Effectiveness of influenza vaccines in adults with chronic liver disease: a systematic review and meta-analysis.

Abstract:

OBJECTIVES:Patients with liver disease frequently require hospitalisation with infection often the trigger. Influenza vaccination is an effective infection prevention strategy in healthy and elderly but is often perceived less beneficial in patients with liver disease. We investigated whether influenza vaccination triggered serological response and prevented hospitalisation and death in liver disease. DESIGN:Systematic review and meta-analysis. DATA SOURCES:MEDLINE, EMBASE, PubMed and CENTRAL up to January 2019. ELIGIBILITY CRITERIA:Randomised or observational studies of the effects of influenza vaccine in adults with liver disease. DATA EXTRACTION AND SYNTHESIS:Two reviewers screened studies, extracted data and assessed risk of bias and quality of evidence. Primary outcomes were all-cause hospitalisation and mortality. Secondary outcomes were cause-specific hospitalisation and mortality, and serological vaccine response. Random-effects meta-analysis was used to estimate pooled effects of vaccination. RESULTS:We found 10 041 unique records, 286 were eligible for full-text review and 12 were included. Most patients had viral liver disease. All studies were of very low quality. Liver patients both with and without cirrhosis mounted an antibody response to influenza vaccination, and vaccination was associated with a reduction in risk of hospital admission from 205/1000 to 149/1000 (risk difference -0.06, 95% CI -0.07 to 0.04) in patients with viral liver disease. Vaccinated patients were 27% less likely to be admitted to hospital compared with unvaccinated patients (risk ratio 0.73, 95% CI 0.66 to 0.80). No effect against all-cause or cause-specific mortality or cause-specific hospitalisation was found. CONCLUSIONS:The low quantity and quality of the evidence means that the protective vaccine effect may be uncertain. Considering the high risk of serious health outcomes from influenza infection in patients with liver disease and the safety and low cost of vaccination, overall, the potential benefits of seasonal vaccination both to patients and the healthcare systems are likely to outweigh the costs and risks associated with vaccination. PROSPERO REGISTRATION NUMBER:CRD42017067277.

journal_name

BMJ Open

journal_title

BMJ open

authors

Härmälä S,Parisinos CA,Shallcross L,O'Brien A,Hayward A

doi

10.1136/bmjopen-2019-031070

subject

Has Abstract

pub_date

2019-09-06 00:00:00

pages

e031070

issue

9

issn

2044-6055

pii

bmjopen-2019-031070

journal_volume

9

pub_type

杂志文章,meta分析

相关文献

BMJ Open文献大全
  • Social media and mobile health technology for cancer screening: a systematic review and meta-analysis protocol.

    abstract:INTRODUCTION:Cancer is one of the leading causes of death globally and many jurisdictions have developed population-based cancer screening programmes to reduce the public health burden of disease. However, screening participation remains suboptimal. Social media and other mobile health (mHealth) technologies are increa...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2019-035411

    authors: Ruco A,Dossa F,Tinmouth J,Llovet D,Kishibe T,Baxter NN MD PhD

    更新日期:2020-02-05 00:00:00

  • Association of acculturation with cardiac structure and function among Hispanics/Latinos: a cross-sectional analysis of the echocardiographic study of Latinos.

    abstract:OBJECTIVE:Hispanics/Latinos, the largest immigrant population in the USA, undergo the process of acculturation and have a large burden of heart failure risk. Few studies have examined the association of acculturation on cardiac structure and function. DESIGN:Cross-sectional. SETTING:The Echocardiographic Study of Lat...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2018-028729

    authors: López L,Swett K,Rodriguez F,Kizer JR,Penedo F,Gallo L,Allison M,Arguelles W,Gonzalez F,Kaplan RC,Rodriguez CJ

    更新日期:2019-11-28 00:00:00

  • When data are not missing at random: implications for measuring health conditions in the Behavioral Risk Factor Surveillance System.

    abstract:OBJECTIVES:To examine the effect on estimated levels of health conditions produced from large-scale surveys, when either list-wise respondent deletion or standard demographic item-level imputation is employed. To assess the degree to which further bias reduction results from the inclusion of correlated ancillary variab...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2011-000696

    authors: Frankel MR,Battaglia MP,Balluz L,Strine T

    更新日期:2012-07-12 00:00:00

  • Longitudinal Youth in Transition Study (LYiTS): protocol for a multicentre prospective cohort study of youth transitioning out of child and adolescent mental health services at age 18.

