Examining the impact of genetic testing for type 2 diabetes on health behaviors: study protocol for a randomized controlled trial.

abstract：BACKGROUND:Autism spectrum disorder (ASD) is found in approximately 1% of the population and includes core symptoms that affect general and social development. Beside these core symptoms, it is suggested that up to 60% of children with ASD suffer from comorbid anxiety disorders which may further affect educational, soc...

journal_title：Trials

authors： Kilburn TR,Sørensen MJ,Thastum M,Rapee RM,Rask CU,Arendt KB,Thomsen PH

更新日期：2018-04-02 00:00:00

abstract：BACKGROUND:In a sham-controlled double-blind trial, we aim to establish the efficacy and safety of the local application of laser therapy in patients with diabetes, onychomycosis and risk factors for diabetes-related foot complications. Onychomycosis leads to thickened and distorted nails, which in turn lead to increas...

journal_title：Trials

authors： Nijenhuis-Rosien L,Kleefstra N,Wolfhagen MJ,Groenier KH,Bilo HJ,Landman GW

更新日期：2015-03-22 00:00:00

abstract：INTRODUCTION:Sample size calculations require assumptions regarding treatment response and variability. Incorrect assumptions can result in under- or overpowered trials, posing ethical concerns. Sample size re-estimation (SSR) methods investigate the validity of these assumptions and increase the sample size if necessa...

journal_title：Trials

authors： Edwards JM,Walters SJ,Kunz C,Julious SA

更新日期：2020-12-04 00:00:00

abstract：BACKGROUND:Cardiovascular diseases are the major cause of death in the world. Current treatments have not been able to reverse this scenario, creating the need for the development of new therapies. Cell therapies have emerged as an alternative for cardiac diseases of distinct causes in experimental animal studies and m...

journal_title：Trials

authors： Tura BR,Martino HF,Gowdak LH,dos Santos RR,Dohmann HF,Krieger JE,Feitosa G,Vilas-Boas F,Oliveira SA,Silva SA,Bozza AZ,Borojevic R,de Carvalho AC

更新日期：2007-01-18 00:00:00

abstract：BACKGROUND:During the last decade, the use of ministernotomy in cardiac surgery has increased. Quality of life and patient satisfaction after ministernotomy have never been compared to conventional full sternotomy in randomised trials. The aim of the study is to determine if this minimally invasive approach improves qu...

journal_title：Trials

authors： Rodríguez-Caulo EA,Guijarro-Contreras A,Otero-Forero J,Mataró MJ,Sánchez-Espín G,Guzón A,Porras C,Such M,Ordóñez A,Melero-Tejedor JM,Jiménez-Navarro M

更新日期：2018-02-17 00:00:00

abstract：BACKGROUND:Effective recruitment is an essential element of successful research but notoriously difficult to achieve. This article examines health care professionals' views on the factors influencing decision-making regarding referral to a stroke rehabilitation trial. METHODS:Semi-structured interviews and a card-sort...

journal_title：Trials

authors： Thomas N,Plant S,Woodward-Nutt K,Prior Y,Tyson S

更新日期：2015-12-18 00:00:00

abstract：BACKGROUND:Isovolemic anemia (decrease in hemoglobin concentration with normal or even increased blood volume) after gastric cancer surgery may negatively influence short- and long-term outcomes. Therefore correction of isovolemic postoperative anemia is supposed to be beneficial. This prospective randomized placebo-co...

journal_title：Trials

authors： Reim D,Kim YW,Nam BH,Kim MJ,Yook JH,Park YK,Roh SH,Yu WS,Bae JM

更新日期：2014-04-05 00:00:00

abstract：BACKGROUND:Patient and public involvement (PPI) in studies carried out by the UK Medical Research Council Clinical Trials Unit (MRC CTU) at University College London varies by research type and setting. We developed a series of case studies of PPI to document and share good practice. METHODS:We used purposive sampling...

journal_title：Trials

authors： South A,Hanley B,Gafos M,Cromarty B,Stephens R,Sturgeon K,Scott K,Cragg WJ,Tweed CD,Teera J,Vale CL

更新日期：2016-07-29 00:00:00

abstract：BACKGROUND:There is considerable evidence showing that injured people who are involved in a compensation process show poorer physical and mental recovery than those with similar injuries who are not involved in a compensation process. One explanation for this reduced recovery is that the legal process and the associate...

journal_title：Trials

authors： Elbers NA,Akkermans AJ,Cuijpers P,Bruinvels DJ

更新日期：2013-07-20 00:00:00

abstract：BACKGROUND:Bariatric surgery is an effective approach to weight loss and long-term comorbidity resolution. Although recommended in several guidelines, supervised exercise has not been systematically prescribed after bariatric surgery. The aim of this study is to determine the effects of two types of exercise, moderate-...

