Nebulised hypertonic saline solution for acute bronchiolitis in infants.

Abstract:

BACKGROUND:Airway oedema and mucus plugging are the predominant pathological features in infants with acute viral bronchiolitis. Nebulised hypertonic saline solution may reduce these pathological changes and decrease airway obstruction. OBJECTIVES:To assess the effects of nebulised hypertonic (≥ 3%) saline solution in infants with acute viral bronchiolitis. SEARCH METHODS:We searched CENTRAL 2013, Issue 4, OLDMEDLINE (1951 to 1965), MEDLINE (1966 to April week 4, 2013), EMBASE (1974 to May 2013), LILACS (1985 to May 2013) and Web of Science (1955 to May 2013). SELECTION CRITERIA:Randomised controlled trials (RCTs) and quasi-RCTs using nebulised hypertonic saline alone or in conjunction with bronchodilators as an active intervention and nebulised 0.9% saline as a comparator in infants up to 24 months of age with acute bronchiolitis. DATA COLLECTION AND ANALYSIS:Two review authors independently performed study selection, data extraction and assessment of risk of bias in included studies. We conducted meta-analyses using the Cochrane statistical package RevMan 5.2. We used the random-effects model for meta-analyses. We used mean difference (MD) and risk ratio (RR) as effect size metrics. MAIN RESULTS:We included 11 trials involving 1090 infants with mild to moderate acute viral bronchiolitis (500 inpatients, five trials; 65 outpatients, one trial; and 525 emergency department patients, four trials). All but one of the included trials were of high quality with a low risk of bias. A total of 560 patients received hypertonic saline (3% saline n = 503; 5% saline n = 57). Patients treated with nebulised 3% saline had a significantly shorter mean length of hospital stay compared to those treated with nebulised 0.9% saline (MD -1.15 days, 95% confidence interval (CI) -1.49 to -0.82, P < 0.00001). The hypertonic saline group also had a significantly lower post-inhalation clinical score than the 0.9% saline group in the first three days of treatment (day 1: MD -0.88, 95% CI -1.36 to -0.39, P = 0.0004; day 2: MD -1.32, 95% CI -2.00 to -0.64, P = 0.001; day 3: MD -1.51, 95% CI -1.88 to -1.14, P < 0.00001). The effects of improving clinical score were observed in both outpatients and inpatients. Four emergency department-based trials did not show any significant short-term effects (30 to 120 minutes) of up to three doses of nebulised 3% saline in improving clinical score and oxygen saturation. No significant adverse events related to hypertonic saline inhalation were reported. AUTHORS' CONCLUSIONS:Current evidence suggests nebulised 3% saline may significantly reduce the length of hospital stay among infants hospitalised with non-severe acute viral bronchiolitis and improve the clinical severity score in both outpatient and inpatient populations.

authors

Zhang L,Mendoza-Sassi RA,Wainwright C,Klassen TP

doi

10.1002/14651858.CD006458.pub3

subject

Has Abstract

pub_date

2013-07-31 00:00:00

pages

CD006458

issue

7

issn

1469-493X

pub_type

杂志文章,meta分析,评审
  • Sensory stimulation for brain injured individuals in coma or vegetative state.

    abstract:BACKGROUND:Coma and vegetative state follow traumatic brain injury in about one out of eight patients, and in patients with non traumatic injury the prognosis is worse. The use of sensory stimulation for coma and vegetative state has gained popularity during the 1980's but beliefs and opinions about its effectiveness v...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD001427

    authors: Lombardi F,Taricco M,De Tanti A,Telaro E,Liberati A

    更新日期:2002-01-01 00:00:00

  • Donepezil for mild and moderate Alzheimer's disease.

    abstract:BACKGROUND:Alzheimer's disease is the most common cause of dementia and is a primary degenerative disease of the brain of unknown cause. Onset is usually late in life with increasing impairment of memory, developing gradually into a global impairment of cognition, orientation, linguistic ability and judgement. The clin...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD001190

    authors: Birks J S,Melzer D

    更新日期:2000-01-01 00:00:00

  • Pentoxifylline for intermittent claudication.

    abstract:BACKGROUND:Intermittent claudication (IC) is a symptom of peripheral arterial disease (PAD) and is associated with high morbidity and mortality. Pentoxifylline, one of many drugs used to treat IC, acts by decreasing blood viscosity, improving erythrocyte flexibility, and promoting microcirculatory flow and tissue oxyge...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析

    doi:10.1002/14651858.CD005262.pub4

    authors: Broderick C,Forster R,Abdel-Hadi M,Salhiyyah K

    更新日期:2020-10-16 00:00:00

  • Methadone at tapered doses for the management of opioid withdrawal.

