Abstract:
BACKGROUND:In order to estimate utilities for cancer studies where the EQ-5D was not used, the EORTC QLQ-C30 can be used to estimate EQ-5D using existing mapping algorithms. Several mapping algorithms exist for this transformation, however, algorithms tend to lose accuracy in patients in poor health states. The aim of this study was to test all existing mapping algorithms of QLQ-C30 onto EQ-5D, in a dataset of patients with malignant pleural mesothelioma, an invariably fatal malignancy where no previous mapping estimation has been published. METHODS:Health related quality of life (HRQoL) data where both the EQ-5D and QLQ-C30 were used simultaneously was obtained from the UK-based prospective observational SWAMP (South West Area Mesothelioma and Pemetrexed) trial. In the original trial 73 patients with pleural mesothelioma were offered palliative chemotherapy and their HRQoL was assessed across five time points. This data was used to test the nine available mapping algorithms found in the literature, comparing predicted against observed EQ-5D values. The ability of algorithms to predict the mean, minimise error and detect clinically significant differences was assessed. RESULTS:The dataset had a total of 250 observations across 5 timepoints. The linear regression mapping algorithms tested generally performed poorly, over-estimating the predicted compared to observed EQ-5D values, especially when observed EQ-5D was below 0.5. The best performing algorithm used a response mapping method and predicted the mean EQ-5D with accuracy with an average root mean squared error of 0.17 (Standard Deviation; 0.22). This algorithm reliably discriminated between clinically distinct subgroups seen in the primary dataset. CONCLUSIONS:This study tested mapping algorithms in a population with poor health states, where they have been previously shown to perform poorly. Further research into EQ-5D estimation should be directed at response mapping methods given its superior performance in this study.
journal_name
Health Qual Life Outcomesjournal_title
Health and quality of life outcomesauthors
Arnold DT,Rowen D,Versteegh MM,Morley A,Hooper CE,Maskell NAdoi
10.1186/s12955-014-0196-ysubject
Has Abstractpub_date
2015-01-23 00:00:00pages
6issn
1477-7525pii
s12955-014-0196-yjournal_volume
13pub_type
杂志文章abstract:BACKGROUND:The Oxford Shoulder Score (OSS) and the Shoulder Pain and Disability Index (SPADI) are patient-based outcome scores with valid psychometric properties which are widely used for shoulder interventions. OBJECTIVE:The purpose of the study is to adapt both questionnaires cross-culturally to Spanish, and to test...
journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/s12955-015-0256-y
更新日期:2015-05-23 00:00:00
abstract:BACKGROUND:The long-term fate of severely injured patients in terms of their quality of life is not well known. Our aim was to assess the quality of life of patients who have suffered moderate to severe trauma and to identify primary factors of long-term quality of life impairment. METHODS:A prospective monocentric st...
journal_title:Health and quality of life outcomes
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doi:10.1186/s12955-020-01652-1
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-6-109
更新日期:2008-12-04 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12955-020-01416-x
更新日期:2020-06-02 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-5-68
更新日期:2007-12-19 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/s12955-016-0423-9
更新日期:2016-02-17 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/s12955-020-01605-8
更新日期:2020-11-09 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-2-16
更新日期:2004-03-23 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-12-33
更新日期:2014-03-10 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-4-90
更新日期:2006-11-27 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/s12955-019-1206-x
更新日期:2019-08-02 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/s12955-017-0728-3
更新日期:2017-08-01 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-9-117
更新日期:2011-12-22 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-12-85
更新日期:2014-06-09 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-9-19
更新日期:2011-03-29 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/s12955-016-0560-1
更新日期:2016-11-15 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/s12955-020-01490-1
更新日期:2020-07-20 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-11-123
更新日期:2013-07-23 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-7-47
更新日期:2009-05-28 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/s12955-019-1185-y
更新日期:2019-07-16 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-6-15
更新日期:2008-02-15 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-2-59
更新日期:2004-10-25 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-6-36
更新日期:2008-05-27 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/s12955-020-01579-7
更新日期:2021-01-06 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1477-7525-10-29
更新日期:2012-03-13 00:00:00
abstract:BACKGROUND:The EORTC-QLQ-C30 is a widely used health related quality of life (HRQoL) questionnaire in lung cancer patients. Small HRQoL treatment effects are often reported as mean differences (MDs) between treatments, which are rarely justified or understood by patients and clinicians. An alternative approach using od...
journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/s12955-015-0374-6
更新日期:2015-11-14 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/s12955-021-01676-1
更新日期:2021-01-22 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-5-1
更新日期:2007-01-03 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/s12955-015-0304-7
更新日期:2015-08-22 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章,评审
doi:10.1186/s12955-017-0836-0
更新日期:2018-01-23 00:00:00