Abstract:
PURPOSE:The Dutch IBD Biobank aims to facilitate the discovery of predictors for individual disease course and treatment response in patients with inflammatory bowel disease (IBD). In this paper, we aim to describe the establishment of the Dutch IBD Biobank, including the facilitators and barriers to establishment. Moreover, we aim to provide a complete overview of the content of the Dutch IBD Biobank. PARTICIPANTS:Since 2007, every patient with IBD treated in one of the eight Dutch university medical centres is asked to participate in the Dutch IBD Biobank in which 225 standardised IBD-related data items and biomaterials, such as serum, DNA, biopsies and a stool sample, are collected. FINDINGS TO DATE:As of June 2014, the Dutch IBD Biobank had enrolled 3388 patients with IBD: 2118 Crohn's disease (62.5%), 1190 ulcerative colitis (35.1%), 74 IBD-unclassified (2.2%) and 6 IBD-indeterminate (0.2%). The inclusion of patients with IBD is ongoing. The quality of the biomaterials is good and serum, DNA and biopsies have been used in newly published studies. FUTURE PLANS:The genotyping (750 000 genetic variants) of all participants of the Dutch IBD Biobank is currently ongoing, enabling more genetic research. In addition, all participants will start reporting disease activity and outcome measures using an online platform and mobile app.
journal_name
BMJ Openjournal_title
BMJ openauthors
Spekhorst LM,Imhann F,Festen EAM,van Bodegraven AA,de Boer NKH,Bouma G,Fidder HH,d'Haens G,Hoentjen F,Hommes DW,de Jong DJ,Löwenberg M,Maljaars PWJ,van der Meulen-de Jong AE,Oldenburg B,Pierik MJ,Ponsioen CY,Stokkers PCdoi
10.1136/bmjopen-2017-016695subject
Has Abstractpub_date
2017-11-08 00:00:00pages
e016695issue
11issn
2044-6055pii
bmjopen-2017-016695journal_volume
7pub_type
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