    abstract:INTRODUCTION:Transition between health services is widely recognised as a problematic hurdle. Yet, the factors necessary for successful transition out of child and adolescent mental health services (CAMHS) as youth reach the service boundary at age 18 are poorly understood. Further, fragmentation and variability among ...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2019-035744

    authors: Cleverley K,Bennett KJ,Brennenstuhl S,Cheung A,Henderson J,Korczak DJ,Kurdyak P,Levinson A,Pignatiello A,Stinson J,Voineskos AN,Szatmari P

    更新日期:2020-02-12 00:00:00

  • Protocol for a prospective longitudinal study of risk factors for hypertension incidence in a Mexico City population: the Tlalpan 2020 cohort.

    abstract:INTRODUCTION:Systemic hypertension (HTN) is a common risk factor for cardiovascular disease. In Mexico, HTN prevalence has increased over time and is currently 31%. Nonetheless, information about the country's HTN incidence and its associated risk factors is scarce. Understanding this condition is a priority for identi...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2017-016773

    authors: Colín-Ramírez E,Rivera-Mancía S,Infante-Vázquez O,Cartas-Rosado R,Vargas-Barrón J,Madero M,Vallejo M

    更新日期:2017-07-31 00:00:00

  • Acknowledging unreported problems with active surveillance for prostate cancer: a prospective single-centre observational study.

    abstract:OBJECTIVE:To report outcomes of patients with localised prostate cancer (PCa) managed with active surveillance (AS) in a standard clinical setting. DESIGN:Single-centre, prospective, observational study. SETTING:Non-academic, average-size hospital in Switzerland. PARTICIPANTS:Prospective, observational study at a no...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2015-010191

    authors: Hefermehl LJ,Disteldorf D,Lehmann K

    更新日期:2016-02-17 00:00:00

  • Multi-stakeholder perspectives of locally commissioned enhanced optometric services.

    abstract:OBJECTIVES:To explore views of all stakeholders (patients, optometrists, general practitioners (GPs), commissioners and ophthalmologists) regarding the operation of community-based enhanced optometric services. DESIGN:Qualitative study using mixed methods (patient satisfaction surveys, semi-structured telephone interv...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2016-011934

    authors: Baker H,Harper RA,Edgar DF,Lawrenson JG

    更新日期:2016-10-25 00:00:00

  • Nutrition interventions for children aged less than 5 years following natural disasters: a systematic review protocol.

    abstract:INTRODUCTION:Malnutrition among children is a serious public health problem in the aftermath of any natural disaster. We will review the various nutrition interventions for children aged <5 years in countries where natural disasters occurred and analyse the effect on nutrition-related outcomes. METHODS AND ANALYSIS:We...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2015-009525

    authors: Pradhan PM,Dhital R,Subhani H

    更新日期:2015-11-30 00:00:00

  • Availability and use of mHealth for disease diagnosis and treatment support by health workers in sub-Saharan Africa: a scoping review protocol.

    abstract:INTRODUCTION:Improving healthcare for all is one of the global health priorities, particularly in disease burdened settings such as sub-Saharan Africa (SSA). Considering the high penetration rate of mobile phones in SSA, mobile health (mHealth) could be used to achieve universal health coverage. The proposed study will...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2019-036641

    authors: Osei E,Kuupiel D,Mashamba-Thompson TP

    更新日期:2020-10-20 00:00:00

  • Determinants of return at work of breast cancer patients: results from the OPTISOINS01 French prospective study.

    abstract:INTRODUCTION:Return to work (RTW) after breast cancer (BC) is still a new field of research. The factors determining shorter sick leave duration of patients with BC have not been clearly identified. The aim of this study was to describe work during BC treatment and to identify factors associated with sick leave duratio...

    journal_title:BMJ open

    pub_type: 杂志文章,多中心研究

    doi:10.1136/bmjopen-2017-020276

    authors: Arfi A,Baffert S,Soilly AL,Huchon C,Reyal F,Asselain B,Neffati S,Rouzier R,Héquet D

    更新日期:2018-05-18 00:00:00

  • Retention in care prior to antiretroviral treatment eligibility in sub-Saharan Africa: a systematic review of the literature.