    abstract:BACKGROUND:Despite use in many countries of tapered methadone for detoxification from opiate, the evidence of efficacy to prevent relapse and promote lifestyle change has not been systematically evaluated. OBJECTIVES:To determine whether tapered methadone is effective to manage withdrawal from opioids. SEARCH STRATEG...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD003409

    authors: Amato L,Davoli M,Ferri M,Ali R

    更新日期:2002-01-01 00:00:00

  • Accommodative intraocular lens versus standard monofocal intraocular lens implantation in cataract surgery.

    abstract:BACKGROUND:Following cataract surgery and intraocular lens (IOL) implantation, loss of accommodation or postoperative presbyopia occurs and remains a challenge. Standard monofocal IOLs correct only distance vision; patients require spectacles for near vision. Accommodative IOLs have been designed to overcome loss of ac...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD009667.pub2

    authors: Ong HS,Evans JR,Allan BD

    更新日期:2014-05-01 00:00:00

  • Family therapy for anorexia nervosa.

    abstract:BACKGROUND:Anorexia Nervosa (AN) is characterised by distorted body image and deliberately maintained low body weight. The long term prognosis is often poor, with severe medical, developmental and psychosocial complications, high rates of relapse and mortality. Different variants of family therapy have been commonly us...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD004780.pub2

    authors: Fisher CA,Hetrick SE,Rushford N

    更新日期:2010-04-14 00:00:00

  • Mohs micrographic surgery versus surgical excision for periocular basal cell carcinoma.

    abstract:BACKGROUND:Basal cell carcinoma (BCC) is the commonest skin cancer in the white population. It is traditionally treated by surgical excision (SE) or by Mohs micrographic surgery (MMS). OBJECTIVES:The objective of this review was to compare the effectiveness, cost, complications and acceptability of periocular BCCs whe...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD007041.pub2

    authors: Narayanan K,Hadid OH,Barnes EA

    更新日期:2009-04-15 00:00:00

  • Medical treatment for early fetal death (less than 24 weeks).

    abstract:BACKGROUND:In most pregnancies that miscarry, arrest of embryonic or fetal development occurs some time (often weeks) before the miscarriage occurs. Ultrasound examination can reveal abnormal findings during this phase by demonstrating anembryonic pregnancies or embryonic or fetal death. Treatment has traditionally bee...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章

    doi:10.1002/14651858.CD002253.pub4

    authors: Lemmers M,Verschoor MA,Kim BV,Hickey M,Vazquez JC,Mol BWJ,Neilson JP

    更新日期:2019-06-17 00:00:00

  • Antibiotic treatment for Burkholderia cepacia complex in people with cystic fibrosis experiencing a pulmonary exacerbation.

    abstract:BACKGROUND:Chronic pulmonary infection is one of the hallmarks of lung disease in cystic fibrosis. Infections dominated by organisms of the Burkholderia cepacia complex, a group of at least 17 closely-related species of gram-negative bacteria, are particularly difficult to treat. These infections may be associated with...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD009529.pub2

    authors: Horsley A,Jones AM

    更新日期:2012-10-17 00:00:00

  • Donepezil for dementia due to Alzheimer's disease.

    abstract:BACKGROUND:Alzheimer's disease is the most common cause of dementia in older people. One of the aims of therapy is to inhibit the breakdown of a chemical neurotransmitter, acetylcholine, by blocking the relevant enzyme. This can be done by a group of chemicals known as cholinesterase inhibitors. However, some (like tac...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD001190

    authors: Birks JS,Harvey R

    更新日期:2003-01-01 00:00:00

  • Transcutaneous electrical nerve stimulation (TENS) for pain relief in labour.

    abstract:BACKGROUND:Transcutaneous nerve stimulation (TENS) has been proposed as a means of reducing pain in labour. The TENS unit emits low-voltage electrical impulses which vary in frequency and intensity. During labour, TENS electrodes are generally placed on the lower back, although TENS may be used to stimulate acupuncture...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD007214.pub2

    authors: Dowswell T,Bedwell C,Lavender T,Neilson JP

    更新日期:2009-04-15 00:00:00

  • Pericyazine for schizophrenia.

    abstract:BACKGROUND:Pericyazine is a 3-cyano-10 (3-4'-hydroxypiperidinopropyl) phenothiazine. It is overall pharmacologically similar with chlorpromazine, though particularly sedating. Dopamine receptor subtype analysis has not been performed for pericyazine, but the drug appears to induce greater noradrenergic than dopaminergi...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD007479.pub2

    authors: Matar HE,Almerie MQ,Makhoul S,Xia J,Humphreys P

    更新日期:2014-05-13 00:00:00

  • Music during caesarean section under regional anaesthesia for improving maternal and infant outcomes.

