Pain in patients with COPD: a systematic review and meta-analysis.

abstract：OBJECTIVES:To conduct a fully independent, external validation of a research study based on one electronic health record database using a different database sampling from the same population. DESIGN:Retrospective cohort analysis of β-blocker therapy and all-cause mortality in patients with cancer. SETTING:Two UK nati...

journal_title：BMJ open

authors： Springate DA,Ashcroft DM,Kontopantelis E,Doran T,Ryan R,Reeves D

更新日期：2015-04-13 00:00:00

abstract：INTRODUCTION:Inflammation and dysregulated immune responses play a crucial role in atherosclerosis, underlying ischaemic heart disease (IHD) and acute coronary syndromes (ACSs). Immune responses are also major determinants of the postischaemic injury in myocardial infarction. Regulatory T cells (CD4+CD25+FOXP3+; Treg) ...

journal_title：BMJ open

authors： Zhao TX,Kostapanos M,Griffiths C,Arbon EL,Hubsch A,Kaloyirou F,Helmy J,Hoole SP,Rudd JHF,Wood G,Burling K,Bond S,Cheriyan J,Mallat Z

更新日期：2018-09-17 00:00:00

abstract：OBJECTIVE:To assess the association of socioeconomic deprivation (SED) with survival after stroke in China. DESIGN:A systematic literature review and a new population-based cohort study. SETTING AND PARTICIPANTS:In urban and rural communities in Anhui, China, 2978 residents aged ≥60 years took part in baseline invest...

journal_title：BMJ open

authors： Chen R,Hu Z,Chen RL,Zhang D,Xu L,Wang J,Wei L

更新日期：2015-01-30 00:00:00

abstract：OBJECTIVE:The reasons that physicians leave the institutions have not been extensively studied. We aimed to evaluate these reasons, which include the desire to work at another hospital or the intention to make a career change, among physicians in tertiary hospitals in China and explore the associations between the indi...

journal_title：BMJ open

authors： Zhang C,Hu L,Ma J,Wu S,Guo J,Liu Y

更新日期：2019-03-13 00:00:00

abstract：INTRODUCTION:Mycobacterium tuberculosis (Mtb) is transmitted from person to person via airborne droplet nuclei. At the community level, Mtb transmission depends on the exposure venue, infectiousness of the tuberculosis (TB) index case and the susceptibility of the index case's social network. People living with HIV inf...

journal_title：BMJ open

authors： Zetola NM,Modongo C,Moonan PK,Click E,Oeltmann JE,Shepherd J,Finlay A

更新日期：2016-05-09 00:00:00

abstract：INTRODUCTION:The appropriateness of using routinely collected laboratory data combined with administrative data for estimating influenza vaccine effectiveness (VE) is still being explored. This paper outlines a protocol to estimate influenza VE using linked laboratory and administrative data which could act as a compan...

journal_title：BMJ open

authors： Scott AN,Buchan SA,Kwong JC,Drews SJ,Simmonds KA,Svenson LW

更新日期：2019-09-30 00:00:00

abstract：OBJECTIVES:Atrial fibrillation (AF) is the most common cardiac rhythm disorder with a significant health burden. The aim of this study was to characterise patients with recently diagnosed AF and to estimate the rates of comorbidities and outcome events requiring hospitalisation in routine clinical practice. DESIGN:Pha...

journal_title：BMJ open

authors： Gallagher AM,van Staa TP,Murray-Thomas T,Schoof N,Clemens A,Ackermann D,Bartels DB

更新日期：2014-01-27 00:00:00

abstract：INTRODUCTION:High flow (HF) therapy is an increasingly popular mode of non-invasive respiratory support for preterm infants. While there is now evidence to support the use of HF to reduce extubation failure, there have been no appropriately designed and powered studies to assess the use of HF as primary respiratory sup...