    abstract:OBJECTIVE:We aimed at summarising rates and factors associated with retention in HIV care prior to antiretroviral treatment (ART) eligibility in sub-Saharan Africa. DESIGN:We conducted a systematic literature review (2002-2014). We searched Medline/Pubmed, Scopus and Web of Science, as well as proceedings of conferenc...

    journal_title:BMJ open

    pub_type: 杂志文章,评审

    doi:10.1136/bmjopen-2014-006927

    authors: Plazy M,Orne-Gliemann J,Dabis F,Dray-Spira R

    更新日期:2015-06-24 00:00:00

  • Cluster randomised controlled trial of a guided self-help mental health intervention in primary care.

    abstract:OBJECTIVES:To ascertain whether an ultrabrief intervention (UBI) improves mental health outcomes for patients in general practice with mild-to-moderate mental health concerns. TRIAL DESIGN:Two-arm cluster randomised controlled trial. METHODS:Participants: general practitioners (GPs) were invited based on working in a...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2018-023481

    authors: Mathieson F,Stanley J,Collings CS,Tester R,Dowell A

    更新日期:2019-02-27 00:00:00

  • Impact of point-of-care panel tests in ambulatory care: a systematic review and meta-analysis.

    abstract:OBJECTIVES:This article summarises all the available evidence on the impact of introducing blood-based point-of-care panel testing (POCT) in ambulatory care on patient outcomes and healthcare processes. DESIGN:Systematic review and meta-analysis of randomised-controlled trials and before-after studies. DATA SOURCES:O...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2019-032132

    authors: Goyder C,Tan PS,Verbakel J,Ananthakumar T,Lee JJ,Hayward G,Turner PJ,Van Den Bruel A

    更新日期:2020-02-27 00:00:00

  • Disease history and risk of comorbidity in women's life course: a comprehensive analysis of the Japan Nurses' Health Study baseline survey.

    abstract:OBJECTIVE:To classify diseases based on age at peak incidence to identify risk factors for later disease in women's life course. DESIGN:A cross-sectional baseline survey of participants in the Japan Nurses' Health Study. SETTING:A nationwide prospective cohort study on the health of Japanese nurses. The baseline surv...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2014-006360

    authors: Nagai K,Hayashi K,Yasui T,Katanoda K,Iso H,Kiyohara Y,Wakatsuki A,Kubota T,Mizunuma H

    更新日期:2015-03-11 00:00:00

  • A survey of early health effects of the Eyjafjallajokull 2010 eruption in Iceland: a population-based study.

    abstract:OBJECTIVE:To estimate physical and mental health effects of the Eyjafjallajökull volcanic eruption on nearby residents. DESIGN:Cross-sectional study. SETTING:The Icelandic volcano Eyjafjallajökull erupted on 14 April 2010. The eruption lasted for about 6 weeks and was explosive, ejecting some 8 million tons of fine p...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2011-000343

    authors: Carlsen HK,Gislason T,Benediktsdottir B,Kolbeinsson TB,Hauksdottir A,Thorsteinsson T,Briem H

    更新日期:2012-03-08 00:00:00

  • Implementation of maternal and perinatal death reviews: a scoping review protocol.

    abstract:INTRODUCTION:Maternal and perinatal death surveillance and response (MPDSR), or any related form of audit, is a systematic process used to prevent future maternal and perinatal deaths. While the existence of MPDSR policies is routinely measured, measurement and understanding of policy implementation has lagged behind. ...

    journal_title:BMJ open

    pub_type: 杂志文章,评审

    doi:10.1136/bmjopen-2019-031328

    authors: Kinney MV,Walugembe DR,Wanduru P,Waiswa P,George AS

    更新日期:2019-11-27 00:00:00

  • Use of FMEA analysis to reduce risk of errors in prescribing and administering drugs in paediatric wards: a quality improvement report.

    abstract:OBJECTIVE:Administering medication to hospitalised infants and children is a complex process at high risk of error. Failure mode and effect analysis (FMEA) is a proactive tool used to analyse risks, identify failures before they happen and prioritise remedial measures. To examine the hazards associated with the process...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2012-001249

    authors: Lago P,Bizzarri G,Scalzotto F,Parpaiola A,Amigoni A,Putoto G,Perilongo G

