We previously identified Jumonji domain containing 2A (JMJD2A) as a critical mediator of breast cancer proliferation, migration and invasion. We now report that JMJD2A could promote breast cancer progression th...

journal_title：Breast cancer research : BCR

authors： Li LL,Xue AM,Li BX,Shen YW,Li YH,Luo CL,Zhang MC,Jiang JQ,Xu ZD,Xie JH,Zhao ZQ

更新日期：2014-05-30 00:00:00

abstract：:Advances in genotyping technology have provided us with a large number of genetic loci associated with cancer susceptibility; however, our ability to understand the functional effects of the genetic variants of these loci remains limited. In the previous issue, Smits and colleagues demonstrate the use of congenic rat ...

journal_title：Breast cancer research : BCR

authors： Blackburn AC

更新日期：2011-10-12 00:00:00

abstract：INTRODUCTION:The Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab) is a multidisciplinary, collaborative framework for the investigation of familial breast cancer. Based in Australia, the primary aim of kConFab is to facilitate high-quality research by amassing a large and comp...

journal_title：Breast cancer research : BCR

authors： Mann GJ,Thorne H,Balleine RL,Butow PN,Clarke CL,Edkins E,Evans GM,Fereday S,Haan E,Gattas M,Giles GG,Goldblatt J,Hopper JL,Kirk J,Leary JA,Lindeman G,Niedermayr E,Phillips KA,Picken S,Pupo GM,Saunders C,Scott CL

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:CRIPTO is a multi-functional signaling protein that promotes stemness and oncogenesis. We previously developed a CRIPTO antagonist, ALK4L75A-Fc, and showed that it causes loss of the stem cell phenotype in normal mammary epithelia suggesting it may similarly inhibit CRIPTO-dependent plasticity in breast canc...

journal_title：Breast cancer research : BCR

authors： Balcioglu O,Heinz RE,Freeman DW,Gates BL,Hagos BM,Booker E,Mirzaei Mehrabad E,Diesen HT,Bhakta K,Ranganathan S,Kachi M,Leblanc M,Gray PC,Spike BT

更新日期：2020-11-13 00:00:00

abstract：INTRODUCTION:Bcl-2 and Bcl-xL confer resistance to apoptosis, thereby reducing the effectiveness of chemotherapy. We examined the relationship between the expression of Bcl-2 and Bcl-xL and chemosensitivity of breast cancer cells, with the aim of developing specific targeted therapy. METHODS:Four human breast cancer c...

journal_title：Breast cancer research : BCR

authors： Emi M,Kim R,Tanabe K,Uchida Y,Toge T

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Bisphosphonates have become standard therapy for the treatment of skeletal complications related to breast cancer. Although their therapeutic effects mainly result from an inhibition of osteoclastic bone resorption, in vitro data indicate that they also act directly on breast cancer cells, inhibiting proli...

journal_title：Breast cancer research : BCR

authors： Journé F,Kheddoumi N,Chaboteaux C,Duvillier H,Laurent G,Body JJ

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Although recent models suggest that the detection of Circulating Tumor Cells (CTC) in epithelial-to-mesenchymal transition (EM CTC) might be related to disease progression in metastatic breast cancer (MBC) patients, current detection methods are not efficient in identifying this subpopulation of cells. Furth...

journal_title：Breast cancer research : BCR

authors： Bulfoni M,Gerratana L,Del Ben F,Marzinotto S,Sorrentino M,Turetta M,Scoles G,Toffoletto B,Isola M,Beltrami CA,Di Loreto C,Beltrami AP,Puglisi F,Cesselli D

更新日期：2016-03-09 00:00:00

abstract：:Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate that is effective and generally well tolerated when administered as a single agent to treat advanced breast cancer. Efficacy has now been demonstrated in randomized trials as first line, second line, and later than the second line treatment of advanced breast...

journal_title：Breast cancer research : BCR

authors： Barok M,Joensuu H,Isola J

更新日期：2014-03-05 00:00:00

abstract：INTRODUCTION:The purpose of this work was to study the prognostic influence in breast cancer of thioredoxin reductase 1 (TXNRD1) and thioredoxin interacting protein (TXNIP), key players in oxidative stress control that are currently evaluated as possible therapeutic targets. METHODS:Analysis of the association of TXNR...

journal_title：Breast cancer research : BCR

authors： Cadenas C,Franckenstein D,Schmidt M,Gehrmann M,Hermes M,Geppert B,Schormann W,Maccoux LJ,Schug M,Schumann A,Wilhelm C,Freis E,Ickstadt K,Rahnenführer J,Baumbach JI,Sickmann A,Hengstler JG

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Sustained HER2 signaling at the cell surface is an oncogenic mechanism in a significant proportion of breast cancers. While clinically effective therapies targeting HER2 such as mAbs and tyrosine kinase inhibitors exist, tumors overexpressing HER2 eventually progress despite treatment. Thus, abrogation of ...

journal_title：Breast cancer research : BCR

authors： Ren XR,Wei J,Lei G,Wang J,Lu J,Xia W,Spector N,Barak LS,Clay TM,Osada T,Hamilton E,Blackwell K,Hobeika AC,Morse MA,Lyerly HK,Chen W

更新日期：2012-06-07 00:00:00

abstract：BACKGROUND:Chromogenic in situ hybridization (CISH) is emerging as a practical, cost-effective, and valid alternative to fluorescent in situ hybridization in testing for gene alteration, especially in centers primarily working with immunohistochemistry (IHC). METHODS:We assessed Her-2/neu alteration using CISH on form...

journal_title：Breast cancer research : BCR

authors： Madrid MA,Lo RW

更新日期：2004-01-01 00:00:00

abstract：INTRODUCTION:Classification of breast cancers according to the HER-2 oncogene status is of central importance in the selection of post-surgical therapies. A decrease in the proportion of HER-2-positive breast cancer has been suspected, but no data on the incidence trends at population level have been reported. METHODS...

journal_title：Breast cancer research : BCR

authors： Köninki K,Tanner M,Auvinen A,Isola J

更新日期：2009-01-01 00:00:00

abstract：:Recent insights into the molecular and cellular mechanisms underlying cancer development have revealed that immune cells functionally regulate epithelial cancer development and progression. Moreover, accumulated clinical and experimental data indicate that the outcome of an immune response toward an evolving breast ne...

journal_title：Breast cancer research : BCR

authors： DeNardo DG,Coussens LM

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:The therascreen PIK3CA mutation assay and the alpha-specific PI3K inhibitor alpelisib are FDA-approved for identifying and treating patients with advanced PIK3CA-mutated (PIK3CAmut) breast cancer (BC). However, it is currently unknown to what extend this assay detects most PIK3CA mutations in BC. This informati...

journal_title：Breast cancer research : BCR

authors： Martínez-Sáez O,Chic N,Pascual T,Adamo B,Vidal M,González-Farré B,Sanfeliu E,Schettini F,Conte B,Brasó-Maristany F,Rodríguez A,Martínez D,Galván P,Rodríguez AB,Martinez A,Muñoz M,Prat A

更新日期：2020-05-13 00:00:00

abstract：INTRODUCTION:Endocrine therapies target oestrogenic stimulation of breast cancer (BC) growth, but resistance remains problematic. Our aims in this study were (1) to identify genes most strongly associated with resistance to endocrine therapy by intersecting global gene transcription data from patients treated presurgic...

journal_title：Breast cancer research : BCR

authors： Ribas R,Ghazoui Z,Gao Q,Pancholi S,Rani A,Dunbier A,Dowsett M,Martin LA

更新日期：2014-10-31 00:00:00