journal_title：BMJ open

authors： Roberts CT,Owen LS,Manley BJ,Donath SM,Davis PG

更新日期：2015-06-24 00:00:00

abstract：INTRODUCTION:High-grade gliomas (HGGs) are the most malignant type of brain tumours. The 5-year survival is 10% and a significant part of the ongoing research aims to increase survival through surgical and oncological treatments. Accordingly, there is an increasing need for investigating the HGG trajectory in order to ...

journal_title：BMJ open

authors： Piil K,Jarden M,Jakobsen J,Christensen KB,Juhler M

更新日期：2013-07-11 00:00:00

abstract：OBJECTIVE:Animal and in vitro studies suggest that viral acute respiratory infection (VARI) can predispose to pneumococcal infection. These findings suggest that the prevention of VARI can yield additional benefits for the control of pneumococcal disease (PD). In population-based studies, however, the evidence is not i...

journal_title：BMJ open

authors： Li Y,Peterson ME,Campbell H,Nair H

更新日期：2018-04-21 00:00:00

abstract：INTRODUCTION:Dexamethasone is a drug used to prolong the postoperative analgesia in children after peripheral nerve blockade, although the dose usually used (0.2 mg/kg) has not been studied yet. This study is a monocentric, prospective, randomised, placebo-controlled, double-blinded study in a university hospital in Fr...

journal_title：BMJ open

authors： Vautrin N,Thilly N,Bernard Y,Wurtz F,Meistelman C

更新日期：2020-09-30 00:00:00

abstract：BACKGROUND:The Baby Friendly Hospital Initiative (BFHI) is a practice guideline for healthcare providers to promote breastfeeding and increase breastfeeding rates. OBJECTIVE:This study aimed to examine reported experiences and views on breastfeeding of women using prenatal and postnatal services, and opinions of staff...

journal_title：BMJ open

authors： Mosher C,Sarkar A,Hashem AA,Hamadah RE,Alhoulan A,AlMakadma YA,Khan TA,Al-Hamdani AK,Senok A

更新日期：2016-12-16 00:00:00

abstract：OBJECTIVES:To better model underlying trends in cervical cancer incidence so as to model past trends, to estimate the impact of cervical screening on cervical cancer rates at different ages and to obtain a counterfactual baseline under a no-screening scenario. DESIGN:Trend analysis of cancer registry data recorded bet...

journal_title：BMJ open

authors： Pesola F,Sasieni P

更新日期：2019-01-24 00:00:00

abstract：OBJECTIVES:Current research on the perceptions of overdiagnosis or overdetection of breast cancer has largely been conducted outside of the USA and with women younger than 70 years.Therefore, we explored older women's perceptions about the concept of overdetection of breast cancer and its influence on future screening ...

journal_title：BMJ open

authors： Pappadis MR,Volk RJ,Krishnan S,Weller SC,Jaramillo E,Hoover DS,Giordano SH,Tan A,Sheffield KM,Housten AJ,Goodwin JS

更新日期：2018-06-14 00:00:00

abstract：OBJECTIVES:French authorities are considering the implementation of a simplified nutrition labelling system on food products to help consumers make healthier food choices. One of the most documented candidates (Five-Colour Nutrition Label/Nutri-score) is based on the British Food Standards Agency Nutrient Profiling Sys...

journal_title：BMJ open

authors： Deschasaux M,Julia C,Kesse-Guyot E,Lécuyer L,Adriouch S,Méjean C,Ducrot P,Péneau S,Latino-Martel P,Fezeu LK,Fassier P,Hercberg S,Touvier M

更新日期：2017-06-08 00:00:00

abstract：INTRODUCTION:Robot-assisted laparoscopic prostatectomy (RALP) offers potential cure for localised prostate cancer but is associated with considerable toxicity. Potency and urinary continence are improved when the neurovascular bundles (NVBs) are spared during a nerve spare (NS) RALP. There is reluctance, however, to pe...

journal_title：BMJ open

authors： Dinneen E,Haider A,Allen C,Freeman A,Briggs T,Nathan S,Brew-Graves C,Grierson J,Williams NR,Persad R,Oakley N,Adshead JM,Huland H,Haese A,Shaw G