    更新日期:2012-12-18 00:00:00

  • Evaluation of use and cost of medical care of common lumbar disorders in Korea: cross-sectional study of Korean Health Insurance Review and Assessment Service National Patient Sample data.

    abstract:OBJECTIVES:To assess medical care and costs of the 3 highest prevalence lumbar disorders-non-specific low back pain (nLBP), intervertebral disc disorder (IDD) and spinal stenosis (SS)-from national billing data to provide basic information for standards of appropriate management. DESIGN:Retrospective analysis of Natio...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2016-012432

    authors: Ahn YJ,Shin JS,Lee J,Lee YJ,Kim MR,Park KB,Lee JH,Shin KM,Ha IH

    更新日期:2016-09-12 00:00:00

  • Hepatitis B vaccination coverage, knowledge and sociodemographic determinants of uptake in high risk public safety workers in Kaduna State, Nigeria: a cross sectional survey.

    abstract:OBJECTIVES:To estimate hepatitis B vaccination (HBVc) coverage, and knowledge and sociodemographic determinants of full dose uptake in Federal Road Safety Corps (FRSC) members, Kaduna State, Nigeria, to inform relevant targeted vaccination policies. DESIGN:A cross sectional survey of FRSC members, Kaduna Sector Comman...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2017-015845

    authors: Ochu CL,Beynon CM

    更新日期:2017-06-02 00:00:00

  • Body composition: population epidemiology and concordance in Australian children aged 11-12 years and their parents.

    abstract:OBJECTIVES:Overweight and obesity remain at historically high levels, cluster within families and are established risk factors for multiple diseases. We describe the epidemiology and cross-generational concordance of body composition among Australian children aged 11-12 years and their parents. DESIGN:The population-b...

    journal_title:BMJ open

    pub_type: 杂志文章,多中心研究

    doi:10.1136/bmjopen-2018-023698

    authors: Clifford SA,Gillespie AN,Olds T,Grobler AC,Wake M

    更新日期:2019-07-04 00:00:00

  • Retrospective cohort study of clinical characteristics of 2199 hospitalised patients with COVID-19 in New York City.

    abstract:OBJECTIVE:The COVID-19 pandemic is a global public health crisis, with over 33 million cases and 999 000 deaths worldwide. Data are needed regarding the clinical course of hospitalised patients, particularly in the USA. We aimed to compare clinical characteristic of patients with COVID-19 who had in-hospital mortality ...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2020-040736

    authors: Paranjpe I,Russak AJ,De Freitas JK,Lala A,Miotto R,Vaid A,Johnson KW,Danieletto M,Golden E,Meyer D,Singh M,Somani S,Kapoor A,O'Hagan R,Manna S,Nangia U,Jaladanki SK,O'Reilly P,Huckins LM,Glowe P,Kia A,Timsina P

    更新日期:2020-11-27 00:00:00

  • An exploratory study of cannabis withdrawal among Indigenous Australian prison inmates: study protocol.

    abstract:INTRODUCTION:Cannabis use and dependence is a serious health and criminal justice issue among incarcerated populations internationally. Upon abrupt, enforced cessation of cannabis, prisoners may suffer irritability and anger that can lead to threatening behaviour, intimidation, violence, sleep disturbances and self-har...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2013-002951

    authors: Rogerson B,Copeland J,Buttner P,Bohanna I,Cadet-James Y,Sarnyai Z,Clough AR

    更新日期:2013-05-28 00:00:00

  • Delirium in an adult acute hospital population: predictors, prevalence and detection.

    abstract:BACKGROUND:To date, delirium prevalence and incidence in acute hospitals has been estimated from pooled findings of studies performed in distinct patient populations. OBJECTIVE:To determine delirium prevalence across an acute care facility. DESIGN:A point prevalence study. SETTING:A large tertiary care, teaching hos...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2012-001772

    authors: Ryan DJ,O'Regan NA,Caoimh RÓ,Clare J,O'Connor M,Leonard M,McFarland J,Tighe S,O'Sullivan K,Trzepacz PT,Meagher D,Timmons S

    更新日期:2013-01-07 00:00:00

  • Are trends in billing for high-intensity emergency care explained by changes in services provided in the emergency department? An observational study among US Medicare beneficiaries.

