Abstract:
:Interleukin-12 immune stimulation lacks efficacy in established solid tumor models. Disruption of tumor microenvironment homeostasis by low-dose cyclophosphamide prior to interleukin-12 gene therapy led to CD8+ T cell-driven established tumor rejection. This only takes place when inflammatory myeloid cells infiltrate the tumor bed, and is crucial for the latter antitumor response.
journal_name
Oncoimmunologyjournal_title
Oncoimmunologyauthors
Medina-Echeverz J,Berraondo Pdoi
10.4161/onci.1.1.18049subject
Has Abstractpub_date
2012-01-01 00:00:00pages
118-120issue
1eissn
2162-4011issn
2162-402Xpii
2011ONCOIMM0030journal_volume
1pub_type
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