Abstract:
:Tumor-associated macrophages play a central role in tumor progression and metastasis. Macrophages can also promote the resistance of malignant cells to chemotherapy by stimulating the upregulation of cytidine deaminase, an intracellular enzyme that catabolizes the active form of gemcitabine. Targeting macrophage-dependent chemoresistance may reduce tumor-associated morbidity and mortality.
journal_name
Oncoimmunologyjournal_title
Oncoimmunologyauthors
Amit M,Gil Zdoi
10.4161/onci.27231subject
Has Abstractpub_date
2013-12-01 00:00:00pages
e27231issue
12eissn
2162-4011issn
2162-402Xpii
2013ONCOIMM0321journal_volume
2pub_type
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