    abstract:OBJECTIVE:There has been concern that an increase in billing for high-intensity emergency care is due to changes in coding practices facilitated by electronic health records. We sought to characterise the trends in billing for high-intensity emergency care among Medicare beneficiaries and to examine the degree to which...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2017-019357

    authors: Burke LG,Wild RC,Orav EJ,Hsia RY

    更新日期:2018-01-30 00:00:00

  • 'Be on the TEAM' Study (Teenagers Against Meningitis): protocol for a controlled clinical trial evaluating the impact of 4CMenB or MenB-fHbp vaccination on the pharyngeal carriage of meningococci in adolescents.

    abstract:INTRODUCTION:Capsular group B Neisseria meningitidis (MenB) is the most common cause of invasive meningococcal disease (IMD) in many parts of the world. A MenB vaccine directed against the polysaccharide capsule remains elusive due to poor immunogenicity and safety concerns. The vaccines licensed for the prevention of ...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2020-037358

    authors: Carr J,Plested E,Aley P,Camara S,Davis K,MacLennan JM,Gray S,Faust SN,Borrow R,Christensen H,Trotter C,Maiden MCJ,Finn A,Snape MD,‘Be on the TEAM’ investigators.

    更新日期:2020-10-22 00:00:00

  • Patients' views about screening for atrial fibrillation (AF): a qualitative study in primary care.

    abstract:OBJECTIVES:There has been increased interest in screening for atrial fibrillation (AF) with commissioned pilot schemes, ongoing large clinical trials and the emergence of inexpensive consumer single-lead ECG devices that can be used to detect AF. This qualitative study aimed to explore patients' views and understanding...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2019-033061

    authors: Lown M,Wilcox CR,Hughes S,Santer M,Lewith G,Moore M,Little P

    更新日期:2020-03-18 00:00:00

  • Effects of participating in community assets on quality of life and costs of care: longitudinal cohort study of older people in England.

    abstract:OBJECTIVES:Improving outcomes for older people with long-term conditions and multimorbidity is a priority. Current policy commits to substantial expansion of social prescribing to community assets, such as charity, voluntary or community groups. We use longitudinal data to add to the limited evidence on whether this is...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2019-033186

    authors: Munford LA,Wilding A,Bower P,Sutton M

    更新日期:2020-02-06 00:00:00

  • Evaluation of cytokines as a biomarker to distinguish active tuberculosis from latent tuberculosis infection: a diagnostic meta-analysis.

    abstract:OBJECTIVES:With a marginally effective vaccine and no significant breakthroughs in new treatments, a sensitive and specific method to distinguish active tuberculosis from latent tuberculosis infection (LTBI) would allow for early diagnosis and limit the spread of the pathogen. The analysis of multiple cytokine profiles...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2020-039501

    authors: Qiu B,Liu Q,Li Z,Song H,Xu D,Ji Y,Jiang Y,Tian D,Wang J

    更新日期:2020-10-07 00:00:00

  • Design of an ecological momentary assessment study of exposure to radiofrequency electromagnetic fields and non-specific physical symptoms.

    abstract:INTRODUCTION:Idiopathic Environmental Intolerance (IEI) attributed to electromagnetic fields (EMF) refers to self-reported sensitivity mainly characterised by the attribution of non-specific physical symptoms to low-level EMF exposure emitted from sources such as mobile phones. Scientific studies have not provided evid...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2013-002933

    authors: Bogers RP,Bolte JF,Houtveen JH,Lebret E,van Strien RT,Schipper CM,Alkadhimi M,Baliatsas C,van Kamp I

    更新日期:2013-08-29 00:00:00

  • Refused and referred-persistent stigma and discrimination against people living with HIV/AIDS in Bihar: a qualitative study from India.

    abstract:OBJECTIVES:This study aimed to explore barriers to accessing care, if any, among people living with HIV/AIDS (PLHA) in two districts of Bihar. We also aimed to assess attitudes towards PLHA among healthcare providers and community members. DESIGN:This qualitative study used an exploratory study design through thematic...

    journal_title:BMJ open

    pub_type: 杂志文章

    doi:10.1136/bmjopen-2019-033790

    authors: Nair M,Kumar P,Pandey S,Harshana A,Kazmi S,Moreto-Planas L,Burza S

    更新日期:2019-11-25 00:00:00