More breast cancer genes?

Abstract:

:A new gene associated with a high risk of breast cancer, termed BRCAX, may exist on chromosome 13q. Tumours from multicase Nordic breast cancer families, in which mutations in BRCA1 and BRCA2 had been excluded, were analyzed using comparative genomic hybridization in order to identify a region of interest, which was apparently confirmed and refined using linkage analysis on an independent sample. The present commentary discusses this work. It also asks why there should exist genetic variants associated with susceptibility to breast cancer other than mutations in BRCA1 and BRCA2, and what might be their modes of inheritance, allele frequencies and risks. Replication studies will be needed to clarify whether there really is a tumour suppressor gene other than BRCA2 on chromosome 13q.

journal_name

Breast Cancer Res

authors

Hopper JL

doi

10.1186/bcr290

keywords:

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

154-7

issue

3

eissn

1465-5411

issn

1465-542X

journal_volume

3

pub_type

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