Inducible transgenics. New lessons on events governing the induction and commitment in mammary tumorigenesis.

Abstract:

:Breast cancer arises from multiple genetic events that together contribute to the established, irreversible malignant phenotype. The development of inducible tissue-specific transgenics has allowed a careful dissection of the events required for induction and subsequent maintenance of tumorigenesis. Mammary gland targeted expression of oncogenic Ras or c-Myc is sufficient for the induction of mammary gland tumorigenesis in the rodent, and when overexpressed together the rate of tumor onset is substantially enhanced. In an exciting recent finding, D'Cruz et al discovered tetracycline-regulated c-Myc overexpression in the mammary gland induced invasive mammary tumors that regressed upon withdrawal of c-Myc expression. Almost one-half of the c-Myc-induced tumors harbored K-ras or N-ras gene point mutations, correlating with tumor persistence on withdrawal of c-Myc transgene expression. These findings suggest maintenance of tumorigenesis may involve a second mutation within the Ras pathway.

journal_name

Breast Cancer Res

authors

Hulit J,Di Vizio D,Pestell RG

doi

10.1186/bcr297

keywords:

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

209-12

issue

4

eissn

1465-5411

issn

1465-542X

journal_volume

3

pub_type

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