更新日期：2019-06-11 00:00:00

abstract：OBJECTIVE:To determine ethnic differences in the progression of chronic kidney disease (CKD) and risk of end-stage renal failure (ESRF) and death in adults with type 2 diabetes mellitus (T2DM), and to identify predictors of rapid renal decline. DESIGN:Observational community-based cohort study undertaken from 2006 to ...

journal_title：BMJ open

authors： Mathur R,Dreyer G,Yaqoob MM,Hull SA

更新日期：2018-03-27 00:00:00

abstract：INTRODUCTION:Although cardiologists were 'late-comers' to the multidisciplinary team-contributing to the complex care of patients with Duchenne muscular dystrophy (DMD), they now recognise the importance of systematic cardiac surveillance and timely therapy to prolonged survival in patients with DMD. Empirical deployme...

journal_title：BMJ open

authors： Bourke JP,Watson G,Muntoni F,Spinty S,Roper H,Guglieri M,Speed C,McColl E,Chikermane A,Jayawant S,Adwani S,Willis T,Wilkinson J,Bryant A,Chadwick T,Wood R,Bushby K,DMD Heart Protection study group.

更新日期：2018-12-19 00:00:00

abstract：INTRODUCTION:Binge-eating disorder (BED) was included as its own diagnostic entity in the Fifth Edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). An increasing number of treatment studies have been published, but an up-to-date comprehensive meta-analysis on diverse treatment approaches for B...

journal_title：BMJ open

authors： Hilbert A,Petroff D,Herpertz S,Kersting A,Pietrowsky R,Tuschen-Caffier B,Vocks S,Schmidt R

更新日期：2017-03-29 00:00:00

abstract：INTRODUCTION:Gut microbiome and diet may be important in irritable bowel syndrome (IBS), inflammatory bowel disease (IBD) and comorbid psychiatric conditions, but the mechanisms are unclear. We will create a large cohort of patients with IBS, IBD and healthy controls, and follow them over time, collecting dietary and m...

journal_title：BMJ open

authors： Moayyedi P,MacQueen G,Bernstein CN,Vanner S,Bercik P,Madsen KL,Surette M,Rioux JD,Dieleman LA,Verdú E,de Souza RJ,Otley A,Targownik L,Lavis J,Cunningham J,Marshall DA,Zelinsky S,Fernandes A

更新日期：2020-10-21 00:00:00

abstract：OBJECTIVES:We conducted a retrospective review of patients with extrapulmonary small cell carcinomas (EPSCCs) to explore the distribution, treatments, patterns of relapse and outcomes by primary site. SETTING:We have reviewed the outcomes of one of the largest data sets of consecutive patients with EPSCC identified fr...

journal_title：BMJ open

authors： Gennatas S,Noble J,Stanway S,Gunapala R,Chowdhury R,Wotherspoon A,Benepal T,Popat S

更新日期：2015-01-14 00:00:00

abstract：OBJECTIVE:This study aimed to evaluate the duration of intensive care unit (ICU) stay prior to onset of invasive candidiasis (IC)/candidaemia. DESIGN:Systematic review and meta-analysis. DATA SOURCES:PubMed, Cochrane, Embase and Web of Science databases were searched through June 2019 to identify relevant studies. E...

journal_title：BMJ open

authors： Zhang Z,Zhu R,Luan Z,Ma X

更新日期：2020-07-12 00:00:00

abstract：INTRODUCTION:In breast cancer, local tumour control is thought to be optimised by administering higher local levels of cytotoxic chemotherapy, in particular doxorubicin. However, systemic administration of higher dosages of doxorubicin is hampered by its toxic side effects. In this study, we aim to increase doxorubicin...

journal_title：BMJ open

authors： de Maar JS,Suelmann BBM,Braat MNGJA,van Diest PJ,Vaessen HHB,Witkamp AJ,Linn SC,Moonen CTW,van der Wall E,Deckers R