    abstract:BACKGROUND:Evidence on the benefits of music during caesarean section under regional anaesthesia to improve clinical and psychological outcomes for mothers and infants has not been established. OBJECTIVES:To evaluate the effectiveness of music during caesarean section under regional anaesthesia for improving clinical ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD006914.pub2

    authors: Laopaiboon M,Lumbiganon P,Martis R,Vatanasapt P,Somjaivong B

    更新日期:2009-04-15 00:00:00

  • Theory-based interventions for contraception.

    abstract:BACKGROUND:The explicit use of theory in research helps expand the knowledge base. Theories and models have been used extensively in HIV-prevention research and in interventions for preventing sexually transmitted infections (STIs). The health behavior field uses many theories or models of change. However, educational ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD007249.pub2

    authors: Lopez LM,Tolley EE,Grimes DA,Chen-Mok M

    更新日期:2009-01-21 00:00:00

  • Effect of partogram use on outcomes for women in spontaneous labour at term.

    abstract:BACKGROUND:The partogram (sometimes known as partograph) is usually a pre-printed paper form on which labour observations are recorded. The aim of the partogram is to provide a pictorial overview of labour, to alert midwives and obstetricians to deviations in maternal or fetal wellbeing and labour progress. Charts ofte...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD005461.pub3

    authors: Lavender T,Hart A,Smyth RM

    更新日期:2012-08-15 00:00:00

  • Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth.

    abstract:BACKGROUND:Both paracetamol and ibuprofen are commonly used analgesics for the relief of pain following the surgical removal of lower wisdom teeth (third molars). In 2010, a novel analgesic (marketed as Nuromol) containing both paracetamol and ibuprofen in the same tablet was launched in the United Kingdom, this drug h...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD004624.pub2

    authors: Bailey E,Worthington HV,van Wijk A,Yates JM,Coulthard P,Afzal Z

    更新日期:2013-12-12 00:00:00

  • Mucolytic agents for chronic bronchitis or chronic obstructive pulmonary disease.

    abstract:BACKGROUND:Individuals with chronic bronchitis or chronic obstructive pulmonary disease (COPD) may suffer recurrent exacerbations with an increase in volume and/or purulence of sputum. Because of the personal and healthcare costs associated with exacerbations, any therapy that reduces the number of exacerbations is use...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD001287.pub3

    authors: Poole P,Black PN

    更新日期:2010-02-17 00:00:00

  • Psychosocial interventions to reduce alcohol consumption in concurrent problem alcohol and illicit drug users.

    abstract:BACKGROUND:Problem alcohol use is common among illicit drug users and is associated with adverse health outcomes. It is also an important factor in poor prognosis among drug users with hepatitis C virus (HCV) as it impacts on progression to hepatic cirrhosis or opiate overdose in opioid users. OBJECTIVES:To assess the...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD009269.pub2

    authors: Klimas J,Field CA,Cullen W,O'Gorman CS,Glynn LG,Keenan E,Saunders J,Bury G,Dunne C

    更新日期:2012-11-14 00:00:00

  • WITHDRAWN: Heparin for the prevention of venous thromboembolism in general medical patients (excluding stroke and myocardial infarction).

    abstract:BACKGROUND:Venous thromboembolic disease has been extensively studied in surgical patients. The benefit of thromboprophylaxis is now generally accepted, but it is medical patients who make up the greater proportion of the hospital population. Medical patients differ from surgical patients with regard to their health an...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD003747.pub3

    authors: Alikhan R,Cohen AT

    更新日期:2010-02-17 00:00:00

  • End-of-life care pathways for improving outcomes in caring for the dying.

    abstract:BACKGROUND:In many clinical areas, integrated care pathways are utilised as structured multidisciplinary care plans which detail essential steps in caring for patients with specific clinical problems. Particularly, care pathways for the dying have been developed as a model to improve the end-of-life care of all patient...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD008006.pub2

    authors: Chan R,Webster J

    更新日期:2010-01-20 00:00:00

  • Antiretroviral therapy (ART) for treating HIV infection in ART-eligible pregnant women.

    abstract:BACKGROUND:This systematic review focuses on antiretroviral therapy (ART) for treating human immunodeficiency virus (HIV) infection in ART-eligible pregnant women. Mother-to-child transmission (MTCT) is the primary means by which children worldwide acquire HIV infection. MTCT occurs during three major timepoints during...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD008440

    authors: Sturt AS,Dokubo EK,Sint TT

    更新日期:2010-03-17 00:00:00

  • Antiviral prophylactic intervention for chronic hepatitis C virus in patients undergoing liver transplantation.

