Abstract:
OBJECTIVE:To provide a broader evidence summary to inform dietary guidelines of the effect of tree nuts on criteria of the metabolic syndrome (MetS). DESIGN:We conducted a systematic review and meta-analysis of the effect of tree nuts on criteria of the MetS. DATA SOURCES:We searched MEDLINE, EMBASE, CINAHL and the Cochrane Library (through 4 April 2014). ELIGIBILITY CRITERIA FOR SELECTING STUDIES:We included relevant randomised controlled trials (RCTs) of ≥3 weeks reporting at least one criterion of the MetS. DATA EXTRACTION:Two or more independent reviewers extracted all relevant data. Data were pooled using the generic inverse variance method using random effects models and expressed as mean differences (MD) with 95% CIs. Heterogeneity was assessed by the Cochran Q statistic and quantified by the I(2) statistic. Study quality and risk of bias were assessed. RESULTS:Eligibility criteria were met by 49 RCTs including 2226 participants who were otherwise healthy or had dyslipidaemia, MetS or type 2 diabetes mellitus. Tree nut interventions lowered triglycerides (MD=-0.06 mmol/L (95% CI -0.09 to -0.03 mmol/L)) and fasting blood glucose (MD=-0.08 mmol/L (95% CI -0.16 to -0.01 mmol/L)) compared with control diet interventions. There was no effect on waist circumference, high-density lipoprotein cholesterol or blood pressure with the direction of effect favouring tree nuts for waist circumference. There was evidence of significant unexplained heterogeneity in all analyses (p<0.05). CONCLUSIONS:Pooled analyses show a MetS benefit of tree nuts through modest decreases in triglycerides and fasting blood glucose with no adverse effects on other criteria across nut types. As our conclusions are limited by the short duration and poor quality of the majority of trials, as well as significant unexplained between-study heterogeneity, there remains a need for larger, longer, high-quality trials. TRIAL REGISTRATION NUMBER:NCT01630980.
journal_name
BMJ Openjournal_title
BMJ openauthors
Blanco Mejia S,Kendall CW,Viguiliouk E,Augustin LS,Ha V,Cozma AI,Mirrahimi A,Maroleanu A,Chiavaroli L,Leiter LA,de Souza RJ,Jenkins DJ,Sievenpiper JLdoi
10.1136/bmjopen-2013-004660subject
Has Abstractpub_date
2014-07-29 00:00:00pages
e004660issue
7issn
2044-6055pii
bmjopen-2013-004660journal_volume
4pub_type
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