Abstract:
:The correlation between tumor-infiltrating lymphocyte (TIL)-expression of programmed cell death ligand 1 (PD-L1) and clinical responsiveness to the PD-1 blocking antibody nivolumab implicates adaptive immune evasion mechanisms in cancer. We review our findings that tumor cell PD-L1 expression is induced by interferon γ (IFNγ) producing TILs. We provide a mechanistic rationale for combining IFNγ+ T helper type 1 (Th1)-inducing cancer vaccines with PD-1 immune checkpoint blockade.
journal_name
Oncoimmunologyjournal_title
Oncoimmunologyauthors
Kim YJdoi
10.4161/21624011.2014.954868subject
Has Abstractpub_date
2015-01-07 00:00:00pages
e954868issue
12eissn
2162-4011issn
2162-402Xpii
954868journal_volume
3pub_type
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