    abstract:BACKGROUND:It is not clear whether prophylactic antiviral therapy is indicated in patients undergoing liver transplantation for chronic decompensated hepatitis C virus (HCV) infection. OBJECTIVES:To compare the benefits and harms of different prophylactic anti-viral therapies for patients undergoing liver transplantat...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD006573.pub2

    authors: Gurusamy KS,Tsochatzis E,Davidson BR,Burroughs AK

    更新日期:2010-12-08 00:00:00

  • Inhaled non-steroid anti-inflammatories for children and adults with bronchiectasis.

    abstract:BACKGROUND:Chronic neutrophilic inflammation, both in the presence and absence of infection, is a feature of bronchiectasis in adults and children. The anti-inflammatory properties of non-steroid anti-inflammatory drugs (NSAIDs) may be beneficial in reducing airway inflammation and thus potentially improve lung functio...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD007525.pub2

    authors: Pizzutto SJ,Upham JW,Yerkovich ST,Chang AB

    更新日期:2010-04-14 00:00:00

  • Gowning by attendants and visitors in newborn nurseries for prevention of neonatal morbidity and mortality.

    abstract:BACKGROUND:Overgowns are widely used in newborn nurseries and neonatal intensive care units. It was thought that they may help to prevent the spread of nosocomial infection and serve as a reminder to staff and visitors to wash their hands before contacts with the infant. OBJECTIVES:The objective of this review was to ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD003670

    authors: Webster J,Pritchard MA

    更新日期:2003-01-01 00:00:00

  • Early enteral nutrition within 24 hours of lower gastrointestinal surgery versus later commencement for length of hospital stay and postoperative complications.

    abstract:BACKGROUND:This is an update of the review last published in 2011. It focuses on early postoperative enteral nutrition after lower gastrointestinal surgery. Traditional management consisted of 'nil by mouth', where patients receive fluids followed by solids after bowel function has returned. Although several trials hav...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析

    doi:10.1002/14651858.CD004080.pub3

    authors: Herbert G,Perry R,Andersen HK,Atkinson C,Penfold C,Lewis SJ,Ness AR,Thomas S

    更新日期:2018-10-24 00:00:00

  • Lifestyle intervention for improving school achievement in overweight or obese children and adolescents.

    abstract:BACKGROUND:The prevalence of overweight and obesity in childhood and adolescence is high. Excessive body fat at a young age is likely to persist into adulthood and is associated with physical and psychosocial co-morbidities, as well as lower cognitive, school and later life achievement. Lifestyle changes, including red...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD009728.pub2

    authors: Martin A,Saunders DH,Shenkin SD,Sproule J

    更新日期:2014-03-14 00:00:00

  • Adenoidectomy for otitis media in children.

    abstract:BACKGROUND:Adenoidectomy, surgical removal of the adenoids, is a common ENT operation worldwide in children with otitis media. A systematic review on the effectiveness of adenoidectomy in this specific group has not previously been performed. OBJECTIVES:To assess the effectiveness of adenoidectomy versus non-surgical ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD007810.pub2

    authors: van den Aardweg MT,Schilder AG,Herkert E,Boonacker CW,Rovers MM

    更新日期:2010-01-20 00:00:00

  • Honey and lozenges for children with non-specific cough.

    abstract:BACKGROUND:Chronic non-specific cough is a chronic, dry cough of in the absence of identifiable respiratory disease or known aetiology. Although it is usually not reflective of an underlying severe illness, it does cause significant morbidity, and as such relief from it is often sought. The use of honey and lozenges to...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD007523.pub2

    authors: Mulholland S,Chang AB

    更新日期:2009-04-15 00:00:00

  • Clonazepam add-on therapy for drug-resistant epilepsy.

    abstract:BACKGROUND:This is an updated version of the original Cochrane Review published in 2018, Issue 5. Epilepsy affects over 70 million people worldwide, and nearly a quarter of patients with seizures have drug-resistant epilepsy. People with drug-resistant epilepsy have increased risks of premature death, injuries, psychos...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章

    doi:10.1002/14651858.CD012253.pub3

    authors: Song L,Liu F,Liu Y,Zhang R,Ji H,Jia Y

    更新日期:2020-04-20 00:00:00

  • Intra-aortic balloon pump counterpulsation (IABP) for myocardial infarction complicated by cardiogenic shock.

    abstract:BACKGROUND:Intra-aortic balloon pump counterpulsation (IABP) is currently the most commonly used mechanical assist device for patients with cardiogenic shock due to acute myocardial infarction.Although there is only limited evidence by randomised controlled trials, the current guidelines of the American Heart Associati...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD007398.pub2

    authors: Unverzagt S,Machemer MT,Solms A,Thiele H,Burkhoff D,Seyfarth M,de Waha A,Ohman EM,Buerke M,Haerting J,Werdan K,Prondzinsky R

    更新日期:2011-07-06 00:00:00