journal_title：Trials

authors： Herrera-Santelices A,Tabach-Apraiz A,Andaur-Cáceres K,Zamunér AR

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:This randomized controlled clinical trial aims to evaluate the efficacy and safety of opposing needling in patients undergoing unilateral total knee arthroplasty (TKA). Opposing needling is one of the special needling methods used in acupuncture and moxibustion therapy. It involves needling acupoints on the ...

journal_title：Trials

authors： Huang H,Song X,Zhao L,Zheng L,Xiao L,Chen Y

更新日期：2020-05-07 00:00:00

abstract：BACKGROUND:With a survival rate of 6 to 11%, out-of-hospital cardiac arrest (OHCA) remains a healthcare challenge with room for improvement in morbidity and mortality. The guidelines emphasize the highest possible quality of cardiopulmonary resuscitation (CPR) and chest compressions (CC). It is essential to minimize CC...

journal_title：Trials

authors： Buléon C,Parienti JJ,Morilland-Lecoq E,Halbout L,Cesaréo E,Dubien PY,Jardel B,Boyer C,Husson K,Andriamirado F,Benet X,Morel-Marechal E,Aubrion A,Muntean C,Dupire E,Roupie E,Hubert H,Vilhelm C,Gueugniaud PY,CILICA-HS

更新日期：2020-07-08 00:00:00

abstract：BACKGROUND:Tinnitus is the perception of a sound in the absence of an objective physical source. Up to now, there is no generally accepted view how these phantom sounds come about, and also no efficient treatment. Patients are turning to complementary or alternative medical therapies, such as acupuncture. Based on the ...

journal_title：Trials

authors： Shi GX,Han LL,Liu LY,Li QQ,Liu CZ,Wang LP

更新日期：2012-11-23 00:00:00

abstract：BACKGROUND:Cognitive behavioural therapy is an effective treatment for depression. However, one third of the patients do not respond satisfactorily, and relapse rates of around 30 % within the first post-treatment year were reported in a recent meta-analysis. In total, 30-50 % of remitted patients present with residual...

journal_title：Trials

authors： Hvenegaard M,Watkins ER,Poulsen S,Rosenberg NK,Gondan M,Grafton B,Austin SF,Howard H,Moeller SB

更新日期：2015-08-11 00:00:00

abstract：BACKGROUND:Small incision lenticule extraction or SMILE is a novel form of 'flapless' corneal refractive surgery that was adapted from refractive lenticule extraction (ReLEx). SMILE uses only one femtosecond laser to complete the refractive surgery, potentially reducing surgical time, side effects, and cost. If success...

journal_title：Trials

authors： Ang M,Tan D,Mehta JS

更新日期：2012-05-31 00:00:00

abstract：BACKGROUND:Stroke is a common cause of cognitive impairment and dementia. However, effective strategies for reducing the risk of post-stroke dementia remain undefined. Potential strategies include intensive lowering of blood pressure and/or lipids. METHODS/DESIGN: DESIGN:multi-centre prospective randomised open-label...

journal_title：Trials

authors： Blackburn DJ,Krishnan K,Fox L,Ballard C,Burns A,Ford GA,Mant J,Passmore P,Pocock S,Reckless J,Sprigg N,Stewart R,Wardlaw J,Bath PM

更新日期：2013-11-22 00:00:00

abstract：BACKGROUND:This study was carried out as a prospective clinical field study with the aim of evaluating the clinical performance of Equia Fil® with a nanofilled resin coating and the conventional Fuji IX GP® fast with an LC coating according to the World Dental Federation (FDI) restoration material evaluation criteria. ...

journal_title：Trials

authors： Klinke T,Daboul A,Turek A,Frankenberger R,Hickel R,Biffar R

更新日期：2016-05-08 00:00:00

abstract：BACKGROUND:The Northwestern University Center for Education and Research on Therapeutics (CERT), funded by the Agency for Healthcare Research and Quality, is one of seven such centers in the USA. The thematic focus of the Northwestern CERT is 'Tools for Optimizing Medication Safety.' Ensuring drug safety is essential, ...

journal_title：Trials

authors： Przytula K,Bailey SC,Galanter WL,Lambert BL,Shrestha N,Dickens C,Falck S,Wolf MS

更新日期：2015-01-27 00:00:00

abstract：BACKGROUND:Despite recent advances in the medical and surgical fields, complications such as infection, pneumonia, or brain swelling may occur after a craniotomy. In some patients, perioperative antibiotic prophylaxis causes adverse effects such as itching, rash, or digestive conditions. Certain patients still develop ...

journal_title：Trials

authors： Cho SY,Yang SB,Shin HS,Lee SH,Koh JS,Kwon S,Jung WS,Moon SK,Park JM,Ko CN,Park SU

更新日期：2017-01-10 00:00:00

abstract：BACKGROUND:Postoperative knee swelling is common and impairs early postoperative function following total knee arthroplasty. It was hypothesised that the use of a short-stretch, inelastic compression bandage would reduce knee swelling and improve pain and early function. The aim of this study was to provide preliminary...

