当前位置： SCI文献检索 > 期刊下所有文献 > Second-Line Tests in the Diagnosis of Adrenocorticotropic Hormone-Dependent Hypercortisolism.

Second-Line Tests in the Diagnosis of Adrenocorticotropic Hormone-Dependent Hypercortisolism.

Abstract：

:Cushing's syndrome (CS) is a rare disease caused by chronic and excessive cortisol secretion. When adrenocorticotropin hormone (ACTH) is measurable, autonomous adrenal cortisol secretion could be reasonably ruled out in a differential diagnosis of CS. ACTH-dependent CS accounts for 80%-85% of cases and involves cortisol production stimulated by uncontrolled pituitary or ectopic ACTH secretion. Pituitary adenoma is not detected in up to one-third of cases with pituitary ACTH secretion, whereas cases of CS due to ectopic ACTH secretion may be associated with either malignant neoplasia (such as small cell lung carcinoma) or less aggressive neuroendocrine tumors, exhibiting only the typical symptoms and signs of CS. Since the differential diagnosis of ACTH-dependent CS may be a challenge, many strategies have been proposed. Since none of the available tests show 100% diagnostic accuracy, a step-by-step approach combining several diagnostic tools and a multidisciplinary evaluation in a referral center is suggested. In this review, we present a clinical case to demonstrate the diagnostic work-up of ACTH-dependent CS. We describe the most commonly used dynamic tests, as well as the applications of conventional or nuclear imaging and invasive procedures.

journal_name

Ann Lab Med

journal_title

Annals of laboratory medicine

authors

Pinelli S,Barbot M,Scaroni C,Ceccato F

doi

10.3343/alm.2021.41.6.521

keywords:

["Cushing’s syndrome","Differential diagnosis","Ectopic ACTH secretion","Pituitary adenoma"]

subject

Has Abstract

pub_date

2021-11-01 00:00:00

pages

521-531

issue

6

eissn

2234-3806

issn

2234-3814

pii

alm.2021.41.6.521

journal_volume

41

pub_type

杂志文章,评审

相关文献

文献大全