更新日期：2020-11-26 00:00:00

abstract：INTRODUCTION:Pharmacotherapy plays an important role in the treatment of major depression. At the initiation of antidepressant treatment, both improvement of symptoms in the short term and relapse prevention in the long term should be taken into account. However, there is insufficient evidence regarding the efficacy an...

journal_title：BMJ open

authors： Shinohara K,Efthimiou O,Ostinelli EG,Tomlinson A,Geddes JR,Nierenberg AA,Ruhe HG,Furukawa TA,Cipriani A

更新日期：2019-05-19 00:00:00

abstract：INTRODUCTION:Smoking remains the leading cause of preventable death in the USA but can be reduced through policy interventions. Computational models of smoking can provide estimates of the projected impact of tobacco control policies and can be used to inform public health decision making. We outline a protocol for sim...

journal_title：BMJ open

authors： Tam J,Levy DT,Jeon J,Clarke J,Gilkeson S,Hall T,Feuer EJ,Holford TR,Meza R

更新日期：2018-03-23 00:00:00

abstract：OBJECTIVES:To evaluate the risk profile, achievement of cardiometabolic goals, and frequency and optimal use of cardiovascular preventive therapies among nonagenarians with type 2 diabetes mellitus (T2DM). To investigate possible sex differences. DESIGN AND SETTING:A cross-sectional population study of 11 645 persons ...

journal_title：BMJ open

authors： Salinero-Fort MA,Mostaza-Prieto JM,Lahoz-Rallo C,Vicente Díez JI,Cárdenas-Valladolid J

更新日期：2019-09-20 00:00:00

abstract：OBJECTIVES:Multimorbidity is the presence of 2 or more medical conditions. This increasingly used assessment has not been assessed in a surgical population. The objectives of this study were to assess the prevalence of multimorbidity and its association with common outcome measures. DESIGN:A cross-sectional observatio...

journal_title：BMJ open

authors： Hewitt J,McCormack C,Tay HS,Greig M,Law J,Tay A,Asnan NH,Carter B,Myint PK,Pearce L,Moug SJ,McCarthy K,Stechman MJ

更新日期：2016-03-31 00:00:00

abstract：PURPOSE:The Dutch IBD Biobank aims to facilitate the discovery of predictors for individual disease course and treatment response in patients with inflammatory bowel disease (IBD). In this paper, we aim to describe the establishment of the Dutch IBD Biobank, including the facilitators and barriers to establishment. Mor...

journal_title：BMJ open

authors： Spekhorst LM,Imhann F,Festen EAM,van Bodegraven AA,de Boer NKH,Bouma G,Fidder HH,d'Haens G,Hoentjen F,Hommes DW,de Jong DJ,Löwenberg M,Maljaars PWJ,van der Meulen-de Jong AE,Oldenburg B,Pierik MJ,Ponsioen CY,Stokkers PC

更新日期：2017-11-08 00:00:00

abstract：OBJECTIVES:Retirement villages (RV) have expanded rapidly, now housing perhaps one in eight people aged 75+ years in New Zealand. Health service initiatives might better support residents and offer cost advantages, but little is known of resident demographics, health status or needs. This study describes village reside...

journal_title：BMJ open

authors： Broad JB,Wu Z,Bloomfield K,Hikaka J,Bramley D,Boyd M,Tatton A,Calvert C,Peri K,Higgins AM,Connolly MJ

更新日期：2020-09-18 00:00:00

abstract：OBJECTIVES:To analyse the prevalence and incidence of pregabalin and gabapentin (P/G) prescriptions, typical therapeutic uses of P/G with special attention to pain-related diagnoses and discontinuation rates. DESIGN:Secondary data analysis. SETTING:Primary and secondary care in Germany. PARTICIPANTS:Four million pat...

journal_title：BMJ open

authors： Viniol A,Ploner T,Hickstein L,Haasenritter J,Klein KM,Walker J,Donner-Banzhoff N,Becker A

更新日期：2019-03-30 00:00:00