journal_title：Trials

authors： Brock TM,Sprowson AP,Muller S,Reed MR

更新日期：2017-01-09 00:00:00

abstract：BACKGROUND:Randomised controlled trials are being increasingly used to evaluate new surgical interventions. There are a number of problematic methodological issues specific to surgical trials, the most important being identifying whether patients are eligible for recruitment into the trial. This is in part due to the d...

journal_title：Trials

authors： Parsons NR,Kulikov Y,Girling A,Griffin D

更新日期：2011-12-13 00:00:00

abstract：BACKGROUND:Resistant hypertension is defined as an uncontrolled blood pressure despite treatment at best-tolerated doses with at least three antihypertensive agents including a diuretic. It is an emerging public health problem. At present clinical trial data on management of resistant hypertension is limited. Managemen...

journal_title：Trials

authors： Constantine GR,Ranasinghe P,Weeratunga P,Weeraratne C,Galappatthy P,Rajapakse S,Senarath U,Katulanda P

更新日期：2017-03-14 00:00:00

abstract：BACKGROUND:Bipolar disorder (BD) is commonly associated with cognitive and functional impairments even during remission periods, and although a growing number of studies have demonstrated the benefits of psychotherapy as an add-on to pharmacological treatment, its effectiveness appears to be less compelling in severe p...

journal_title：Trials

authors： Gomes BC,Rocca CC,Belizario GO,Lafer B

更新日期：2017-03-28 00:00:00

abstract：BACKGROUND:Young men in South Africa face concurrent epidemics of HIV, drug and alcohol abuse, and unemployment. Standard HIV prevention programs, located in healthcare settings and/or using counseling models, fail to engage men. Soccer and vocational training are examined as contexts to deliver male-specific, HIV prev...

journal_title：Trials

authors： Rotheram-Borus MJ,Tomlinson M,Mayekiso A,Bantjes J,Harris DM,Stewart J,Weiss RE

更新日期：2018-08-03 00:00:00

abstract：BACKGROUND:Process evaluations are an important component in the interpretation and understanding of outcomes in trials. The Online Remote Behavioural Intervention for Tics (ORBIT) study is a randomized controlled trial evaluating the effectiveness of an Internet-delivered behavioural intervention (called BIP TIC) comp...

journal_title：Trials

authors： Khan K,Hollis C,Hall CL,Davies EB,Mataix-Cols D,Andrén P,Murphy T,Brown BJ,Murray E,Glazebrook C

更新日期：2020-01-02 00:00:00

abstract：BACKGROUND:Cesarean delivery has already become a very common method of delivery around the world, especially in low-income countries. Hypertrophic scars and wound infections have affected younger mothers and frustrated obstetricians for a long time. Mesenchymal stem cells (MSCs) have strong potential for self-renewal ...

journal_title：Trials

authors： Fan D,Xia Q,Wu S,Ye S,Liu L,Wang W,Guo X,Liu Z

更新日期：2018-03-02 00:00:00

abstract：BACKGROUND:Depression Care for People with Lung Cancer is a complex intervention delivered by specially trained cancer nurses, under the supervision of a psychiatrist. It is given as a supplement to the usual care for depression, which patients receive from their general practitioner and cancer service. The third Sympt...

journal_title：Trials

authors： Walker J,Cassidy J,Sharpe M,SMaRT Oncology-3 Trialists.

更新日期：2009-09-30 00:00:00

abstract：BACKGROUND:Parkinson's Disease is a degenerative neurological condition that causes movement problems and other distressing symptoms. People with Parkinson's disease gradually lose their independence and strain is placed on family members. A multidisciplinary approach to rehabilitation for people with Parkinson's is re...

journal_title：Trials

authors： Gage H,Ting S,Williams P,Bryan K,Kaye J,Castleton B,Trend P,Wade D

更新日期：2011-11-23 00:00:00

abstract：BACKGROUND:Hospitalized older persons with Alzheimer's disease and related dementias are at greater risk for functional decline and increased care dependency after discharge due to a combination of intrinsic factors, environmental, policy, and care practices that restrict physical and cognitive activity, lack of family...

journal_title：Trials

authors： Boltz M,Kuzmik A,Resnick B,Trotta R,Mogle J,BeLue R,Leslie D,Galvin JE

更新日期：2018-09-17 00:00:00

abstract：BACKGROUND:Classroom-based stuttering intervention addressing negative peer attitudes, perceptions, teasing and bullying of children who stutter (CWS) is required as part of holistic stuttering management because of its occurrence in primary school. This study was conducted in 2017, in 10 primary schools in the Western...

journal_title：Trials

authors： Mallick R,Kathard H,Borhan ASM,Pillay M,Thabane L

更新日期：2018-11-29 00:00:00